EDC Science Weekly, Nov. 7-13, 2025

Post author:HEEDS
Post published:November 13, 2025
Post category:EDC Science Weekly

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Events, Regulations/Policy, Methods/Tools/Screening, Commentaries, Reviews/Meta-Analyses, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Highlights:

Science summaries and highlights

Events

Nov. 13 webinar: Protecting Our Health: Toxic Threats, Trusted Solutions [Toxic-Free Future]

Nov. 14 webinar: OECD Guidance Document on the Generation, Reporting and Use of Research data for Regulatory Assessments [Organisation for the Economic Cooperation and Development (OECD)]

Nov. 14 CME event: Cancer and Environment [Silent Spring, Columbia University]

Nov. 17 webinar: Plastic Pollution and Human Health: What We Know and What We Can Do [UCSF]

Nov. 20 webinar: EDCs & Female Reproductive Health: A growing health concern [EDC Strategies Partnership]

Dec. 1: Due date for Reach the Decisionmakers 2026 [UCSF]

Dec. 4: ICEDA Scientific Symposium (in Montreal and on zoom) Intersectoral Centre for Endocrine Disruptor Analysis (ICEDA)

Dec. 10 webinar: CHE Café: Why Parkinson’s disease is preventable [CHE]

Dec. 11 webinar: Corporate Influence on science in a shifting political landscape [PRHE, UCS, CHE]

Jan. 11-14: Microplastics exposure and human health conference [in person in Santa Fe; late-breaking abstracts due Dec. 1]

Jan. 15: application due date for May 26- June 9 course, Endocrine-Disrupting Chemicals: Hazards and Opportunities (ECHO) [Marine Biological Laboratory]

June 28 – July 3: New and emerging threats, approaches, and mitigation strategies for environmental endocrine disruptors [Gordon Research Conference] and accompanying Gordon Research Seminar June 27-8, Harnessing interdisciplinary evidence for endocrine disruption.

Regulations/Policy

Scientists’ warning: we must change paradigm for a revolution in toxicology and world food supply

More EDC policy, FPF’s regulations open for comment, and Science’s Trump-Tracker.

Methods/Tools/Screening

How Problems with Microplastics in Research and Application Can be Overcome: Lessons From the Experience of Plastics Stakeholders.

Using in vitro data to derive acceptable exposure levels for environmental chemicals: A case study on p,p’-DDE obesogenicity.

A pragmatic upstream network for disrupted steroidogenesis through reduced enzyme activity and steroid hormone production for Adverse Outcome Pathway building.

Refining the AOP for retinoid-induced teratogenicity: Insights into RAR/RXR overactivation and RXR cross-talk with retinoic acid and thyroid hormone signaling.

¹³C metabolic tracing in human SGBS cells provides a potential new approach methodology for assessing metabolism-disrupting properties of environmental chemicals.

Commentaries

Editorial: Environmental challenges and endocrine dysregulation. [intro to a research topic in Frontiers in Endocrinology]

Ecotoxicology undergoing transition: addressing the complex challenges of global change.

Reviews/Meta-Analyses

Numerous Chemicals/Mixtures

Potential health risks from contaminated fish in Lake Victoria: A 25-year systematic review of pollutants and management challenges.

Parabens/Triclosan/Antimicrobials

From personal hygiene products to health threats: Triclosan and its impact on endocrine health.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Hormesis induced by persistent organic pollutants: Mechanisms, ecological implications, and challenges for risk assessment.

PFAS

Levels of per- and polyfluoroalkyl substances (PFAS) in foodstuffs: a review of dietary exposure, health risks, and regulatory challenges.

Pesticides

A systematic review of organophosphorus pesticides detection in biological matrices.

Pesticides and parkinson’s disease: causal relationship at the population and individual level?

Metals/Metalloids

Heavy Metals and Human Reproductive Toxicity: Mechanisms, Pregnancy Outcomes, and Mitigation Strategies.

Systematic Review on Neurotoxic Implications of Lead-Induced Gene Expression Alterations in the Etiology of Alzheimer’s Disease.

Microplastics/Nanomaterials

Micro- and Nanoplastics: Emerging Environmental Threats to the Developmental Origins of Health and Disease.

Impact of Microplastics and Nanoplastics on Human Health: Mechanistic Insights and Exposure Pathways.

Axis-based propagation of nanoplastic toxicity: Organ-organ crosstalk and systemic pathophysiological outcomes.

A systematic review of the potential neurotoxicity of micro-and nanoplastics: the known and unknown.

