EDC Science Weekly, Apr. 18-24, 2025

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Events, Regulations/Policy, Methods/Tools/Screening, Commentaries, Reviews/Meta-Analyses, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

News: Due to recent changes in operational resources, EHP and JHP are currently unable to consider new manuscript submissions for peer review or publication.

Highlights:

Gestational exposures to mixtures of multiple chemical classes and autism spectrum disorder
Endocrine disruption potential of dust in children’s indoor environments

Science summaries and highlights

Events

Apr. 24 webinar: Childhood cancer and the environment: Prevention opportunities [CHE-Alaska]

Apr. 27-29 conference: Break the Cycle of Children’s Environmental Health Disparities

Apr. 30 webinar: Ultra-Processed Food & Plastics: A Toxic Relationship [Beyond Plastics and Interfaith Public Health Network]

May 8 webinar: Changes at NIH: What do they mean for environmental health? [EDC Strategies Partnership]

May 10-13: EDC sessions at European endocrinology society meeting [European Society for Pediatric Endocrinology (ESPE) and the European Society of Endocrinology (ESE)]

May 14: Minimising the impact of endocrine disrupting chemicals on health and environment [a scientific update following the Joint Congress of ESPE and ESE, sponsored by ESE]

May 15 webinar: Microplastics’ Impact on the Brain & Heart [Beyond Plastics, PSR NY, Environmental Advocates]

June 10 conference: Preventing diseases by reducing exposure to harmful chemicals (hybrid) [Health and Environment Alliance (HEAL)]

June 16-17 workshop: Roadmap to phase out animal testing for chemical safety assessments [The European Chemicals Agency (ECHA)]

July 30 – Aug. 1 conference: U.S. Developmental Origins of Health and Disease (DOHaD) Society Annual Meeting

More events

Regulations/Policy

Exploring the Essential Use Concept for Primary Microplastics Regulation in the EU.

Advancing EFSA’s regulatory science: Updated research and innovation needs.

A Proposal to Permanently Ban Flame Retardant Chemicals to Meet California’s Flammability Standard for Upholstered Furniture.

More EDC policy, FPF’s regulations open for comment, Science’s Trump-Tracker, and links to preserved resources removed from U.S. federal websites

Methods/Tools/Screening

EU roadmap for phasing out animal testing for chemical safety assessments: Recommendations from a multi-stakeholder roundtable.

Contributions of the joint FAO/WHO expert committee on food additives to international food safety: celebrating the 100th meeting of the committee.

Assessment of immunotoxicity in the 21st century: where we are and what we need to replace animals

Interlaboratory Comparison Reveals State of the Art in Microplastic Detection and Quantification Methods.

Read-across-driven binary classification for the developmental and reproductive toxicity of organic compounds tested according to the OECD test guidelines 421/422.

DockTox: Targeting Molecular Initiating Events in Organ Toxicity through Molecular Docking.

A comparative review of organ-on-a-chip technologies for micro- and nanoplastics versus other environmental toxicants.

Interpretation of thyroid-relevant bioactivity data for comparison to in vivo exposures: A prioritization approach for putative chemical inhibitors of in vitro deiodinase activity.

Proof-of-concept for using machine learning to facilitate data extraction for human health chemical assessments: a study protocol.

Low-rank longitudinal factor regression with application to chemical mixtures

Commentaries

Editorial: Xenosensors as the targets of endocrine-disrupting chemicals [intro to a research topic in Frontiers in Endocrinology]

Chemical risk analysis competence in the Nordics is at stake.

Drosophila fruit fly an in vivo model to determine hazardous effects following exposure to nanoplastics utilizing the One Health approach.

Reviews/Meta-Analyses

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Concentrations of DDT metabolites in different food items and public health risk in Africa regions: systematic review and metal analysis.

PFAS

Antioxidant system alterations and oxidative stress caused by polyfluoroalkyl substances (PFAS) in exposed biota: a review.

Pesticides

Pesticide exposure and the development of Parkinson disease: a systematic review of Brazilian studies.

Metals/Metalloids

Essential and Non-Essential Metals and Metalloids and Their Role in Atherosclerosis.

The impact of heavy metals exposure on male fertility: a scoping review of human studies.

Microplastics/Nanomaterials

Unseen Dangers: The Effects of Micro- and Nanoplastics on Human Reproductive Health – A Narrative Review.

Tiny trouble: microplastics, nanoplastics, and their heartfelt impact on cardiovascular health.

Metabolic Dysfunction-Associated Steatotic Liver Disease Induced by Microplastics: An Endpoint in the Liver-Eye Axis.

Impacts of microplastics on gut health: Current status and future directions.

Pharmaceuticals/Personal Care Products

Sunscreens and Their Impact on Human Health and the Environment: A Review.

Miscellaneous

Polyhydroxyalkanoates production from laboratory to industrial scale: A review.

Human Health Studies

Numerous Chemicals/Mixtures

Gestational exposures to mixtures of multiple chemical classes and autism spectrum disorder in the MARBLES study.

Detection of novel organophosphorus flame retardants and plasticizers in children urines: Associations with oxidative stress damage and thyroid nodule risk.

