EDC Science Weekly, Oct. 31- Nov. 6, 2025

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Events, Regulations/Policy, Methods/Tools/Screening, Commentaries, Reviews/Meta-Analyses, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Science summaries

Events

Nov. 8 livestream: How do we solve plastic pollution by 2040? [TEDxGreatPacificGarbagePatch]

Nov. 12 webinar: Plastics in the built environment: Considerations related to artificial turf [CHE]

Nov. 12 webinar: Toxic chemicals in plastics [Beyond Plastics]

Nov. 13 webinar: Protecting Our Health: Toxic Threats, Trusted Solutions [Toxic-Free Future]

Nov. 14 webinar: OECD Guidance Document on the Generation, Reporting and Use of Research data for Regulatory Assessments [Organisation for the Economic Cooperation and Development (OECD)]

Nov. 14 CME event: Cancer and Environment [Silent Spring, Columbia University]

Nov. 17 webinar: Plastic Pollution and Human Health: What We Know and What We Can Do [UCSF]

Nov. 20 webinar: EDCs & Female Reproductive Health: A growing health concern [EDC Strategies Partnership]

Dec. 1: Due date for Reach the Decisionmakers 2026 [UCSF]

Dec. 4: ICEDA Scientific Symposium (in Montreal and on zoom) Intersectoral Centre for Endocrine Disruptor Analysis (ICEDA)

Dec. 10 webinar: CHE Café: Why Parkinson’s disease is preventable [CHE]

Dec. 11 webinar: Corporate Capture of Regulatory Science [PRHE, UCS, CHE]

Jan. 11-14: Microplastics exposure and human health conference [in person in Santa Fe; late-breaking abstracts due Dec. 1]

Jan. 15: application due date for May 26- June 9 course, Endocrine-Disrupting Chemicals: Hazards and Opportunities (ECHO) [Marine Biological Laboratory]

June 28 – July 3: New and emerging threats, approaches, and mitigation strategies for environmental endocrine disruptors [Gordon Research Conference] and accompanying Gordon Research Seminar June 27-8, Harnessing interdisciplinary evidence for endocrine disruption.

Regulations/Policy

Regulatory framework of phthalates and two common alternatives: A review of the European Union legislation.

Daily briefing: How the plastics-treaty breakdown could pave the way for something better.

The deficit of regulation of plastic waste and microplastics in Latin America: about health and bioaccumulation in México.

Why are PFOS ecological surface water quality criteria so different between countries? A review of differences in regulatory guidance.

More EDC policy, FPF’s regulations open for comment, and Science’s Trump-Tracker.

Methods/Tools/Screening

A Protein Interactome-Based Framework Reveals the General Toxicity of Chemicals.

The PrecisionTox Chemical Library: Creation of a Chemical Collection to Discover Evolutionary Conserved Biomolecular Signatures of Toxicity.

The scientific imperative: why human-centered models must replace animal experimentation?

Commentaries

Dismantling of US federal agencies will ‘destroy science’

Upstream Perspective on Maternal-Child Environmental Health.

Bisphenol F-TLR4 interaction: uncovering new mechanisms in unexplained miscarriage.

Ambient Air Pollution and Environmental Injustice in Perinatal Health.

Reviews/Meta-Analyses

Numerous Chemicals/Mixtures

Impact of endocrine disruptors on female fertility: an update.

Air pollution, emerging chemical exposures, and systemic lupus erythematosus: a meta-epidemiology study.

Application of intestinal microbiota in marine fish for assessing the toxicity of typical pollutants: a literature review.

Bisphenols

Bisphenol A and reproductive health: a comprehensive overview of toxicological effect.

Phthalates

A potential threat of the phthalate acid esters (PAEs) in the different environmental matrices to public health: a systematic review.

Comprehensive Insights into DEHP Neurotoxicity Across the Lifespan: Behavioral Effects, Mechanisms, and Preventive Strategies.

Pesticides

Identifying the safe operating space for food systems.

Metals/Metalloids

Association of maternal exposure to trace elements and toxic metals with repeated measurements of foetal and early-childhood growth: a systematic review.

Environmental toxins and toxic metals in autoimmune diseases: Sex differences, hormonal influences, and immune dysregulation.

Associations between cadmium and lead exposure and thyroid disorders: A systematic review and meta-analysis.

Lead exposure and antisocial behavior: A systematic review of human and animal evidence.

Fluoride and Neurodevelopmental Hazard Modelling: An Assessment of Concentration-Response Analysis.