Microplastics and Cancer: A Comprehensive Review of Their Impact on Tumor Progression and Mechanisms of Carcinogenesis.

Microplastics from Food Packaging: Polymer Degradation Pathways, Environmental Distribution, and Effects on the Human Gastrointestinal Tract.

Microplastics, Nanoplastics and Heart Contamination: The Hidden Threat.

Air Pollution

Climate Change, Air Pollution and the Global Obesity Syndemic: a Review of Current Evidence.

Pharmaceuticals/Personal Care Products

Maternal paracetamol (acetaminophen) use during pregnancy and risk of autism spectrum disorder and attention deficit/hyperactivity disorder in offspring: umbrella review of systematic reviews

Human Health Studies

Numerous Chemicals/Mixtures

Organophosphate ester flame retardants and plasticizers in house dust and Child Behavior Checklist outcomes: A nested study in the Canadian CHILD Birth Cohort.

Exposure to individual organophosphate esters and their mixture in relation to semen quality in Chinese men.

Phthalates

Gene expressions in newborns and the association with prenatal exposure to phthalate plasticizers – The Taiwan Maternal and Infant Cohort Study (TMICS).

Di-2-ethylhexyl phthalate may exaggerate allergic response in boys with atopic dermatitis – 4-year follow-up of the Taiwan Maternal and Infant Cohort Study.

Parabens/Triclosan/Antimicrobials

Metabolic effects of paraben exposure in geriatric serum: non-targeted metabolomics profiling and association analysis of perturbed metabolic pathways.

Association between triclosan/triclocarban exposure and esophageal carcinoma development: A nested case-control study in a prospective cohort.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Cross-sectional and longitudinal relationships of dichlorodiphenyltrichloroethane and its metabolites and polygenic risk scores with dyslipidemia.

PFAS

First evidence of legacy and emerging per- and polyfluoroalkyl substances (PFAS) in the follicular fluid of a cohort of North Carolina in vitro fertilization (IVF) patients.

Associations of PFAS exposure with obstetric and birth outcomes in the Japan Environment and Children’s Study (JECS): Is maternal endometriosis an effect modifier?

Associations between per- and polyfluoroalkyl substances and reproductive outcomes among women undergoing in vitro fertilization/intracytoplasmic sperm injection treatment.

Assessing PFAS mixture exposure and thyroid function in U.S. adolescents: insights from NHANES 2011-2012.

Pesticides

Association between urinary organophosphate pesticide metabolites and blood lipid levels in US children.

Atrazine use and markers of kidney function and nephrotoxicity among male farmers in the Biomarkers of Exposure and Effect in Agriculture Study.

Metals/Metalloids

Prenatal fluoride exposure and autistic behaviors in preschool-aged children: the Maternal-Infant Research on Environmental Chemicals (MIREC) cohort study.

Toxic metals and trace elements in maternal blood and urinary tract infection during the first 2 years of life: The Japan Environment and Children’s Study.

Association of pre-and postnatal mercury exposure with cardiometabolic risk factors in children: the role of the telomere length and telomerase reverse transcriptase polymorphisms.

Placental transfer efficiency of metals and its association with cognitive development in offspring: Roles of placental inflammatory cytokines and oxidative stress markers.

Diagnostic Utility of Hair Toxic Metals in Autism Spectrum Disorder: Unlocking Biomarkers Among Egyptian Children.

Metal and Metalloid Exposure and Cognitive Function among Copper Mine Workers: A Three-Year Longitudinal Study.

Association of Arsenic, Lead, and Mercury with Liver Function Markers in German Outpatients.

Microplastics/Nanomaterials

Elevated blood microplastics and their potential association with Parkinson’s disease.

Air Pollution

Wildfire-specific fine particulate matter and preterm birth: a US ECHO Cohort analysis.

Maternal exposure to indoor and outdoor air pollution during pregnancy increases offspring risk of autism spectrum disorder.

Preconception, gestation, and childhood exposure to air pollution and risk of polycystic ovary syndrome (PCOS) in a US girls cohort study.

Long-term exposure to traffic-related air pollution is associated with epigenetic age acceleration.

A case-crossover analysis of short-term PM_2.5 exposure and COVID19-related hospitalizations in the National Clinical Cohort Collaborative.

Exposure to household air pollution in relation to stomach and esophageal cancer in Xuanwei, China.

Pharmaceuticals/Personal Care Products

Sexual behavior and sexual identity in female offspring of women exposed in utero to diethylstilbestrol (DES).

