EDC Science Weekly, June 19-26, 2025

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Events, Regulations/Policy, Methods/Tools/Screening, Commentaries, Reviews/Meta-Analyses, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Highlights:

Food contact articles as source of micro- and nanoplastics [see related article here]
Changes in PFAS concentrations in firefighters accessing a PFAS reduction treatment program.
The paradox of clean eating: Neuroactive dysbiosis and pesticide residues in fruit- and vegetable-based diets.

Science summaries and highlights

Events

July 8 webinar: Communicating about EDCs & Health: Why words matter [CHE]

July 28-30: DOHaD summer course [Developmental Origins of Health and Disease (DOHaD) Society]

July 30 – Aug. 1 conference: U.S. DOHaD Society Annual Meeting

July 31 webinar: Excellent Alternatives to Plastic Packaging [Beyond Plastics]

Aug. 17 in-person workshop: How to conduct gold-star systematic reviews [PRHE, at the ISEE-ISES conference]

Sept. 15: ECHO symposium: translating science to action [hybrid] [NIH Environmental Influences on Child Health Outcomes (ECHO)]

Sept. 22-23 save the date: Second Annual Scientific Symposium on Plastics and Human Health [NYU Langone Health Center for the Investigation of Environmental Hazards (CIEH)]

More events

Regulations/Policy

Transforming the Evaluation of Agrochemicals: A Conceptual Model.

More EDC policy, FPF’s regulations open for comment, Science’s Trump-Tracker, and links to preserved resources removed from U.S. federal websites

Methods/Tools/Screening

Beware of Sealing Film of Petri Dishes!-Alters the Expression of a Large Number of Genes.

Bats, bugs, and babies: why stringent guidelines are needed for cause-and-effect interpretation in epidemiological studies.

The intracellular free concentration of endocrine disrupting chemicals enables translation between cell-free and cell-based estrogenic activity assays.

An Electrochemiluminescence Biosensor for the Screening of Environmental Estrogens Using a Peptide Probe Targeting the Activated Estrogen Receptor.

Assessing the Impact of In Vitro Xenobiotic Metabolism on Estrogenic Chemical Bioactivity in High-Throughput Profiling Assays.

Identification of developmental and reproductive toxicity of biocides in consumer products using ToxCast bioassays data and machine learning models.

Evaluating High-Throughput Assays for Pesticide Ecological Risk Assessment.

Commentaries

Biodegradable Elastomers: Where Is the Solution?

Reviews/Meta-Analyses

Numerous Chemicals/Mixtures

Endocrine disrupting chemicals exposure and health: An umbrella review.

Exposing Inequality: Environmental Injustice and Cardiovascular Health Disparities.

Endocrine Disruptors and Attention Deficit Hyperactivity Disorder: A Systematic Review.

BPA/Phenols

Cytotoxicity and Endocrine Disruption in Materials Used for Removable Orthodontic Retainers: A Comprehensive Review.

The prevention effect of prebiotics and probiotics on bisphenol A caused neurotoxicity and mood disorders from the perspective of regulating gut microbiota

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Health Hazards Associated with Exposure to Endosulfan: A Mini-Review.

PFAS

Relationship between PFAS and attention-deficit/hyperactivity disorder or autism spectrum disorder: Epidemiological and experimental evidence.

Decontamination of PFAS-contaminated firefighting equipment – A review.

The association between per-fluoroalkyl and poly-fluoroalkyl substances exposure and thyroid cancer: a meta-analysis

Epigenetic Consequences of In Utero PFAS Exposure: Implications for Development and Long-Term Health.

Pesticides

A review on experimental and epidemiological research exploring the pathophysiology and progression of pesticide-induced diabetes mellitus.

Neurotoxic Effects of Pesticides: Implications for Neurodegenerative and Neurobehavioral Disorders.

Metals/Metalloids

Metals, cardiovascular risk, and the interplay with oxidative stress: a mini-review.

Microplastics/Nanomaterials

Food contact articles as source of micro- and nanoplastics: a systematic evidence map.

Effects of microplastics and nanoplastics on the kidney and cardiovascular system.

Effects of microplastics on the bones: a comprehensive review.

Carcinogenic effects of paraquat-based herbicides: a comprehensive review.

Microplastic pollutant exposures and Cancer: a pooled analysis.

Micro and nano-plastics on environmental health: a review on future thrust in agro-ecotoxicology management.

Unveiling the hidden chronic health risks of nano- and microplastics in single-use plastic water bottles: A review.

