EDC Science Weekly, Oct. 17-23, 2025

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Events, Regulations/Policy, Methods/Tools/Screening, Commentaries, Reviews/Meta-Analyses, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Highlights:

Science summaries and highlights

Events

Today, soon! Oct. 23 webinar: Science and Democracy Under Siege [PRHE’s Science Action Network]

Today, also soon! Oct. 23 webinar: Defend Our Health: Authors & Friends featuring a discussion of plastics.

Oct. 27-31: Children’s Environmental Health Week daily webinars [California Nurses for Environmental Health and Justice]

Oct. 28 webinar: Ancestral Voices: Breast Cancer, Toxic Chemicals & Alaska Native Language Revitalization [CHE Alaska]

Oct. 29 webinar: Understanding the Link Between Firefighting and Cancer: Opportunities for Prevention and Awareness [Cancer and Environment Network of Southwestern Pennsylvania]

Oct. 31 webinar: Informing and advising on the state of the art, gaps, and future needs in micro- and nanoplastic and health research in Europe [CUSP]

Nov. 5 webinar: Weakening of Chemical Regulation under Zeldin’s EPA [PRHE, UCS, CHE]

Nov. 3 and 10 webinar series: From Cells to Solutions: Emerging Tools for Studying Health and Disease [NIEHS Superfund Research Program]

Nov. 12 webinar: Plastics in the built environment: Considerations related to artificial turf [CHE]

Nov. 12 webinar: Toxic chemicals in plastics [Beyond Plastics]

Nov. 13 webinar: Protecting Our Health: Toxic Threats, Trusted Solutions [Toxic-Free Future]

Nov. 14 CME event: Cancer and Environment [Silent Spring, Columbia University]

Nov. 17 webinar: Plastic Pollution and Human Health: What We Know and What We Can Do [UCSF]

Nov. 20 webinar: EDCs & Female Reproductive Health: A growing health concern [EDC Strategies Partnership]

Dec. 1: Due date for Reach the Decisionmakers 2026 [UCSF]

Dec. 10 webinar: CHE Café: Why Parkinson’s disease is preventable [CHE]

Dec. 11 webinar: Corporate Capture of Regulatory Science [PRHE, UCS, CHE]

Jan. 11-14: International Conference on Microplastics [in person in Santa Fe; late-breaking abstracts due Dec. 1]

Regulations/Policy

Per- and polyfluoroalkyl substances (PFAS) in the United States: Current knowledge and regulatory context.

More EDC policy, FPF’s regulations open for comment, Science’s Trump-Tracker, and links to preserved resources removed from U.S. federal websites

Methods/Tools/Screening

The Decision Tree approach as a strategy for the global phase out of animal testing for acute and local toxicity for chemicals: recommendations from an expert workshop

Advancing human health risk assessment: the role of new approach methodologies

Advancing fish embryo tests for endocrine disruptor testing: assessing endocrine adversity in non-protected life stages.

Development of a network formation assay for developmental neurotoxicity hazard screening using 3D human iPSC derived BrainSpheres.

Fetal Response to Maternal Exposures of Environmental Chemicals: Utility of a Four-Cell Human Feto-Maternal Interface Organ-on-Chip.

Dried blood spots analysis for targeted and non-targeted exposomics.

A supplement in the European Journal of Endocrinology on the EndoCompass project includes these and many more articles:

Commentaries

Dark Chocolate, Heavy Metals, and Neurodevelopment in children.

The Case for Stronger Government Action on Ultraprocessed Foods

Editorial: The acetaminophen scare: association vs causation.

Overlooked Microplastic Contamination to Challenge the Conventional Clinical Treatment of In Vitro Fertilization re Microplastic Contamination of Human Sperm before In Vitro Fertilization Warrants Attention for Early Life Exposure Risks

Reviews/Meta-Analyses

Numerous Chemicals/Mixtures

Bibliometric and visual analysis of global research on endocrine-disrupting chemicals and children’s health: evidence, emerging concerns, and research gaps.

The impact, mechanisms and prevention strategies of environmental endocrine disruptors on male reproductive health.

Evidence that declining human fecundity contributes to the fertility crisis.

Traditional medicine, environmental exposures, and cultural practices in cancer risk: insights from low- and middle-income countries.

Environmental toxicants and Parkinson’s disease: recent evidence, risks, and prevention opportunities.

