May 22-27, 2026

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Note: This newsletter will not publish next week due to vacation.

Contents: Events, Regulations/Policy, Methods/Tools/Screening, Commentaries, Reviews/Meta-Analyses, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Highlights:

Science summaries and highlights

Events

May 29 conference: HEEDS EDC-North Carolina Annual Scientific Meeting (in person in Raleigh NC) [HEEDS]

June 2 webinar: Why highly persistent chemicals are always a hazard [ChemSec]

June 8-10: National PFAS Conference (in Tucson, AZ)

June 10: TSCA Reform: 10 years later (hybrid) [Environmental Law Institute]

June 25 webinar: Reporting on Toxics & Health: Lessons from covering “forever chemicals” [CHE]

June 28 – July 3: New and emerging threats, approaches, and mitigation strategies for environmental endocrine disruptors [Gordon Research Conference] and accompanying Gordon Research Seminar June 27 – 28, Harnessing interdisciplinary evidence for endocrine disruption.

July 8-10: U.S. Developmental Origins of Health and Disease (DOHaD) annual meeting (Raleigh NC); Trainee day July 8.

Regulations/Policy

Report: The use of alternatives to testing on animals for the REACH Regulation [Sixth report by ECHA]

More EDC policy, FPF’s regulations open for comment, and Science’s Trump-Tracker.

Methods/Tools/Screening

A curated geospatial dataset of chemicals used in hydraulic fracturing and their functions.

A combined in silico and in vitro new approach methodology for early detection of liver steatogenic chemicals.

Commentaries

Empowering Youth to Participate in Chemicals Management: A Youth Perspective.

Protecting the developing brains of children from Plastics-Derived chemicals and microplastic particles.

Profiles in Comparative Endocrinology: Louis J. Guillette, Jr.

Advancing the Discovery of Emerging Contaminants: A Leap in Technology and Data.

A cautionary tale of neurodevelopment gone wrong: roundup the zebra(fish).

Reviews/Meta-Analyses

Bisphenols

Transgenerational exposure to plastics-derived endocrine-disrupting bisphenol A and its analogs on male infertility: impact of gut dysbiosis and epigenetic regulation.

Organotins

Effects of tributyltin as an obesogen chemical on mammalian adipose tissue.

Pesticides

Application, ecotoxicology and regulation of insecticides with special reference to neonicotinoids.

Microplastics/Nanomaterials

Microplastics as a Silent Threat to Child Neurodevelopment: Evidence and Perspectives on Autism.

Prenatal and early-life exposure to micro- and nanoplastics and autism-relevant neurodevelopment: An integrated review of human, experimental, and mechanistic evidence.

Micro- and nanoplastics in the central nervous system: Transport pathways, neurotoxicity, and implications for brain disorders.

Exposure to Microplastics in Biological Matrices and Neurodevelopmental Outcomes in Children: A Systematic Review.

Pathophysiological Impact of Nano- and Microplastics on the Kidney and Their Potential Role in Blood Pressure Regulation.

Microplastics and the Endocrine-Metabolic Interface: Novel Diagnostic Tools Targeting Thyroid-Adipose Axis.

Nano- and Microplastics in the Cardiovascular System: Current Insights and Biological Implications.

Microplastics Disrupt Intestinal Physiology: from Microbiota Composition to Intestinal Barrier Integrity.

A global analysis of microplastics research: Mapping strategic funding, national research capacity, scientific priorities, and policy frameworks.

Miscellaneous

Comprehensive Insight into the Male Dog Reproductive System in Health and Diseases: Developmental, Genetic, and Environmental Factors-Review on Research and Clinical Trials.

Human Health Studies

Numerous Chemicals/Mixtures

Unraveling Plastic-Related Chemical Exposures during Pregnancy and Their Associations with Pregnancy Outcomes Using Suspect Screening Analysis.

Chemical mixtures and birth weight: comparison of multipollutant models in the Maternal-Infant Research on Environmental Chemicals (MIREC) study.

Phthalates

Urinary phthalates and phthalate alternatives, and their associations with oxidative stress biomarkers in Chinese adults: A multi-city population study.

Baseline and long-term changes in phthalate exposure are differentially associated with lipid peroxidative but not DNA oxidative stress in adolescents and young adults: A 10-year prospective cohort study.

