EDC Science Weekly, May 16-22, 2025

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Events, Regulations/Policy, Methods/Tools/Screening, Commentaries, Reviews/Meta-Analyses, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Highlights:

Science summaries and highlights

Events

May 29 webinar: Corporate Drivers of Disease: Exploring the UCSF Industry Documents Library [CHE, UCSF PRHE]

June 5 virtual events: Persevering for an Equitable and Holistic Environmental Protection System and Protecting Public Science: How to Defend Scientific Integrity in a New Era of Interference [Union of Concerned Scientists]

June 10 conference: Preventing diseases by reducing exposure to harmful chemicals (hybrid) [Health and Environment Alliance (HEAL)]

June 16-17 workshop: Roadmap to phase out animal testing for chemical safety assessments [The European Chemicals Agency (ECHA)]

June 18 webinar: Defend Our Health: Authors & Friends, feat. Sharon Udasin [Defend Our Health and Island Press]

June 19 webinar: Key areas of regulatory challenge: research needs and opportunities [ECHA]

July 8 webinar: Communicating about EDCs & Health: Why words matter [CHE]

July 30 – Aug. 1 conference: U.S. Developmental Origins of Health and Disease (DOHaD) Society Annual Meeting

Sept. 22-23 save the date: Second Annual Scientific Symposium on Plastics and Human Health [NYU Langone Health Center for the Investigation of Environmental Hazards (CIEH)]

More events

Regulations/Policy

Derivation of Provisional Drinking Water Tolerance Values for Several PFAS Not Included in the Austrian Drinking Water Regulation.

United States Environmental Protection Agency’s Perfluorooctanoic Acid, Perfluorooctane Sulfonic Acid, and Related Per- and Polyfluoroalkyl Substances 2024 Drinking Water Maximum Contaminant Level: Part 1 – Analysis of Public Comments.

More EDC policy, FPF’s regulations open for comment, Science’s Trump-Tracker, and links to preserved resources removed from U.S. federal websites

Methods/Tools/Screening

DeTox: an In-Silico Alternative to Animal Testing for Predicting Developmental Toxicity Potential.

External Validation of STopTox – Novel Alternative Method (NAM) for Acute Systemic and Topical Toxicity.

Statistical methods for chemical mixtures: a roadmap for practitioners using simulation studies and a sample data analysis in the PROTECT cohort.

Quantitative and qualitative concordance between clinical and nonclinical toxicity data.

Predicting estrogen receptor agonists from plastic additives across various aquatic-related species using machine learning and AlphaFold2.

New Approach Methods (NAMs) for genotoxicity assessment of nano- and advanced materials; Advantages and challenges.

Making safety decisions for a sunscreen active ingredient using next-generation risk assessment: Benzophenone-4 case study.

A reference list of neurotoxicants based on CLP harmonised classifications.

Commentaries

Mitigating the environmental effects of healthcare: the role of the endocrinologist.

How to organise a successful toxicology workshop? A participant perspective on the Collaboration to Harmonise the Assessment of Next Generation Evidence (CHANGE) workshop in Oslo, 18-20 June 2024.

2024 International Academy of Toxicologic Pathology (IATP) Satellite Symposium: New Approach Methodologies (NAMs) for Neurotoxicity Assessment and Regulatory Perspectives.

Towards a ‘theory of change’ for ocean plastics: a socio-oceanography approach to the global challenge of plastic pollution.

PFAS Information for Clinicians From ATSDR.

The potential impact of the Trump administration policies on health research in the USA

Editorial: Women in nanotoxicology 2023-2024. [intro to a research topic in Frontiers in Toxicology]

Leaving synthetic pesticides behind. [Letter in Science]

Reviews/Meta-Analyses

Numerous Chemicals/Mixtures

Health impacts of exposure to synthetic chemicals in food.

Endocrine-disrupting chemicals as prostate carcinogens.

BPA/Phenols

A comprehensive review on the neurobehavioural effects of bisphenol compounds and the underlying molecular mechanisms in zebrafish (Danio rerio).

Phthalates

Plasticizers, brain & behavior.

Flame Retardants

Adverse Effects of Aryl Organophosphate Esters on Reproduction.

Pesticides

The 2023 European Union report on pesticide residues in food.

Metals/Metalloids

Heavy Metals in Breast Implants and Implications for Breast Implant Illness: A Systematic Review of the Literature.

Microplastics/Nanomaterials

The clinical relevance of microplastic exposure on colorectal cancer: A systematic review.

Microplastics: Hidden drivers of antimicrobial resistance in aquatic systems.

Air Pollution

Air pollution and its role in the rising burden of type 2 diabetes in India: urgent call for action.

Ambient air pollution and childhood obesity from infancy to late childhood: An individual participant data meta-analysis of 10 European birth cohorts.

Pharmaceuticals/Personal Care Products

Clear Cell Adenocarcinoma of the Uterine Cervix and Vagina in Children Without Exposure to Diethylstilbestrol.

Human Health Studies

Numerous Chemicals/Mixtures

Urinary Levels of Endocrine-Disrupting Chemicals and Breast Density in Young Women.

