EDC Science Weekly, Aug. 14-20, 2026

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Events, Regulations/Policy, Methods/Tools/Screening, Commentaries, Reviews/Meta-Analyses, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Highlights:

Urinary bisphenol exposure and risk of type 1 diabetes and glycemic traits in Chinese children
Adolescent personal care product use and social media engagement in NJ high school students.
Multiple generation distinct toxicant exposures and epigenetic transgenerational inheritance of sex‑specific outcross impacts on sperm epigenetics and obesity pathology.

Science summaries and highlights

Events

Aug 20 (today!) webinar: Microplastics Updates: Monitoring Orders, Study Design, and Lessons Learned [Water Environment Federation]

Sept. 2 webinar: Plastic Expelled: Exposing Industry Propaganda in Schools [Plastic Pollution Coalition]

Sept. 15 webinar: The Social Cost of Plastic [Beyond Plastics, Duke, NRDC]

Sept. 22-23: 2026 Plastics and Human Health Symposium (in NYC with streaming) [NYU Langone Health’s Center for the Investigation of Environmental Hazards (CIEH) and the Food Packaging Forum]

Sept. 30: Application due date for the HEEDS Lou Guillette Jr. Outstanding Young Investigator Award.

Oct. 1: Application due date for the Seeding Change/Agents of Change cohort.

Oct. 6 webinar: Glyphosate Science: Cancer, neurotoxicity & endocrine disruption [CHE]

Dec. 15 due date for AJPH Call for Papers on Microplastics, Community Health, and Public Health Actions

Regulations/Policy

Tattoo Ink as a Chronic Intradermal Chemical Exposure: A Policy and Research Agenda for US Regulation

Less air pollution previously related to clean air and climate policies is linked to improved cognitive scores over time in NYC children.

Ethical and Scientific Consequences of Abrupt Federal Grant Terminations in Community-Engaged Environmental Health Research.

More EDC policy, FPF’s regulations open for comment, and Science’s Trump-Tracker.

Methods/Tools/Screening

Widespread environmental chemicals disrupt GRα and PPARγ signaling: Evidence from an integrated experimental and computational screening approach.

Toward internal threshold for toxicological concern: in vitro hepatocyte metabolism testing of 207 chemicals using cryopreserved suspended hepatocytes for physiologically based pharmacokinetic modeling.

Commentaries

Toxic chemicals: the fight for planetary health.

Putting endocrine signaling on the neurodevelopmental map.

Correction to “PFAS Toxicity: What’s True, What’s Not, and What Really Matters”.

Reviews/Meta-Analyses

Numerous Chemicals/Mixtures

Paternal Exposure to Endocrine Disrupting Chemicals and Couples’ Pregnancy Outcomes: A Qualitative Review of the Literature.

Bisphenols

Bisphenol A and Its Analogs: Toxicity Analysis in Mouse and Rat Liver-A Review.

Bisphenol A-Induced Nephrotoxicity: Mechanistic Insights Into Oxidative Stress, Inflammation, and Cellular Dysfunction.

PFAS

Hepatotoxicity of OBS: A Review of the Emerging PFOS Substitute.

Flame Retardants

Unraveling the mechanisms and drivers of brominated flame retardant toxicity in aquatic animals.

Metals/Metalloids

Friend and Foe?: Metals as Facilitators and Disruptors of Steroid Nuclear Receptor Signaling.

Microplastics/Nanomaterials

Microplastics and female infertility: reproductive toxicity and underlying mechanisms.

Microplastics and Male Reproductive Toxicity: Research Progress on Injury Pathways and Regulatory Mechanisms.

Effects of Micro- and Nanoplastic Exposure During Critical Developmental Periods on the Central Nervous System: A Systematic Review of Rodent Models.

The silent threat of microplastics: their impact on digestion and potential of co-carcinogenesis.

How harmless are alternative bioplastics? A review of their toxicological outcomes in aquatic organisms.

Human Health Studies

Bisphenols

Urinary bisphenol exposure and risk of type 1 diabetes and glycemic traits in Chinese children: a case-control study.

Linking bisphenol a exposure to pancreatic cancer: Evidence from population epidemiology, multi-omics screening, and cellular validation.

Phthalates

Investigation of Exposure to Plasticizers Among Electronic Waste Recycling Workers and Their Health: Protocol for a Cross-Sectional Study.

Parabens/Triclosan/Antimicrobials

Association between urinary paraben concentrations and skin cancer among US Adults.

[Association of urinary personal care products levels with diabetes in adults aged 18 years and above in China] [in Chinese].

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Associations between Pre-Disease Biomarkers of Persistent Organic Pollutants and Amyotrophic Lateral Sclerosis Survival in the Danish Diet, Cancer and Health Study Cohort.

PFAS

Prenatal PFAS Exposure and Early Childhood Sleep Quality in the ECHO Cohort.

Metabolomic signatures and sex-specific associations of prenatal per- and polyfluoroalkyl substances exposure with fetal growth: A meet-in-the-middle and high-dimensional mediation analysis.

