EDC Science Weekly, July 4-10, 2025

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Events, Regulations/Policy, Methods/Tools/Screening, Commentaries, Reviews/Meta-Analyses, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Highlights:

Negotiating the plastics treaty to protect health and the environment.
Plastics pollution is surging – the planned UN treaty to curb it must be ambitious.
Exploring overlooked bisphenol exposure sources through a comprehensive 7-day investigation.
Phthalates and bisphenols early-life exposure, and childhood allergic conditions.

Note:

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Science summaries and highlights

Events

July 15 webinar: Defend Our Health: Authors & Friends with Kristina Marusic and Dr. Rachel Criswell [Defend Our Health]

July 28-30: DOHaD summer course [Developmental Origins of Health and Disease (DOHaD) Society]

July 30 – Aug. 1 conference: U.S. DOHaD Society Annual Meeting

July 30 webinar: How waterless products make plastic-free packaging possible [Plastic Pollution Coalition]

July 31 webinar: Excellent Alternatives to Plastic Packaging [Beyond Plastics]

Aug. 17 in-person workshop: How to conduct gold-star systematic reviews [PRHE, at the ISEE-ISES conference]

Sept. 15: ECHO symposium: translating science to action [hybrid] [NIH Environmental Influences on Child Health Outcomes (ECHO)]

Sept. 22: Plastics, Human Health, and Solutions Symposium [NYU Langone Health Center for the Investigation of Environmental Hazards (CIEH)]

Sept. 29 conference: REACH revision 2025: simpler, faster, bolder, in Brussels [HEAL and CHEM Trust]

More events

Regulations/Policy

Negotiating the plastics treaty to protect health and the environment.

French ban grants exemption to “cancer causing” pesticide despite protests. [News item in BMJ]

More EDC policy, FPF’s regulations open for comment, Science’s Trump-Tracker, and links to preserved resources removed from U.S. federal websites

Methods/Tools/Screening

Adverse Outcome Pathway (AOP) Coaching Program-How it functions and contributes to a more harmonized approach to AOP development and construction of AOP networks with regulatory utility.

Guidance on minimum information requirements (MIR) from designing to reporting human biomonitoring (HBM).

Assessing risk of bias in toxicological studies in the era of artificial intelligence.

Exploring thyroid development and function: A systems biology search for new chemical disruptor targets.

An End-of-Life Plastic and Additive Flow Tracker Tool for Scenario Forecasting.

Screening and prediction of potential androgen receptor agonists in indoor dust.

Commentaries

Plastics pollution is surging – the planned UN treaty to curb it must be ambitious. [Editorial in Nature re two articles, Mapping the chemical complexity of plastics and Nanoplastic concentrations across the North Atlantic. The latter is accompanied by news articles in Nature, Nanoplastics make up most of the plastic pollutants in the North Atlantic Ocean and Millions of tonnes of nanoplastics are polluting the ocean.]

A Call to Action: Advancing New Approach Methodologies (NAMs) in Regulatory Toxicology through a Unified Framework for Validation and Acceptance

Reviews/Meta-Analyses

Numerous Chemicals/Mixtures

Effects of environmental toxicant exposures on oxytocin and vasopressin systems in the developing brain: Factors imparting risk and resilience.

Endocrine-disrupting chemicals (EDCs) and epigenetic regulation in embryonic development: Mechanisms, impacts, and emerging trends.

Exploring the Impact of Endocrine Disruptors on Hormonal regulation and Adipose Tissue in Health and Obesity.

BPA/Phenols

The impact of bisphenol A and its analogs on female reproductive health.

Bisphenol A Exposure and Behavioral Outcomes in Children: A Systematic Review and Meta-Analysis of Evidence Limited to the BASC Assessment Tool.

Phthalates

Phthalate Exposure: Prevalence, Health Effects, Regulatory Frameworks, and Remediation.

PFAS

Insights derived from testing a library of per- and polyfluoroalkyl substances (PFAS) in a battery of new approach methods (NAMs).

Per- and Poly-Fluoroalkyl Substances (PFAS) and Human Health: A Review of Exposure Routes and Potential Toxicities Across the Lifespan.

