EDC Science Weekly, July 31 – Aug. 6, 2026

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Events, Regulations/Policy, Methods/Tools/Screening, Reviews/Meta-Analyses, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Events

Sept. 15 webinar: The Social Cost of Plastic [Beyond Plastics, Duke, NRDC]

Sept. 22-23: 2026 Plastics and Human Health Symposium (in NYC with streaming) [NYU Langone Health’s Center for the Investigation of Environmental Hazards (CIEH) and the Food Packaging Forum]

Sept. 30: Application due date for the HEEDS Lou Guillette Jr. Outstanding Young Investigator Award.

Oct. 1: Application due date for the Seeding Change/Agents of Change cohort.

Oct. 6 webinar: Glyphosate Science: Cancer, neurotoxicity & endocrine disruption [CHE]

Regulations/Policy

Planetary Boundary for Novel Entities: Time for a Reboot

Sweden plans to restrict PFAS.

Scientific Opinion on waiving of the dog studies in the regulatory process of agrochemicals approval.

Global Framework for Lip Product Safety: A Review of the Regulatory Blind Spot in the Modern Market.

The Permeable Lip: A Critical Knowledge Gap for Systemic Exposure to Lip Cosmetic Chemicals.

More EDC policy, FPF’s regulations open for comment, and Science’s Trump-Tracker.

Methods/Tools/Screening

Editorial: European partnership on the assessment of risks from chemicals (PARC): continued focus on new approach methodologies (NAMs) and data gap filling.

Report of collaboration to harmonise the assessment of next generation evidence (CHANGE) 2nd workshop in Oslo, June 24 – 26, 2025 – participants perspectives on the Change working methodology

Integrated approaches to testing and assessment (IATA) for the estrogenic response of 14 commonly used chemicals in consumer products.

From application-first to science-first: A two-phase validation framework for complex in vitro NAMs.

AOP report: Adverse outcome pathway network for developmental androgen signaling inhibition leading to hypospadias.

Reviews/Meta-Analyses

Numerous Chemicals/Mixtures

Precocious puberty in boys: current insights into etiology, genetic advances, and environmental factors.

Chemical Exposures as Risk Factors for the Development of Thyroid Cancer.

The silent threats on plate: health impacts of established and emerging foodborne toxins and contaminants.

Environment and health impacts of synthetic food packaging: materials, synthesis, causes, and potential solutions.

Environmental Pollutants and Testicular Toxicity in Male Reproductive Health: Basic Evidence and Translational Prospects – A Narrative Review.

PFAS

Prenatal PFAS exposure and offspring health: evidence review and implications for intergenerational risk assessment.

Pesticides

Postnatal Exposure to Current Use Pesticides and Neurodevelopmental Outcomes in Children and Adolescents: A Systematic Review.

Agricultural chemicals and gut microbiota dysbiosis: implications for the pathogenesis of inflammatory bowel disease.

Occupational exposure to pesticides increases the risk of amyotrophic lateral sclerosis: a systematic review and meta-analysis.

Metals/Metalloids

Impact of common heavy metals and trace elements on semen quality: a meta-analysis and bibliometrics.

Association Between Heavy Metal Exposure and Autism Spectrum Disorders: Discrepancies, Research Gaps, and Future Priorities of Human Epidemiological Studies.

Elevated Exposure to Lead, Mercury, or Chromium in Relation to Polycystic Ovary Syndrome: A Meta Analysis.

Microplastics/Nanomaterials

Micro(nano)plastics as Dynamic Vectors for Hazardous Agents: Bridging Environmental Transport to Health Impacts.

Micro- and nanoplastics as emerging disruptors of Leydig cell function: A systematic review of experimental evidence.

Micro-nanoplastics in Cardiovascular Disease: A Critical Update from Environmental Exposure to Clinical Implications.

The link between microplastics and colorectal cancer.

Dietary coexposure to micro- and nano-plastics and metabolism-disrupting chemicals: Combined hepatotoxicity – insights from mammalian and cellular models.

Human Health Studies

Numerous Chemicals/Mixtures

Cardiovascular risks of plastic-associated chemicals: Integrating mixture modeling and SHAP-explained machine learning to unravel linear and non-linear associations.

A pilot autism case-control study of pesticides and plasticizers in shed baby teeth.

Phthalates

Conditional neuroprotection: Blood selenium attenuates the cognitive toxicity of DEHP metabolites in older adults.

Urinary monoester phthalate metabolites and thyroid function in healthy adults: Sex- and obesity-specific associations.

PFAS

Association of PFAS exposure with maternal blood pressure and hypertension during pregnancy in the PROTECT cohort.

Associations between serum per- and polyfluoroalkyl substances and serum metabolomic profiles in elite athletes: a cross-sectional multi-sport study.

Per- and polyfluoroalkyl substances and type 2 diabetes risk: Evidence from metabolomics and triglyceride-glucose index-related pathways.

Healthy lifestyle modifies the association between per- and polyfluoroalkyl substances and hyperlipidemia: A propensity score-matched case-control study.

