EDC Science Weekly, Jan. 16-22, 2026

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Events, Regulations/Policy, Methods/Tools/Screening, Commentaries, Reviews/Meta-Analyses, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Events

Jan. 22 webinar (today!): CHE Café: How states can lead on environmental health [CHE]

Jan. 23: application due date for the Endocrine Society’s Research Experiences for Graduate and Medical Students program.

Jan. 27 webinar: Policy, Prevention & Protection: Opportunities for states to lead on toxic chemicals & plastics [CHE-Alaska]

Feb. 5-6 conference: Forever Ends Here: PFAS & Policy for Worker Health and Safety [Berkeley Center for Occupational and Environmental Health]

Feb. 10 – June 9: Environment and Health webinar series [Mount Sinai]

Feb. 12 webinar: EDCs & Reproductive Health: Effects of chemical mixtures on ovarian function [EDC Strategies Partnership]

Feb. 27 application due date for the Endocrine Society’s Kaiser-Goldberg Research Fellowship program.

Mar. 1-2: 2026 Our Planet, Our Health Convention, hybrid/Arlington VA [Medical Society Consortium on Climate and Health]

June 28 – July 3: New and emerging threats, approaches, and mitigation strategies for environmental endocrine disruptors [Gordon Research Conference] and accompanying Gordon Research Seminar June 27 – 28, Harnessing interdisciplinary evidence for endocrine disruption. Abstracts due Jan 20, submit here.

Save the date: Oct. 12-16, conference: MICRO 2026: Plastic pollution from macro to nano [in Cadiz, Spain]

Regulations/Policy

Tracking the Impact of PFAS Regulations: Long-Term Analysis of Roe Deer Livers From 1998 Until 2022.

Nurses’ Plans and Actions to Advocate for Legislation to Phase Out Use of Select Di(2-Ethylhexyl) Phthalate Plastic Supplies in Health Services Delivery in North Carolina.

More EDC policy, FPF’s regulations open for comment, and Science’s Trump-Tracker.

Methods/Tools/Screening

New approach methodologies for contaminant risk assessment in environmental justice communities: Let’s not miss the opportunity.

ToxFCDB: Toxicity Database for Forever Chemicals.

“The Dose Makes the Poison”: Relevance of Paracelsus’s Principle for Modern Chemical Hazard Assessment with New Approach Methodologies.

A Biomarker-Driven Ovary-Endometrium Organ-on-a-Chip Mimicking 3D Multicellular Complexity and Menstrual Cyclicity for Predicting Reproductive Toxicity.

Advances in the application of computational toxicology in cosmetic safety assessment.

From Policy to Practice: Advancing Environmental Toxicology through New Approach Methodologies.

Machine Learning Models for High-Throughput Screening of Obesogens Based on Pathway Network.

Molecular networking, conformal predictions and revised fingerprint-based models for discovering endocrine disruptors in mixtures.

Commentaries

Beyond glyphosate: Is it feasible to counterbalance perverse incentives to profit from preventable disease?

The organ-on-a-chip mirage: Animal replacement, plastic channels, and plastic claims: The False Narrative Behind the War on Animal Research.

PFAS in biosolids used in US food supply could pose cancer risk. [News item]

Reviews/Meta-Analyses

Numerous Chemicals/Mixtures

Nephrotoxic Effects of Endocrine-Disrupting Chemicals: A Systematic Review.

Cancer and Environmental Xenobiotics: Mechanisms, Controversies, and Innovations.

The China Birth Cohort-Environmental and Genetic Factors (CBC-EG) Study: Design, Aims, Protocol, Findings, and Prospects.

Bisphenols

Gene-Environment Interactions in Autism Spectrum Disorders: The Role of Bisphenol A in Modulating Genetic Susceptibility.

A Review of the Literature on the Endocrine Disruptor Activity Testing of Bisphenols in Caenorhabditis elegans.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Reproductive toxicity of endosulfan: Mechanisms and impacts on female and male reproductive health.

PFAS

Exposure to Per- and Polyfluoroalkyl Substances and Liver Cancer: A Systematic Review of Animal and Epidemiological Studies.

Minus technologies revolutionizing per- and polyfluoroalkyl substances removal: Strategies for safe drinking water.

Pesticides

Neonicotinoid-Induced Neurotoxicity in Developing Brain: A Systematic Review.

Effects of atrazine on the HPG and HPA axes and steroidogenic pathways in females: relevance to reproductive function and breast, ovarian and uterine cancer.

Metals/Metalloids

Heavy metal exposure and all health outcomes: An umbrella review of meta-analyses.

Exploring the Association between Arsenic Exposure and Sperm Quality: A Systematic Review and Meta-analysis.

Microplastics/Nanomaterials

The environmental journey of micro- and nanoplastics: fate, transport, and toxicity.