Mechanisms of micro- and nanoplastics on blood-brain barrier crossing and neurotoxicity: Current evidence and future perspectives.

Environmental nanoplastics induce mitochondrial dysfunction: A review of cellular mechanisms and associated diseases.

Microplastic Pollution: A Global Environmental Crisis Impacting Marine Life, Human Health, and Potential Innovative Sustainable Solutions.

Micro- and Nano-Plastics in Drinking Water: Threat or Hype? Critical State-of-the-Art Analysis of Risks and Approaches.

Toxicity of nanoplastics: machine learning combined with meta-analysis

Miscellaneous

A comprehensive review on plant protein-based food packaging: Beyond petroleum-based polymers.

Epigenetic effects of endogenous and exogenous glucocorticosteroids during pregnancy on the offspring: a systematic-narrative review.

Human Health Studies

Numerous Chemicals/Mixtures

Quantitative identification and prioritization of combined effects of multiple endocrine disrupting compound exposure on oxidative stress.

Combined Effect of Metals, PFAS, Phthalates, and Plasticizers on Cardiovascular Disease Risk.

Combined Effects of Metals, PCBs, Dioxins, and Furans on Cardiovascular Dysfunction.

Association between exposure to bisphenols and per- and polyfluoroalkyl substances and behavioral problems among Chinese preschoolers.

Divergent effects of EDCs on bone maturation: Role of body mass index and puberty.

Exposure to a Multitude of Environmental Chemicals During Pregnancy and Its Association with the Risk of Gestational Diabetes Mellitus.

Cancer Burden in Neighborhoods With Greater Racial Diversity and Environmental Burden.

Integrated Metabolic Profiling of Coexposure to Legacy and Emerging Contaminants: A Perspective of Paired Serum and Urine Metabolomics.

The Combined Effects of Per- and Polyfluoroalkyl Substances, Metals, and Behavioral and Social Factors on Depressive Symptoms.

BPA/Phenols

A population-based study to understand the association between Bisphenol-A (BPA) and Polycystic Ovarian Syndrome (PCOS): correlating with anthropometric parameters and clinical features.

Phthalates

Moderating effects of reduced Morning and Evening Questionnaire scores on the association between urinary phthalate metabolites and inflammatory cytokines among Chinese young adults: a human biomonitoring study.

Parabens/Triclosan/Antimicrobials

Triclosan exposure potentiates ischemic stroke risk: Multi-omics integration and molecular docking unveil neurotoxic mechanisms.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Serum polychlorinated biphenyl levels and risk of incident chronic kidney disease: A prospective study in the Dongfeng-Tongji cohort.

PFAS

The relationship between prenatal perfluorine and polyfluoroalkyl substances (PFAS) exposure and infant neurodevelopment: Modifying effects of DHA revised.

Associations of prenatal exposure to legacy and emerging PFAS with anogenital distance growth trajectories during early childhood: A prospective cohort study.

Interpretable machine learning insights into the association between PFAS exposure and diabetes mellitus.

Exploring the relationship between per- and polyfluoroalkyl substances exposure and rheumatoid arthritis risk using interpretable machine learning.

Associations between per- and polyfluoroalkyl substances exposure and renal function as well as poor prognosis in chronic kidney disease patients.

Association of Per- and Polyfluoroalkyl Substances with Pan-Cancers Associated with Sex Hormones.

Associations of per- and polyfluoroalkyl substances in follicular fluid with polycystic ovarian syndrome in infertile women may be mediated by sex hormones

Flame Retardants

Integrated network toxicology and population-based analysis uncovers organophosphate flame retardant exposure as a risk factor for hepatic steatosis and fibrosis: mechanistic and clinical insights.

Polybrominated diphenyl ethers (PBDEs), Occupational Exposures and Thyroid Function among U.S. and Canadian Firefighters: A Cross-sectional Study.

Pesticides

Associations between follicular fluid and serum neonicotinoid insecticide exposure and sex hormones and ovarian reserve: A retrospective study among women undergoing IVF/ICSI.

Evaluation of pesticide health risks and its associated metabolic health Status among nursery operators in Peninsular Malaysia.

The Paradox of Clean Eating: Neuroactive Dysbiosis and Pesticide Residues in Fruit- and Vegetable-Based Diets.

Metals/Metalloids

Effects of in utero exposure to multiple metal(loid)s on neonatal birth size and hormones in the growth hormone/insulin-like growth factor axis: A mixture analysis.

Associations Between Urinary Metal Levels and Incident Heart Failure: A Multi-Cohort Analysis.