Incidence of pollution, bioaccumulation, biomagnification, and toxic effects of per- and polyfluoroalkyl substances (PFAS) in aquatic ecosystems: A review.

Pesticides

Scoping Review of the Relationship between Glyphosate-Based Herbicide Exposures and Autism Spectrum Disorder.

Association between pesticide exposure and colorectal cancer risk: a systematic review and meta-analysis.

Metals/Metalloids

Lead and arsenic toxicity: emerging mechanisms, immunotoxic effects, and future research perspectives.

Volcanic environments and thyroid disruption – A review focused on As, Hg, and Co.

Microplastics/Nanomaterials

The Interplay Between Climate Warming Driven by Greenhouse Gas Emissions and the Ecotoxicological Effects of Microplastics: Insights From a Meta-Analysis.

Microplastics and human health: unraveling the toxicological pathways and implications for public health.

Toxicological Effects of Micro/Nano-plastics on Human Reproductive Health: A Review.

Microplastics: A threat to Fetoplacental unit and Reproductive systems.

Deciphering the Neurotoxic Burden of Micro- and Nanoplastics: From Multi-model Experimental Evidence to Therapeutic Innovation.

Advanced starch-based films for food packaging: Innovations in sustainability and functional properties.

Human Health Studies

Numerous Chemicals/Mixtures

Phthalates and bisphenols early-life exposure, and childhood allergic conditions: a pooled analysis of cohort studies.

BPA/Phenols

Pregnancy urinary phenol biomarker concentrations in relation to serum levels of inflammatory cytokines: Results from the EARTH study.

Phenol biomarker concentrations in human ovarian follicular fluid and the associations with in-vitro fertilization outcomes.

Phthalates

Prenatal exposure to phthalates and alternative plasticizers and emotional and behavioral outcomes in early childhood in the Environmental influences on Child Health outcomes (ECHO) cohort.

Association between phthalates exposure and urine flow rate.

Parabens/Triclosan/Antimicrobials

Paraben exposures and satiety hormones in preschool children: an ENVIRONAGE study.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Ambient dioxin exposure and incidence of lymphoid malignancies in large prospective US cohorts of female nurses.

PFAS

Association between prenatal exposure to per- and polyfluoroalkyl substances and blood pressure among preschool-aged children: The moderating effect of child-age and the mediating effect of inflammatory cytokine.

Per- and polyfluoroalkyl substances, genetic factors, and sleep health in reproductive-aged women: a cross-sectional study of the Shanghai Birth Cohort.

Assessing the effect of perfluoroalkyl and polyfluoroalkyl substances on cardiovascular-kidney-metabolic syndrome: Insights from an interpretable machine learning model.

Sex differences in ischemic heart disease and evidence gathering related to exposure risk, prevention, and treatment of per- and poly-fluoroalkyl substances.

Levels of serum per- and polyfluoroalkyl substances and association with dyslipidemia in the Korean population.

Flame Retardants

Prenatal exposure to organophosphate ester flame retardants and behavioral outcomes in early childhood in the Environmental influences on Child Health Outcomes (ECHO) cohort.

Socioeconomic and racial-ethnic disparities in flame retardant exposure and executive function skills in preschool children.

Pesticides

Maternal exposure to pesticides and gestational diabetes mellitus in the Elfe Cohort.

Metals/Metalloids

Association between urinary heavy metal concentrations, thyroid hormones, and birth outcomes among pregnant women in Isfahan City.

Arsenic in drinking water and breast cancer: a case-control study from a high exposure area in Northern Chile.

Microplastics/Nanomaterials

Multimodal detection and analysis of microplastics in human clear cell renal cell carcinoma.

Laboratory Studies

Numerous Chemicals/Mixtures

In vitro effects of environmentally relevant concentrations of nonylphenol and selected pyrethroid metabolites on a mouse Sertoli cell line (TM4).

Estrogenic activity of mixtures in the Salish Sea: The use of high throughput toxicity data with chemical information from fish bile and other matrices.

Postnatal exposure to various benzophenones at environmentally relevant levels enhances the susceptibility of mammalian testes to cyclophosphamide-induced spermatogenic stress in adulthood.