Laboratory Studies

Numerous Chemicals/Mixtures

Toxicity Assessment of Mixture Effects of Insecticides and Perfluorinated Chemicals (PFAS) in Zebrafish (Danio rerio): A Case Study With Chlorpyrifos and Perfluorohexanoic Acid (PFHxA).

Integrating Multi-omics and Machine Learning to Decipher the Role of GSTP1 in Endocrine-Disrupting Chemical-Induced Prostate Cancer Pathogenesis.

Co-exposure effects of arsenite and bisphenol A on zebrafish: A focus on gut microbiota’s role in arsenobetaine biosynthesis-related toxicity.

Bisphenols

Vitamin D Exhibits Hepatoprotective Properties Against Bisphenol A-Induced Hepatic Injury in Rats via Mitigating Oxidative Stress, Inflammation, and Apoptosis.

Curcumin Alleviates Bisphenol A-Induced Blood-Testis Barrier Disruption in Mice by Targeting Surfactant Protein B (SFTPB) to Suppress Oxidative Stress-Activated NLRP3 Inflammasome.

Pineal melatonin improves bisphenol A-induced enterotoxicity via tryptophan/AhR/mitochondria signaling in pregnant mice.

Replacing BPA: Structural Substitutes BPAF Binding to the Progesterone Receptor Elevates Breast Cancer Risk.

Novel in silico Evidence of Bisphenol A as a Neuroinflammatory Modulator through the cGAS-STING-NLRP3 Pathway.

Bisphenol S promotes hepatic fibrosis through macrophage polarization- and autophagy-mediated activation of hepatic stellate cells.

Bisphenol S impairs courtship, grooming, and locomotor behaviors in Drosophila melanogaster.

Phthalates

Nicotinamide mononucleotide rescues Di-n-butyl phthalate induced blood-brain barrier damage via NAD⁺/Sirt1/FOXO1a pathway activation.

The novel regulatory role of miR-101a in CRH expression following low-concentration DEHP exposure in zebrafish embryos.

Parabens/Triclosan/Antimicrobials

Methylparaben and propylparaben promote bladder cancer invasion via MMP2 and PPARG modulation.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Relevance of Aryl hydrocarbon receptor signalling in the inhibitory effect of environmental pollutant TCDD on promoter-specific aromatase (CYP19A1) expression in granulosa cells.

PFAS

Integrated in silico and in vitro assessment of estrogen and androgen receptor activity of 10 selected PFAS within an Integrated Approach to Testing and Assessment (IATA).

Differential Activation of Peroxisome Proliferator-Activated Receptor Alpha by Per- and Polyfluoroalkyl Substances.

F-53B exposure induced testicular premature aging through ZBP1-mediated programmed necrosis.

Exploring the mechanism of PFTrDA on human hepatic metabolic diseases based on network toxicology and molecular docking.

Exposure to environmentally relevant levels of perfluorotetradecanoic acid (PFTeDA) affects respiratory and reproductive functions of Mytilus trossulus: An experimental study.

Photodynamic priming (PDP) targets platinum resistance from chronic perfluoroalkyl substances (PFAS) exposure in ovarian cancer cells.

Perfluorooctanoic Acid Disrupts Splenic Immunity and Antiviral Responses in the LCMV Model: Insights from Single-Cell Transcriptomics.

The Effects of Prenatal GenX (HFPO-DA) Exposure on Gut Microbiota and Metabolic Function in Pregnant Rats and Their Offspring.

Flame Retardants

The associated long-term disturbance of diethyl phosphonate on the growth phenotype, gut microbiota and SCFAs of offspring rats.

1,2-bis(2,4,6-tribromophenoxy) ethane, a novel brominated flame retardant, induces hepatic fibrosis: New insights into crosstalk between macrophage extracellular traps and stellate cell activation.

Immunotoxicity and cancer risk exacerbation induced by tris(1,3-dichloro-2-propyl) phosphate exposure: insights from macrophage inflammatory responses and in vivo tumor models.

Organotins

Metabolomics analysis reveals lipid metabolism disorders caused by triphenyltin via upregulation of PPARγ pathway.

Pesticides

From Molecular Structure to Food Safety: Mechanistic Analysis of Strobilurin-Induced Cardiotoxicity in Zebrafish and LC₅₀-Based QSAR Modeling for Toxicity Prediction.

Exploring the Androgen Receptor Binding Affinity of Azole Derivatives through Multiscale Computational and Experimental Approaches.