Microplastics/Nanomaterials

Reproductive toxicity of micro- and nanoplastics: Insights from experimental and human studies.

Neurotoxicity of Microplastic Particles in the Human Brain: A Systematic Review.

Microplastics: A Narrative Review on Modes of Exposure and Impact on Human Health.

Micro and nanoplastics in human carcinogenesis: Insights from in vitro studies.

Do Microplastics (MPs) and Nanoplastics (NPs) Directly Contribute to Human Carcinogenesis?

Silent saboteurs: How microplastics disrupt stem cells and tissue regeneration.

Neurological effects induced by micro- and nanoplastics in fish: A systematic review and meta-analysis.

Microplastics and microbial interactions in marine environments: A critical review on biogeochemical cycling and ecological impacts.

Pharmaceuticals/Personal Care Products

Gender, self-care and toxic exposures: a narrative review of personal care product use and health equity implications.

Miscellaneous

Derivation of acute aquatic life screening values for 6PPD and 6PPD-quinone in freshwaters by USEPA Office of Water.

Human Health Studies

Numerous Chemicals/Mixtures

An interpretable machine learning model predicts the interactive and cumulative risks of different environmental chemical exposures on depression.

Environmental chemical factors associated with human biological age acceleration: an interpretable machine learning study.

Prenatal exposure to bisphenols, metals, and risk of fetal chromosome numerical abnormalities in high-risk pregnancies: Independent, combined, and interactive effects.

Co-exposure of PFASs, PAHs and metals, immune inflammation and triglyceride-glucose index: Exploring associations and mediation effects in children.

Phthalates

Association Between Di-(2-Ethylhexyl) Phthalate and Childhood Asthma Through Plasma Metabolome Alterations.

PFAS

Translational framework linking perfluoroheptanoic acid (PFHpA) exposure to metabolic dysfunction associated steatotic liver disease in adolescents.

Mediating Role of Proteomics in the Association Between Per- and Polyfluoroalkyl Substance Exposure and Blood Pressure in Youth.

Flame Retardants

Exploring the association between brominated flame retardant exposure and the risk of rheumatoid arthritis: A comprehensive analysis.

Polybrominated diphenyl ethers (PBDEs) exposure in elderly agro-pastoralists of Inner Mongolia: Ethnic disparities, dietary drivers, and metabolic-inflammatory implications.

Pesticides

Pyrethroid Exposure in Premature Newborns: A Pilot Study on Materno-Fetal Transmission and Early Postnatal Evolution.

Sex-Specific Associations of Early Life Exposure to the Pesticide Mixture with Cardiometabolic Outcomes in CHAMACOS Young Adults.

Postnatal pesticide exposure and behavioural outcomes in children and adolescents: findings from South Africa.

Assessing the Role of Pesticide Exposure and Menopausal Status in Breast Cancer Prognosis Among Rural Women.

Association of organophosphate pesticide exposure with serum lipid profiles in US adults: an analysis of NHANES 2003-2020.

Household herbicide use is associated with the risk of Parkinson’s disease and a younger age at onset in PPMI and Fox Insight cohorts.

Exposure to pesticides and renal function in agricultural workers in Rafsanjan, Iran: a case-control study.

Metals/Metalloids

Prenatal exposure to heavy metals and the trajectory of autistic traits in childhood.

Urinary fluoride and dental fluorosis in relation to kidney and liver function in adolescents and young adults in the United States.

Air Pollution

Ambient particulate air pollution is associated with higher risk of microvascular complications and diabetic ketoacidosis among persons with type 1 diabetes mellitus in an observational survival study.

Laboratory Studies

Numerous Chemicals/Mixtures

Study on the neurotoxicity of single and combined exposure of phthalate esters and lead to zebrafish brain tissue.

In vitro bioassays for quantifying mixture effects of organic micropollutants extracted from caged fish, water and sediment.

Bisphenols

Chronic Bisphenol-A Exposure Enhances ROS and AGEs Production via the RAGE/PI3K/AKT/mTOR Signaling Pathway, Inducing Apoptosis in Human Pancreatic β-Cells.

The Role of ER/ERK/CREB Pathway Mediated Mitophagy in Bisphenol F-Induced Cognitive Function Changes in Young Female Rats.

Stage-specific cardiotoxicity induced by bisphenol A using human pluripotent stem cell-derived 2D- and 3D-cardiomyocyte models.

Assessing the role of bisphenol A in female reproductive cancers using network toxicology, molecular dynamics, and preliminary experimental validation.

