EDC Science Weekly, June 12-18, 2026

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Events, Regulations/Policy, Methods/Tools/Screening, Commentaries, Reviews/Meta-Analyses, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Note: HEEDS and ICEDA would like your feedback: Developing an EDC Training Portal – Share Your Input

Highlights:

Gestational Exposure to 10 Classes of Priority Chemicals and Birth Outcomes in the ECHO Cohort.
Lactation Interrupted: PFAS Impact on Capacity to Breastfeed Ignored.
Metabolism-disrupting compounds and metabolic health during the menopausal transition: a narrative review.

Science summaries and highlights

Events

June 25 webinar: Reporting on Toxics & Health: Lessons from covering “forever chemicals” [CHE]

June 28 – July 3: New and emerging threats, approaches, and mitigation strategies for environmental endocrine disruptors [Gordon Research Conference] and accompanying Gordon Research Seminar June 27 – 28, Harnessing interdisciplinary evidence for endocrine disruption.

July 8-10: U.S. Developmental Origins of Health and Disease (DOHaD) annual meeting (Raleigh NC); Trainee day July 8.

Regulations/Policy

Health and plastics: avenues for strengthening the plastics treaty.

Global pMDI Use and the Potential Impact of European PFAS Legislation on Access to These Essential Inhaled Medications.

Canine environmental health: An EPA blind spot? Canine physiology, environmental exposure, and the regulatory gap in U.S. policy.

More EDC policy, FPF’s regulations open for comment, and Science’s Trump-Tracker.

Methods/Tools/Screening

Screening for the ovarian toxicity of industrial chemicals – ovarian follicles and corpora lutea counts in rats, an inter- and intra-laboratory comparison.

Advancing chemical mixture toxicity assessment using advanced in vitro NAMs: current status and future perspectives.

Comparative Evaluation of hiPSC-Derived Brain Organoids as Platforms for Assessing Thyroid Hormone System Disrupting Chemicals

ToxiSpecies: Task-Aware Meta-Learning for Cross-Species Modeling of Acute Chemical Toxicity under Distribution Shift.

Opportunities and challenges for analytical chemists: organ-on-chip devices as new approach methods (NAMs) for identifying potential toxins.

Analysis of in vitro profiling data of cosmetic ingredients within the Tox21 10K compound library for bioactivity and potential toxicity.

Commentaries

Hormones, sex differences, and autism: From single-cause theories to integrated developmental systems. [from a special issue on Endocrine considerations in autism spectrum disorders in Hormones and Behavior]

Words Matter in Toxicology and Risk Assessment as They Impact Risk Communication.

Lost in a Sea of Information: The Microplastics Publication Deluge.

Reviews/Meta-Analyses

Numerous Chemicals/Mixtures

Living in a chemical cocktail: real-world mixture exposures and their impact on ovarian function.

Metabolism-disrupting compounds and metabolic health during the menopausal transition: a narrative review.

Environmental roots of neonatal health: how social and structural exposures shape early-life outcomes.

Environmental endocrine disruptors and endometrial cancer risk: a systematic review and meta-analysis of cadmium and polychlorinated biphenyls, with emerging evidence on PFAS, phthalates, and bisphenols.

From exposure to infection: mechanisms linking emerging pollutants to increased viral susceptibility.

Safe or risky products: A systematic review on the environmental risk assessment of recycled products from waste.

Bisphenols

Toxic Effects of Bisphenol A and Its Analogs on Ovarian Structure and Function: A Narrative Review of Ovary-Focused Studies.

Emerging evidence for skeletal muscle as a target of BPA exposure.

Bisphenols and follicle function in farm species.

Phthalates

Prevalence and Reproductive Toxicity of Di-2-ethylhexyl Terephthalate (DEHTP) and Other Substituted Benzene Carboxylic Acid Derivatives Used as Phthalate Alternatives.

PFAS

Lactation Interrupted: PFAS Impact on Capacity to Breastfeed Ignored.

Environmental toxins, PFAS exposure, and brain metabolism: A new angle in Alzheimer’s disease pathophysiology.

