EDC Science Weekly, June 6-12, 2025

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Events, Regulations/Policy, Methods/Tools/Screening, Commentaries, Reviews/Meta-Analyses, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Highlights:

Assessment of Endocrine Disruptors in the European Union: Current Regulatory Framework, Use of New Approach Methodologies (NAMs) and Recommendations for Improvements.
Dismantling EPA’s research office jeopardizes environmental safety, public health, and US competitiveness.

Science summaries and highlights

Events

June 16: Early-bird deadline for Skills for Health and Research Professionals (SHARP) Training registration [Columbia Mailman School of Public Health]

June 16-17 workshop: Roadmap to phase out animal testing for chemical safety assessments [The European Chemicals Agency (ECHA)]

June 17 webinar: Community engagement for breast cancer prevention [CHE]

June 18 webinar: Defend Our Health: Authors & Friends, feat. Sharon Udasin [Defend Our Health and Island Press]

June 19 webinar: Key areas of regulatory challenge: research needs and opportunities [ECHA]

June 19 conference: Endocrine disruption: Perspectives from the 2024 ICEDA Awardees [Intersectoral Centre for Endocrine Disruptor Analysis (ICEDA)]

June 24 webinar: Environmental health research at EPA: What’s happening at ORD? [EDC Strategies Partnership]

June 25 online conference: TSCA reform- Nine years later [Environmental Law Institute]

July 8 webinar: Communicating about EDCs & Health: Why words matter [CHE]

July 28-30: DOHaD summer course [Developmental Origins of Health and Disease (DOHaD) Society]

July 30 – Aug. 1 conference: U.S. Developmental Origins of Health and Disease (DOHaD) Society Annual Meeting

Aug. 17 in-person workshop: How to conduct gold-star systematic reviews [PRHE, at the ISEE-ISES conference]

Sept. 15: ECHO symposium: translating science to action [hybrid] [NIH Environmental Influences on Child Health Outcomes (ECHO)]

Sept. 22-23 save the date: Second Annual Scientific Symposium on Plastics and Human Health [NYU Langone Health Center for the Investigation of Environmental Hazards (CIEH)]

More events

Regulations/Policy

Assessment of Endocrine Disruptors in the European Union: Current Regulatory Framework, Use of New Approach Methodologies (NAMs) and Recommendations for Improvements.

Learning from Experience: A Retrospective Analysis of Read-across Strategies for Surfactants under REACH.

Next Generation Risk Assessment and New Approach Methodologies for Safe and Sustainable by Design chemicals and materials: perspectives and challenges for Occupational Health.

More EDC policy, FPF’s regulations open for comment, Science’s Trump-Tracker, and links to preserved resources removed from U.S. federal websites

Methods/Tools/Screening

Unlocking the Power of Data Harmonization in Environmental Health Sciences: A Comprehensive Exploration of Significance, Use Cases, and Recommendations for Standardization Efforts.

Current approaches and advances in placental toxicology.

Development and characterization of reference environmentally relevant micro-nano-plastics for risk assessment studies.

The ENTAiLS Toolkit: an integrated workflow to perform non-targeted analysis of per- and polyfluoroalkyl substances.

The Chemical and Products Database v4.0, an updated resource supporting chemical exposure evaluations.

Commentaries

Dismantling EPA’s research office jeopardizes environmental safety, public health, and US competitiveness.

Plastics tracking strategy: Plastic-related small molecules as chemical fingerprints.

Ecological risks of biodegradable plastics.

The Urgent Need to Assess and Prevent the Deposits of Microplastics and Nanoplastics in Our Brain.

Reflecting on Dark Waters: A Call for Awareness and Investigation of Forever Chemicals Contacting the Skin.

PFAS Are Widespread, Not Ubiquitous: Clarifying Misconceptions About the Prevalence of “Forever Chemicals”.

Letter to the editor: Comments on diethyl-hexyl-cyclohexane (DEHCH) is a safer phthalate alternative that does not elicit new endocrine disrupting effects (Kang et al., 2025 [1]).

Reviews/Meta-Analyses

Numerous Chemicals/Mixtures

Intergenerational and transgenerational effects of endocrine-disrupting chemicals in the offspring brain development and behavior.

Potential effects of environmental toxicants on sperm quality and potential risk for fertility in humans.