Microplastics and Nanoplastics as Carriers for Viral Transmission: Effects on Viral Properties, Infection, Immune Response, and Public Health.

From Bakelite to Biohazard: The Century-Long Rise of Microplastics.

Sex-based differences in toxicity after exposure to microplastics or nanoplastics in aquatic and terrestrial organisms: A systematic review.

Neurotoxicity of Micro- and Nanoplastics: A Comprehensive Review of Central Nervous System Impacts.

Impact of Textile-Derived Micro- and Nanoplastics on Brain Health: An Emerging Environmental Risk.

Human Health Studies

Numerous Chemicals/Mixtures

Environmental pollutants associated with blood glucose levels in healthy individuals.

Exploring the mechanism link between endocrine disrupting chemicals and metabolic diseases: Observational and GWAS evidence.

Effect of Perinatal Multiple Exposures to Heavy Metals and Dioxins on Serum Steroids in Preschool Children-A Follow-Up Study in an E-Waste Contaminated Area in China.

Residential proximity to Superfund sites and breast cancer incidence in a nationwide cohort.

Combined effects of persistent organic pollutants and endocrine-disrupting chemicals on thyroid disease risk: A WQS-XGBoost analysis of US population data.

Effects of endocrine disrupting chemicals and plasma metabolome on female reproductive diseases: A multidimensional Mendelian randomization study.

Phthalates

Fetal phthalate exposure and asthma outcomes from infancy to adolescence: Individual participant data meta-analysis in the EU Child Cohort Network.

Parabens/Triclosan/Antimicrobials

Associations between paraben exposure and breast cancer risk: An integrative epidemiologic, network toxicology, multi-omics and experimental analysis.

PFAS

Effects of an information shock on registry-based health indicators: Evidence from a Swedish PFAS crisis.

Association between 6:2 chlorinated polyfluoroalkyl ether sulfonic acid exposure and glucolipid metabolism in Chinese adults: a meta-analysis.

Association of emerging alternatives to per- and polyfluoroalkyl substances with polycystic ovary syndrome among Chinese women: a case-control study.

Flame Retardants

Maternal serum polybrominated diphenyl ether concentrations during pregnancy and adolescent bone mineral density at age 12 years.

Gestational PBDE concentrations and functional connectivity in adolescents: The HOME Study.

Association between brominated flame retardants and diagnosis or symptoms of allergies among a nationally representative sample in the US.

Metals/Metalloids

Associations of metal mixtures with insulin resistance and glucose homeostasis in U.S. adults from the NHANES 2011-2018.

Serum mercury, lead, cadmium, and arsenic and incidence of type 2 diabetes among adults: A nested case-control study.

Drinking water arsenic, urinary arsenic biomarkers, and cognitive impairment in the REGARDS Study.

Association between arsenic levels in toenails and urine and prostate cancer risk: Findings from the MCC-Spain study.

Prenatal urinary biomarkers of metal and metalloid exposure and child neurodevelopmental outcomes in Puerto Rico.

Prenatal arsenic speciation and thyroid hormone levels during pregnancy and adolescence.

Associations of arsenic exposure and folate in maternal leukocyte DNA methylation: a case-control study of mothers with spina-bifida affected children.

Air Pollution

Alterations in Cardiometabolic Markers Associated with Canada-Wide and Sector-Specific Multiple Air Pollutant Exposures.

Air pollution and muscle-fat imbalance: How PM_2.5 components and ozone drive sarcopenic obesity through inflammation.

Fine and ultrafine particulate matter components and autism spectrum disorder (ASD).

Polygenic risk and air pollution trends in relation to type 2 diabetes: evidence from the Taiwan Biobank.

Laboratory Studies

Numerous Chemicals/Mixtures

Effects of Perfluorooctane sulfonate (PFOS) and Tetrabromobisphenol A (TBBPA) on Reproductive Development in Rats.

Phthalates

Prenatal exposure to di(2-ethylhexyl) phthalate alters the association of glutamatergic proteins with PTEN in the hippocampus of male rat offspring.

Developmental Mono(2-ethylhexyl) Phthalate Exposure Impairs Offspring Neurobehavior through Suppression of CYP450 Transcriptional Pathways.

Parabens/Triclosan/Antimicrobials

Methyl triclosan alters amino acid and glycerophospholipid metabolism in human ovarian granulosa cells.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

1,3,6,8-Tetrabromocarbazole induces neurodegenerative damage in mice: Mechanistic insights from combined transcriptomic and metabolomic profiling.

PFAS

PFOA and PFOS impair human sperm capacitation by inducing mitochondrial-mediated apoptosis and ferroptosis.

Perfluorooctane sulfonates drives colitis via a gut microbiota-bile acid-endoplasmic reticulum stress axis in mice: Mechanistic validation and targeted interventions.