PFAS

A case-control study of the association between per- and polyfluoroalkyl substances (PFAS) and risk of postmenopausal breast cancer in the Danish Diet Cancer and Health cohort.

PFAS associated with dysglycemia and glucose trajectories: A prospective cohort study from the Isomers of C8 Health Project in China.

Associations of Prenatal Individual and Mixture Per- and Polyfluoroalkyl Substances (PFAS) Exposures with Fetal Growth Trajectories: Modifying Effects of Maternal Micronutrient Status.

Pesticides

The impact of prenatal organophosphate exposure on children’s neurodevelopment: a quantitative analysis with regional comparison.

Metals/Metalloids

Beneficial roles of selenium and docosahexaenoic acid against prenatal methylmercury-induced adverse effects on child neurodevelopment: The Tohoku Study of Child Development at 42 months.

Impact of 14 weeks combined exercise on serum cadmium levels, DNA methylation, and epigenetic aging in older women.

Microplastics/Nanomaterials

Can Plasma Exchange Be Used to Lower the Circulating Burden of Microplastics in Human Patients?

Pharmaceuticals/Personal Care Products

Prenatal over-the-counter acetaminophen use and birth outcomes in the ECHO cohort.

Miscellaneous

Blood Trihalomethane Concentrations and Gestational Diabetes Mellitus: A Nationwide Cross-Sectional Study.

Laboratory Studies

Bisphenols

Chronic bisphenol A exposure activates the cGAS-STING-NLRP3 axis driving persistent hippocampal neuroinflammation and cognitive impairment.

Bisphenol Analog-Induced Cytotoxicity: Unraveling Endoplasmic Reticulum (ER) Stress and Apoptotic Pathways.

Parental Bisphenol S exposure induces oxidative stress and disrupts serotonergic and cholinergic neurotransmission in zebrafish offspring.

Phthalates

Association of phthalate exposure during early pregnancy with fetal growth and the effect modification by gestational stress.

Pharmacological Attenuation of Endoplasmic Reticulum Stress Restores Sexual Behavior and Spermatogenesis in DEHP-Exposed Male Wistar Rats.

Pre-existing liver dysfunction modulates di-(2-ethylhexyl) phthalate (DEHP)-associated biological responses through host-microbiome networks.

High-Volume Plasticizer di(2-Propylheptyl) Phthalate DPHP Induced Ecotoxic Effects in Aquatic and Terrestrial Arthropods.

Quercetin Reverses DEHP-Induced ZBP1-Mediated PANoptosis in Thymus by Targeting NF-κB to Regulate the TNF-α/ROS Signaling Pathway.

In vivo recovery and in vitro quality assessment of apheresis red blood cells stored for 42 days in non-DEHP disposable sets.

Parabens/Triclosan/Antimicrobials

Maternal triclosan exposure impairs female offspring neurodevelopment via MeCP2 hypomethylation and enhanced MeCP2/HDAC3 interaction.

PFAS

PFAS exacerbates diabetic wound healing by targeting GRP94 glycosylation, antagonized by ligustilide.

Histopathology and Transcriptomics in Male Zebrafish Livers from a PFOS Multi-Generational Exposure Informs Adverse Outcome Pathway Development for Liver Steatosis.

Developmental exposure to a PFAS mixture impairs the anamnestic response to influenza A virus infection in mice.

Intermolecular interactions of perfluoroalkyl acids with human heart-type fatty acid-binding protein.

Effect of Perfluorooctanesulfonic Acid on Fibrin Clot Properties and Thrombin Generation: Linking Environmental Pollution with Cardiovascular Diseases.

PFOA/PFOS induce ferroptosis in bladder epithelial cells through inhibition of ACSL4 ubiquitination.

The pharmacokinetics of perfluorobutanoic acid in female rats.

Pesticides

Early postnatal exposure to permethrin and deltamethrin mixtures induces sex-specific hippocampal neurobehavioral and neurochemical alterations in adulthood.

Melatonin attenuates reproductive toxicity of prothioconazole and its metabolite via spermatogenesis and oxidative stress.

Redox-driven mechanisms link pesticide-induced microglial immunotoxicity to neurobehavioural impairment in an invertebrate ecotoxicological model.

Integrating network toxicology and transcriptomics reveals the potential targets of chlorfenapyr-induced myocardial injury.