Postmortem Inductively Coupled Plasma Mass Spectrometry Analysis Reveals Elevated Heavy Metal Concentrations in Coronary Arteries: A Comparative Autopsy Study Supporting a Toxic Inflammatory Hypothesis for Atherosclerosis.

The independent and combined effects of blood heavy metal concentrations on all-cause mortality and cardiovascular mortality in adult patients with diabetes mellitus.

Air Pollution

Using ventilation hood during cooking reduced household air pollution exposure and brought cardiometabolic and pulmonary health benefits: A community-based, cluster-randomized controlled intervention study.

Long-term exposure to air pollution and risk of dementia among older individuals of a Danish nationwide administrative cohort.

Miscellaneous

Long-term exposure to ambient benzene and incident type 2 diabetes mellitus in a national cohort: the modifying effect of genetic susceptibility.

Laboratory Studies

Numerous Chemicals/Mixtures

Unveiling Hidden Health Risks: Machine Learning Enhanced Modeling of Plastic Additive Release Kinetics in Fresh Produce Packaging.

BPA/Phenols

High-throughput transcriptomics analysis of equipotent and human relevant mixtures of BPA alternatives reveal additive effects in vitro.

Multiple nuclear receptor-regulated endocrine disrupting effects: A case study for bisphenol-induced crosstalk between RARα and ERα signaling pathways.

Bisphenol A caused abnormal spermatogenesis of Eriocheir sinensis through es-ERR/es-KIF4A pathway with discussion of BPA substitutes.

Prenatal Bisphenol B Exposure Induces Adult Male Offspring Reproductive Dysfunction via ERα Inhibition-Triggered MHC I-Mediated Testicular Immunological Responses.

Influence of microplastics on bisphenol A and bisphenol AF toxicity in aquatic environments: Mechanistic insights for environmental risks.

Bisphenol AF Induced Neurodevelopmental Toxicity of Human Neural Progenitor Cells via Nrf2/HO-1 Pathway.

Role of NR1D1 in Bisphenol A-Induced Anxiety-like Behavior and Inflammation in Zebrafish Larvae.

An Endocrine-Disrupting Chemical, Bisphenol A Diglycidyl Ether (BADGE), Accelerates Neuritogenesis and Outgrowth of Cortical Neurons via the G-Protein-Coupled Estrogen Receptor.

Phthalates

DEHP and its metabolite MEHP exposure impairs endometrial decidualization during early pregnancy via up-regulation of Mtmr6.

Phthalate Exposure During Pregnancy and Lactation Transgenerationally Impairs the Epididymis in the Offspring of Rats.

The tissue-specific ferroptosis in zebrafish (Danio rerio) exposed to dibutyl phthalate at environmental-relevant concentrations.

In vitro assessment of di(2-ethylhexyl) phthalate effect on epididymal sperm quality in dromedary camels

Parabens/Triclosan/Antimicrobials

Effects of triclosan on cytokine production by human immune cells in vitro.

Sustained exposure to triclocarban and triclosan at environmental relevant concentration disrupts gut-liver axis in the black-spotted frog.

Rumex hastatus leaves extract alleviates Triclosan-induced reproductive toxicity and improves fertility by modulating oxidative stress.

PFAS

Estrogenic and transgenerational effects of perfluorocarboxylic acids through estrogen-related receptor γ pathway.

Chronic PFAS Exposure Induces Chemotherapy Resistance by Promoting Mitochondria-Related Alterations in Ovarian Cancer Cells.

Vitamin A attenuates PFOS-induced neurotoxicity and alters early proximity patterns to conspecifics in zebrafish larvae.

PFOA and its substitutes disrupt fatty acid metabolism and impair erythrocyte homeostasis in zebrafish.

Intestinal inflammation mediates PFOA-induced sleep fragmentation and growth impairment in Drosophila.

Non-targeted metabolomics studies revealed the effects of environmentally relevant concentrations of perfluorooctane sulfonic acid (PFOS) on carbohydrate metabolism in red claw crayfish (Cherax quadricarinatus).

Perfluorooctane sulfonic acid impairs spermatogenesis via the liver-gut microbiota-testis axis: a central role of chenodeoxycholic acid metabolism.

Metabolic flux analysis elucidates perfluorooctanoic acid-induced mitochondrial metabolic dysregulation in human lung cells.

Immunotoxicity of Four Per- and Polyfluoroalkyl Substances Following 28-Day Oral Repeat Dosing in Rats Assessed by the Anti-Sheep Red Blood Cell IgM Response.