Mixture analysis of associations between environmental and workplace toxins and liver damage and telomere length, stratified by race/ethnicity.

Association between mixed exposure of phenols, parabens, phthalates and cognitive function in US elders.

Nontargeted Urinary Profiling Strategy for Endocrine-Disrupting Chemicals in Women with Ovarian Malignancies.

The Fire Fighter Cancer Cohort Study: Protocol for a Longitudinal Occupational Cohort Study.

Unraveling the connection between endocrine-disrupting chemicals and anxiety: An integrative epidemiological and bioinformatic perspective.

BPA/Phenols

Endocrine-disrupting chemicals in human adipose tissue and associations between exposure and obesity.

Revealing the role of bisphenol A on prostate cancer progression and identifying potential targets: A comprehensive analysis from population cohort to molecular mechanism. [human and lab]

Phthalates

Prenatal phthalate exposure and anogenital distance in infants at 12 months.

Parabens/Triclosan/Antimicrobials

Exposure to phenols mixture, oxidative stress, and fasting blood glucose: Association and potential mediation analyses. [parabens]

PFAS

Association of per-and polyfluoroalkyl substances with thyroid hormones in the umbilical cord blood of neonates born by spontaneous delivery.

Effect of PFAS serum exposure pattern on the lipid metabolism: Time to step-forward in causal inference in epidemiology.

Per- and polyfluoroalkyl substances in eutopic endometrium tissue and risk of endometriosis: findings from the Investigating Mixtures of Pollutants and Endometriosis in Tissue (IMPLANT) Study.

Pre-diagnostic serum concentrations of per- and polyfluoroalkyl substances and risk of endometrial cancer in a US cohort.

Association between per- and polyfluoroalkyl substances with serum hepatobiliary system function biomarkers in patients with acute coronary syndrome.

Serum PFAS and lipid concentrations in Ecuadorian adolescents.

High serum perfluorooctanoic acid (PFOA) concentrations and interstitial lung disease in former and current workers in a fluorochemical company.

Flame Retardants

Sex-and stage-specific effect of prenatal exposure to organophosphate esters with children’s physical growth patterns and adiposity rebound timing: Modification by breastfeeding.

Pesticides

Exposure to pesticides and cognitive function in school-age children of the Bolivar Department (Colombia).

Metals/Metalloids

Associations of exposure to arsenic species and endogenous sex hormones with oral cancer: a hospital-based study in Southeastern China.

Associations between dietary exposure to profiles of metalloestrogens and estrogen-receptor positive breast cancer risk in the French E3N cohort.

Air Pollution

Childhood Exposure to Air Pollution, Body Mass Index Trajectories, and Insulin Resistance Among Young Adults.

Miscellaneous

Correlation between 6PPD-Q and immune along with metabolic dysregulation induced liver lesions in outdoor workers.

Associations between maternal urinary metabolite concentrations of selected volatile organic compounds and child neurocognitive development at two years of age.

Trimester-specific associations of exposure to epoxide alkanes, alkenals, and 1,3-butadiene with preschool children’s intellectual development: A birth cohort study in Wuhan, China.

Laboratory Studies

Numerous Chemicals/Mixtures

Impact of Persistent Endocrine-Disrupting Chemicals on Human Nuclear Receptors: Insights from In Silico and Experimental Characterization.

Endocrine disruption potential of dust in children’s indoor environments: Associations with multiple chemicals from various compound classes across exposure matrices used for health risk assessment.

BPA/Phenols

Network toxicology and molecular docking techniques to explore the mechanism of bisphenol A on obesity.

Chronic adulthood exposure to bisphenol A causes behavioral changes via suppressing dopamine transporter trafficking.

Impact of BPA and its analogs on sperm hyperactivity, acrosome reaction, epigenetic profiles and in vitro embryo development.

The sprouting angiogenesis and vascular dysfunction triggered by bisphenol S and tetrabromobisphenol S through disrupting vascular endothelial-cadherin in zebrafish.

Clustering of bisphenols based on toxicity predictions for key aquatic species: Daphnia magna, Pimephales promelas, and Oryzias latipes.

Effect of Bisphenol A on the neuro-immune-endocrine mechanisms controlling the reproductive axis response during an inflammatory event.

Bisphenol-A-induced ovarian cancer: Changes in epithelial diversity, apoptosis, antioxidant and anti-inflammatory mechanisms.

UPLC-QqQMS based targeted metabolomics reveal combination impact on metabolism caused by bisphenol AF and fructose combined exposure in male mice.

Phthalates

Multi-approach study on diethylhexyl phthalate and monoethylhexyl phthalate binding to lysozyme: In silico, bioactivity and surface plasmon resonance analyses.

Bayesian benchmark dose modeling analysis and derivation of points of departure for female reproductive toxicity following exposure to di(2-ethylhexyl) phthalate (DEHP) – effects on reproductive hormones, folliculogenesis and estrous cyclicity.

Evaluation of phthalates induced cardiotoxicity using human iPSCs-derived cardiomyocyte and dual-cardiotoxicity evaluation methods.