Per- and polyfluoroalkyl substances and the human urinary system: Molecular mechanisms, biomarker discovery, and translational perspectives for risk mitigation.

Urine-to-Blood Partitioning of Per- and Polyfluoroalkyl Substances in Human Biomonitoring: Implications for Environmental Exposure Analysis and Bioaccumulation Assessment.

Adsorption of Forever Chemical Pollutants: The Physical Chemistry of PFAS Near Surfaces.

Flame Retardants

A review of the environmental distribution, sources, transformation, and (eco)toxicities of tetrabromobisphenol A, its derivatives, and by-products.

Pesticides

Elucidating Neonicotinoid Exposure Risks: A Structure-Informed Review of Trends, Hazards, and a Sustainable Development Framework

Pesticides, Environmental Contamination, and Public Health: A One Health Perspective.

Metals/Metalloids

Determinants of potentially toxic element concentrations in human milk: a scoping review

Environmental pollutants as vascular poisons: rethinking mesenteric ischemia through the lens of heavy metal toxicity.

Microplastics/Nanomaterials

Environmental diabetogens: biochemical links between microplastic exposure, endocrine disruption, and glucose metabolic dysfunction.

Combined Toxicity Effects and Health Risks of Microplastics and Multiple Pollutants.

Epigenetic rescue of the male germline: Plant-derived bioactive compounds as modulators of transgenerational reproductive risks induced by bisphenols and microplastics.

Air Pollution

Industrial Pollution and Health in Louisiana: A Systematic Review of Quantitative and Qualitative Studies

Human Health Studies

Numerous Chemicals/Mixtures

Gestational Exposure to 10 Classes of Priority Chemicals and Birth Outcomes in the ECHO Cohort.

Associations of Exposure to Common Plasticizers and Organophosphate Pesticides during Pregnancy and in Childhood with Cognitive Performance in Adolescents: A Population-Based Study.

Residential proximity to oil and gas development and risk of gestational diabetes mellitus.

Intraprostatic steroid hormones and endocrine disruptors in prostate cancer.

Effects of a Virtual Reality Intervention on Women’s Menstrual Problems Related to Endocrine Disruptors: A Randomized Controlled Repeated-Measures Pilot Study.

Sex-specific associations between prenatal exposure to environmental pollutants and birth outcomes: a meconium biomonitoring study.

Association between urinary heavy metals, phthalates, phytoestrogens, and polycyclic aromatic hydrocarbons and endometriosis: A cross-sectional study from NHANES 1999 to 2016.

Application of non-targeted analysis for the identification of novel environmental contaminants in amniotic fluid [see related blog]

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Early-Life Exposure to DDT from Indoor Residual Spraying and Adult Risk of Reproductive Cancers: A Nationwide Study with Long-Term Follow-Up in Taiwan.

PFAS

Handling of multicohort data in pooled analysis of environmental exposures: confounding by cohort of the relationship between perfluoroalkyl substances and birthweight in the ECHO Program.

Per- and polyfluoroalkyl substances, Vitamin D, and Risk of Preterm Birth in a Canadian Cohort

Seru m PFAS concentrations and circulating vitamin D in U.S. children: evidence of a paradox.

PFAS exposure is associated with retinal neurotoxicity in Chinese adolescents: Mechanistic insights from integrated toxicogenomic and in vitro analyses.

Prenatal exposure to per- and polyfluoroalkyl substances and postpartum new-onset hypertension: Mediating role of systemic inflammation indicators.

Flame Retardants

Association of brominated flame retardant exposure with thyroid disease risk: A cross-sectional study of US adults.

Pesticides

Glyphosate exposure and hormonal disruption in pregnancy: evidence from a birth cohort in Puerto Rico.

Agricultural pesticide use and Alzheimer’s disease dementia prevalence across US counties in a mixed supervised-unsupervised analysis.

The Green Parkinson’s Belt: agricultural regions associated with increased Parkinson’s disease burden in Mexico.