Combined glyphosate and chlorpyrifos-based pesticides impair innate and adaptive immune functions: an in vitro approach.

Whole genome bisulfite sequencing reveals epigenetic drivers of chronic chlorpyrifos exposure induced liver cell neoplasia.

The role of the pentose phosphate pathway in the development of metabolic disorders in the testes during rat intoxication with cypermethrin.

Chlormequat chloride inhibited thyroid hormone in the pregnant rats by regulating sodium/iodide symporter.

Effects of pyrethroid insecticides on sex ratios in agile frogs (Rana dalmatina).

Metals/Metalloids

Prenatal and postnatal exposure to environmental level arsenic declines male reproductive function by affecting spermatogenesis and maturation in offspring.

Reproductive effects of chronic dietary exposure to arsenic-contaminated oligochaetes in Zebrafish (Danio rerio).

Oral cadmium exposure to environmental doses induces visceral adiposopathy in Wistar rats.

Microplastics/Nanomaterials

Multigenerational growth inhibition and oxidative stress of polystyrene micro(nano)plastics on earthworms (Eisenia fetida).

Co-exposure to microplastics and bisphenol A increases viral susceptibility in largemouth bass (Micropterus salmoides) via oxidative stress.

Ingested PET microplastics alter the metabolomic profile of the porcine pancreas.

Assessment on intestinal health from polylactic acid microplastics degradation on rare minnow (Gobiocypris rarus): Inflammation regulation by mitochondrial dysfunction.

Size-dependent impacts from polystyrene micro- and nanoplastics on freshwater invertebrates: A mesocosm study combining environmental DNA metabarcoding and morphological identification.

Toxicity and transcriptome sequencing analyses of nanoplastics combined with acetaminophen on zebrafish bone development.

Melatonin mitigates polystyrene nanoplastics-induced impairment of oocyte maturation in mice.

Different Toxic Effects of Polystyrene Microplastics and Nanoplastics on Caenorhabditis elegans.

Pharmaceuticals/Personal Care Products

Melatonin ameliorates oxybenzone-induced meiotic defects in mouse oocytes via regulation of mitochondrial dynamics and calcium signaling.

An in utero exposure to the synthetic estrogen diethylstilbestrol affects the fat pad composition in post-natal mammary glands.

Miscellaneous

Assessment of the sub-lethal effects induced by three tire rubber-derived contaminants on zebrafish larvae.

6-PPD induces mitochondrial dysfunction and reduces healthspan and lifespan through SKN-1 in Caenorhabditis elegans.

A toxicological comparison of tire and road wear particles emitted on rural and urban roads, alone or with the co-exposed pollutant benzo[a]pyrene: Size and origin as key factors in controlling the in vitro proinflammatory response.

Maternal Exposure to Iopanoic Acid Disrupts Thyroid Hormone Metabolism and Impairs Development of the Rodent Brain.

Chronic cylindrospermopsin exposure impairs oocyte growth and maturation by stress-induced endocrine disruption and immune activation of NF-κB/TNF-α pathway in female zebrafish.

Exposure/Environment Studies

Numerous Chemicals/Mixtures

Chemical exposure in childhood: A study on organophosphate flame retardants and plasticizers in a Flemish birth cohort.

Assessment of exposure to pesticides, anticoagulant rodenticides, and PFASs in the blood of top-predator birds by LC-MS/MS analysis.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Increasing concentrations of polychlorinated biphenyls (PCBs) in Eurasian otters (Lutra lutra) from Wales suggest remobilisation from sediment sinks.

PFAS

PFAS dynamics in the American black bear (Ursus americanus): Physiological stages (hyperphagia, hibernation, and post-hibernation), and temporal trends from 1989 to 2015.

Per- and polyfluoroalkyl substances in municipal solid waste incineration ash: occurrence and management implications.

The role of DOM on the allocation of PFASs between water and sediment within a river system.

Pesticides

Exploring the intricacies of indoor dust pollution from neonicotinoid insecticides and its human health impacts: An exemplar from eleven agricultural communities in Ghana, West Africa.

Pesticide contamination and human exposure risk in municipal and commercially purified water from an urban zone in Mexico.

Simultaneous determination of three fluorinated pesticides and a metabolite in various food processing matrices and chronic dietary risk assessments.

Metals/Metalloids

One Century of Change: Monitoring Heavy Metal Pollution through Herbarium Bryophytes in Bratislava (Slovakia).