Flame Retardants

Organophosphate Flame Retardants Exposure Disrupts Serum Lipid Metabolism and Induces Hepatotoxicity: Evidence from the Population and Mouse Model.

Pesticides

Serum Molecular Fingerprints of Oxidative Stress Underlying Neurocognitive and Motor Dysfunction in Pesticide-Exposed Populations.

Glyphosate’s role in renal tubular injury at low exposure levels: evidence from a patient cohort.

Metals/Metalloids

Association between heavy metal exposure and epigenetic modifications in patients with urinary bladder cancer.

Microplastics/Nanomaterials

Dose-dependent association of prenatal microplastic exposure with gestational diabetes Mellitus: A prospective cohort analysis.

Laboratory Studies

Numerous Chemicals/Mixtures

The EDC mixture ‘NeuroMix’ Alters Neuroendocrine Physiology, Fatty Food Preference, and the Central Reward Transcriptome.

Chronic exposure to mining-contaminated borehole water impairs the entire male reproductive axis: partial mitigation by alpha-lipoic acid in Wistar rats.

Bisphenols

Bisphenol A disrupts mitochondrial homeostasis and promotes metabolic alterations in cervical cancer cells.

Endoplasmic reticulum stress is associated with cardiac effects of bisphenol S independently of a high-fat diet.

BPAF-induced inflammatory response via estrogen signaling: insights from in vivo and in vitro evidence.

In vivo and in silico analyses reveal hub genes drive Bisphenol A-induced metabolic dysfunction in male Drosophila melanogaster.

Integrative Multi-Omics Analysis Identifies Key Molecular Targets Linking Bisphenol A Exposure to Gestational Diabetes Mellitus.

Phthalates

Network toxicology and experimental validation reveal the molecular mechanism of DEHP-induced cochlear hair cell apoptosis and hearing loss.

Di(2-ethylhexyl) Phthalate (DEHP) Exposure Exacerbates Subarachnoid Hemorrhage by Inducing Astrocyte-Mediated Inflammation and Oxidative Stress through the ADORA1/PI3K-Akt/MAPK Axis.

Parabens/Triclosan/Antimicrobials

Exploring potential toxicological pathways of triclosan in human ovarian dysfunction via integrated network toxicology and experimental validation.

PFAS

Human-relevant co-exposure to 6:2 Cl-PFESA and PFHxS impairs sperm motility and blood-testis barrier integrity in male mice: Evaluation of combined effects.

Perfluorooctanoic acid-induced exacerbation of myocardial ischemia-reperfusion injury: Roles of peroxisome proliferation activated receptor alpha-related fatty acid metabolism.

Flame Retardants

Chronic Toxic Effects of BDE-47 in C3H/He Mice Following Oral Exposure.

Integrated network toxicology and bioinformatics approaches explore potential mechanisms linking organophosphate flame retardant exposure to rheumatoid arthritis.

Acute and Chronic Toxicity of Triphenyl Phosphate in Cervical Epithelial Cells: Involvement of Ferroptosis Dysregulation.

Enduring autism-like phenotypes and deregulated hypothalamic prosocial peptides after early-life exposure to indoor flame retardants in male C57BL/6 mice.

Metals/Metalloids

10-Gingerol Alleviates Arsenic Trioxide-Induced Cardiotoxicity: Mechanisms Involving the PI3K/AKT Pathway Revealed by Network Pharmacology and Experimental Validation.

Microplastics/Nanomaterials

Polyamide-66 microplastics and early-onset ischemic stroke: a systems toxicology, multi-omics, and molecular dynamics simulation analysis.

Polystyrene microplastics-induced gut-liver axis injury in mice: Protective effect and mechanisms of sodium humate.

Transcriptomic responses in Daphnia magna exposed to PLA, PBAT, and PET microplastics: Insights into different molecular toxicity pathways.

Miscellaneous

Acute exposure to 6PPD-Q at environmentally relevant concentrations induces lipid and energy metabolism dysregulation in rainbow trout.

6PPD-quinone disrupts the MARCHF2-EXOC7 ubiquitin axis to drive ferroptosis and redox imbalance in podocytes.

Environmental Contaminant Auramine O, a Synthetic Dye Exposure Induces Multiorgan Toxicity via Inflammatory and Apoptotic Pathways in Sprague-Dawley Rats.

Exposure/Environment Studies

PFAS

Serum PFAS levels in UK firefighters.

Bioaccumulation and Partitioning of PFAS in an AFFF-Impacted Freshwater System: Invasive Asian Clams as Indicators of Surface Water Contamination.

Per- and polyfluoroalkyl substances in archived Antarctic penguin feathers.

Bioaccumulation and effects of per- and polyfluoroalkyl substances in bivalves: A review.

Microplastics/Nanomaterials

Microplastics in intravenous fluids: Occurrence, characterization, and risk indicators.

Microplastic prevalence in commercially available petfoods.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Industry-funded articles are included without notation. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. There are searchable archives. Compiled by Sarah Howard of Healthy Environment and Endocrine Disruptor Strategies (HEEDS), a program of Environmental Health Sciences.

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