Capsaicin supplementation modulates the nutrigenomic signature essential for energy metabolism in adipose tissue and liver of bisphenol-A exposed mice.

The effects of bisphenol compounds on endocrine disruption and reproductive function from epidemiological analysis to animal exposure: A mixture analysis.

Bisphenol-A at an environmentally plausible dose caused gut microbiota-led impaired cognitive performances in adult mice.

Shared and compound-specific pathways of bisphenol A and its analogues in male infertility: An integrative approach combining network toxicology, omics analysis, and molecular docking.

Combining network toxicology, machine learning and molecular docking to explore the mechanism of bisphenol A-induced Asthma.

Parabens/Triclosan/Antimicrobials

Triclosan induces spermatogenic damage via the oxidative stress-P53-apoptosis pathway in zebrafish.

Endocrine disruptive effects and mechanisms of isothiazolinone analogs in marine medaka (Oryzias melastigma) embryos and H295R cells.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Prevention of prolactin reduction: a novel strategy countering multi-generational growth retardation caused by maternal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin.

DDT Exposure Induces Microglial Activation and Disease-Associated Microglial Signatures: Relevance to Mechanisms of Alzheimer’s Disease.

Exploring toxicity and mechanisms of DDTs in Alzheimer’s disease through network toxicology and molecular docking insights.

Real-life Organochlorine Mixture-Induced Lipid Dysregulation and Oxidative Stress in Leydig TM3 Cells: Mechanistic Insights into Male Reprotoxicity.

PFAS

Integration of Transfer Learning and Multitask Learning To Predict the Potential of Per/Polyfluoroalkyl Substances in Activating Multiple Nuclear Receptors Associated with Hepatic Lipotoxicity.

Temporal Effects of perfluorononanoic acid (PFNA) Exposure on Metabolic Disorders and Gut-Liver Axis Injury in Large Yellow Croaker (Larimichthys crocea).

Receptor-specific inhibition of pro-inflammatory cytokine secretion induced by PFAS in THP1-derived macrophages: a structure-activity relationship study.

Mixture toxicity of perfluoroalkyl substances on the aquatic invertebrate Gammarus roeselii.

Marine ecotoxicity evaluation of 10 per- and poly-fluoroalkyl acids using three USEPA short-term chronic bioassays.

Perfluoroundecanoic Acid Inhibits Liver Cell Development in Pubertal Male Rats via Inducing Oxidative Stress.

Network toxicology and molecular simulation identify key genes and pathways in PFAS-induced premature ovarian insufficiency.

Flame Retardants

Developmental PBDE exposure persistently impairs mast cell function in vivo and drives sex-specific morphological and transcriptional changes in bone marrow-derived mast cells.

Environmental relevant concentrations of TBBPA cause complex toxicological mechanisms.

Autophagy modulates oxidative damage in BDE-47-exposed kidney cells of large yellow croaker (Larimichthys crocea).

Pesticides

Parental permethrin exposure disrupts offspring metabolism via microbiota-tryptophan axis and is rescued by Lactobacillus plantarum Y1.

Prothioconazole induced stereoselective developmental toxicity and liver injury in zebrafish embryos via ferroptosis.

Atrazine alters nitric oxide secretion and cytokines production in LPS-stimulated BalB/c mice, RAW264.7 macrophage and THP-1 cell lines.

Cytotoxic and gene expression effects of deltamethrin and acetamiprid on MDA-MB-231 breast cancer cells: a molecular and functional study.

Exploring the mechanism of methyl parathion and its degradation product on depression through network toxicology and molecular docking.

Double trouble: The synergistic threat of environmental stressors and pesticide mixtures.

Facing multiple threats: Diet-pesticide interactions in bumblebees.

Metals/Metalloids

SLC25A12-mediated glutamate translocation contributes to NaAsO₂-induced ferroptosis and islet β-cell dysfunction.

Arsenic Exposure Alters Liver Metabolism and Accelerates Skeletal Muscle Atrophy in Female BALB/c Mice.

Gallic acid mitigates cadmium-induced reproductive damage: Effects on sperm, antioxidants, and apoptosis in mice.

Cadmium exposure during adolescence and young adulthood induces signatures of metabolic dysfunction-associated steatotic liver disease.

Microplastics/Nanomaterials

Toxic effects of biodegradable polylactic acid nanoplastics on developing zebrafish (Danio rerio).

Prenatal exposure to polystyrene nanoparticles induces neuroimmune dysregulation in the adult mouse brain.