Prenatal exposure to per- and polyfluoroalkyl substances and child bone mineral density from the Shanghai Birth Cohort.

Associations between PFAS exposure and 25-hydroxyvitamin D levels among Hispanic children.

Exposure to Poly- and Perfluoroalkyl Substances and Risk of Hepatocellular Carcinoma in Male Patients with Cirrhosis Related to Hepatitis C Virus Infection.

Integrating Lipid Metabolomics and Epidemiology: A Mediation Analysis of Blood Lipids between Per- and Polyfluoroalkyl Substances (PFAS) and Renal Impairment.

PFAS Penetrate the Bone Marrow Microenvironment and Alter Immunometabolic Homeostasis.

Correction to “Predictors of Serum Per- and Polyfluoroalkyl Substances (PFAS) Concentrations in a Rural Agricultural Community Affected by Biosolids Application”.

Flame Retardants

Higher Maternal Serum Alkyl-substituted Organophosphate Ester Concentrations at 9 to 13⁺⁶ Gestational Weeks Are Associated with Increased Birth Weight and Large-for-Gestational-Age Risk: A Prospective Cohort Study.

Prenatal Organophosphate Esters Exposure and Neonatal Birth Outcomes: A Cross-Sectional Study From an Electronic Waste Area.

Prenatal Exposure to Organophosphate Esters and Infantile Neurobehavior: Integrating the Gut Microbiome and Metabolome.

Pesticides

Associations between urinary dialkyl phosphate metabolites and cardiometabolic and kidney outcomes in U.S. children.

Visual expectation reaction time and attentional control associated with prenatal maternal biomarkers of organophosphate and pyrethroid exposures in a Thai birth cohort.

Urinary organophosphate metabolites, DNA methylation aging, and heart disease mortality in middle-aged and older adults: an exploratory cohort study with in vitro evidence of biological plausibility.

Metals/Metalloids

Metals in tap water across child care and home environments: association between lead and early childhood executive function.

Microplastics/Nanomaterials

Microplastics in pediatric asthma: Clinical associations with disease severity.

Air Pollution

Synergistic and antagonistic interactions of PM_2.5 with high and low temperatures on sperm motility: Evidence from a prospective cohort study.

Association between exposure to air pollution and age at natural menopause: The Study of Women’s Health Across the Nation.

Association of air pollution with diabetic microvascular complications: A prospective cohort study.

Miscellaneous

Human Exposure to Tire-Derived p-Phenylenediamines and 6PPD-Quinone: Associations with Thyroid Nodules and Mechanistic Insights.

Laboratory Studies

Numerous Chemicals/Mixtures

Multiple generation distinct toxicant exposures and epigenetic transgenerational inheritance of sex‑specific outcross impacts on sperm epigenetics and obesity pathology.

Postnatal Exposure Sensitizes for Zinc/Paraquat-Induced Neuronal Apoptosis, Adulthood Exposure Leads to the Final Effects.

Industrial phenolic compounds targeting 11β-hydroxysteroid dehydrogenase 2: A comparative in silico and structure-activity investigation in humans and rats.

Bisphenols

Tracing the epigenetic trajectory of EDC toxicity: Maternal BPAF drives uterine injuries via DNA methylation reprogramming.

In vitro characterization of the role of aryl hydrocarbon receptor and bisphenol A on IL-17A regulation in mouse and human CD4+ T cells.

Bisphenol A-mediated GPER1/PPARγ/ACC/FAS signaling induces de novo lipogenesis and lipid accumulation in luminal and triple-negative breast cancer cells to regulate epithelial-mesenchymal plasticity.

Assessment of Reproductive Risks of Bisphenol S in male BALB/c mice through functional histological and multi-omics investigations.

AMPK/mTOR/ULK1 Signaling Mediates NCOA4-Dependent Ferritinophagy in BPA-Induced Ferroptosis in HT-22 Hippocampal Neuronal Cells.

Bisphenol F Exposure Induces Ovarian Ferroptosis via the ERβ-ATM-Ferritinophagy Axis.

Phthalates

Computational Prediction of Hesperetin Modulatory Targets in Dibutyl Phthalate-Associated Steatotic Liver Injury: An Integrated Network Toxicology, Molecular Docking, and AOP-Based Study

Repeated exposure of bumblebee workers to field-realistic doses of di-2-ethylhexyl and di-n-butyl phthalates lowers worker survival and induces obesity-related phenotypes in workers and brood.

Topical exposure to di(2-ethylhexyl) phthalate aggravates atopic dermatitis: an integrated network toxicology, bioinformatics, and experiment analysis.

Parabens/Triclosan/Antimicrobials

Unraveling the association between triclosan and breast cancer: A multidimensional research strategy integrating machine learning, mendelian randomization, and molecular dynamics simulations.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Long-chain chlorinated paraffins exposure induces premature ovarian failure by disrupting the balance of mitochondrial fission.

