EDC Science Weekly, Oct. 30 – Nov. 5, 2026

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Events, Regulations/Policy, Methods/Tools/Screening, Commentaries, Reviews/Meta-Analyses, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Highlights:

The New Frontiers in Endocrine Disruption Research and Policy.
Parenteral Nutrition as a Source of Xenobiotic Exposure in Preterm Infants in a Single-Center Case Study.

Science summaries and highlights

Events

Nov. 7, 10, or 12: Grassroots advocacy trainings [Beyond Plastics]

Nov. 12 webinar: OECD work on assessment of children’s exposure to chemicals [Organisation for Economic Co-operation and Development]

Nov. 17 webinar: Reducing EDC Exposures: From informed consumers to policy solutions [EDC Strategies Partnership]

Nov. 17 webinar: Keeping Fracking Out and Reining Fracking In: Protecting Public Health with New Research Data [Catskill Mountainkeeper and NY PSR]

Nov. 17: Health and Chemicals Forum [Food Packaging Forum and NYU Grossman School of Medicine] in conjunction with:

Nov. 16-20 First International Conference: Global Framework on Chemicals [UNEP]

Nov. 17-18: UCSF Industry Documents Library Workshop [UCSF]

Nov. 19 webinar: Systems Thinking and Collaboration for One Health: Bridging Chemicals, Environment and Health in Europe [ECHA]

Nov. 25 webinar: ChemScore 2026 [ChemSec]

Dec. 7-8 workshop: Plastics, Microplastics, and Plastic Chemicals: Emerging Impacts on Human Heart, Lung, Blood, and Sleep Health [NIEHS and NHLBI]

Dec. 15 due date for Call for Papers: Microplastics, Community Health, and Public Health Actions [American Journal of Public Health]

Jan. 25, 2027 due date for abstracts: The Microplastics and Nanoplastics Summit, May 9-12, 2027 in Lincoln, Nebraska

Mar. 31, 2027 due date for Call For Papers: The Chemical Safety Knowledge Landscape: Mapping What We Know and What We Need to Know [ACS Publications]

Regulations/Policy

The New Frontiers in Endocrine Disruption Research and Policy.

Guidance on the data requirements for the safety assessment of bisphenols other than Bisphenol A (BPA) and their derivatives [EFSA]

More EDC policy, FPF’s regulations open for comment, and Science’s Trump-Tracker.

Methods/Tools/Screening

Testing strategy for the identification of thyroid hormone system disrupting chemicals.

Commentaries

Dr. Shanna Swan’s Legacy: Bridging Human and Animal Studies to Better Understand How Environmental Factors Impact Human Reproductive and Developmental Health.

PFAS: the persistent problem of forever chemicals and health.

Gone forever. [re PFAS]

PFAS: UK population exposure to be examined in new study.

What human biomonitoring can and cannot yet tell us about synthetic turf: an international research agenda, with Australia as a case example.

Reviews/Meta-Analyses

Numerous Chemicals/Mixtures

Environmental endocrine-disrupting chemicals as ototoxicants: a systematic review of epidemiological evidence.

PFAS

Effects of Perfluorohexane Sulfonic Acid on Female Reproductive Function and Oocyte Quality.

Per- and polyfluoroalkyl substances (PFAS) and cancer: knowledge mapping and emerging trends based on a bibliometric analysis.

Pesticides

Endocrine disrupting pesticides and fish hypothalamic-pituitary-gonadal (HPG) axis: a review on reproductive and developmental endpoints.

From Pesticide Exposure to Persistent Molecular Damage: An Integrated Framework of Genomic Instability, Epigenetic Dysregulation, and Long-Term Toxicity.

Pesticide exposure and risk of Parkinson’s disease: an umbrella review of systematic reviews and meta-analyses.

Metals/Metalloids

Combined Heavy Metal Exposure and Metabolic Health: Epidemiological Evidence, Mechanistic Pathways, and Mixture Toxicology.

The hidden threat: Integrated molecular mechanisms of lead-induced reproductive toxicity from endocrine disruption to epigenetic reprogramming.

From epidemiology to molecular pathology: current research status and future prospects on the role of toxic metal exposure in the development and progression of bladder cancer.

Microplastics/Nanomaterials

Microplastic exposure and obesity-related metabolic dysfunction: A proposed gut microbiota-metabolite framework.

Microplastics and human health: exposure pathways, toxicological evidence and mitigation strategies.

Micro- and nanoplastic exposure: male reproductive toxicity, underlying mechanisms, and research prospects.

Microplastics: a comprehensive overview of bioaccumulation, health impacts, global challenges, and green alternatives through bioplastic innovation.

From inert to uncertain: Polypropylene mesh degradation and the microplastics question – a narrative review of the literature.

Pharmaceutical-derived microplastics: sources, detection, and toxicological implications for patient safety.

