EDC Science Weekly, Aug. 22-28, 2025

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Events, Regulations/Policy, Methods/Tools/Screening, Commentaries, Reviews/Meta-Analyses, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Highlights:

How criminology can support environmental health: the case of PFAS.
Traffic-related micro- and nanoplastics in air increase white blood cell counts in healthy young adults.
Protocol for a randomised controlled trial of a low plastic diet and lifestyle intervention for adults with cardiometabolic risk factors.

Science summaries and highlights

Events

Aug. 27 webinar: Plastic bottled water: The poison we pay for [Plastic Pollution Coalition]

Sept. 10 webinar: The Experiences of PFAS Contamination in Impacted Communities [Mass. Breast Cancer Coalition]

Sept. 12 symposium: Highlighting Duke’s environmental health community [hybrid] [Duke Integrated Toxicology and Environmental Health Program]

Sept. 15: ECHO symposium: translating science to action [hybrid] [NIH Environmental Influences on Child Health Outcomes (ECHO)]

Sept. 15 Grand Rounds: PCBs: A legacy pollutant [on zoom] [Region 1 PEHSU and Boston Children’s Hospital; CE credits available]

Sept. 17 webinar: The Health Effects of Chemicals used in Food Packaging [Alliance of Nurses for Healthy Environments]

Sept. 22: Plastics, Human Health, and Solutions Symposium [NYU Langone Health Center for the Investigation of Environmental Hazards (CIEH)]

Sept. 29 conference : REACH revision 2025: simpler, faster, bolder, in Brussels [Heal and CHEM Trust]

Oct. 14 webinar: ToxicDocs: A database of once-secret chemical industry documents [CHE]

Jan. 11-14: International Conference on Microplastics [in person in Santa Fe; abstracts due Oct. 1]

Note: HEEDS is now accepting applications for the Lou Guillette, Jr. Outstanding Young Investigator Award, due Sept. 30.

More events

Regulations/Policy

Mitigating PFAS contamination in the United States: assessing the impact of California’s legislation from 2018 to 2022 on drinking water quality.

More EDC policy, FPF’s regulations open for comment, Science’s Trump-Tracker, and links to preserved resources removed from U.S. federal websites

Methods/Tools/Screening

Human organoids to assess environmental contaminants toxicity and mode of action: towards New Approach Methodologies.

Quality-by-design and current good practices for the production of test and reference materials for micro- and nano-plastic research.

An alternative to in vivo/in vitro toxicity testing: Consensus-based prediction for toxicity assessment and prioritisation of diverse chemicals in Japanese eel to safeguard aquatic and public health.

Development of a Multiplexed, High Content Imaging-Based Assay for Assessing Chemical Effects on Proliferation and Apoptosis in Human Neural Progenitor Cells.

Commentaries

How criminology can support environmental health: the case of PFAS.

Spotlight Nanotoxicology: The Root of Toxicity of Nanoplastics.

From Circularity to Spirality: An Integrated, Systems-Level Approach to Address the Plastics Problem.

A food system in crisis: battle lines for change. [book review re ultraprocessed foods]

Daily briefing: Plastics pollution talks end in stalemate. [News item in Nature]

Reviews/Meta-Analyses

Numerous Chemicals/Mixtures

Epigenetic impact of endocrine-disrupting chemicals on atherosclerosis.

Xenobiotic-induced liver injury: Molecular mechanisms and disease progression.

Mapping the association between environmental pollutants and steatotic liver disease: a systematic review and meta-analysis.

PFAS

Legacy and emerging per- and poly-fluorinated substances (PFASs) as potential pathogenic drivers of diabetes mellitus: Challenges and perspectives.

Birth weight in relation to maternal and neonatal biomarker concentration of perfluorooctane sulfonic acid: a meta-analysis and meta-regression from a systematic review.

Maternal Serum Concentrations of Per- and Polyfluoroalkyl Substances and Gestational Weight Gain: A Systematic Review and Meta-analysis.

Visceral, Neural, and Immunotoxicity of Per- and Polyfluoroalkyl Substances: A Mini Review.

Epigenetic and Genotoxic Mechanisms of PFAS-Induced Neurotoxicity: A Molecular and Transgenerational Perspective.

Human exposure to per- and poly-fluoroalkyl substances (PFAS) in Asia and contributing factors, with a focus on East Asia.

Flame Retardants

Understanding the environmental fate and risks of organophosphate esters: Challenges in linking precursors, parent compounds, and derivatives.

Pesticides

In search of certainty beyond the cholinergic system: a systematic review of developmental chlorpyrifos exposure and neurotransmitter systems disruption in preclinical models.

