EDC Science Weekly, Sept. 18-24, 2026

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Events, Regulations/Policy, Methods/Tools/Screening, Commentaries, Reviews/Meta-Analyses, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Highlights:

Science summaries and highlights

Events

Sept. 25 and future Fridays, webinar series: Coffee and Microplastics [University of New Mexico]

Sept. 30: Application due date for the HEEDS Lou Guillette Jr. Outstanding Young Investigator Award.

Oct. 1: Application due date for the Seeding Change/Agents of Change cohort.

Oct. 1 webinar: The regulatory shield: Defending Europe’s brain health in a volatile world [Brain Health Mission, European Academy of Neurology, Health and Environment Alliance]

Oct. 6 webinar: Glyphosate Science: Cancer, neurotoxicity & endocrine disruption [CHE]

Oct. 6 – Nov. 24 course: Plastics, Microplastics, and Human Health [Physician and Scientist Network Addressing Plastics and Health (P-SNAP)]

Oct. 8: Children’s Environmental Health Day [Children’s Environmental Health Network]

Oct. 13 workshop: What can nurses do about toxic chemicals? Toxics 101, Communicating Effectively About the Science and Health Effects & Opportunities for Action [Alliance of Nurses for Healthy Environments (ANHE)]

Oct. 13 Grand Rounds: Growing Up in a Chemical World: Emerging Contaminants and Children’s Health [New England PEHSU and Boston Children’s Hospital]

Nov. 17 forum: Health and Chemicals [Food Packaging Forum and NYU Grossman School of Medicine] in conjunction with:

Nov. 16-20 First International Conference: Global Framework on Chemicals [UNEP, in Geneva, Switzerland; register by Sept. 30]

Dec. 15 due date for Call for Papers: Microplastics, Community Health, and Public Health Actions [American Journal of Public Health]

Mar. 31 due date for Call For Papers: The Chemical Safety Knowledge Landscape: Mapping What We Know and What We Need to Know [ACS Publications]

Regulations/Policy

Protecting future generations from E-waste: Policy gaps and WHO’s call to action.

Advancing Regulatory Adoption of New Approach Methodologies.

More EDC policy, FPF’s regulations open for comment, and Science’s Trump-Tracker.

Methods/Tools/Screening

Rewriting paracelsus: linking chemical assessment to public health.

Artificial intelligence in toxicology: current advances, challenges and future directions.

Artificial Intelligence for Predictive Mixture Toxicology.

Liver-on-Chip Models as Miniaturized Platforms for In Vitro Hepatotoxicity Testing.

A practical decision-making approach for tiered in silico chemical hazard assessment based on the safe and sustainable by design framework.

The ethical and social significance of NAM terminology and definitions.

Commentaries

The actionable exposome.

Priming Metabolic Failure in an Obesogenic World: Programming of Food Preferences by Environmental Endocrine Disruptors.

Beyond the Single Chemical: A Systems Toxicology Perspective on Water Pollution in the Anthropocene.

Reviews/Meta-Analyses

Numerous Chemicals/Mixtures

Pollutants regulate changes in pathological markers of neurodegenerative diseases: a new perspective in environmental toxicology.

Sertoli cell oxidative stress as a convergent hazard endpoint for environmental toxicants: A systematic review, meta-analysis, and AOP-based assessment.

Advanced Detection and Monitoring of Foodborne Pollutants: Connecting Dietary Exposure to Health Risks.

Association between environmental endocrine disruptors and depression risk: a meta-analysis.

Global Scientometric Analysis of Research on Bisphenol and Other Endocrine-Disrupting Chemicals in Cardiovascular Disease; Trends, Collaboration Networks, and Thematic Shift.

Integrating High-Throughput Toxicity Testing with Mechanistic and Kinetic Modeling for Food Chemical Safety Assessment

PFAS

PFAS at the food-contact interface: transfer mechanisms, drivers, and alternatives.

Pesticides

Advances in the mechanisms of histone modification-mediated developmental toxicity induced by organophosphorus pesticides.

Metals/Metalloids

Systematic Review and Meta-Analysis on the Association Between Cadmium and Mercury, with Polycystic Ovary Syndrome.

Microplastics/Nanomaterials

Microplastics and Nanoplastics and Their Effects on Reproductive Health: Potential Risks and Mechanisms.

Microplastics and Human Cancer Risk: A Comprehensive Review of Environmental, Molecular, and Nanotoxicological Perspectives.

Microplastics in food production systems: Sources, exposure pathways, and gastrointestinal health effects.

Organ-specific apoptotic pathways induced by micro- and nanoplastics: a systematic review of in vitro toxicological evidence.

Microplastics and Nanoplastics: Potential Implications for Testicular Inflammation in Male Mammals.

From Oral Cavity to Whole Body: A Review of the Local and Systemic Toxicity Mechanisms and Health Risks of MNPs.