Comparing the Effects of Glyphosate and Mycotoxins in the Human Follicular Microenvironment: An Exploratory Exposome Study

Metals/Metalloids

Impact of prenatal manganese and selenium exposure on childhood thyroid hormone parameters up to 4 years of age: Japan environment and children’s study.

Placental Toxic Metal Concentrations and Preterm Birth: modification by social stressors.

Low Intake of Zinc and Vitamin D Is Associated with High Blood Lead Level Proportion Amongst Male Workers with Lead Exposure

Sperm-Associated Mercury Species Levels Determine Its Impairment: Evidence from Paired Analyses of Whole Semen and Seminal Plasma.

Association of heavy metal exposure, C-reactive protein, and stroke risk in US adults: A cross-sectional analysis (NHANES 2005-2008).

Air Pollution

Opposing effects of PM2.5 on TSH levels: effect modification by thyroid peroxidase antibody status in a preconception cohort.

Laboratory Studies

Numerous Chemicals/Mixtures

Mechanism-informed prioritization of drinking water mixtures for metabolic liver disease: Integrating AOP-anchored bioactivity and toxicokinetics.

Bisphenols

Bisphenol S induces hepatic steatosis and insulin resistance through AMPK inhibition and endoplasmic reticulum stress.

Bisphenol A exacerbates diabetic foot ulcers through disruption of immune microenvironment and repair processes: a multi-omics analysis of environmental exposure mechanisms.

Melatonin attenuates BPA-induced testicular tissue oxidative stress damage by protecting testicular mitochondrial function and reducing cell apoptosis in mice.

Phthalates

Integrative Biology Approaches Uncover Plasticizers’ Pro-Carcinogenic Role in Prostate Cancer via Molecular Docking and Network Toxicology

Exploring the Toxicological Impact and Mechanisms of DEHP Exposure on Prostate Cancer Through Network Toxicology and Machine Learning Algorithms.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Long-chain chlorinated paraffins (LCCPs) exposure induces testicular aging damage by triggering mitochondrial dysfunction

PFAS

Stage-specific disruption of host resistance and metabolic pathways following developmental PFAS exposure in marine medaka.

Gestational PFOS Exposure Induces Alveolar Developmental Defects by Affecting Immune-Epithelial Crosstalk in Offspring Rats.

Perfluorocarboxylic acid toxicity analysis with albumin/1-anilinonaphthalene-8-sulfonate probe assisted by machine learning.

Probabilistic Concentration-Response Modeling and Risk Prioritization of Defined Mixtures of PFAS Using Human In Vitro Assays.

Chemical speciation significantly shapes the neurotoxicity of perfluoroalkyl acids

Environmental exposure to perfluorooctanoic acid promotes early gastric carcinogenesis via PPAR-γ-mediated ferroptosis.

Early-life PFOS exposure causes lasting impairment of neural stem cell fate, white matter maturation, and olfactory behavior

Perfluorooctane sulfonate (PFOS) increases metastatic potential of thyroid cancer cells in correlation with activation of multiple invasion-related signaling proteins.

From algorithm to verification: based on network toxicology and machine learning, the immunomodulatory role of IGFBP1/MKI67/C9 in perfluorooctanoic acid-induced osteoarthritis was discovered, and a diagnostic model was constructed.

Flame Retardants

Tetrabromobisphenol S (TBBPS)-induced developmental toxicity in zebrafish embryos: impacts on cytoskeletal proteins during gastrulation.

Triphenyl phosphate exacerbates lung cancer metastasis by activating NF-κB signaling pathway.

Pesticides

Neurotoxicity of myclobutanil in zebrafish larvae via thyroid disruption and neuronal apoptosis.

Mechanistic insights into chlorpyrifos-induced nephrotoxicity revealed by network toxicology and molecular docking.

Lipid metabolic disruption: A potential mechanistic pathway for 2,4,6-tribromophenol-induced neurotoxicity in zebrafish

Greater than additive interactions between two phenolic pesticides used to control invasive sea lamprey (Petromyzon marinus): Underlying mechanisms and implications.