Metals/Metalloids

Heavy Metals Toxicity: Mechanism, Health Effects, and Therapeutic Interventions.

A Narrative Review of Heavy Metals and Sperm Quality: The Interplay with Antioxidant Imbalance and Reactive Oxygen Species.

Microplastics/Nanomaterials

Macroalgal (seaweed) derived bioplastic as a sustainable food packaging material – A critical review.

Miscellaneous

Unveiling the Endocrine-Disrupting Potential of Plant-Derived Compounds: An Ecotoxicological Review.

Human Health Studies

Numerous Chemicals/Mixtures

Randomised controlled trial of a low plastic diet and lifestyle intervention for adults with cardiometabolic risk factors: the Plastic Exposure Reduction Transforms Health (PERTH) trial – a protocol.

Association of PFAS and Metals with Cardiovascular Disease Risk: Exploring the Mediating Effect of Diet.

Tfh cell-mediated impairment of rotavirus-specific antibodies by PAH and PFAS co-exposure in seropositive children.

BPA/Phenols/Parabens

Infant urinary bisphenol A concentrations in relation to child neurodevelopment at 2 years of age.

Associations Between Chronic Exposure to Bisphenols and Parabens and Gut Microbiota in Children.

PFAS

Associations between per- and polyfluoroalkyl substances and type 2 diabetes: The modifying effects of lifestyle and genetic risk.

Combined Effects of PFAS, Social, and Behavioral Factors on Liver Health.

Association between per- and polyfluoroalkyl substances exposure and blood pressure: From epidemiological evidence to mechanistic insights.

Pesticides

Effects of children exposure to pyrethroid pesticides during infancy and toddlerhood on their ADHD symptoms at preschool age: A prospective study in Southwestern China.

Pesticide exposome reveals oxidative stress and immune response disruptions in occupationally exposed women with breast cancer.

Pesticide and Liver Biomarkers Among Ecuadorian Adolescents and Adults Living in Agricultural Settings.

Metals/Metalloids

Environmental heavy metal exposure and altering anti-Mullerian hormone levels in women.

Polymorphisms in Hg-related genes and their impact on mercury burden and oxidative stress biomarkers among riverside Amazonian populations.

Cognitive Functions Among Pupils in Schools Near and Around an Electronic Waste Recycling Site at Agbogbloshie in Accra, Ghana.

DNA methylation signature of oxidative stress and its mediating role in response to metal exposure.

Associations of Metal Mixtures During Early Pregnancy With Midlife Obesity and Body Composition: A Prospective Study.

Geographical association of heavy metal exposure and semen quality: A national multi-center study.

Microplastics/Nanomaterials

Air Pollution

Physical activity, air pollution, and incident long-term conditions: a prospective cohort study.

Miscellaneous

Reducing melamine exposure and oxidative stress markers in melamine-exposed workers: A pragmatic intervention study.

Laboratory Studies

Numerous Chemicals/Mixtures

Transcriptomic changes across the HPG axis following prenatal exposure to the EDC mixture NeuroMix.

Exposure of zebrafish larvae to bisphenol A, bisphenol S, di-(2-ethylhexyl) phthalate, and di-(2-ethylhexyl) adipate induces oxidative stress, resulting in hepatotoxicity and disruption in lipid metabolism.

BPA/Phenols

Early-Life Exposure to Bisphenol A Damaged Pancreas That May Increase Offspring Sensitivity to High-Fat Diets.

Bisphenol A induces cellular senescence in SW1353 chondrocytes via miRNA-449a-mediated downregulation of SIRT1.

Unraveling the mechanisms of bisphenol A-Induced lupus nephritis through network toxicology and machine learning approaches.

Coupled In Silico Toxicology Models Reveal Equivalent Ecological Risks from BPA and Its Alternatives in Chinese Surface Waters.

Carnosic Acid Attenuated the Motor Impairment by Bisphenol A is Related to the Regulation of Autophagy Through Parkin in In Vitro and In Vivo.

Lycium Barbarum Polysaccharides Protects Zebrafish Larvae From Nonylphenol-Induced Neurodevelopmental Disorders via the p38/5-HT1A/Wnt/β-Catenin Pathway.

Phthalates

Estrogen Receptor 1 (ESR1) Promotes Di-butyl phthalate (DBP)-induced hypospadias by Regulating Mitophagy through PINK1-Parkin Axis to Inhibit Ferroptosis.

Phthalate-induced disruption of metabolic and redox homeostasis in rat liver via modulation of lactate dehydrogenase activity: Insights from toxicokinetic and computational analyses.

Phthalates promote lenvatinib resistance in hepatocellular carcinoma through the HPX-MAPK pathway.

