EDC Science Weekly, Sept. 5-11, 2025

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Events, Regulations/Policy, Methods/Tools/Screening, Commentaries, Reviews/Meta-Analyses, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Events

Sept. 12 symposium: Highlighting Duke’s environmental health community [hybrid] [Duke Integrated Toxicology and Environmental Health Program]

Sept. 15 webinar: A health sector perspective on forever chemicals [CHEM Trust, Tegengif, and Health Care Without Harm Europe]

Sept. 15: ECHO symposium: translating science to action [hybrid] [NIH Environmental Influences on Child Health Outcomes (ECHO)]

Sept. 15 Grand Rounds: PCBs: A legacy pollutant [on zoom] [Region 1 PEHSU and Boston Children’s Hospital; CE credits available]

Sept. 17 webinar: The Health Effects of Chemicals used in Food Packaging [Alliance of Nurses for Healthy Environments]

Sept. 18 webinar: Chemicals & Children’s Health: The Need for Action [CHE Alaska]

Sept. 22: Plastics, Human Health, and Solutions Symposium [NYU Langone Health Center for the Investigation of Environmental Hazards (CIEH)]

Sept. 29 conference: REACH revision 2025: simpler, faster, bolder, in Brussels [HEAL and CHEM Trust]

Oct. 14 webinar: ToxicDocs: A database of once-secret chemical industry documents [CHE]

Oct. 8 – Nov. 19 class: Plastics, Microplastics, and Human Health [Physician and Scientist Network Addressing Plastics and Health (P-SNAP)]

Jan. 11-14: International Conference on Microplastics [in person in Santa Fe; abstracts due Oct. 1]

Note: HEEDS is now accepting applications for the Lou Guillette, Jr. Outstanding Young Investigator Award, due Sept. 30.

More events

Regulations/Policy

Exploring experiences of the regulatory toxicology system: system-level promoters and inhibitors of new approach methodologies.

More EDC policy, FPF’s regulations open for comment, Science’s Trump-Tracker, and links to preserved resources removed from U.S. federal websites

Methods/Tools/Screening

Bridging Planarian Bioassays and AOP-Based Environmental Assessment: Toward Mechanistic Insights into Pollutant-Induced Disruptions.

Determining a NOAEL for the consortium linking academic and regulatory insights on BPA toxicity (CLARITY-BPA) core study.

Enhancing Toxicity Prediction of Synthetic Chemicals via Novel SMILES Fragmentation and Interpretable Deep Learning.

Testing the effects of two different zebrafish exposure paradigms on transcriptomic-based chemical risk assessment using the flame retardant Triphenyl Phosphate.

A Core Physiologically Based Toxicokinetic (PBTK) Model for Exposure Assessment of Multiple Environmental Phenols.

Generalized Functional Linear Models: Efficient Modeling for High-dimensional Correlated Mixture Exposures.

Commentaries

Perceptions about the use of Behavioral (Eco)Toxicology to protect human health and the environment.

Microplastics and nanoplastics: tiny threats for cardiovascular diseases?

New urgency for answers on the health impacts of microplastics: In this first of a two-part series on early studies of microplastics and nanoplastics, researchers are finding numerous hints of health effects-and warnings of a far greater potential for harm.

Reviews/Meta-Analyses

Numerous Chemicals/Mixtures

Protective Roles of Prebiotics and Probiotics Against Environmental Pollutant-Induced Toxicities: A Systematic Review of Animal Studies.

Endocrine disrupting effects of contaminants on communication and behaviors of insects: from molecular effect to ecological consequences.

Trophic-level accumulation and transfer of legacy and emerging contaminants in marine biota: meta-analysis of mercury, PCBs, microplastics, PFAS, PAHs.

Impact of lifestyle and environmental factors on fertility.

Phthalates

Role of phthalates in breast cancer initiation, progression and drug resistance: a scoping review and recommendations.

Pesticides

Female reproductive toxicity after exposure to malathion or diazinon: a systematic review of rodent and human studies.