BPA/Phenols

Bisphenol AF (BPAF) jeopardizes male fertility and triggers intergenerational defects in zebrafish (Danio rerio).

Bisphenol M exposure promotes adiposity in mice via disrupting hepatic metabolism and gut microbiota homeostasis.

Chronic exposure to Bisphenol S impairs hepatic mitochondrial dynamics, induces endoplasmic reticulum stress, and worsens metabolism in high-fat diet fed mice.

Effects of bisphenol A and S, on oxidative stress, neurotoxicity, and fatty acid composition in sea cucumber, Holothuria poli.

Detrimental impacts of chronic bisphenol A (BPA) exposure on follicular signalling modulation and ovulatory competence in zebrafish (Danio rerio).

Perinatal Exposure to Bisphenol A Induces Depressive-Like Behaviors, ERβ Downregulation, and Dendritic Spine Loss in the Medial Amygdala.

Lifelong impact of BPA: Steroidogenic reprogramming in aged gerbil adrenal glands following developmental exposure.

Bisphenol S Induced Transgenerational Lipid Accumulation by Triggering Intestine-to-Germline Histone H3K4me3 Modification in Caenorhabditis elegans.

Assessment of the Impact of Bidens pilosa on Behavioral, Oxidative Stress and Cerebellar Cortical Histoarchitectural Alterations During Bisphenol A Exposure in Mice.

Phthalates

Omega-3 fatty acid normalizes postsynaptic density related miRNAs and proteins in hippocampus and prevents DEHP-induced impairment of learning and memory in mice.

Dual-Parent Di-(2-ethylhexyl) Phthalate (DEHP) Exposure: A Multigenerational Assessment of Neurocognitive Outcomes in Male Pups.

Early-life DEHP exposure disrupts adult male drosophila sleep homeostasis via Kyat-KYNA-NMDAR pathway in the brain.

Di-(2-ethylhexyl) phthalate (DEHP) and its metabolite promote multiple myeloma progression and bortezomib resistance.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Elucidating the impact of persistent organic pollutants on male reproductive health and testicular structure.

Enhancement of 2,3,7,8-tetrachlorodibenzo-p-dioxin toxicity by lipopolysaccharide in developing zebrafish lacking canonical pattern recognition pathways.

Single-cell transcriptomic insights into endosulfan-induced liver injury: Key pathways and inflammatory responses.

PFAS

Human gut bacteria bioaccumulate per- and polyfluoroalkyl substances.

Investigating the quantitative toxicological relationship between PFAS alkyl fluorine structure and exposure levels leading to changes in blood-based clinical markers in rats.

Inulin alleviates intestinal changes caused by gestational PFOA and GenX exposure in the pups through reshaping maternal gut microbiota and vertically inhibiting the TLR4/NF-κB/NLRP3 inflammatory pathway in the pups.

Perfluorooctanoic Acid (PFOA) Induces Apoptosis by Disrupting Mitochondrial Function via the SIRT1/FOXO1-SOD2 Pathway in Human Granulosa Cells: Implications for PCOS.

Flame Retardants

Maternal exposure to tris (2-chloroethyl) phosphate during pregnancy and suckling period alters gut microbiota and SCFAs metabolism in offspring of rats.

Chronic Exposure to Environmentally Relevant Doses of Triphenyl Phosphate Induces Anxiety- and Depression-Like Behaviors in Mice via the Gut-Brain Axis.

Organotins

Organotins as inhibitors targeting human and rat steroid 5α-reductase 1: structure-activity relationship and docking analysis.

Pesticides

Potential risks of glyphosate-based herbicide spraying on parental and offspring generations of Chrysopa pallens (Neuroptera: Chrysopidae).

Combined exposure to fenvalerate and tebuconazole induces apoptosis, leading to developmental and endocrine toxicity in early life stages of Japanese Medaka (Oryzias latipes).

Long-term disruption of oviductal immune homeostasis in Caiman latirostris following in ovo exposure to endosulfan or atrazine.

Disruption of mitochondrial homeostasis and apoptosis by oryzalin exposure in zebrafish embryos.

Metals/Metalloids

The Complicity of DAAM1, PTMA, RSPH6A, and Steroidogenic Genes in the Fertility of Male Rats Exposed to Cadmium During Gestation and Lactation: Attenuation by PREOG.