Microplastic and endocrine disruptor contamination in infant formula and early health effects: scoping review.

Plastisphere as a global hotspot for antimicrobial resistance: Systematic review and quantitative synthesis.

Human Health Studies

Numerous Chemicals/Mixtures

The chemical exposome during peri-pregnancy, maternal sleep outcomes post-pregnancy, and the potential mediating role of body mass index.

Joint effects of per- and polyfluoroalkyl substances and heavy metals on dyslipidemia: Integrated epidemiological and bioinformatics analysis.

Bisphenols

Beyond medication adherence: bisphenol exposure and its relationship with good glycemic control in type 2 diabetes.

Network pharmacology and molecular docking-based investigation on the mechanism of BPA in depression and experimental verification in offspring mice. [NHANES and lab study]

Phthalates

Prenatal exposure to DEHTP replacement metabolites and odds of preeclampsia and gestational hypertension in a diverse nulliparous U.S. cohort.

Parabens/Triclosan/Antimicrobials

Prenatal paraben exposure and neonatal birth outcomes: The modifying role of mid‑to‑late pregnancy weight gain rate.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Prenatal Exposure to Persistent Organic Pollutants Is Associated with Altered Lipid and Metabolomic Profiles in Mothers and Newborns.

PFAS

Maternal per- and polyfluoroalkyl substances exposure and the co-occurrence of gestational diabetes mellitus and preeclampsia/eclampsia: a nested case-control study.

Serum perfluorooctane sulfonate and perfluorooctanoic acid concentrations and longitudinal systemic lupus outcomes.

Association between mixed per- and polyfluoroalkyl substance exposure and thyroid hormone levels in the general population of Shandong, China.

Per- and polyfluoroalkyl substances levels other than PFOS, PFOA, or PFHxS and liver cancer risk: a nested case-control analysis.

Associations of per- and polyfluoroalkyl substances (PFAS) exposures and firefighting experience with microRNA signatures previously linked to Amyotrophic Lateral Sclerosis (ALS): a cross-sectional analysis of active-duty municipal and airport firefighters.

Per- and polyfluoroalkyl substances and kidney disease: Genetic associations and computational prioritization of candidate toxicogenomic pathways.

Socioeconomic Disparities in PFAS Exposure and Susceptibility to Diabetes in Chinese Adults: A Nationwide Cross-Sectional Study.

Pesticides

Mixture risk assessment of pesticides with acute neurotoxic effects: a novel approach based on urinary exposure biomarkers.

Metals/Metalloids

Association between prenatal trace element and toxic metal exposures and autism spectrum disorder symptoms in children: Potential mediating role of cord serum metabolites.

Association of mixed metal exposure with kidney injury and benchmark dose estimation in Chinese adults aged 40 years and older.

Pharmaceuticals/Personal Care Products

Elevated exposure to Benzophenone-type Ultraviolet filters Is associated with increased endometrial cancer Risk: Mediation by key metabolites.

Miscellaneous

Prenatal exposure to aromatic amines and associations with infant cognition in the ECHO.CA.IL cohorts.

Laboratory Studies

Numerous Chemicals/Mixtures

Transcriptomics-informed systems toxicology prioritizes candidate links between endocrine-disrupting chemicals and chronic kidney disease.

Bisphenols

Integrated multi-omics and experimental analyses reveal VIPR1 as a potential mediator linking environmental bisphenol A exposure to MASH-HCC progression.

Bisphenol A exposure confers resistance to cisplatin in ovarian cancer via ERα-dependent DDIT4-mTOR-AKT signaling.

Perinatal Bisphenol AP Exposure Induces Multigenerational Cardiometabolic Dysfunction via Dysregulation of Cholesterol Synthesis and Transport.

Bisphenol S exacerbates high-fat diet-induced obesity and insulin resistance in offspring: insights from a multi-tissue systemic lipidomic and proteomic atlas.

Gestational Low-Dose Bisphenol A Exposure Enhances Susceptibility to Metabolic Disorders in Adult Offspring Mice: Role of the Gut Microbiota-SCFAs-GPRs Axis.

Cannabis sativa L. stem ethanol extract suppresses ERα-mediated endocrine disrupting effects induced by bisphenol A in a breast cancer cell line.

Phthalates

Evidence of hormesis: Dose-dependent neuroprotective and neurotoxic effects of genistein in diethyl phthalate-exposed zebrafish.

Environmentally relevant phthalic acid exposure promotes pulmonary fibrogenesis through IL-1α/NF-κB pathway: Implications for microplastic-associated respiratory health risks.

PFAS

Gestational Exposure to Low-Dose PFOA During Organogenesis Induces Embryofetal Developmental Alterations in Rats.

Perfluorooctane sulfonate directly interacts with IRF3 to attenuate antiviral innate immunity.