The Sublethal Effects of Neonicotinoids on Honeybees.

Metals/Metalloids

Cadmium-Induced Bone Toxicity: Deciphering the Osteoclast-Osteoblast Crosstalk.

Microplastics/Nanomaterials

Invisible invaders: unveiling the carcinogenic threat of microplastics and nanoplastics in colorectal cancer-a systematic review.

Health Implications of Microplastic Exposure in Pregnancy and Early Childhood: A Systematic Review.

Exploring the Impact of Microplastics and Nanoplastics on Macromolecular Structure and Functions.

Microplastics and exercise: impacts on performance and physiological health.

Decoding the Interactions Between Antibiotics and Microplastics- Chemistry, Environmental Impacts, and Mitigation Approaches- A State-of-the-Art Review.

Micro- and nanoplastic effects on the reproduction of Daphnia spp. – A meta-analysis.

Pharmaceuticals/Personal Care Products

Comprehensive review of avobenzone (butyl methoxydibenzoylmethane) toxicology data and human exposure assessment for personal care products.

Benzophenones: How ultraviolet filters can interfere with reproduction.

Human Health Studies

Numerous Chemicals/Mixtures

Multiple maternal occupational exposures during pregnancy and intrauterine growth: analysis of the French Longitudinal Study of Children – ELFE cohort, using data-driven approaches.

Prenatal environmental risk for adolescent attention, thought, and substance use problems: A mixtures approach to coexposure and psychiatric comorbidities.

Occupational exposure to chemicals and particles and incidence of myocardial infarction-a nationwide cohort study in Sweden.

BPA/Phenols

Exposure Profiles to Bisphenols and Their Impact on Reproductive and Thyroid Hormones in Pregnant Women.

Phthalates

Associations of urinary metabolite concentrations of phthalates and their alternatives with reproductive outcomes among women receiving in vitro fertilization: A repeated measurement analysis.

Parabens/Triclosan/Antimicrobials

Double-edged implications of triclosan for the neuroendocrine system: evidence from the national health and nutrition examination survey (2011-2014 NHANES).

PFAS

Spatial Disparities in Perfluoroalkyl and Polyfluoroalkyl Substances Exposure and Immunosuppressive Effects on Vaccine Induced Antibody Levels in Guangzhou Children.

Prenatal exposure to per- and polyfluoroalkyl substances: Association with child behavior in the environmental influences on child health outcomes (ECHO) Cohort.

Prenatal exposure to a mixture of per- and polyfluoroalkyl substances (PFAS) and lung function and immune-related outcomes among males in childhood and young adulthood.

Exposure to high levels of perfluoroalkyl substances through drinking water and risk of cardiovascular morbidity and mortality in a Swedish register-based study.

Associations of PFOA and PFOS Exposure with Liver Injury: Evidence from the Dongfeng-Tongji Cohort, NHANES 2003-2018, and Integrative Adverse Outcome Pathway Analysis.

Perfluoroalkyl substances exposure and kidney function decline in a community-based prospective cohort.

Depression outcomes correlated to exposure to per- and poly-fluoroalkyl substances (PFAS).

Association Between Per- and Polyfluoroalkyl Substances (PFAS) Exposure and LDL Cholesterol in US Adults: Evidence From NHANES.

Flame Retardants

Associations Between Gestational Polybrominated Diphenyl Ether (PBDE) Serum Concentrations and Child Sleep Outcomes from Ages 2 to 8 Years.

Pesticides

The association between glyphosate use and mosaic loss of chromosome Y in buccal samples among male pesticide applicators in the Agricultural Health Study.

Immunomodulatory effects of the herbicide glyphosate following occupational exposure.

Metals/Metalloids

Blood and cerebrospinal fluid metallomics uncover mercury, chromium, and iron alterations in de novo Parkinson’s disease.

Associations between element mixtures and biomarkers of pathophysiologic pathways related to autism spectrum disorder.