Microplastics/Nanomaterials

Synergistic neurotoxicity of polystyrene nanoparticles and MEHP in zebrafish (Danio rerio).

Microplastics interaction with bisphenol A: Adsorption, desorption, and in vitro biological effects.

Exploring the Mechanism of Kidney Injury in Mice Induced by High-Fat Diet and Polystyrene Nanoplastics Co-Exposure Through the Kidney-Gut Axis.

Polystyrene Microplastics Disrupt Kidney Organoid Development via Oxidative Stress and Bcl-2/Bax/Caspase Pathway.

Impact of polyethylene terephthalate and polylactic acid nanoplastics on cellular uptake and lipid metabolism in differentiated 3T3-L1 adipocytes.

Polystyrene Nanoplastics Exacerbate HFD-induced MASLD by Reducing Cathepsin Activity and Triggering Large Vacuole Formation via Impaired Lysosomal Acidification.

Type-dependent effects of nanoplastics on microglial activation and CXCR2-mediated chemotactic migration.

Tire Wear Particles

Metabolic Effects of Chronic Exposure to Environmentally Relevant Concentrations of N-(1,3-Dimethylbutyl)-N’-phenyl-p-phenylenediamine (6PPD) in Mice During Diet-Induced Obesity Progression.

The Xenometabolome of Early-Life Stage Salmonids Exposed to 6PPD-Quinone.

Environmental toxicity of tire wear and latex particle leachates in zebrafish embryos: Oxidative stress and ferroptosis as key mechanisms.

PAHs

In vitro effects of polycyclic aromatic hydrocarbons on sex steroid production by Arabian sea bream Acanthopagrus arabicus ovarian cells.

Long-term low-dose exposure to 9-chlorophenanthrene induces liver lipid accumulation via disrupting circadian rhythm.

Exposure/Environment Studies

Numerous Chemicals/Mixtures

Environmental contaminants, heavy metals, and essential elements in Norwegian children and adolescents: Data from the Norwegian environmental biobank.

Environmental Factors Influence Goat Immune Response to PFOS and Glyphosate: Difference between Grazing and Stall-Feeding.

BPA/Phenols

Exploring overlooked bisphenol exposure sources through a comprehensive 7-day investigation using time-activity diaries and urinary biomonitoring.

Changes of urinary bisphenol A and alternatives in Korea 2015-2020 and environmental disparities by socioeconomic status.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Environmental exposure to polychlorinated dibenzo-p-dioxins and dibenzofurans among population living in a contaminated area in Lausanne, Switzerland.

PFAS

Regulatory Successes and Lingering Threats: A Decade of Prenatal PFAS Exposure Trends and Risk Transitions in an Urban City in China.

Analysis of legacy PFAS and potential precursors in curtain, sofa, and carpet fabric samples.

Integrating Contaminant Source Indicators, Water Quality Measures, and Ecotoxicity to Characterize Contaminant Mixtures and Per- and Polyfluoroalkyl Substance (PFAS) Variability in an Urban Watershed.

Characteristics of aqueous film forming foam (AFFF) sites impacted with per- and polyfluoroalkyl substances (PFAS): A 37-site study.

Spatial and Temporal Variability of Perfluoroalkyl and Polyfluoroalkyl Substances in Major Rivers of New Mexico, USA.

Flame Retardants

Brominated and Chlorinated Flame Retardants in Pacific Bald Eagles: Sources and Dietary Insights from Stable Isotopes and Fatty Acids.

Pesticides

Spatiotemporal variability of urinary pesticide biomarker levels in 201 South African children sampled five times over two years.

Occurrence of pesticide residues in harvested products of various crops from European conventional and organic farming systems.

Microplastics/Nanomaterials

Biomonitoring of microplastics in saliva and hands of young children in kindergartens: identification, quantification, and exposure assessment.

Air Pollution

Racial Disparities in Childhood Exposure to Neurotoxic Air Pollution.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Industry-funded articles are included without notation. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. There are searchable archives. Compiled by Sarah Howard of Healthy Environment and Endocrine Disruptor Strategies (HEEDS), a program of Environmental Health Sciences.

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