Metals/Metalloids

Resveratrol Alleviates Arsenic-Induced Liver Fibrosis in Rats by Correcting SIRT1-Mediated Disorder of Hepatic Bile Acid Metabolism.

Microplastics/Nanomaterials

In vitro exposure to polystyrene microplastic induces oxidative stress mediated β-cell dysfunction.

Developing a New Approach Methodology Framework to Assess Biological Responses to Nanoplastics: Insights from Polystyrene and Biodegradable Particles.

Maternal exposure to polystyrene nanoplastics triggers ovarian injury in mice offspring: Ferroptosis mediated by the HIF-1α/HO-1 Pathway.

Nano- and Microplastics Induce Size Specific Adipogenic and Metabolic Dysregulation.

Lactational exposure to polystyrene nanoplastics is associated with dose-related ovarian alterations in rat offspring.

Co-exposure to microcystin-LR and polystyrene nanoplastics aggravates neuroinflammation by promoting AhR/NF-κB axis-mediated gut microbiota dysfunction.

Microplastics-Induced Gut Microbiota Dysbiosis Accelerates Alzheimer’s-Like Pathology and Cognitive Decline via the Gut-Brain Axis.

Polystyrene nanoplastics promotes inflammation and aging in young mice through the oral-gut microbiome axis.

Polystyrene nanoplastics elicit early mitochondria-associated phenotypic, metabolic, and functional responses in human hepatocytes.

Human blood-derived neural progenitor cells as a platform for developmental neurotoxicity of micro- and nanoplastics.

Pharmaceuticals/Personal Care Products

Embryonic Developmental Toxicity and Potential Endocrine Disruption in an Estuarine Benthic Fish under Binary and Ternary Exposures to Organic Ultraviolet Absorbents.

Paternal intergenerational thyroid disruption in zebrafish induced by environmental prednisone exposure.

6PPD

Combined exposure to 6PPD and 6PPD-Q induced neurotoxic responses in zebrafish and SH-SY5Y cells: evidence from neurotransmitter disruption, oxidative damage, and apoptosis.

The effects of car tyre additives (6PPD-quinone, DPG, and MBT) on activity behaviours of marine and freshwater amphipods.

Effects of co-exposure of polyethylene nanoplastics and 6PPD on cardiac function in the early developmental stage of zebrafish.

6PPD quinone induces cytokine production in fish cells via oxidative stress.

Chronic Exposure to 6PPD-Q Induces HPO Axis Dysfunction and Metabolic Disturbances in Female Offspring Mice.

Exposure/Environment Studies

Bisphenols

Urinary bisphenol A trends and associations with processed food consumption in Korean adults: Korean National Environmental Health Survey (KoNEHS) 2009-2020.

Parabens/Triclosan/Antimicrobials

Exposure Profiles and Screening-Level Risk Assessment of PCP-Related Chemicals in China: A Focus on Parabens.

PFAS

Occupational PFAS burden in German firefighters: Associations with aqueous film-forming foam contact frequency.

Per- and Polyfluoroalkyl Substances (PFAS) Exposure Profiles and Their Predictors in a Study of US Volunteer Firefighters.

Tracking early-life PFAS exposure in the Ebro Delta flamingo colony: temporal trends and sources.

Per- and Polyfluoroalkyl Substances (PFAS) Fate and Transport in Surface Waters Near Eaker Air Force Base, Arkansas.

Spatial distribution of per- and polyfluoroalkyl substances in the Yellow River basin: Role of suspended sediment on the PFAS partition and accumulation.

Pesticides

Retraction: Health risk assessment of exposure to chlorpyrifos in pregnant women using deterministic and probabilistic approaches.

Metals/Metalloids

Protecting US Children From Lead Exposures: Applications of a Data-Mapping Blueprint for Focusing High-Impact Interventions.

Pollution compounds in human teeth in a Mexican Metropolitan Area.

——-

This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Industry-funded articles are included without notation. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. There are searchable archives. Compiled by Sarah Howard of Healthy Environment and Endocrine Disruptor Strategies (HEEDS), a program of Environmental Health Sciences.

If you enjoy this newsletter, please feel free to donate here! Thank you!