Microplastics/Nanomaterials

Maternal blood metal levels during pregnancy and body mass index z-score, overweight, and obesity among children: Findings of the Japan Environment and Children’s Study.

Association between microplastics exposure and gut microbiota and metabolites in older adults: A cross-sectional study.

Air Pollution

Acute endocrine disrupting effect of fine particulate constituents on thyroid homeostasis: A multicenter cross-sectional study in China.

Laboratory Studies

Numerous Chemicals/Mixtures

The emerging pollutants polycyclic aromatic compounds (PAH’S) bisphenol a (BPA), and phthalates impair immune system function: Effects on human macrophages.

Integration of network toxicology, machine learning and single-cell sequencing reveals the effects of soil pollutants on prostate cancer.

Integration of in vivo stress reporters with transcription profiling to define chemical mixtures mechanisms of toxicity, including trans-generational effects.

BPA/Phenols

Developmental Programming: Differing impact of prenatal testosterone and prenatal bisphenol-A -treatment on hepatic methylome in female sheep.

Bisphenol A exposure promotes proliferation and invasion capabilities of bladder cancer cells: Insights from gene expression and pathway analysis.

Bisphenol E Neurotoxicity in Zebrafish Larvae: Effects and Underlying Mechanisms.

Bisphenol F disrupts lipophagy and lysosomal acidification via ATGL-SIRT1-PPARα signaling in NAFLD-like hepatic changes.

Protective role of vildagliptin against bisphenol-A induced liver injury: targeting oxidative stress, apoptosis, and endoplasmic reticulum stress.

Integrative network toxicology and molecular docking reveal 4-Nonylphenol’s multifaceted mechanisms in breast cancer pathogenesis.

Phthalates

Transcriptomic analysis of the mechanism of male reproductive injuries caused by the mixture of three phthalates in rats.

Integrated multi-omics analysis dissects di-isobutyl phthalate exposure-induced male fertility impairment.

Maternal Phthalate Exposure Alters Prostate Proteome in Rat Offspring: Linking Omics Insights to Prostate Cancer Risk in Humans.

Involvement of Ductal Reaction in Di-(2-ethylhexyl)-Phthalate-Caused Hepatic Fibrosis: Molecular Mechanisms and Potential Intervention Strategies.

Protective effect of osmanthus water extract on liver dysfunction caused by DBP based on organoids and organ chips technologies.

Parabens/Triclosan/Antimicrobials

From Disinfectant to Neurodegeneration: Integrating Machine Learning and Mendelian Randomization Reveals Triclosan as A Novel Environmental Risk Factor for Alzheimer’s Disease.

Comprehensive assessment of triclosan-induced toxicity: impacts on zebrafish development, mammalian cell viability and microbial activity.

HMGCS2 attenuates mitochondrial dysregulation and renal fibrosis induced by triclosan.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Aryl hydrocarbon receptor ligands drive pancreatic cancer initiation and progression through pro-tumorigenic T cell polarization.

Elucidating the correlation between polychlorinated dibenzo-p-dioxins and prostate cancer progression: Insights from gene expression and molecular docking.

Mechanisms of metabolic-associated fatty liver disease induced by 48-week PCB138 exposure and theabrownin intervention.

PFAS

Long-chain PFAS potently disrupt renal carboxylesterase activity and exacerbate nephrotoxicity: an investigation of the chain length-dependent nephrotoxicity of PFAS.

Assessing the impact of perfluoroalkyl substances on liver health: a comprehensive study using multi-donor human liver spheroids.

Network toxicology and molecular docking to investigate the association of perfluorooctane sulfonate and pulmonary arterial hypertension via adverse outcome pathways.

Flame Retardants

Organophosphate Flame Retardants Disrupt Neurodevelopmental Gene Networks with Autism-Relevant Features: A Multi-Omics Study in Rats.

Low-level tetrabromobisphenol a (TBBPA) exposure disrupts early embryonic architecture: molecular impacts on dorsoventral patterning.