Using mixture and exposome methods to assess the associations and interactions of chemical biomarkers with semen parameters.

Enantioselective transplacental transfer of xenobiotics: mechanisms, plasma protein binding, and health implications for fetal development.

Obesity and obesity related disease in adulthood: the dark side of early life exposure to Environmental Chemical Disruptors.

Human health risks from textile chemicals: a critical review of recent evidence (2019-2025).

[Impacts of endocrine disruptors on the placenta]. [in French]

BPA/Phenols

Bisphenols exposure and non-alcoholic fatty liver disease: from environmental trigger to molecular pathogenesis.

The role of long non-coding RNAs in mediating epigenetic changes induced by bisphenol A Exposure: Focus on reproductive and neurodevelopmental outcomes.

Phthalates

Phthalates, an environmental problem: A systematic review of their impact on marine organisms.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

A global review of PCBs and halogenated flame retardants in indoor Air: Implication for human exposure risks.

PFAS

Rethinking the Carcinogenic Classification of Perfluorooctanoic Acid (PFOA).

Reproductive toxicity of per- and polyfluoroalkyl substances

Quantifying the adsorption of PFAS and hydrocarbon surfactants at the air-water interface: A systematic review and meta-analysis of surface-science measurements, molecular-modeling simulations, and environmental-application results.

Microplastics/Nanomaterials

Micro(nano)plastics in the total environment – A holistic review.

Micro- and nanoplastic toxicity in humans: Exposure pathways, cellular effects, and mitigation strategies.

Microplastic contamination in fish: A systematic global review of trends, health risks, and implications for consumer safety.

Mechanism of microplastics in respiratory disease from 2020 to 2024: visualization and bibliometric analysis.

The state of microplastic pollution in México: a review and evolving perspectives.

Transboundary Impacts of Microplastics within Planetary Boundaries: Regulation and Responses of Soil-Plant Systems under Climate Change.

Microplastic-radionuclide complexes: Diffusion mechanisms and multidimensional threats.

Air Pollution

Prenatal exposure to criteria air pollution and traffic-related air toxics and risk of autism spectrum disorder: A population-based cohort study of California births (1990-2018).

Associations between all-cause and ischemic heart disease mortality and long-term ambient ultrafine particles exposure: a comparison of statistical and machine learning exposure models.

Prenatal Air Pollution Exposure and Autism Spectrum Disorder in the ECHO Consortium.

Miscellaneous

Chitosan as a sustainable alternative for fresh food packaging: Structural insights, modification strategies, and innovations for commercial viability.

Human Health Studies

Numerous Chemicals/Mixtures

Impact of e-waste pollutant exposure on renal injury and oxidative stress biomarkers: Evidence from causal machine learning.

Exposures to drinking water contaminants in community water systems and risk of ovarian cancer in the California Teachers Study cohort.

BPA/Phenols

Using Eye Tracking to Evaluate Cognitive and Visual Outcomes of Early Life Phenol Exposure.

Phthalates

Prenatal exposure to phthalate mixtures and child neurodevelopment in toddlers aged 1-3 years from the PROTECT birth cohort.

Plasma phthalate levels in children with speech delay.

Parabens/Triclosan/Antimicrobials

Associations of gestational and childhood urinary triclosan concentrations with atopic and allergic symptoms in Health Outcomes and Measures of the Environment (HOME) Study participants ages 1-12 years.

PFAS

Per- and polyfluoroalkyl substances (PFAS), thyroid hormones, sexual hormones and pubertal development in adolescents residing in the neighborhood of a 3M factory.

Per- and polyfluoroalkyl substances and associated proteomic biomarker patterns of immuno-suppression and cell-proliferation in an adolescent population from Northern Norway: The Fit Futures Study.

In utero per – and polyfluoroalkyl substances (PFAS) exposure and changes in infant T helper cell development among UPSIDE-ECHO cohort participants.

Longitudinal and cross-sectional analysis of perfluoroalkyl substances and kidney function.

Non-linear associations between exposure to a mixture of per- and polyfluoroalkyl substances and thyroid hormone levels in Korean adults.

Dietary exposure to per- and polyfluoroalkyl substances and health risk assessment in 7-year-old children in Shandong, China.

Suppression effect of folate on poly- and perfluoroalkyl substance-induced alterations in lipids and the atherogenic index of plasma in adolescents.