Herbicide Mixture-Driven Neurotoxicity in the Maternal Brain: Combined Exposure Produces Greater-Than-Individual Effects at Regulatory Relevant Doses.

Metals/Metalloids

Long-term arsenic exposure causes epithelial-mesenchymal transition and kidney fibrosis accompanied by renal lipid metabolic disorders.

Ascorbic acid attenuates lead-induced oxidative stress and testosterone suppression in male Wistar rats.

Microplastics/Nanomaterials

Polyethylene terephthalate microplastics activate AKT1 signaling and induce neurotoxic responses in SH-SY5Y cells.

Juvenile and Pubertal Exposure to Polystyrene Nanoplastics Impairs Epididymal Structure and Sperm Quality in Mice.

Exposure to Polystyrene Microplastics Exacerbates Hippocampal Inflammation and Ferroptosis in Mice Following Chronic Sleep Deprivation.

Exposure to polyethylene microplastics induces a male testosterone synthesis disorder via oxidative stress-mediated ferroptosis.

Ferroptosis and Wnt/β-Catenin Signaling Triggered by Environmentally Relevant Nanoscale Polypropylene Plastics in Human Intestinal Models.

Long-term Low-dose Nanoplastic Exposure Induces Neurotoxicity with Oxidative Brain Damage.

Polystyrene Microplastics and Lead Co-Exposure Disturbed Hepatic Lipid Metabolism in C57BL/6 Mice.

Air Pollution

Unveiling the role of air pollution in diabetic kidney disease: an integrated study combining network toxicology, machine learning, and Mendelian randomization.

Miscellaneous

Benzophenone-2 Disrupts Craniofacial Cartilage Development via esr2a-Dependent Inhibition of Endothelin Signaling in Zebrafish Larvae.

Atmospheric aging of tire rubber antioxidants forms complex mixtures that trigger inflammation in human macrophages.

Sustainable closed-loop recyclable bioplastics.

Rapid Fabrication of High-Strength, Water-Resistant Chitin Micro-Nanofiber Films as Bioplastics.

Exposure/Environment Studies

Numerous Chemicals/Mixtures

Heavy metals, carbon monoxide and PBDE exposure among firefighters: a cross-sectional study.

Bisphenols/Phthalates

Exposure to legacy and emerging phthalates and bisphenols in recycling workers: evidence from the GreenMetalWaste study.

Parabens/Triclosan/Antimicrobials

Longitudinal Trends in Serum Triclocarban Levels from 2008 to 2018: Evidence from the Prospective Dongfeng-Tongji Cohort Study.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Are unreported technical polychlorinated biphenyl formulations used in legacy building materials threatening indoor environments of a central Indian City despite the ban?

PFAS

Predictors of Serum Per- and Polyfluoroalkyl Substances (PFAS) Concentrations in a Rural Agricultural Community Affected by Biosolids Application.

The toxicity and bioaccumulation of PFAS in earthworms (Eisenia fetida) exposed to biosolids-amended agricultural soils.

PFAS immobilization with soil amendments – How immobilized is immobilized?

Dietary intakes association with plasma per- and polyfluoroalkyl substances (PFAS) concentrations: A cross-sectional human biomonitoring study in Singapore.

Associations between physical exercise and serum per- and polyfluoroalkyl substances (PFAS) concentrations: findings from Korean National Environmental Health Survey Cycle 4 (2018-2020).

PFAS Mixture Composition and Internal Exposure Profiles Shape Biological Responses under Field-Realistic Exposure.

Mapping the dietary exposure risk of per- and polyfluoroalkyl substances (PFASs) from seafood consumption in Yangtze River Delta Urban Agglomeration, China.

The impact of per- and polyfluoroalkyl substances (PFAS) on freshwater fish and implications for human health.

Microplastics/Nanomaterials

Oral splints, clear aligners, mandibular advancement devices: hidden sources of micro- and nanoplastic exposure?

Aligners do shed microplastics: Evidence is clear, clinical risk is not.

The northern fulmar as a sentinel species for monitoring the environmental health impacts of plastic exposure.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Industry-funded articles are included without notation. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. There are searchable archives. Compiled by Sarah Howard of Healthy Environment and Endocrine Disruptor Strategies (HEEDS), a program of Environmental Health Sciences.

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