The Pharmaceutical Exposome: Micro- and Nanoplastic Leaching From Primary Packaging and Its Toxicological Impact on the Human Gut Microbiota.

Thermal aging of microplastics during food processing: microplastic release and food safety implications.

Nanoplastics as Hepatic Toxicant Vectors: Interactions with Environmental Chemicals, Organelle Dysfunction, and Regulated Cell Death.

Nanoplastics-induced neurotoxicity: neurovascular dysfunction, cognitive impairment, and mechanisms of cell death.

Human Health Studies

Numerous Chemicals/Mixtures

Investigation of individual and cohort-level temporal changes to legacy and emerging endocrine disrupting chemical exposures and their relationship with birth outcomes.

Early pregnancy exposure to polycyclic aromatic hydrocarbons and phthalates: linear and nonlinear associations with fetal growth in a Chinese birth cohort.

Phenols/Phthalates/Parabens

Perinatal phthalate, paraben, and phenol exposure is associated with the neonatal metabolome measured in umbilical cord plasma.

Associations of environmental phenols exposure with gut microbiota in a general population from Shenzhen, China.

Urinary oxidative DEHP metabolites and advanced cardiovascular-kidney-metabolic syndrome: Evidence from NHANES and mechanistic insights into MECPP-related macrophage inflammatory-glycolytic activation.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

The ACCEPT birth cohort: Real-life serum mixtures of Persistent Organic Pollutants in pregnant women disrupt estrogen and androgen receptor transactivity and affect fetal growth.

PFAS

Intrauterine exposures to legacy and emerging PFAS in the first trimester and their associations with early pregnancy loss.

Flame Retardants

Mixture effects of organophosphate flame retardants on human semen quality and sex hormone levels: a weighted quantile sum regression analysis.

Pesticides

Serum concentrations of neonicotinoids and internal exposure linked to biomarkers of liver injury of Budd-Chiari syndrome population.

Metals/Metalloids

Cumulative exposure to heavy metals (chromium, copper, lead, manganese, mercury, nickel, and titanium) and age at natural menopause.

Microplastics/Nanomaterials

Early-Life Polyethylene Microplastic Exposure Exacerbates ADHD-Like Behaviors in Mice via PI3K/AKT1/Nrf2 Signaling: Evidence From the Pilot Cohort and Multi-Omics Analyses. [human and lab study]

Pharmaceuticals/Personal Care Products

Prenatal exposure to paracetamol is associated with smaller testicular volume: a COPANA cohort study of 287 healthy infant boys.

Miscellaneous

Prenatal exposure to perchlorate, thiocyanate, and nitrate: Associations with maternal thyroid function and child neurodevelopment in the MARBLES cohort.

Repeated Measurements of Urinary Polycyclic Aromatic Hydrocarbon Metabolites in relation to Ovarian Reserve and In Vitro Fertilization Outcomes: A Prospective Cohort Study.

Laboratory Studies

Numerous Chemicals/Mixtures

Combined exposure to triphenyl phosphate and haloperidol alters hepatic lipid homeostasis and xenobiotic metabolism beyond single-compound effects.

Effects of food simulants on overall migration and on the migration of metals, phthalates (DBP, DIBP, and DEHP), benzophenone, and BPA from virgin and recycled cellulosic packaging materials.

Bisphenols

Bisphenol S facilitates breast cancer progression through DRP1-mediated mitophagy.

Phthalates

Chronic Neurotoxicity of Di-2-ethylhexyl phthalate (DEHP) at no observed adverse effects level (NOAEL) doses on adult zebrafish links to Neuro-behavioral disorder.

CH5 benzothiazole schiff base protects against DEHP-induced testicular injury via involvement of COX-2-associated inflammatory signaling and spermatogenesis recovery in adult zebrafish.

Assessing the toxicological effects of di(2-ethylhexyl) phthalate on vascular diseases: Insights from network toxicology, Mendelian randomization, single-cell RNA sequencing, and experimental validation.

Life stage-specific endocrine disruption by Tris(2-ethylhexyl) trimellitate (TOTM) in zebrafish: Thyroid-neurobehavioral effects and metabolic-reproductive alterations. [a phthalate alternative]

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

2,4-Dichlorophenol induced sex hormone imbalance in zebrafish ovary via esr1-mediated cholesterol synthesis inhibition.

PFAS

Developmental PFAS exposure impairs host resistance and is associated with immune-developmental molecular signatures in marine medaka.

HFPO‑TA induces developmental hepatotoxicity in hESC‑derived hepatocyte‑like cells by disrupting lipid homeostasis and mitochondrial function.

Dose- and duration-dependent hepatotoxicity of PFO4DA: Divergent PPARα responses and conserved glucocorticoid receptor suppression.

PPAR/RXR Dysregulation Involved in Hepatic Lipid Accumulation in HFPO-TeA-Exposed Zebrafish: Insights from Multi-omics and Spatial Imaging.