Dibutyl phthalate promotes COAD cells growth and migration via the TIMP1/PI3K/AKT signaling axis.

Ferroptosis-driven neurobehavioral impairment in zebrafish embryos: Mechanistic links to developmental dibutyl phthalate exposure.

The Plasticizer Dibutyl Phthalate (DBP) Impairs Pregnancy Vascular Health: Insights into Calcium Signaling and Nitric Oxide Involvement.

Crude saponin from Korean red ginseng alleviates di(2-ethylhexyl) phthalate-induced urogenital damage via regulating p38 MAPK/NF-κB signaling.

Resveratrol: Great potential for alleviating di-2-ethylhexyl phthalate (DEHP)-induced testicular ferroptosis via the SIRT1-HIF-1α axis.

Lycium barbarum Polysaccharide Improves Iron Homeostasis in Spermatocytes and Sertoli Cells via NRF2 to Alleviate DEHP-Induced Male Reproductive Toxicity in Mice.

Lignin-Derived Methoxyterephthalates for Performance-Advantaged Polymers and Plasticizers.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Polychlorinated biphenyls-153 induces fat accumulation and lifespan shortening through CYP450 family genes in Caenorhabditis elegans.

Spatial lipidomics and metabolomics reveal brain region-specific metabolic dysregulation in mice exposed to the emerging persistent organic pollutant methoxychlor.

PFAS

Per- and Polyfluoroalkyl Substances Disrupt Mouse Embryo Compaction by Targeting c-MYC.

Per- and polyfluorinated substances (PFAS) promote osteoclastogenesis and bone loss through PPARα activation.

Elucidating the associations and molecular mechanisms of perfluoroalkyl substances exposure with type 2 diabetes and its complications: A multifaceted approach.

Environmental exposure to perfluorooctane sulfonate and its role in esophageal cancer progression: a comprehensive bioinformatics and experimental study.

PFOS Promotes Lung Adenocarcinoma Cell Proliferation through PI3K/AKT/NF-κB Mediated EMT.

Genome-Scale Metabolic Modeling Predicts Per- and Polyfluoroalkyl Substance-Mediated Early Perturbations in Liver Metabolism.

Distinct Effects of PFOS and OBS on Neurotoxicity via PMK-1 Mediated Pathway in Caenorhabditis elegans.

Gestational GenX Exposure Induces Maternal Hepatotoxicity by Disrupting the Lipid and Bile Acid Metabolism Distinguished from PFOA-Induced Pyroptosis.

Investigating Lipid and Energy Dyshomeostasis Induced by Per- and Polyfluoroalkyl Substances (PFAS) Congeners in Mouse Model Using Systems Biology Approaches.

Stress responses in the honeybee (Apis mellifera L.) midgut triggered by PFOA and PFHxS at environmental residue concentrations detected in bee products.

Incineration of Perfluorooctanoic Acid Leads to Regeneration of Smaller Perfluorocarboxylic Acids.

Flame Retardants

BDE-209-exposed melanoma cells enhance metastasis and chemoresistance in C57BL/6 mice.

BDE-47 Disrupts Gut Microbiota and Exacerbates Prediabetic Conditions in Mice: Therapeutic Potential of Grape Exosomes and Antioxidants.

Embryonic Exposure to TPhP Elicits Osteotoxicity via Metabolic Disruption in Oryzias latipes.

Dual Effects of Maternal Diet and Perinatal Organophosphate Flame Retardant Treatment on Offspring Development, Behavior and Metabolism.

Pesticides

Genome-wide gene expression changes in breast cancer cells following very low-dose exposure to pesticides (glyphosate and atrazine) at drinking water levels.

In vitro confirmation of estrogenic and antiandrogenic pesticide bioactivity using schild regression analysis.

Exposure to chlorpyrifos pesticide at a realistic dose modulates gut microbiome and induces non-obese associated diabetes.

Cluster-based read-across of ToxCast data identifies buprofezin as a partial PPARγ agonist with obesogenic potential.

Effects of herbicide mixtures on the fertilizing capacity of bovine sperm.

Network toxicology reveals glyphosate mechanisms in kidney injury and cancer.

Ecotoxicological assessment of pesticide mixtures: effects of imidacloprid and propiconazole on Danio rerio and Astyanax lacustris.

Kaempferol alleviates cypermethrin induced reproductive toxicity in rats via Nrf2-mediated antioxidant and apoptotic regulation with histopathological evidence: in vivo and in silico study.

Evaluation of the Protective Effects of Noscapine on Paraquat-Induced Parkinson’s Disease in Rats.