Polystyrene microplastics activate NF-κB/MAPK signaling in synovial fibroblasts, promoting inflammation and joint destruction in rheumatoid arthritis.

Polytetrafluoroethylene (PTFE, Teflon) microplastics and nanoplastics induce oxidative stress, mitochondrial damage, and genotoxicity in human intestinal cells.

Combined exposure to microplastics and tetracycline leads to impaired skeletal development in young mice by the microbiotagutbone axis.

Toxicological impact of dietary exposure to polypropylene microplastics in Atlantic salmon (Salmo salar).

Action mechanism as a cause of chronic constipation of inhaled and intravenously injected polystyrene nanoplastics in ICR mice.

Aged polylactic acid microplastics exacerbate lipid metabolism disorders and cardiac dysfunction via PPARγ activation in zebrafish: A comparative study with polymers and oligomers.

Micro- and nanoplastic (MNPs) exposure at single-cell resolution impaired placental function and cellular dynamics.

Pharmaceuticals/Personal Care Products

Subchronic exposure to four organic UV filters disrupted thyroid endocrine and neuronal systems in zebrafish: Insights into underlying toxicological mechanisms at different life stages.

Novel toxicity-associated metabolic pathways of benzotriazole UV stabilizers by cytochrome P450: mechanism-directed analysis.

Tire Wear Particles

Toxicity Identification Evaluation Techniques Isolate Zinc and 6PPD-Q as Causes of Acute Lethality to Rainbow Trout in Road Runoff.

First assessment of the ecotoxicological effects of the tire antioxidant 6PPD on early life stages of the popular sport fish species, the largemouth bass (Micropterus nigricans).

Comparative toxicity of tire wear particle leachates: Zinc as a key toxicant affecting development and motility in zebrafish larvae.

Integrated multi-omics of gut-liver axis to dissect the mechanism underlying hepatotoxicity induced by sub-chronic tire wear particles exposure in mice.

Exposure/Environment Studies

Numerous Chemicals/Mixtures

Knowledge and attitudes of pregnant women about endocrine disruptors.

Unveiling human exposure to organic contaminants during sleeping.

Microbiological and chemical risks in foods: Public perception versus risk ranking.

Bisphenols/Parabens

Analysis of Paraben and Bisphenol A Exposure in Relation to Food Intake Levels and Health Risk Assessments in the Taiwanese Population.

Worldwide systematic analysis of dietary paraben exposure. A scoping review of sources and food categories.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Polychlorinated dibenzo-p-dioxins/dibenzofurans (PCDD/Fs) concentrations in the environment and blood of residents living near industrial waste incinerators in South Korea.

PFAS

Associations between PFAS in public water system drinking water and serum among Southern California adults.

Sensitivity analysis of human health surface water quality criteria: a case study using perfluorooctane sulfonic acid.

Urban possums as sentinels for environmental contamination: First evidence of PFAS in Australian marsupials.

Concentrations of per- and polyfluoroalkyl substances in Canadian sea otters (Enhydra lutris) are higher near urban centers.

PFAS-induced immunotoxicity in freshwater fish of inland China: mechanisms and ecological risks.

Multiple stressors and reproductive success of tree swallows: Perfluoroalkyl acids, chemical mixtures, and ecological factors.

Occurrence and composition of PFAS in disposable straws from the Korean Market: quantitative and suspect screening analyses.

Flame Retardants

Spatial and Temporal Trends of Dissolved Polybrominated Diphenyl Ethers and Non-BDE Flame Retardants in the Aquatic Environment across Countries.

Pesticides

Children’s exposure to herbicides in Jalisco, Mexico-a public health concern perspective.

Dietary exposure to neonicotinoids and related metabolites in early-life nutrition: Contamination profiles and health implications.

Environmental RNA-Based Metatranscriptomics as a Novel Biomonitoring Tool: A Case Study of Glyphosate-Based Herbicide Effects on Freshwater Eukaryotic Communities.

Risk based ranking of prioritized pesticides: where the exposome meets comparative toxicogenomics.

Microplastics/Nanomaterials

Microplastics in drinking water: quantitative analysis of microplastics from source to tap by pyrolysis-gas chromatography-mass spectrometry.

Microplastic in water and wastewater: occurrence, toxicity, analytical approach, and remediation.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Industry-funded articles are included without notation. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. There are searchable archives. Compiled by Sarah Howard of Healthy Environment and Endocrine Disruptor Strategies (HEEDS), a program of Environmental Health Sciences.

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