A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.
Contents: Interesting Research of the Week,Regulations/Policy, Reviews, Human Health Studies, Laboratory Studies, and Wildlife/Environment/Exposure Studies.
Interesting Research of the Week
Firm human evidence on harms of endocrine disrupting chemicals (EDCs) was unlikely to be obtainable for methodological reasons.
Regulations/Policy
Racial/Ethnic Disparities in Disease Burden and Costs Related to Exposure to Endocrine Disrupting Chemicals in the US: an Exploratory Analysis.
Advancements in Life Cycle Human Exposure and Toxicity Characterization.
In vitro-to-in vivo extrapolation (IVIVE) by PBTK modeling for animal-free risk assessment approaches of potential endocrine-disrupting compounds.
Integrated QSAR Models to Predict Acute Oral Systemic Toxicity.
Opinion of the Scientific Committee on Consumer Safety (SCCS) – Revision of the Opinion on hydroxyapatite (nano) in cosmetic products.
Best Practices for QSAR Model Reporting: Physical and Chemical Properties, Ecotoxicity, Environmental Fate, Human Health, and Toxicokinetics Endpoints.
Comparative estrogenicity of endogenous, environmental and dietary estrogens in pregnant women II: Total estrogenicity calculations accounting for competitive protein and receptor binding and potency.
Reviews
Role of Endocrine-Disrupting Engineered Nanomaterials in the Pathogenesis of Type 2 Diabetes Mellitus.
Early Life Origins of Asthma: A Review of Potential Effectors.
Distinguishing between endocrine disruption and non-specific effects on endocrine systems.
Pesticides
Pesticides and Related Toxicants in the Atmosphere.
Persistent Organic Pollutants/PFASs
Human epidemiological evidence about the associations between exposure to organochlorine chemicals and endometriosis: Systematic review and meta-analysis.
Persistent Organic Pollutants and Type 2 Diabetes: A Critical Review of Review Articles.
Socio-Economic Status and Health: Evaluation of Human Biomonitored Chemical Exposure to Per- and Polyfluorinated Substances across Status.
Arsenic
An overview of plant-based interventions to ameliorate arsenic toxicity.
Human Health Studies
BPA/Phenols/Phthalates/Triclosan
Association of serum levels of 4-tertiary-octylphenol with cardiovascular risk factors and carotid intima-media thickness in adolescents and young adults.
Urinary levels of bisphenol A, F and S and markers of oxidative stress among healthy adult men: Variability and association analysis.
Associations between Maternal Exposure to Bisphenol A or Triclosan and Gestational Hypertension and Preeclampsia: The MIREC Study.
Association between exposure to a mixture of phenols, pesticides, and phthalates and obesity: Comparison of three statistical models.
Association of Early Life Exposure to Phthalates With Obesity and Cardiometabolic Traits in Childhood: Sex Specific Associations.
Exposure to phthalates in couples undergoing in vitro fertilization treatment and its association with oxidative stress and DNA damage.
Exposure to phthalates aggravates pulmonary function and airway inflammation in asthmatic children.
Personal Care Products
Maternal urinary benzophenones and infant birth size: Identifying critical windows of exposure.
Persistent Organic Pollutants
Prenatal exposure to persistent organic compounds and their association with anogenital distance in infants.
Methodological issues in a prospective study on plasma concentrations of persistent organic pollutants and pancreatic cancer risk within the EPIC cohort.
Functional and structural liver abnormalities in former PCB exposed workers – analyses from the HELPcB cohort.
Perfluoroalkyl Substances
Perfluoroalkyl substances and kidney function in chronic kidney disease, anemia, and diabetes.
Perfluoroalkyl substances follow inverted U-shaped distributions across various stages of glomerular function: Implications for future research.
Flame Retardants
Exposure to polybrominated diphenyl ethers (PBDEs) during childhood and adiposity measures at age 8 years.
Pesticides
Estimated Residential Exposure to Agricultural Chemicals and Premature Mortality by Parkinson’s Disease in Washington State.
Arsenic/Metals
Urinary metals and leukocyte telomere length in American Indian communities: The Strong Heart and the Strong Heart Family Study.
Urinary metals and metal mixtures and oxidative stress biomarkers in an adult population from Spain: The Hortega Study.
Elevated arsenic exposure and efficient arsenic metabolism in indigenous women around Lake Poopó, Bolivia.