Eugenol Mitigates Glyphosate-Induced Testicular Toxicity via Modulation of Oxidative Stress, ER Stress, RAGE/NLRP3 and PI3K/AKT Signaling Pathways in Rats.

Probiotic Subsp. longum 5^1A Protects Mice from Genotoxic and Metabolic Alterations Induced by Subchronic Exposure to a Low-Dose Pesticide Cocktail.

Soy isoflavones mitigate atrazine-induced dopaminergic neuron damage via reshaping short-chain fatty acid-producing bacteria in gut microbiota and modulating the GPR43/GLP-1/GLP-1R axis.

Metals/Metalloids

The m6A modification-mediated upregulation of ETS2 translation drives arsenic-induced spermatogonial senescence.

Protective Effects of Vanillic Acid on Arsenic-Induced Hepatotoxicity and Diabetes in Mice; the Role of PPARγ and NF-κB Signaling.

Microplastics/Nanomaterials

Is bisphenol A sorbed onto microplastics less bioavailable than freely dissolved bisphenol A? Implications for the gut health in a murine model.

Aged nanoplastics reprogram the ER stress-autophagy crosstalk: A mechanistic gateway to skeletal malformations in zebrafish.

Polystyrene nanoplastics impair endometrial decidualization via cell cycle arrest and JNK-MAPK pathway-mediated oxidative stress in early pregnant mice.

Comparative analysis of acute and chronic toxicological exposure effects of polystyrene nanoparticles on Macrobrachium rosenbergii: Implications for antioxidative defense and immunosuppression.

Comparative analysis of reproductive toxicity of polystyrene-nanoplastics and polystyrene-microplastics in rat Sertoli cells.

Insights into mouse metabolic health and gut microbiota responses to conventional and biodegradable microplastics released from plastic food containers.

Simultaneous determination of persistent and emerging organic pollutants in microplastics.

High-throughput screening of combined toxicity of nanoplastics and scoexisting pollutants using luminescent bacterium.

Pharmaceuticals/Personal Care Products

Effects of Diethylstilbestrol on Uterus Structure and Immunological Function in Mice During Early Pregnancy.

Miscellaneous

Interactions among microplastics, spilled oil and dispersant: Impacts of marine environmental conditions.

Exposure/Environment Studies

Numerous Chemicals/Mixtures

Invisible pressures: A global review of unconventional coastal pollution sources and their environmental impacts.

Non-targeted and suspect screening analysis of non-phthalate ester plasticizers in house and car dust.

Non-targeted screening of organic micropollutants in drinking water: Evidence of contamination from purification systems and plastic materials.

Survey of polar organic micropollutants in German tap waters.

BPA/Phenols/Phthalates

Urinary levels and estimated daily intake of phthalates and phenols in kidney transplanted Norwegian children.

Bisphenol A migration and associated health risk in polyethylene terephthalate-bottled yogurt drinks (Doogh) under different storage scenarios.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Human Exposure to Persistent Organic Pollutants in Switzerland: The Role of Diet, Age, Smoking, and Body Composition.

PFAS

Species- and sex-specific bioaccumulation, tissue-specific distribution, and maternal transfer of per- and polyfluoroalkyl substances in tiger frogs (Hoplobatrachus chinensis) and forest frogs (Rana chensinensis).

Biomagnification and potential health effects of per- and polyfluoroalkyl substances (PFAS) in a terrestrial food web.

Elaborating PFAS characteristics for Chinese electroplating industry by target and nontarget analysis.

Detection and Quantitation of Per- and Polyfluoroalkyl Substances in North Carolina Sea Foam and the Corresponding Sea Water.

Distribution of Legacy and Emerging PFASs in a Terrestrial Ecosystem Located near a Fluorochemical Manufacturing Facility.

Flame Retardants

Airborne and Dust-Bound PBDEs Indoors and Outdoors in İzmir, Türkiye: A Multi-Route Exposure – Risk Assessment.

Organophosphate esters (OPEs) in a marine food web of the Yellow Sea, China: Bioaccumulation, trophodynamics, and model prediction.

Microplastics/Nanomaterials

Microplastics in Human Bronchoalveolar Lavage Fluid.

Unraveling micro/nanoplastics and phthalates in infusion solutions: A novel integrated approach for quantification and cardiovascular cytotoxicity evaluation.

Miscellaneous

Patterns, variability, and predictors of p-phenylenediamine quinones and parent p-phenylenediamines in pregnant women across three trimesters.

——-

This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Industry-funded articles are included without notation. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. There are searchable archives. Compiled by Sarah Howard of Healthy Environment and Endocrine Disruptor Strategies (HEEDS), a program of Environmental Health Sciences.

If you enjoy this newsletter, please feel free to donate here! Thank you!