PFAS

Chronic Perfluorooctanoic Acid Exposure in Young Adult Zebrafish Affects Scale and Internal Skeleton Bone Metabolism, as Well as Offspring Bone Development.

Integrative machine learning and single-nucleus transcriptomics reveal MAPK-centered neuronal responses underlying the potential Alzheimer’s disease risk of GenX.

Systems toxicology integration uncovers trophoblast apoptosis as a pivotal mechanism underlying PFAS-related recurrent miscarriage.

Integrated Computational and In Vivo Evidence Prioritizes MYH6 as a Candidate Node in PFOS-Associated HCM-like Cardiac Remodeling.

Impairment of placental function and maternal-fetal immunity cross-talk by per- and polyfluoroalkyl substances during early pregnancy.

Hijacked Pathways: PFOS, the ATF2/WT1 Axis, and the Mitochondrial Dysfunction in Sertoli Cells.

Flame Retardants

Integrative computational toxicology and experimental validation unveils ESR1-mediated steroidogenic disruption in triphenyl phosphate-induced female reproductive toxicity.

Neurobehavioral and metabolic consequences of embryonic triphenyl phosphate exposure across the lifespan in zebrafish.

Pesticides

Endoplasmic Reticulum Stress Is Involved in Chronic Chlorpyrifos-Induced Jejunal Barrier Injury in Weaned Mice.

Multi-Omics Analysis Reveals Coordinated Epigenetic Dysregulation in Atrazine-Induced Dopaminergic Neurotoxicity.

Low-Dose Chlorothalonil Induces Testicular Injury Through Disruption of Steroidogenic Signaling in Adult Male Mice.

Metals/Metalloids

Protective Effects of Metformin and Memantine Against Arsenic-Induced Neurotoxicity: Insights from In-Silico and In-Vivo Studies.

Sex Differences in Oxidative Stress and Depression-Like Behavior Following Chronic Lead Exposure from Pregnancy to Adulthood.

Microplastics/Nanomaterials

Early-life exposure to polypropylene microplastics and DEHP induces ASD-relevant neurodevelopmental alterations involving mTOR-regulated autophagy impairment.

Maternal co-exposure to polystyrene microplastics and DEHP impairs thyroid function in adult rat offspring.

Single-nucleus transcriptomics reveals cell-type-resolved brain responses to concurrent exposure to polyethylene nanoplastics and butyl benzyl phthalate.

Acute In Vitro Effects of Polystyrene Microplastics on Cell Viability, Oxidative Status, and DNA Integrity in Zebrafish Erythrocytes.

Distinct cellular responses in liver macrophages to short- and long-term exposure to pristine and artificially aged polystyrene microplastic particles.

Polyethylene microplastics affect osmoregulation, overall metabolism and induce anxiety in zebrafish.

Dietary patterns reshape organ-specific biodistribution and toxicity upon exposure to polystyrene nanoplastics: Role of ROS-mediated intestinal senescence.

Air Pollution

Association of prenatal exposure to PM_2.5 and its chemical constituents with early childhood obesity: A population-based study.

Tire Wear Chemicals

Physiological vulnerability drives species-specific toxicity of 6PPD-Q in salmonids revealed by a damage-coupled biokinetic model.

Peri-implantation 6PPD-Q exposure impairs endometrial decidualization and induces pregnancy loss.

6PPDQ Exposure Induces Mammary Developmental Damage through Mitochondrial Dysfunction Mediated by the p38 MAPK Signaling Pathway.

Exposure/Environment Studies

Phthalates

Phthalates in sediments and aquatic biota across 30 rivers in Taiwan-long-term background monitoring of the environmental distribution of chemical substances trends, congener shifts, and ecological risks.

PFAS

Retraction notice to “Perfluorinated compound correlation between human serum and drinking water: Is drinking water a significant contributor?” [Sci. Total Environ. 873 (2023) 162471].

Exposure to PFAS induced differential oxidative stress-related responses in nestlings of two resident passerine birds nearby a Fluoropolymer Production Plant.

Flame Retardants

Dechlorane Plus isomers in Andean condors across Chile: spatial patterns and isotopic associations.

Pesticides

Rethinking crop protection: EU trends in low-risk and basic substances as alternatives to conventional pesticides.

Metals/Metalloids

Mercury in skin lightening and skin care products purchased in New York City, 2009-2022.

Microplastics/Nanomaterials

Microplastic exposure through coffee consumption: evidence from instant and ground brewed coffee.

Microplastic Emissions from Domestic Laundry in China.

Additive fingerprinting of airborne plastic-related particulate matter in occupational environments: Insights from targeted and untargeted analysis.

Pharmaceuticals/Personal Care Products

Adolescent personal care product use and social media engagement: a pilot study in NJ high school students.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Industry-funded articles are included without notation. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. There are searchable archives. Compiled by Sarah Howard of Healthy Environment and Endocrine Disruptor Strategies (HEEDS), a program of Environmental Health Sciences.

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