Microplastics/Nanomaterials

The dawn of a new air pollutant: inhalable microplastics as emerging vectors of hazardous contaminants and their implications for human health.

Microplastics detection from packaged milk: Estimation, diagnosis of probable sources, evaluation of dietary exposure, pollution load, and risk assessment.

Microplastic pollution from protective measures in urban construction should not be overlooked: A case study in Changzhou, China.

A new risk for the recovered Tibetan antelope (Pantholops hodgsonii): Co-exposure of microplastics with organophosphates in their habitats.

Global Meta-Analysis Integrated with Machine Learning Assesses Context-Dependent Microplastic Effects on Soil Microbial Biomass Carbon and Nitrogen.

Arctic macrosources of the microplastic pollution (Longyearbyen, Spitsbergen): Spectral characterization and first insight into the fungal diversity on the arctic plastisphere.

Pharmaceuticals/Personal Care Products

Evaluation of the efficacy of PREVENIR (PREVention ENvIronment Reproduction) platforms on urinary markers of chemical exposure in pregnant women: protocol for an unblinded randomised clinical trial (PREVENIR-G).

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Industry-funded articles are included without notation. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. There are searchable archives. Compiled by Sarah Howard of Healthy Environment and Endocrine Disruptor Strategies (HEEDS), a program of Environmental Health Sciences.

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EHN EHN

Gordon Research Conference on environmental endocrine disruptors
by Sarah Howard on January 16, 2026 at 4:02 pm
This year's Gordon Research Conference on endocrine disruptors will be held June 28-July 3, with the accompanying Gordon Research Seminar on June 27-28, in Newry, Maine. These conferences bring together graduate students, post-docs, professors, and researchers who work on endocrine disrupting chemicals, and are an invaluable source of discussion. Apply to attend and submit your abstract by January 20th if you would like to be considered for one of these short talks using this link.
National PFAS Conference
by Sarah Howard on January 15, 2026 at 10:15 pm
The University of Arizona is hosting the National PFAS Conference, in person in Tucson on June 8-10, 2026.
Webinar recording: Effects of chemical mixtures on ovarian function
by Sarah Howard on January 15, 2026 at 7:07 pm
In this Feb. 12 webinar, Dr. Shuo Xiao introduced his lab research that focuses on integrating in vivo, in vitro, and in silico models to study the impacts of real-world mixtures of endocrine disrupting chemicals (EDCs) on female ovarian function, reproductive outcomes, and the molecular mechanisms involved. Dr. Xiao is the 2025 winner of the Lou Guillette, Jr Outstanding Young Investigator Award from Healthy Environment and Endocrine Disruptor Strategies (HEEDS), a program of Environmental Health Sciences. Sponsored by the EDC Strategies Partnership and Young EDC Scientists Showcase (YESS).

EHN EHN

Every stage of plastic use — from production to disposal — harms human health
by Environmental Health Sciences Staff on March 6, 2026 at 2:36 pm
In a recent study published by The Lancet Planetary Health, researchers examined the health costs of pollutants released by plastics across their full lifecycle and emphasized the need for international policy that reduces plastic production.
Babies are exposed to more forever chemicals in utero than previously thought
by EHN Curators on March 6, 2026 at 12:10 pm
New research into umbilical cord blood shows a startling number of PFAS.
Study links cell tower and cell phone radiation to changes in blood cells tied to immune health
by Environmental Health Sciences Staff on February 27, 2026 at 2:24 pm
A recent study published in Electromagnetic Biology and Medicine found people living close to cell towers and wireless base station network antennas had higher radiofrequency (RF) radiation exposures, along with measurable changes in certain white blood cells, suggesting a biological stress response and altered immune activity.

EHN EHN

After years of gains, GOP pushes to roll back chemical regulations
by EHN Curators on March 6, 2026 at 12:15 pm
In Texas, environmental activists and experts raise the alarm about the impact on the state's petrochemical industry.
Senate GOP backs speedier chemical reviews; Dems cite health risks
by EHN Curators on March 5, 2026 at 12:20 pm
Proposed changes to the nation’s premier chemical safety law are necessary for American competitiveness, Senate Republicans said in a hearing on Wednesday, as Democrats warned the changes will harm public health.
Former EPA staff detail expanding pollution risks under Trump
by EHN Curators on March 4, 2026 at 6:00 pm
The Trump administration’s relentless rollback of public health and environmental protections has allowed widespread toxic exposures to flourish, warn experts who helped implement safeguards now under assault.