Flame Retardants

Sublethal Effects of Diphenyl Ether on Zebrafish Embryo: Developmental, Morphological, Cardiac and Neurotoxic Implications.

Black carbon modulates BDE-47-induced developmental toxicity in zebrafish larvae: Dual roles as pollutant carrier and toxic alleviator.

Chronic Reproductive Toxicity of Fomtec Enviro USP, a Fluorine-Free Firefighting Foam, to Northern Bobwhite (Colinus virginianus).

Pesticides

Neburon induced cardiotoxicity in embryonic and adult male zebrafish via over-activation of the Ahr-Notch1 signaling pathway.

Physicochemical Exploration and Computational Analysis of Bone After Subchronic Exposure to Kalach 360 SL in Female Wistar Rats.

Exploring the Role of Bifenthrin in Recurrent Implantation Failure and Pregnancy Loss Through Network Toxicology and Molecular Docking.

Metals/Metalloids

Chronic Low-Dose Cadmium Exposure Disrupts Gut Microbiota and Lipid Metabolism to Induce Liver Injury.

Microplastics/Nanomaterials

Effects of leachates from black recycled polyethylene plastics on mRNA expression of genes involved in adipogenesis and endocrine pathways in zebrafish embryos.

PPARγ mediated lysosomal membrane permeabilization and lipophagy blockage were involved in microplastics and di (2-ethylhexyl) phthalate co-exposure induced immature testis injury.

Transfer toxicity of polystyrene microplastics in vivo: Multi-organ crosstalk.

Exposure of Polystyrene Nanoplastics Led to Ferroptosis on Cardiomyocytes.

Co-exposure to polystyrene nanoplastics and glyphosate exacerbates NETs-mediated pyroptosis by activating the NLRP3 inflammasome in mouse liver.

Photo-aged polylactic acid microplastics causes severe transgenerational decline in reproductive capacity in C. elegans: Insight into activation of DNA damage checkpoints affected by multiple germline histone methyltransferases.

Miscellaneous

In-line NMR guided orthogonal transformation of real-life plastics [and related Mixed plastics turned into valuable chemicals].

Exposure/Environment Studies

Phthalates

Extensive exposure to di-n-hexyl phthalate with significant seasonal variation across infants, children and adults including pregnant women in Denmark.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Obituary for Dr. Rosalinda C. Montone: A key contributor to persistent organic pollutant studies in Antarctica and remote Atlantic Islands.

PFAS

Changes in serum perfluorooctane sulfonic acid and perfluorohexane sulfonic acid concentrations in firefighters accessing a voluntary perfluoroalkyl and polyfluoroalkyl substances reduction treatment program.

Tracking Early-Life PFAS Exposure in Children at Ages 4, 8, and 14 years: A Longitudinal Study from the INMA Spanish Birth Cohort.

Unregulated and Regulated PFASs in Bottled and Tap Water: Occurrence, Co-Occurrence Patterns, and Implications for Human Health and Regulatory Frameworks.

Nontargeted Analysis of Surface and Groundwaters Impacted by Historic PFAS Waste Sites.

High-resolution source apportionment and spatiotemporal drivers of per- and polyfluoroalkyl substances (PFAS) across China’s largest river-estuary continuum: Toward sustainable management of emerging contaminants.

Retrospective Identification of Novel and Legacy Per- and Polyfluoroalkyl Substances in German Archived Fish Livers Using a Combined High-Resolution Mass Spectrometry Approach.

Bioaccumulation of per- and polyfluoroalkylated substances (PFAS) in marine invertebrates and fishes from Antarctica and different coastal areas of Chile.

Pesticides

Ecotoxicological Impact of Agro-Industry on Streams From a South American Basin: Amphibian Tadpoles as Indicators of Environmental Health.

Metals/Metalloids

Short Communication: Simultaneous Removal of Co-occurring Contaminants Reduces Drinking Water-Attributed Cancer Risk: A United States Case Study.

Meta-analytical evidence for the endocrine-disrupting properties of mercury exposure in wild birds.

Microplastics/Nanomaterials

Post-mortem evidence of microplastic bioaccumulation in human organs: insights from advanced imaging and spectroscopic analysis.

Miscellaneous

Measurement of vinyl acetate monomer in consumer products and modeled estimates of consumer exposure.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Industry-funded articles are included without notation. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. There are searchable archives. Compiled by Sarah Howard of Healthy Environment and Endocrine Disruptor Strategies (HEEDS), a program of Environmental Health Sciences.

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