Flame Retardants

Exposure to organophosphate ester flame retardants and plasticizers during pregnancy and autism-related outcomes in the ECHO Cohort.

Pesticides

Residential proximity to agricultural fields, urinary glyphosate levels and breast cancer risk: a case-control study in Argentina.

Metals/Metalloids

Arsenic exposure, genetic susceptibility, lifestyle, and glucose-insulin homeostasis impairment: Revealing the association and interaction in a repeated-measures prospective study.

The association between metal exposure in follicular fluid and PCOS risk in reproductive-aged women: Mediating Roles of LH/FSH ratio and androgens.

The Association of Blood Lead with Cardiovascular Disease Incidence and Mortality: Findings from the Strong Heart Study Cohort.

The miRNA-based liquid biopsies for environmental health risk assessment: Insights into arsenic-induced hepatotoxicity and systemic health impacts.

The Association of Arsenic Exposure and Metabolism Biomarkers with Subclinical Measures of Liver Disease: a cross-sectional investigation in the Multi-Ethnic Study of Atherosclerosis.

Association between heavy metal exposure and pregnancy loss: evidence from NHANES 2011-2016.

Air Pollution

Air pollution and anti-Müllerian hormone: the Doetinchem Cohort Study.

Exposure-response relationship of household air pollution on body mass index among women in rural areas of Guatemala, India, Peru and Rwanda: household air pollution intervention network trial.

Prenatal exposure to ambient air pollution and fetal growth trajectories in Wuhan, China.

Pharmaceuticals/Personal Care Products

Elevated follicular fluid concentrations of ultraviolet filters associated with diminished ovarian reserve: A case-control study.

Laboratory Studies

Numerous Chemicals/Mixtures

Study of endocrine-disrupting effects of disposable biodegradable tableware and key migrants based on in vitro assays, mass spectrometry analysis, and in silico predictions.

BPA/Phenols

Molecular mechanism of bisphenols induction of breast cancer through PGR revealed by network toxicology and transcriptomics integration analysis.

A Drosophila ecdysone-deficient model to assess the endocrine disruptor activity of Bisphenol A.

Exposure to environmental concentrations of 4-n-nonylphenol: impacts on oxidative stress in guppy (Poecilia vivipara).

Phthalates

Elucidating the Mechanisms of DEHP-Induced Insulin Resistance: A Comprehensive Network Toxicology and In Vitro Approach.

Dibutyl phthalate promotes central precocious puberty through primordial follicle activation by downregulating BMP15.

Revealing the Impact of Mono(2-ethylhexyl) Phthalate (MEHP) on Prostate Cancer Based on Network Toxicology and Molecular Docking Approaches.

Uncovering the effects of ATBC plasticizers on intracerebral hemorrhage outcomes based on network toxicology and in vitro and in vivo experimental validation. [a phthalate replacement]

Parabens/Triclosan/Antimicrobials

Triclocarban and Triclosan disturb Lipometabolism via PPAR in black-spotted frogs: In vivo and molecular dynamics simulation studies.

Epigenetic Responses Induced by Transgenerational and Multigenerational Exposure Alter the Plasticity of Fish to Neurotoxic Effects of Triclosan.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Assessing placental transfer and in utero reproductive effects in rats of a short-chained paraffin with in vitro endocrine disrupting properties.

In vitro to in vivo evidence for chemical disruption of glucocorticoid receptor signaling.

PFAS

Toxicokinetics, tissue distribution, and toxic potency of PFOS alternative OBS in adult zebrafish (Danio rerio) based on flow-through exposure system.

Sesamin Alleviates Ferroptosis in Perfluorooctanesulfonate-Induced Liver Injury by Targeting Foxo1.

Prenatal exposure to polyfluoroalkyl substances and visual acuity in preschool children: Findings from the Guangxi Zhuang birth cohort in China.

Integrative in silico analysis of per- and polyfluorinated alkyl substances (PFAS)-associated molecular alterations in human cancers: a multi-cancer framework for predicting toxicogenomic disruption.

Binding of per- and polyfluoroalkyl substances with liver and serum proteins in rats: implications for physiologically based pharmacokinetic modelling.

Toxicokinetics and Perfluorooctanesulfonic Acid-Induced Liver Protein Expression Are Markedly Altered in Mice Lacking Albumin.