A prospective exposome-based gene-environment interaction study on the effects of prenatal environmental exposure on fetal growth in the Shanghai Birth Cohort.

BPA/Phthalates

Plasticizer Exposure and Reproductive Dysfunction: Assessing Bisphenol A and Phthalate Esters Impact on Ovarian Reserve in Women with PCOS-Associated Infertility.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Serum level of dioxin-like polychlorinated biphenyls and blood pressure in primary school children.

PFAS

Circulating per- and polyfluoroalkyl substances and liver cancer risk: a nested case-control analysis of individual participant data from 12 prospective cohorts.

Per- and Polyfluoroalkyl Substances (PFAS) in placental compartments: histopathological and toxicological data integration in an Italian cohort.

Flame Retardants

Association between ovarian reserve and organophosphate flame retardants in women of childbearing age.

Pesticides

The association between maternal exposure to ten neonicotinoid insecticides and preterm birth in Guangxi, China.

Metals/Metalloids

Prenatal Exposure to Arsenic, Umbilical Cord Blood DNA Methylation, and Child Neurodevelopment: A Prospective Birth Cohort Study.

Associations of prenatal exposure to lead and mercury with auditory function in infants.

Long-Term Exposure to Uranium and Arsenic in Community Drinking Water and CKD Risk Among California Women.

Air Pollution

Exploring the link between grandmaternal air pollution exposure and Grandchild’s ASD risk: A multigenerational population-based study in California.

The effect of air pollution exposure on menstrual cycle health using self-reported data from a mobile health app: a prospective, observational study

Household fuel use and kidney disease-related mortality: the Golestan Cohort Study.

Miscellaneous

The impact of polycyclic aromatic hydrocarbon metabolites on reproductive hormone levels and follicle count in patients with polycystic ovary syndrome: a case-control study.

Dietary intake of polycyclic aromatic hydrocarbons (PAHs) and breast cancer risk: Evidence from the French E3N-Generations prospective cohort.

Association between exposure to terpene compounds and risk of metabolic syndrome: exploring the potential mediating role of inflammatory response.

Laboratory Studies

Numerous Chemicals/Mixtures

Integrating Network Analysis and Machine Learning to Elucidate Chemical-Induced Pancreatic Toxicity in Zebrafish Embryos.

Low-dose bisphenol A plus arsenite: Continuous or intermittent exposures in Sprague-Dawley rats; Effects on kidney oxidative stress, DNA damage, ferroptosis, and fibrosis.

BPA/Phenols

Network toxicology and molecular docking to investigate the mechanism of bisphenol A toxicity in human diabetic cardiomyopathy.

Bisphenol S induces brown adipose tissue whitening and aggravates diet-induced obesity in an estrogen-dependent manner.

Avian-Specific Evidence for an Estrogen Receptor Agonism Adverse Outcome Pathway Based on Chicken Embryos and LMH 3D Spheroids Exposed to Ethinylestradiol and Bisphenol A.

Are BPA effects on Connexins and key downstream microRNAs in bovine COCs correlated to miR-21 expression?

Hydroxytyrosol Inhibits BPS-Induced NF-κB Signaling Pathway Activation, Mitigates Oxidative Stress, and Reduces Neuronal Apoptosis.

Bisphenol Z inhibits the function of Leydig cells via upregulation of METTL3 expression in adult male rats.

Perinatal exposure to 4-hydroxy-4′-isopropoxydiphenylsulfone alters the adipogenesis in adult mice: A sex-specific study.

Impact of 4-tert-Butylphenol on Inflammation and Glycogen Metabolism in Cyprinus carpio L via the miR-363/PKCδ Axis.

Phthalates

Di(2-ethylhexyl) Phthalate (DEHP) Exacerbates Food Allergy via Intestinal Barrier Dysfunction and Enhancing Allergic Sensitization.

Exposure risk assessment of di(2-ethylhexyl)phthalate (DEHP) using human population pharmacokinetic modeling of DEHP and its major in vivo metabolites.

Unraveling DINCH – Induced hepatotoxicity mechanisms via network toxicology and molecular docking with experimental validation.

Parabens/Triclosan/Antimicrobials

Triclosan promotes neurotoxicity in diabetic conditions: an in vivo molecular assessment using zebrafish model.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

In Vitro Cytotoxic Mechanism and Exposure Risk Assessments of Banned Organochlorine Pesticides in Indo-Pacific Humpback Dolphins.

Effects of exposure of dairy cows to a mixture of polychlorinated dibenzo-p-dioxins (PCDDs) and dibenzofurans (PCDFs), dioxin-like (dl) polychlorinated biphenyls (PCBs), and non-dl-PCBs during the period of negative and positive energy balance on health traits and on aryl hydrocarbon receptor (AHR)-signaling.

PFAS

Perfluorooctanoic Acid Destabilizes Hemoglobin Structure at Submicromolar Concentrations.

Perfluorinated compounds exposure and atherogenic risk characteristics in a high-fat diet condition: In vitro/in vivo models and population panel study.