One-carbon metabolism nutrient intake and the association between body mass index and urinary arsenic metabolites in adults in the Chihuahua cohort.
Relative miRNA and mRNA expression involved in arsenic methylation.
Arsenic exposure and young adult’s mortality risk: A 13-year follow-up study in Matlab, Bangladesh.
PAHs
Cardiometabolic traits mediated the relationship from urinary polycyclic aromatic hydrocarbons metabolites to heart rate variability reduction: A community-based study.
Mediation effect of AhR expression between polycyclic aromatic hydrocarbons exposure and oxidative DNA damage among Chinese occupational workers.
Oil/Gas/Petrochemicals
Relationships between indicators of cardiovascular disease and intensity of oil and natural gas activity in Northeastern Colorado.
Increased cancers among residents living in the neighborhood of a petrochemical complex: A 12-year retrospective cohort study.
Laboratory Studies
Mixtures
In vitro estrogenic activity of representative endocrine disrupting chemicals mixtures at environmentally relevant concentrations. [BPA, phenols, phthalates]
BPA/Phenols
A novel experimental approach for liver analysis in rats exposed to Bisphenol A by means of LC-mass spectrometry and infrared spectroscopy.
Bisphenol S exposure affects gene expression related to intestinal glucose absorption and glucose metabolism in mice.
Reduced body weight at weaning followed by increased post-weaning growth rate interacts with part-per-trillion fetal serum concentrations of bisphenol A (BPA) to impair glucose tolerance in male mice.
Repeated exposure to 4-methyl-2,4-bis(4-hydroxyphenyl)pent-1-ene (MBP), an active metabolite of bisphenol A, aggressively stimulates breast cancer cell growth in an estrogen receptor β (ERβ)-dependent manner.
Bisphenol A as an environmental pollutant with dual genotoxic and DNA-protective effects.
Effects of BPA on expression of apoptotic genes and migration of ovine trophectoderm (oTr1) cells during the peri-implantation period of pregnancy.
Protective effects of selenium and nano-selenium on bisphenol-induced reproductive toxicity in male rats.
DPTIP, a newly identified potent brain penetrant neutral sphingomyelinase 2 inhibitor, regulates astrocyte-peripheral immune communication following brain inflammation.
Phoenixin Expression Is Regulated by the Fatty Acids Palmitate, Docosahexaenoic Acid and Oleate, and the Endocrine Disrupting Chemical Bisphenol A in Immortalized Hypothalamic Neurons.
In utero exposure to bisphenol A disrupts fetal testis development in rats.
Metabolic perturbation, proliferation and reactive oxygen species jointly contribute to cytotoxicity of human breast cancer cell induced by tetrabromo and tetrachloro bisphenol A.
The effects of Bisphenol A (BPA) on sympathetic nerve fibers in the uterine wall of the domestic pig.
Phthalates
Effects of DEHP on post-embryonic development, nuclear receptor expression, metabolite and ecdysteroid concentrations of the moth Spodoptera littoralis.
Maternal di-(2-ethylhexyl) phthalate exposure inhibits cerebellar granule precursor cell proliferation via down-regulating the Shh signaling pathway in male offspring.
Differences in root physiological and proteomic responses to dibutyl phthalate (DBP) exposure between low- and high-DBP accumulation cultivars of Brassica parachinensis.
The effect of di-2-ethylhexyl phthalate on inflammation and lipid metabolic disorder in rats.
Di-2-ethylhexylphthalate promotes thyroid cell proliferation and DNA damage through activating thyrotropin-receptor-mediated pathways in vitro and in vivo.
Interaction between three marine microalgae and two phthalate acid esters.
Persistent Organic Pollutants
Elucidation of endocrine-disrupting polychlorinated biphenyls binding potency with steroidogenic genes: Integration of in silico methods and ensemble docking approaches.
Polychlorinated biphenyl (PCB) tissue-concentration thresholds for survival, growth, and reproduction in fish.
Prenatal exposure to PCBs in Cyp1a2 knock-out mice interferes with F1 fertility, impairs long-term potentiation, reduces acoustic startle and impairs conditioned freezing contextual memory with minimal transgenerational effects.
2,3,7,8-Tetrachlorodibenzo-p-dioxin promotes migration ability of primary cultured rat astrocytes via aryl hydrocarbon receptor.
2,3,7,8‑Tetrachlorodibenzo‑p‑dioxin suppresses the growth of human liver cancer HepG2 cells in vitro: Involvement of cell signaling factors.