A PLAN to address the Parkinson pandemic.

Offspring’s exposome: a narrative review on the influence of early-life factors on childhood obesity risk.

BPA/Phenols

Tetramethyl Bisphenol F: Organ- and System-Specific Toxicity, Current Status, and Perspectives.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Association between DDT or its byproducts and T2DM: a systematic review and meta-analysis.

PFAS

Human health risk assessment of Per- and polyfluoroalkyl substances (PFAS)

Pesticides

Pesticides, an urgent challenge to global environmental health and planetary boundaries.

Metals/Metalloids

Systematic Review of Cardiotoxicity Associated with Oral Cadmium Exposure.

The Role of Heavy Metals as a Biomarker in the Pathogenesis of Dyslexia and Specific Learning Disabilities: A Systematic Review.

Microplastics/Nanomaterials

Exposure to Nanoplastics and Co-Contaminants in Foods and Environment: Threats to Human Health.

A systematic review on the effect of microplastics on the hypothalamus-pituitary-ovary axis based on animal studies.

Plants and microplastics: Growing impacts in the terrestrial environment.

Pharmaceuticals/Personal Care Products

Thyroid disrupting effects of exposure to sunscreens: in vitro and in vivo evidence of the impact of organic UV-filters.

Valproate-Induced Autism and Sexual Hormone Disturbances: A Literature Review and Hypotheses.

Miscellaneous

Advances in Eco-friendly Materials for Sustainable Packaging and Single-Use Utensils: A Decade of Innovation in Preparation, Characterization, and Applications.

Tire wear particles in aquatic environments: A systematic review of sources, detection, distribution, and toxicological impacts.

Human Health Studies

Numerous Chemicals/Mixtures

Effects of exposure to 17 endocrine disrupting chemicals on sex steroid hormone levels in 12- to 19-year-old males in the United States.

Transplacental transfer efficiency of environmental chemicals in association with gestational diabetes mellitus.

BPA/Phenols

Bisphenol A exposure modulates ovarian cancer gene expression and oxidative stress markers: a case-control study.

Phthalates

Prenatal Phthalate Exposure, Leptin in Early Childhood, and Mediating Role of DNA Methylation.

Parabens/Triclosan/Antimicrobials

Associations of parabens and age at natural menopause in women in the USA: National Health and Nutrition Examination Survey.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Chlordecone exposure in women and time to pregnancy: the Timoun cohort study in Guadeloupe, French West Indies.

PFAS

Perfluorooctanesulfonic acid (PFOS) exposure and multiple sclerosis: Evidence of association and mechanistic insights.

Flame Retardants

Organophosphate Flame Retardants, Obesity, and Depressive Symptoms among 1019 Young Healthy Men

Pesticides

Maternal organophosphate pesticide exposure in relation to birthweight: Modification by placenta transporter genotype.

Metals/Metalloids

Prenatal and Early Postnatal Lead Exposure, Sensitive Periods, and Later Adult Mental Health

Prenatal Exposure to Environmental Metal Mixtures and Social Development in Early Childhood: Evidence from a Birth Cohort and Mechanistic Study.

Assessment of the Association Between Anthropometric Indices Related to Overweight and Obesity and Selected Trace Elements and Heavy Metals: A Cross-Sectional Study.

Environmental exposures to lead, mercury, cadmium, manganese, and arsenic and obesity in Korean adults: Korean National Environmental Health Survey 2009-2017.

Associations of pre- and postnatal levels of three heavy metals with visual impairment in 3-year-old children.

Associations of children’s urinary metals with blood RNA N⁶-methyladenosine and 2′-O-methyladenosine.

Heavy Metals, Gut Microbiota, and Biochemical Markers: Unraveling the Complexities of Obesity.

Pharmaceuticals/Personal Care Products

Prenatal exposure profiles to Benzophenones and their impacts on thyroid hormones.

Miscellaneous

Tetrachloroethylene Is Associated With Presence of Significant Liver Fibrosis: A National Cross-Sectional Study in US Adults.

Laboratory Studies

Numerous Chemicals/Mixtures

Assessment of the Binding Patterns for Endocrine Disrupting Chemicals in Complex with Estrogen and Androgen Receptors by Leveraging the Asclepios Enalos KNIME Nodes.