Integrated multi-omics and experimental evidence implicate DVL3-associated Wnt/β-catenin signaling in PFHxS-related colorectal cancer progression.

Flame Retardants

Developmental exposure to PBDE-47 induces sex- and organ-specific glucose uptake alterations linked to thyroid hormone disruption in rats: phenotypic parallels to early cardiorenal-metabolic crosstalk.

Early Life Stage Exposure to Environmentally Relevant Concentrations of TCPP Induces Multigenerational Reproductive Toxicity in Estuarine Fish: A Study Based on Whole-Genome Methylation and Steroidogenesis Pathway.

Tributyl phosphate disrupts neuronal autophagy: potential involvement of TLR4 in cell and rat models.

Paternal Preconception Calcitriol Intervention Rescued DBDPE-Induced Transgenerational Developmental and Visual Toxicity in Zebrafish.

Pesticides

Prenatal low-dose glyphosate exposure impairs ovarian development in offspring rats via disruption of maternal tryptophan metabolism.

Glyphosate exposure alters the faecal corticosterone metabolite profile in a lizard: Validation and application of an enzyme immunoassay in Podarcis bocagei.

Pyriproxyfen Induces Reproductive Toxicity via Hormonal Disruption, Testicular Damage, and Altered Biochemical Parameters in Adult Male Sprague Dawley Rats.

Developmental Toxicity Induced by Waterborne Mancozeb Exposure in Zebrafish Larvae: Morphological, Cardiac, and Oxidative Alterations.

Towards realistic lower-tier toxicological testing: Species, sex and behaviour shape sensitivity to pesticide exposure.

Metals/Metalloids

MMP-9 and MMP-2 Contribute to Arsenic-Induced Blood-Brain Barrier Disruption Through Tight Junction Protein Loss in Cerebral Microvascular Endothelial Cells.

Chronic Arsenic Exposure Induces Hepatocyte Proliferation in Rats via the Gut-Liver Axis: Interventions With Fecal Microbiota Transplantation and/or Arsenic Withdrawal.

Microplastics/Nanomaterials

Co-exposure to octocrylene and polystyrene nanoplastics induces neuro- and reproductive toxicity in zebrafish: Association with circadian rhythm and HPG axis disruption.

Brain metabolomics reveals metabolic alterations associated with chronic polystyrene microplastic-induced neurotoxicity in Drosophila melanogaster.

Polystyrene nanoplastics exacerbate hepatic insulin resistance and glycolipid metabolism disorders in high‑fat diet‑induced obese mice.

Multi-omics reveals that polystyrene microplastic exposure induces bone loss in mice by disrupting intestinal glycine metabolism.

Nano-plastics disrupt systemic metabolism by remodeling the bile acid-microbiota axis and driving hepatic-intestinal dysfunction.

Molecular mechanism of microplastic intake promoting gastric epithelial cell carcinogenesis.

CA1-Associated Epithelial-State Remodeling in Colon Cancer Cells Exposed to Polystyrene Nanoplastics: Integrated Multi-Omics and In Vitro Analyses.

Detoxification-associated polyvinyl chloride micro- and nanoplastics clearance and liver metabolomic responses in mice.

Exposure/Environment Studies

Numerous Chemicals/Mixtures

Parenteral Nutrition as a Source of Xenobiotic Exposure in Preterm Infants in a Single-Center Case Study.

Phthalates

Behavior-weighted wearable passive sampling of personal airborne phthalate exposure among university students.

Parabens/Triclosan/Antimicrobials

Characterizing paraben exposure in the general Korean population (2015-2023): Temporal trends, vulnerable subgroups, and exposure determinants.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Breastfeeding duration and residential setting in relation to childhood exposure to organochlorine pesticides and PCBs: a longitudinal study of the Rhea cohort in Crete.

PFAS

Nationwide sustainability assessment of PFAS treatment in U.S. water utilities.

The Fate of Per- and Polyfluoroalkyl Substances (PFAS) in Municipal Solid Waste Incineration: Atmospheric Emissions from a Waste-to-Energy Plant.

Temporal trends and ecological predictors of PFAS in Great Lakes top predator fishes.

Global occurrence and monitoring coverage of PFAS pesticides in surface waters: ecological risks and persistent transformation-product concerns.

Pharmaceuticals/Personal Care Products

Three estrogens drive the majority of estrogenic activity in global rivers.

Regulatory aspects of risks posed by veterinary medicinal products to European necrophagous birds: A case study with nonsteroidal anti-inflammatory drugs (NSAIDs).

Miscellaneous

Tiered human health risk assessment of colorants of emerging regulatory concern in household products.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Industry-funded articles are included without notation. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. There are searchable archives. Compiled by Sarah Howard of Healthy Environment and Endocrine Disruptor Strategies (HEEDS), a program of Environmental Health Sciences.

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