Perfluoroalkyl Substances
8:2 Fluorotelomer alcohol causes immunotoxicity and liver injury in adult male C57BL/6 mice. [precursors to PFASs]
Uptake and elimination of emerging polyfluoroalkyl substance F-53B in zebrafish larvae: Response of oxidative stress biomarkers.
The concentration of dissolved organic matter impacts the metabolic response in Daphnia magna exposed to 17α-ethynylestradiol and perfluorooctane sulfonate.
Hepatoprotective benefits of vitamin C against perfluorooctane sulfonate-induced liver damage in mice through suppressing inflammatory reaction and ER stress.
Stabilization of Liposomes by Perfluorinated Compounds.
Flame Retardants
Metabolic profiling study on potential toxicity in male mice treated with Dechlorane 602 using UHPLC-ESI-IT-TOF-MS.
Evaluation of development, locomotor behavior, oxidative stress, immune responses and apoptosis in developing zebrafish (Danio rerio) exposed to TBECH (tetrabromoethylcyclohexane).
Mutational analysis of pentabrominated diphenyl-induced hepatocellular tumors in rats and mice, tissue levels of PBDE congeners in rats and mice, and AhR genotyping of Wistar Han rats.
In vitro exposure to 2,2′,4,4′-tetrabromodiphenyl ether (PBDE-47) impairs innate inflammatory response.
Effects of organophosphate ester flame retardants on endochondral ossification in ex vivo murine limb bud cultures.
Pesticides
Atrazine hinders PMA-induced neutrophil extracellular traps in carp via the promotion of apoptosis and inhibition of ROS burst, autophagy and glycolysis.
In utero Exposure to Atrazine Disrupts Rat Fetal Testis Development.
Developmental toxicity of kresoxim-methyl during zebrafish (Danio rerio) larval development.
An imazamox-based herbicide causes apoptotic changes in rat liver and pancreas.
Arsenic/Metals
Impact of maternal low-level cadmium exposure on glucose and lipid metabolism of the litter at different ages after weaning.
Arsenic modifies serotonin metabolism through glucuronidation in pancreatic β-cells.
Comparative transcriptome analysis in the hepatopancreas of Helice tientsinensis exposed to the toxic metal cadmium.
Potential ability for metallothionein and vitamin E protection against cadmium immunotoxicity in head kidney and spleen of grass carp (Ctenopharyngodon idellus).
Immunosuppression, oxidative stress, and glycometabolism disorder caused by cadmium in common carp (Cyprinus carpio L.): Application of transcriptome analysis in risk assessment of environmental contaminant cadmium.
Taurine rescues the arsenic-induced injury in the pancreas of rat offsprings and in the INS-1 cells.
Enhanced histone H3K9 tri-methylation suppresses steroidogenesis in rat testis chronically exposed to arsenic.
The Effect of Mercury Chloride and Boric Acid on Rat Erythrocyte Enzymes.
Adaptions of Lichen Microbiota Functioning Under Persistent Exposure to Arsenic Contamination.
Role of thymoquinone and ebselen in the prevention of sodium arsenite-induced nephrotoxicity in female rats.
Organotins
Toxic function of CD28 involving in the TLR/MyD88 signal pathway in the river pufferfish (Takifugu obscurus) after exposed to tributyltin chloride (TBT-Cl).
The protective effects of Nile tilapia (Oreochromis niloticus) scale collagen hydrolysate against oxidative stress induced by tributyltin in HepG2 cells.
Pharmaceuticals
Early-life exposure to the endocrine disruptor 17-α-ethinylestradiol induces delayed effects in adult brain, liver and ovotestis proteomes of a self-fertilizing fish.
Feminization, altered gonadal development, and liver damage in least killifish (Heterandria formosa) exposed to sublethal concentrations of 17α-ethinylestradiol.
Comparison of steroidogenic gene expression in mummichog (Fundulus heteroclitus) testis tissue following exposure to aromatizable or non-aromatizable androgens.
Nanotechnology
Toxicological evaluation of metal oxide nanoparticles and mixed exposures at low doses using zebra fish and THP1 cell line.
Nanotoxicity Assessment Using Embryonic Zebrafish.
Foliar uptake of arsenic nanoparticles by spinach: an assessment of physiological and human health risk implications.
Wildlife/Environment/Exposure Studies
Variability Over Time
Correlation and temporal variability of urinary biomarkers of chemicals among couples: Implications for reproductive epidemiological studies.