Pesticides

Evaluating the Effects of Neburon Exposure on Ovarian Folliculogenesis Using Zebrafish and Mouse Granulosa Cell Line.

Effect of cypermethrin on thyroid follicular epithelial cell injury via the ROS-NF-κB-NLRP3 pathway.

Metals/Metalloids

Arsenic-induced neurocardiac toxicity and protective role of Resveratrol: histopathological and molecular insights.

Microplastics/Nanomaterials

Polystyrene Microplastics-Induced Thyroid Dysfunction in Mice: A Study of Gene Expression, Oxidative Stress, and Histopathological Changes.

Lifetime co-exposure of parental zebrafish to benzophenone-3 and titanium dioxide nanoparticles leads to developmental neurotoxicity and thyroid endocrine disruption in their offspring.

Nanoplastics transport in zebrafish brain: Molecular and phenotypic behavioral impacts.

Diverse Perspectives Illuminate the Intestinal Toxicity of Traditional and Biodegradable Agricultural Film Microplastics to Eisenia fetida under Varying Exposure Sequences.

Integrated transcriptomics and metabolomics to explore the varied hepatic toxicity induced by aged- and pristine-microplastics: in vivo and human-originated liver organoids-based in vitro study.

Nanoplastics disrupt hepatic lipid metabolism via the inhibition of PPARγ: a study based on digestive system exposure.

Toxic effects of co-exposure to polystyrene nanoplastics and arsenic in zebrafish (Danio rerio): Oxidative stress, physiological and biochemical responses.

Impacts of polystyrene nanoplastics on zebrafish gut microbiota and mechanistic insights.

Polystyrene nanoplastics exposure induces cognitive impairment in mice via induction of oxidative stress and ERK/MAPK-mediated neuronal cuproptosis.

Aquatic toxicity of UV-irradiated commercial polypropylene plastic particles and associated chemicals.

Photoaging Promotes Toxic Micro/Nanoplastics Release from PLA/PBAT Biodegradable Plastic in Gastrointestinal Condition.

Vitamin K2 prevents postoperative cognitive impairments, anxiety-like behavior, and motor dysfunction induced by nanoplastics in young adult mice.

Pharmaceuticals/Personal Care Products

Impact of the Environmental Endocrine Disruptor Flutamide on Cryptorchidism: Molecular Mechanisms Involving Connexin-43 and p38-MAPK Signaling.

Miscellaneous

Hypothesis-driven weight of evidence evaluation indicates ethylbenzene lacks endocrine disruption potential by EATS pathways.

Early developmental exposure to sodium perchlorate disrupts thyroid, liver, and testicular development in mice.

Exposure/Environment Studies

Numerous Chemicals/Mixtures

Associations between dietary patterns and environmental contaminants in children from the Norwegian Environmental Biobank: a cross-sectional analysis.

Young Children’s Exposure to Chemicals of Concern in Their Sleeping Environment: An In-Home Study

BPA/Phthalates

Associations of maternal behaviours and environmental exposures with melamine and bisphenol analogs in breast milk: a cross-sectional study.

Dietary exposure to environmental phenols and phthalates in Korean adults: data analysis of the Korean National Environmental Health Survey (KoNEHS) 2018-2020.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Exposure and hormone associations of pesticides and flame retardants among primates in Uganda.

PFAS

Nontarget Screening and Occurrence of Emerging Per- and Polyfluoroalkyl Substances in Municipal and Semiconductor Industrial Wastewater: A Large-Scale Survey in China.

Distributions and compositional characteristics of per- and polyfluoroalkyl substances (PFASs) in sediments of the regional seas of South Korea.

Distribution and variability of per- and polyfluoroalkyl substances (PFASs) across three categories of wastewater treatment plants in Kaohsiung, the industrial hub of Taiwan.

Hair analysis as a non-invasive method for assessing the exposure of wildlife to per- and poly-fluoroalkyl substances (PFAS).

Emerging and legacy per- and polyfluoroalkyl substances from offshore oilfields and receiving water in China.

National Assessment of PFAS in Landfill Leachate in China: Non-Negligible Ultrashort-Chain Components and Socioeconomic Impacts.

Flame Retardants

High-resolution mass spectrometry recognized Tetrabromobisphenol A bis (2,3-dibromo-2-methylpropyl ether) (TBBPA-DBMPE) as a contaminant in sediment from a flame retardant manufacturing factory.

Pesticides

Deciphering pollinator exposure hazards: Systemic translocation and accumulation of seed-coating pesticides in maize and their synergistic exposure risk to bees.

Glyphosate threatens lizard adaptation to warming: Disruption to maternal effects.

Microplastics/Nanomaterials

Micro(nano)plastics (< 4 μm): An important but ignored concern during intravenous infusion.

Breakdown of plastic waste into microplastics during an industrial Composting: A case study from a biowaste facility.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Industry-funded articles are included without notation. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. There are searchable archives. Compiled by Sarah Howard of Healthy Environment and Endocrine Disruptor Strategies (HEEDS), a program of Environmental Health Sciences.

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