Transport of Perfluoroalkyl Substances (PFAS) by Three Renal Transporters: Implications for PFAS Bioaccumulation Mechanisms.

Unlocking the Catalytic Potential of PFAS: Upcycling Forever Chemicals Into Effective Catalysts.

Flame Retardants

Gut microbiota and neurotransmitter network underlies EHDPP-induced neurotoxicity in zebrafish.

Long-term developmental alterations in intestinal microbiota, metabolism, and T-cell homeostasis in offspring rats following maternal tetrabromobisphenol A exposure.

Pesticides

2,4-dichlorophenoxyacetic acid (2,4-D) Potentiates Vanadium-Induced Parkinsonian Neurodegeneration: Evidence from Mitochondrial Bioenergetic Dysfunction and Dopaminergic and GABAergic Neurodegeneration.

Cyproconazole-Induced Systemic Neuro-Immunotoxicity: An Integrated In Vivo and In Silico Study of Oxidative Stress, NLRP3-Related Inflammatory Signaling, and Cholinergic Disruption.

Metals/Metalloids

Maternal arsenic exposure induces autism-like behaviors via astrocyte-mediated neuronal apoptosis: Protective effects of Taurine.

TDP-43 Post-transcriptionally Regulates SLC7A7 to Promote Ferroptosis and Metabolic Dysfunction-Associated Steatohepatitis upon Arsenic Exposure.

A comparative zebrafish atlas of metallic toxicity identifies vanadium as a multi-target neurobehavioral toxicant and reveals effective chelation protection.

Microplastics/Nanomaterials

Polystyrene microplastic uptake drives Inflammatory, Epitranscriptomic, and Metabolic Reprogramming in Human Aortic Endothelial cells.

Simultaneous challenge with polystyrene nanoplastics and BDE-47 elicits cooperative cytotoxic impairment in human spermatozoa.

Enhanced reproductive toxicity following co-exposure to disposable container leachates and alcohol involves proteomic identification.

Microplastic co-exposure increases PFAS bioaccumulation without universally amplifying toxicity in aquatic organisms: A multi-endpoint meta-analysis.

Differential sensitivity of Lemna minor and Moina macrocopa to polyethylene terephthalate (PET) microplastic fibers: hazard characterization and scenario-based risk assessment.

Exposure to Polystyrene Nanoplastics Induces Ferroptosis-Associated Cardiac Injury: Cell-Based Evidence for Lysosome-Associated NLRX1 Loss and an NLRX1-STING-NCOA4 Response.

The mechanism of vascular injury caused by polystyrene microplastics: Involving ferroptosis and metabolomics.

The Potential Immunotoxicity Induced by Long-Term Exposure to Polystyrene Nanoplastics in Rats.

Biointerface interactions and mechanistic ecotoxicity of polystyrene micro/nanoplastics and imidacloprid in juvenile Carassius auratus under single and combined exposure.

Lactational exposure to polystyrene nanoplastics induces oxidative stress, testicular histological alterations, and impaired sperm quality in rat offspring.

Tire Wear Chemicals

Single Tire-Derived Pollutant (6-PPD) Exposure Triggers Lung Injury and Mitochondrial Disruption in Mice.

Toxicity assessment of 6PPDQ and Its hydroxy metabolites in fish cell lines and coho salmon.

Environmental-related concentrations of 6PPD-quinone drives intestinal toxicity via neutrophil extracellular traps: A novel mechanism of rubber-additive contamination.

Exposure/Environment Studies

PFAS

Dietary and social predictors of PFAS exposure in Hispanic children from Northern Virginia.

Dietary exposure to per- and polyfluoroalkyl substances among the general population in Jinan, Shandong Province, China: An integrated approach combining deterministic assessment, probabilistic assessment, and the toxicological priority index.

Drinking waters contamination by per- and poly-fluoroalkyl substances of the anthropized area of Fos-Berre, France.

A Legacy of Exposure: Lactational PFAS Transfer and Early-Life Accumulation in Northern Elephant Seals.

Flame Retardants

Safe and Sustainable by Design Assessment of Flame Retardant Alternatives in Household Electronic Devices: A Comparison of Phosphinate-Based and Brominated Systems.

Metals/Metalloids

Speciation of Arsenic in Urine from the Health Effects of Arsenic Longitudinal Study (HEALS) Revealing New Arsenic Species and Individual Variability.

Microplastics/Nanomaterials

Microplastics in urban environments: The dog as a bioindicator of exposure and human gastrointestinal risk.

Landfill: time capsule of plastic waste but microplastic generation source.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Industry-funded articles are included without notation. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. There are searchable archives. Compiled by Sarah Howard of Healthy Environment and Endocrine Disruptor Strategies (HEEDS), a program of Environmental Health Sciences.

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