Variations in repeated serum concentrations of UV filters, phthalates, phenols and parabens during pregnancy.
BPA/Phenols
Study on endocrine disruptors levels in raw milk from cow’s farms: Risk assessment.
Steroidal and phenolic endocrine disrupting chemicals (EDCs) in surface water of Bahe River, China: Distribution, bioaccumulation, risk assessment and estrogenic effect on Hemiculter leucisculus.
Testing baby bottles for the presence of residual and migrated bisphenol A.
Vertical profiles and distributions of aqueous endocrine-disrupting chemicals in different matrices from the Pearl River Delta and the influence of environmental factors.
Phthalates
Exposure to di-2-ethylhexyl terephthalate in the U.S. general population from the 2015-2016 National Health and Nutrition Examination Survey.
Phthalate Exposure in Pregnant Women: Risk Perception and Preventive Advice of Perinatal Health Professionals.
Parabens/Triclosan/Antimicrobials
Parabens and triclosan in shellfish from Shenzhen coastal waters: Bioindication of pollution and human health risks.
Persistent Organic Pollutants
Body burden of organohalogenated pollutants and polycyclic aromatic hydrocarbons in Romanian population: Influence of age, gender, body mass index, and habitat.
Temporal trends of persistent organic pollutants in Arctic marine and freshwater biota.
Temporal trends of persistent organic pollutants in Barents Sea polar bears (Ursus maritimus) in relation to changes in feeding habits and body condition.
Linking organochlorine contaminants with demographic parameters in free-ranging common bottlenose dolphins from the northern Adriatic Sea.
An unnoticed issue: Organochlorine pesticides in tobacco products around the world.
Complex effects of pollution on fish in major rivers in the Czech Republic.
Emission of Unintentionally Produced Persistent Organic Pollutants from Some Industrial Processes in Northern Vietnam.
Perfluoroalkyl Substances
Perfluoroalkyl substances in diamondback terrapins (Malaclemys terrapin) in coastal South Carolina.
Do concentrations of perfluoroalkylated acids (PFAAs) in isopods reflect concentrations in soil and songbirds? A study using a distance gradient from a fluorochemical plant.
Variation in PFAA concentrations and egg parameters throughout the egg-laying sequence in a free-living songbird (the great tit, Parus major): Implications for biomonitoring studies.
Flame Retardants
Polybrominated diphenyl ethers (PBDEs) in plasma from E-waste recyclers, outdoor and indoor workers in the Puget Sound, WA region.
Field evaluation of sequential hand wipes for flame retardant exposure in an electronics recycling facility.
Arsenic/Metals
Chemical fractionation of heavy metals in fine particulate matter and their health risk assessment through inhalation exposure pathway.
Long-term leaching of arsenic from pressure-treated playground structures in the northeastern United States.
Assessment of potentially toxic trace element contamination in urban allotment soils and their uptake by onions: A preliminary case study from Sheffield, England.
Inherent bacterial community response to multiple heavy metals in sediment from river-lake systems in the Poyang Lake, China.
The Effect of Environmental Factors on Total Arsenic Accumulation in Sarcodia suiae, Rhodophyta.
Heavy Metal and Metalloid Pollution of Soil, Water and Foods in Bangladesh: A Critical Review.
Assessment of Trace Metals in Consumer Chickens in Bangladesh.
Evaluation of Possible Human Health Risk of Heavy Metals from the Consumption of Two Marine Fish Species Tenualosa ilisha and Dorosoma cepedianum.
Organotins
Organotin contamination in commercial and wild oysters from China: Increasing occurrence of triphenyltin.
Pharmaceuticals
Environmentally-relevant mixture of pharmaceutical drugs stimulates sex-steroid hormone production and modulates the expression of candidate genes in the ovary of juvenile female rainbow trout.
Ecotoxicological effects, water quality standards and risk assessment for the anti-diabetic metformin.
Miscellaneous
Swine farm wastewater discharge causes masculinization of western mosquitofish (Gambusia affinis).
Potential toxicity of complex mixtures in surface waters from a nationwide survey of United States streams: Identifying in vitro bioactivities and causative chemicals.
Integrated chemical exposure assessment of coastal green turtle foraging grounds on the Great Barrier Reef.
This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different than dates added to PubMed. Compiled by Sarah Howard, Diabetes and Environment Program at Commonweal