PBDE Flame Retardant Exposure Causes Neurobehavioral and Transcriptional Effects in First-Generation but Not Second-Generation Offspring Fish.

Pesticides

The Effects of Imidacloprid Exposure on the Mouse Ovary In Vivo.

The effect of neonicotinoid insecticides and triazole fungicides on prostate cancer progression via CYP enzymes, miRNAs, and TF-mediated disruption of steroidogenesis: An integrated in silico approach.

Assessment of Cell Death and Genotoxic Potential of Glyphosate and Cypermethrin Formulations, Individually and in Combination, in HEp-2 Cells.

Non-target metabolomic approach of the toxic effects of glyphosate in zebrafish (D. rerio).

Paraquat Induced Neuro-immunotoxicity: Dysregulated Microglial Antigen Processing and Mitochondrial Activated Mechanisms.

Therapeutic Effect of Physical Activity in a Male Wistar Rat Model of Paraquat and Maneb-Induced Parkinson’s Disease.

Metals/Metalloids

The effects of cadmium and high fructose diet on metabolic and reproductive health in female CD-1 mice.

Berberine contributes to protecting against the cadmium-induced pancreatic damage: role of intestinal microbiome modulation and barrier function.

Arsenic Exposure Induces Cognitive Impairment in Mice with Increased Acetylcholinesterase Activity and Inflammation in the Cortex and Hippocampus: Implications for Alzheimer’s Disease.

Involvement of the PI3K/Nrf2 Pathway in Arsenic-Induced Endocrine and Thyroid Toxicity in Rats.

Microplastics/Nanomaterials

Polyethylene Terephthalate Microplastics Induce Immune Evasion and Malignant Remodeling in Breast Cancer Through Multi-Omics-Identified Immune Checkpoints.

Maternal polystyrene nanoplastics suppress zebrafish offspring development and locomotion through mitochondrial dysfunction.

Microplastic exposure aggravates pneumococcus-induced inflammation in macrophages by activating ferroptosis.

Hepatotoxicity induced by polylactic acid microplastics: The mediating role of gut microbiota and uric acid metabolism.

Combined effects of nanoplastics and 3-BHA at environmentally relevant concentrations significantly aggravated kidney injury via TGF-β/SMAD signaling pathway in mice.

Microplastic-induced hypertension in rats: A two-hit model exploring oxidative stress and gut microbiota.

Analyzing the toxicological effects of PET-MPs on male infertility: Insights from network toxicology, mendelian randomization, and transcriptomics.

Exposure/Environment Studies

Numerous Chemicals/Mixtures

Sweat-amplified dermal transfer and combined toxicity of per- and polyfluoroalkyl substances and organophosphate esters mixtures in children’s textiles.

PFAS

Per- and polyfluoroalkyl substances in agricultural systems: Human dietary exposure via beef raised on corn stover from a field with contaminated biosolids.

Bioaccumulation and Transfer of Per- and Polyfluoroalkyl Substances (PFAS) in a Stream and Riparian Food Web Contaminated by Food Processing Wastewater.

Occurrence, spatial distribution, and risk assessment of per- and polyfluoroalkyl substances in soil and groundwater of a petrochemical industrial park in China.

Occurrence, distribution characteristics, and potential ecological risks of perfluorinated compounds in major estuaries and adjacent offshore areas in Hainan Island.

Flame Retardants

Risk Assessment from Potential Exposure to Tetrabromobisphenol A (TBBPA) from Its Use in Electronics.

Metals/Metalloids

Production of Methylmercury in Peatlands Following Permafrost Thaw Increases along a Trophic Gradient.

Microplastics/Nanomaterials

Airborne microplastics and plastic additives in a school environment: identification, quantification, and associated inhalation risks.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Industry-funded articles are included without notation. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. There are searchable archives. Compiled by Sarah Howard of Healthy Environment and Endocrine Disruptor Strategies (HEEDS), a program of Environmental Health Sciences.

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