Parabens/Triclosan/Antimicrobials

New insight into intestinal toxicity accelerated by aged microplastics with triclosan: Inflammation regulation by gut microbiota-bile acid axis.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Environmental toxicant 2,3,7,8-tetrachlorodibenzo-p-dioxin induces non-obstructive azoospermia: New insights from network toxicology, integrated machine learning, and biomolecular modeling.

PFAS

Perfluorooctane sulfonic acid: a possible risk factor of endothelial dysfunction based on in silico and in vitro studies.

Dietary protein deficiency exacerbates perfluorohexane sulfonate (PFHxS)-induced reproductive abnormalities and metabolic disruptions in female rats.

Embryonic exposure to GenX causes reproductive toxicity by disrupting the formation of the blood-testis barrier in mouse offspring.

Mitigation of PFAS toxicity through sorbent treatment in Sprague-Dawley rats during prenatal and postnatal exposure.

Flame Retardants

Long-term exposure to environmentally relevant concentrations of tri-m-cresyl phosphate induces fecundity decline and gonadal dysplasia by disrupting reproductive endocrine homeostasis.

Opposing Visual Impairments Induced by Structurally Similar Organophosphate Flame Retardants TPHP and CDP in Zebrafish Larvae.

Organotins

Tributyltin affects the growth of ovarian granulosa cells in polycystic ovary syndrome by upregulating YY1-mediated CDKN1C via the PI3K/AKT pathway.

Pesticides

Comparative assessment of thyroid disrupting effects of ethiprole and its metabolites: In silico, in vitro, and in vivo study.

Glyphosate Induces Anxiety-Like Behaviors in Mice via Activating NLRP3-Mediated Hippocampal Microglia Pyroptosis.

Neurotoxicity induced by difenoconazole in zebrafish larvae via activating oxidative stress and the protective role of resveratrol.

Sub-chronic exposure of hexaconazole may induce metabolic and neuropathic diseases: The evidence from gut microbiota

Fungicide consumption exacerbates the negative effects of a common gut parasite in bumble bee microcolonies.

Protective effects of resveratrol on honeybee health: Mitigating pesticide-induced oxidative stress and enhancing detoxification

Microplastics/Nanomaterials

Gut dysbiosis exacerbates inflammatory liver injury induced by environmentally relevant concentrations of nanoplastics via the gut-liver axis.

Interaction of Polystyrene Nanoplastics with Biomolecules and Environmental Pollutants: Effects on Human Hepatocytes.

Alteration to Organismal Behavior due to Microplastic Exposure.

Oral exposure to nanoplastics and food allergy in mice fed a normal or high-fat diet.

Polystyrene microplastics and cypermethrin exposure interfered the complexity of antibiotic resistance genes and induced metabolic dysfunction in the gut of adult zebrafish.

Miscellaneous

Ovarian toxicity of 2,6-di-tert-butyl-hydroxytoluene on female Ruditapes philippinarum: Reproductive endocrine disruption and oxidative stress.

Transformation of Bamboo: From Multiscale Fibers to Robust and Degradable Cellulose-Based Materials for Plastic Substitution.

New Psychoactive Substance Esketamine Causes Endocrine-Disrupting Effects and Developmental Toxicity.

Exposure/Environment Studies

Numerous Chemicals/Mixtures

Exposure to plasticizers in city waste recycling: Focused on the size-fractioned particulate-bound phthalates and bisphenols.

BPA/Phenols

A comparative evaluation of salivary and plasma bisphenol-A levels in patients released from four different orthodontic appliances: ultra-performance liquid chromatography-mass spectrometry study. A non-randomized clinical trial.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Associations of maternal diet with nutritional and chemical exposure markers in human milk from the LACTACOL cohort of preterm infants.

PFAS

Fluorinated Liquid-Crystal Monomers Distribution in Paired Urine from Mothers and Infants.

Perfluorooctanoic acid serum concentrations and half-lives in a community exposed to contaminated drinking water in New York State.

Per- and polyfluoroalkyl substances (PFAS) in the marine environment: An overview and prospects.

Pesticides

Relationships of residential distance to greenhouse floriculture and organophosphate, pyrethroid, and neonicotinoid urinary metabolite concentration in Ecuadorian Adolescents.

Endocrine-disrupting pesticides in infant formulas marketed in Brazil: Interference-free GC-MS analysis and early-life dietary exposure assessment.

Exposure to pesticides is correlated with gut microbiota alterations in a farmland raptor.

Microplastics/Nanomaterials

Microplastic pollution found in insect casing from 1971.

Plastic pollution in shooting ranges and warfare areas – an overlooked environmental issue.

Textile Recycling’s Hidden Problem: Surface-Modified Fiber Fragments Emitted at Every Stage.

Miscellaneous

Analysis of 6PPD-Q in finfish, shellfish, and marine mammal tissues.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Industry-funded articles are included without notation. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. There are searchable archives. Compiled by Sarah Howard of Healthy Environment and Endocrine Disruptor Strategies (HEEDS), a program of Environmental Health Sciences.

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