Pesticides

Azole fungicides: Potential endocrine disrupting effects and impact on placental steroidogenesis via inhibiting human and rat 3β-hydroxysteroid dehydrogenase.

Acetamiprid-induced testicular toxicity in mice: ameliorative effect and potential mechanisms of morin.

Chronic exposure to pyraclostrobin induced hepatic toxicity and glucolipid metabolism dysfunction in adult zebrafish.

Carcinogenic effects of long-term exposure from prenatal life to glyphosate and glyphosate-based herbicides in Sprague-Dawley rats.

Dietary supplementation of Lactobacillus casei alleviates permethrin exposure-induced zebrafish testis damage through modulation of TLR4/NF-κB and AKT/Nrf2 pathways: Oxidative stress, inflammation and ferroptosis.

Microplastics/Nanomaterials

Microplastics (MPs) exposure impairs porcine oocyte quality by triggering oxidative stress-directed DNA damage and apoptosis with metabolomic alterations.

Polystyrene nanoplastics trigger pyroptosis in dopaminergic neurons through TSC2/TFEB-mediated disruption of autophagosome-lysosome fusion in Parkinson’s disease.

Unraveling the impact of polystyrene microplastics with varying particle sizes and concentrations on lipid in vitro digestion and ex vivo absorption.

Limited passage and functional effects of polystyrene micro- and nanoplastics in a physiologically-relevant in vitro human placental co-culture model.

Co-exposure to triclosan and polystyrene nanoplastics on neurodevelopmental toxicity and gut microbiota dysbiosis in zebrafish (Danio rerio).

Polystyrene nanoplastics induced transgenerational reproductive toxicity in Caenorhabditis elegans through enhanced DNA damage accompanied by DNA repair inhibition.

Tire Wear Particles

Evaluation of 6PPD-Quinone Lethal Toxicity and Sublethal Effects on Disease Resistance and Swimming Performance in Coastal Cutthroat Trout (Oncorhynchus clarkii clarkii).

6-PPD quinone induces response of nuclear hormone receptors in the germline associated with formation of reproductive toxicity in Caenorhabditis elegans.

Multi-omics insights into 6PPD- and 6PPDQ-induced gut-liver axis disruption and non-alcoholic fatty liver disease progression in zebrafish (Danio rerio).

Chronic toxicity mechanisms of 6PPD and 6PPD-Quinone in zebrafish.

An environmentally relevant concentration of 6-PPD quinone inhibits two types of mitophagy to cause mitochondrial dysfunction and lifespan reduction in Caenorhabditis elegans.

Vehicle-Specific Toxicological Profiles of Tire Wear Particles: Physiological, Microbial, and Transcriptomic Disruptions in Zebrafish Induced by Light and Heavy-Duty Vehicle Emissions.

Miscellaneous

Zearalenone and its metabolites provoke contrasting modulatory responses on estrogen and androgen receptors: Insights into the molecular basis of endocrine disruption in live cells.

Exposure/Environment Studies

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Determination of chlordecone in indoor dust by GC/MS/MS and associated human exposure in the French West Indies.

PFAS

Trends in serum levels of emerging and legacy per- and polyfluoroalkyl substances from 2008 to 2018: a longitudinal study in China.

Occurrence and patterns of legacy and emerging per- and polyfluoroalkyl substances (PFAS) in bones of white-beaked dolphin (Lagenorhynchus albirostris) using target, suspect, and non-target screening.

Flame Retardants

Seasonal variation and human exposure characteristics of PBDEs in indoor dust, airborne particles and vapor phase in office environments.

Pesticides

Pesticide Exposure Estimation across Census Tracts in Washington State: Identifying Vulnerable Areas and Populations.

Characterising neonicotinoid insecticide exposures among the Irish population using human biomonitoring.

Metals/Metalloids

Descriptive analysis of whole blood concentrations of toxic, essential, and trace elements in adult females from the MIREC-ENDO study.

HBM4EU E-Waste Study – Occupational Exposure Assessment to Chromium, Cadmium, Mercury and Lead During E-Waste Recycling.

——-

This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Industry-funded articles are included without notation. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. There are searchable archives. Compiled by Sarah Howard of Healthy Environment and Endocrine Disruptor Strategies (HEEDS), a program of Environmental Health Sciences.

If you enjoy this newsletter, please feel free to donate here! Thank you!