Bisphenols

Serotonergic and Cholinergic Imbalance in the Offspring of Rats Exposed to Bisphenol A and Bisphenol S During Pregnancy and Lactation: Short- and Long-Term Effects.

Bisphenol AF Induces Hepatic Steatosis via Succinate-SUCNR1-Mediated Macrophage-Hepatocyte Interactions: An Adverse Outcome Pathway Study in Male C57BL/6 Mice.

Bisphenol A Interferes with Mast Cell-Mediated Promotion of Cellular Processes Critical for Spiral Artery Remodeling.

Exposure to Bisphenol B and S Increases the Risk of Male Reproductive Dysfunction in Middle Age.

Prenatal BPB exposure at environmentally relevant dose induces male-specific neuropsychiatric disorders: Impaired neuropeptide-mediated synaptic transmission via lncRNA-dependent ceRNA networks.

Deleterious Effects of Plastic Component Bisphenol A on Mitochondrial Function in Human Intestinal Cells.

Bisphenol A disrupts renal metabolism via MAPK-mediated steroid hormone dysregulation identified by transcriptomic and metabolomic analyses.

Bisphenol A Disrupts Spermatogenesis via Excessive Mitophagy-Driven Ferroptosis.

Bisphenol S as an emerging osteotoxicant: Mechanistic insights from osteoblasts and zebrafish models.

Bisphenol S chronic exposure impairs pancreatic function and induces obesity in male mice independently of high-fat diet intake.

Investigating the potential causal link between BPA and ovarian carcinogenesis: a network toxicology and mendelian randomization study on the CTRC/PRDX1/SKP1 pathway.

Phthalates

Di-(2-ethylhexyl) phthalate exposure disrupts glucose homeostasis through inhibition of PI3K/Akt/FoxO1 pathway triggering β-cell dedifferentiation in male rats.

Behavioral and transcriptomic analyses reveal neurotoxicity and mechanism of action of DEHP in female pubertal mice with or without type 2 diabetes mellitus.

Mediating roles of oxidative stress and nuclear factor kappa B signaling in benzyl butyl phthalate-aggravated allergic asthma.

Responses of zebrafish to phthalate exposure and recovery: Insights into transcriptome-based molecular mechanisms.

Parabens/Triclosan/Antimicrobials

Utilizing Network Toxicology and Molecular Dynamics Simulations to Efficiently Evaluate the Neurotoxicity and Underlying Mechanisms of the Endocrine-Disrupting Chemical Triclosan.

Triclosan induced obesity via gut microbiota dysbiosis and butyrate reduction.

The impact of triclosan exposure during the growth and development period on ovarian differentiation in female zebrafish and its mechanisms.

Long-Term Maternal Exposure to Triclosan Provokes Pulmonary Fibrosis in Mouse Offspring

In vivo and in silico assessment of endocrine disruption in Clarias gariepinus exposed to methylparaben, chloroxylenol, and benzalkonium chloride.

PFAS

Bile acids and apical sodium-dependent bile acid transporter impact per- and polyfluoroalkyl substances absorption: Evidence from in vivo and cross-sectional studies.

Computational evidence of cancer and reproductive toxicological potential from short-chain PFAS exposure through network toxicology and docking approaches.

Pesticides

Machine learning prediction model combined with network toxicology analysis identifies potential cardiotoxic components and mechanisms among 741 pesticides.

Metabolomic insights into clothianidin induced disorders of hepatic lipid metabolism in mice via AMPK signaling pathway.

Differential cognitive, behavioral, and neurochemical responses to acute chlorpyrifos exposure in normotensive compared to hypertensive adult rats.

Histopathological and oxidative stress responses in the honey bee Apis mellifera larvae chronically exposed to environmentally relevant concentrations of cyantraniliprole.

Metals/Metalloids

Investigation of the cardioprotective potential of dantrolene in mitigating arsenic-induced cardiac dysfunction in rats.

Enhanced pancreatic toxicity induced by cadmium and a high-fat diet: attenuation by naringin through the modulation of oxidative stress, apoptosis, and inflammatory signaling.

Microplastics/Nanomaterials

Detection and degradation of bisphenols in honey using matrix-induced dispersive liquid-liquid microextraction: Insights into the release of bisphenol A from polycarbonate microplastics.