Comprehensive 26-week subchronic toxicity assessment of perfluoroheptanoic acid in Sprague-Dawley rats: implications for human health.

Flame Retardants

Developmental and metabolic toxicity of diphenyl phosphate: insights from an integrative mechanistic framework in zebrafish embryos.

Tissue uptake, distribution, elimination and neurotoxicity of decabromodiphenyl ethane (DBDPE) in adult zebrafish (Danio Rerio).

Integrative proteomics and metabolomics approach to elucidate the multi-organ developmental toxicity of decabromodiphenyl ethane in zebrafish larvae.

Pesticides

Chronic low-dose exposure to chlorpyrifos reduces life span in a wild fish by accelerating aging.

Chlorpyrifos induced dysregulation of arginine biosynthesis pathway aggravates Alzheimer’s disease progression in 5XFAD mice via microbiota-gut-brain axis crosstalk.

Hepatic toxicity induced by exposure to glyphosate/aminomethylphosphonic acid and oxytetracycline alone or in combination in zebrafish: A novel mechanism of the gut-liver axis.

Young honey bees Apis mellifera learn to avoid pollen contaminated with glyphosate or imidacloprid.

Metals/Metalloids

Cadmium exposure is associated with impaired ovarian function: Potential role of cadmium-induced ferroptosis in granulosa cells.

Microplastics/Nanomaterials

Airborne polystyrene nanoplastic exposure leads to splenic cell senescence and immune imbalance.

Nanoplastic toxicity and uptake in kidney cells: differential effects of concentration, particle size, and polymer type.

Synergistic kidney toxicity of polylactic acid nanoplastics and Cr(VI): Ferroptosis aggravated by mitophagy.

Developmental exposure to polystyrene nanoplastics induces persistent neurobehavioral changes and alters later-life susceptibility to hexabromocyclododecane in zebrafish.

Contrasting effects of micro- and nano-plastics on accumulation and toxicity of tris(1,3-dichloro-2-propyl) phosphate in zebrafish embryo revealed by toxicokinetic-toxicodynamic model.

Miscellaneous

6PPD and its metabolites induce locomotor dysfunction in zebrafish through dopaminergic disruption with brain accumulation.

Exposure/Environment Studies

Numerous Chemicals/Mixtures

Qualitative non-targeted screening by high resolution mass spectrometry of chemicals transference from plastic food contact materials after cooking.

Bisphenols

Occurrence Patterns of Bisphenol Analogues in Human Blood, Subcutaneous Fat, and Visceral Fat.

PFAS

High serum PFAS levels in a population after exposure through drinking water in western Tokyo, Japan and their half-lives estimation.

A Cross-Sectional Analysis of Blood Spot per- and Polyfluoroalkyl Substances (PFAS) from Adolescents in Chitwan Valley, Nepal.

Human blood concentrations of perfluoroalkyl substances resulting from consumption of contaminated meat in Korsør, Denmark.

Predictors of serum per- and polyfluoroalkyl substances (PFAS) levels among U.S. career firefighters.

Evaluating Legacy and Emerging PFAS in Human Blood Collected from 2003 to 2021.

Deriving Predicted No-Effect Concentrations for PFASs to Protect Threatened and Endangered Fish: A Comparison of Water- and Tissue-Residue-Based Toxicity Data.

Non-target screening and laboratory experiments reveal the transformation products and negligible trifluoroacetic acid formation potential of PFAS pesticides and pharmaceuticals in wastewater treatment plants.

Understanding the scale and potential contributions of background PFAS in the environment.

Traditional and Emerging Per- and Polyfluoroalkyl Substances in the Amundsen Sea Polynya, Antarctica: Physical and Biogeochemical Drivers.

Seasonal Shift in Exposure and Accumulation of PFAS and Heavy Metals in High Arctic Reindeer.

Per- and polyfluoroalkyl substances (PFAS) in wastewater treatment plants: an overview of their occurrence, fate, effects, and ecological risks.

Flame Retardants

Dechlorane Plus in air, dust, hand wipes, and hair at a typical e-waste site in South China: implications for human exposure.

Pesticides

Exposure trends of neonicotinoids from 2008 to 2018 and health risk in a longitudinal study in China.

Common birds have higher abundances in croplands with lower pesticide purchases.

Towards reduced pesticide use in agriculture: A multiple-case study of agrosupply business models for low pesticide solutions.

Microplastics/Nanomaterials

Microplastics in poultry: Sources, bioaccumulation and human health consequences.

Honey as a bioindicator of microplastic pollution: insights from industrial and special honey types.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Industry-funded articles are included without notation. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. There are searchable archives. Compiled by Sarah Howard of Healthy Environment and Endocrine Disruptor Strategies (HEEDS), a program of Environmental Health Sciences.

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