Polystyrene microplastics (PS-MPs) disturb skeleto-muscular energy metabolism and tissue architecture following sub-acute exposure: A dose-responsive study.

Nanoplastics internalization impairs mitochondrial activity in equine sperm.

Evolution of Microplastics Released from Tea Bags into Water.

Microplastic exposure and allergic rhinitis: Network toxicology, and molecular docking insights.

Extracellular vesicles and PET microplastics: toward a biomarker framework for systemic endocrine-microbiome disruption.

A new insight of size-dependent plastics particles kinetics with regarding of metabolomics effects in liver and kidney.

Adolescent exposure to polylactic acid microplastics causes cardiac fibrosis by promoting cardiomyocyte senescence.

Chronic PET-Microplastic Exposure: Disruption of Gut-Liver Homeostasis and Risk of Hepatic Steatosis.

Pharmaceuticals/Personal Care Products

The Endocrine-Disrupting Chemical Benzophenone-3 in Concentrations Ranging from 0.001 to 10 µM Does Not Affect the Human Decidualization Process in an In Vitro Setting.

Miscellaneous

Investigating the hepatic developmental toxicity of synthetic phenolic antioxidant 3-BHA: A comprehensive network-based approach combined with human embryonic stem cell-derived hepatocyte models.

Mechanistic study on nonylphenol-induced liver fibrosis via Pink1/Parkin-mediated mitophagy and lipid droplet degradation in hepatic stellate cells.

Exploring the Toxicological Impact of 6PPDQ Exposure on Psoriasis through Network Toxicology, Machine Learning, and Multidimensional Bioinformatics Analysis.

Exposure/Environment Studies

Numerous Chemicals/Mixtures

Occurrence of volatile organic compounds (VOCs) and phthalate acid esters (PAEs) in recycled PET: Implications for food packaging materials.

Food safety in enteral nutrition formulas: Investigation of the presence of polychlorinated biphenyls (PCBs), phenols, and phthalate esters (PAEs) and potential health risks.

Silicone Ankle Bands as a Tool to Assess Infant Exposures to Semivolatile Organic Chemicals in Indoor Environments.

Phthalates

Exposure Levels and Health Risks of Phthalate Alternatives: A Urinary Metabolite Study

PFAS

Per- and polyfluoroalkyl substances in dog blood serum levels and semen quality.

Quantification of per- and polyfluoroalkyl substances (PFASs) in aqueous film-forming foam (AFFF)-impacted water: Comparisons between methodologies and laboratories.

Discovery of Comprehensive Sets of Chemical Constituents as Markers of PFAS Sources through a Nontarget Screening and Machine Learning Approach.

Profiles of per- and polyfluoroalkyl substances in firefighter turnout gear and their impact on exposure assessment.

Evaluating environmental health communication: The readability of factsheets about per- and polyfluoroalkyl substances (PFAS).

Pesticides

Occurrence and trends of fluorinated pesticides in food commodities marketed in Luxembourg (2011-2024).

Determination of pesticide residues in essential oils and related risk assessment for consumers: a pilot study.

Metals/Metalloids

Strong Association between Children’s Elevated Blood Lead Levels and Lead Service Lines: A Census Tract-Level Analysis for Two Midwest Cities.

Methods and Uncertainty in Predictions of Arsenic Exposure and Health Outcomes for Private Well Users in Massachusetts.

Microplastics/Nanomaterials

Assessment of Nanosized Plastics Exposure in Children: Evaluating the Impact of Daily Interaction with Plastic Items on Saliva Contamination.

Nanoplastics in infusion system remains underexplored: Evidence from detected nanoplastics in hospital-sourced infusion products.

Fire-exposed polypropylene as a potential source of nanoplastics in aquatic environments.

Honeybees as active bioindicators of plastic pollution: Environmental exposure, analytical strategies, and monitoring perspectives.

Sedimentology of plastics: state of the art and future directions. [intro to a special issue of Philos Trans A Math Phys Eng Sci.], includes Bridging the gap: a review on the interaction between (micro)plastics and climate change.

Pharmaceuticals/Personal Care Products

Hidden Hazard: The detrimental effect of personal care products on amphibian species.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Industry-funded articles are included without notation. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. There are searchable archives. Compiled by Sarah Howard of Healthy Environment and Endocrine Disruptor Strategies (HEEDS), a program of Environmental Health Sciences.

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