EDC Science Weekly, Mar. 28 – Apr. 3, 2025

Post author:HEEDS
Post published:April 3, 2025
Post category:EDC Science Weekly

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Events, Regulations/Policy, Methods/Tools/Screening, Commentaries, Reviews/Meta-Analyses, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Highlights:

Science summaries and highlights

Events

Apr. 15 webinar: Children’s Health: Assessing impacts of the exposome [EDC Strategies Partnership]

Apr. 15-16: Iowa PFAS Conference, in person in Iowa City [Iowa College of Engineering]

Apr. 17 webinar: Scientific Principles to Protect Public Health [PRHE’s Science Action Network]

Apr. 24 webinar: Childhood cancer and the environment: Prevention opportunities [CHE-Alaska]

CANCELLED: Apr. 25: HEEDS EDC-North Carolina group 5th Annual Meeting [HEEDS]

Apr. 27-29 conference: Break the Cycle of Children’s Environmental Health Disparities

May 8 webinar: Changes at NIH: What do they mean for environmental health? [EDC Strategies Partnership]

May 10-13: EDC sessions at European endocrinology society meeting [European Society for Pediatric Endocrinology (ESPE) and the European Society of Endocrinology (ESE)]

May 14: Minimising the impact of endocrine disrupting chemicals on health and environment [a scientific update following the Joint Congress of ESPE and ESE, sponsored by ESE]

June 16-17 workshop: Roadmap to phase out animal testing for chemical safety assessments [The European Chemicals Agency (ECHA)]

July 30 – Aug. 1 conference: U.S. Developmental Origins of Health and Disease (DOHaD) Society Annual Meeting

More events

Regulations/Policy

Identifying potential chemicals of concern in children’s products in a regulatory context: a systematic evidence mapping approach.

More EDC policy, FPF’s regulations open for comment, Science’s Trump-Tracker, and links to preserved resources removed from U.S. federal websites

Methods/Tools/Screening

Three pillars for ensuring public access and integrity of chemical databases powering cheminformatics.

Nuclear hormone receptors control fundamental processes of human fetal neurodevelopment: Basis for endocrine disruption assessment.

Endocrine-Disrupting Effects of 24 Colorants Used in Food Contact Materials: in vitro and in silico Studies.

Toxic Alerts of Endocrine Disruption Revealed by Explainable Artificial Intelligence.

Advancing non-target analysis of emerging environmental contaminants with machine learning: Current status and future implications.

Endocrine-Disrupting Activities of Flavones on Steroid Receptors: Structural Requirements and Synthesis of Novel Flavone with Improved Estrogenic Activity.

Selection of the critical effect size alters hazard characterization – a retrospective analysis of key studies used for risk assessments of PFAS.

Commentaries

Editorial: Global excellence in toxicology: Asia, Australia and New Zealand. [intro to a research topic in Frontiers in Toxicology]

Editorial: Pre-natal and post-natal environmental impacts on metabolic control. [intro to a research topic in Frontiers in Endocrinology]

Heavy Metals and Inflammatory Bowel Disease.

Comment on “IARC Workshop on the Key Characteristics of Carcinogens: Assessment of End Points for Evaluating Mechanistic Evidence of Carcinogenic Hazards” and the response.

Reviews/Meta-Analyses

Numerous Chemicals/Mixtures

The Role of Endocrine Disruptors in Childhood Obesity – Unraveling the Obesogens.

Overview of the hazardous impacts of metabolism-disrupting chemicals on the progression of fatty liver diseases.

BPA/Phenols

The Ovary as a Target Organ for New Generation Bisphenols Toxicity.

Phthalates

Phthalates and Non-Phthalate Plasticizers and Thyroid Dysfunction: Current Evidence and Novel Strategies to Reduce Their Spread in Food Industry and Environment

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

PCDD/Fs in human tissues: A review of global biomonitoring data.

PFAS

The Association Between Per- and Polyfluoroalkyl Substances Exposure and Thyroid Hormones in Men and Non-Pregnant Women: A Systematic Review and Meta-Analysis

Per- and Poly-fluoroalkyl Substances (PFAS) (Chemicals and Contaminants). [risk assessment report by the Food Safety Commission of Japan]

Flame Retardants

Intersecting circular economy and child health: A scoping review of legacy brominated flame retardants in plastic childcare products and toys.

Pesticides

Serum Concentrations of Fipronil and Metabolites in Japanese Pregnant Women: Relationship with Thyroid Hormone Levels

Pesticide Exposure in Agricultural Workplaces and Resultant Health Effects in Women.

Metals/Metalloids

Effects of Environmental Non-Essential Toxic Heavy Metals on Epigenetics During Development

Public health concerns of multifaceted exposures to metal and metalloid mixtures: a systematic review.

Microplastics/Nanomaterials/Plastics

Micro-nanoplastic induced cardiovascular disease and dysfunction: a scoping review.

Mesoplastics: A Review of Contamination Status, Analytical Methods, Pollution Sources, Potential Risks, and Future Perspectives of an Emerging Global Environmental Pollutant

Biocatalytic recycling of plastics: facts and fiction.

Miscellaneous

Polycyclic Aromatic Hydrocarbons (PAHs) in the Environment: Occupational Exposure, Health Risks and Fertility Implications

Human Health Studies

Numerous Chemicals/Mixtures

Endocrine disrupting chemicals and persistent nausea among pregnant women enrolled in the Illinois Kids Development Study (I-KIDS).

Association between organic micropollutants in tap water and human exposure and birth outcomes: Implications for environmental health in northern Puerto Rico.

Gestational Exposure to Endocrine-Disrupting Chemicals of Emerging Concern and the Risk of Developing Gestational Diabetes Mellitus: A Comprehensive Investigation of Sex-Specific and Trimester-Specific Associations.

Interpretable machine learning-based insights into early-life endocrine disruptor exposure and small vulnerable newborns.

Endocrine disruptors as risk factors for idiopathic premature thelarche in girls: A case-control study.

BPA/Phenols

Maternal urinary concentrations of bisphenol A during pregnancy and birth size in children from the Odense Child Cohort.

Phthalates

Impact of prenatal phthalate exposure on newborn metabolome and infant neurodevelopment.

Infants’ Dermal Exposure to Phthalates from Disposable Baby Diapers and Its Association with DNA Oxidative Damage

Parabens/Triclosan/Antimicrobials

Urinary concentrations of early and mid-pregnancy parabens and gestational diabetes: A nested case-control study within the PETALS cohort.

Mediating effects of insulin resistance on lipid metabolism with elevated paraben exposure in the general Taiwan population.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Prenatal exposure to persistent organic pollutants and associations with child behavior problems at 1-5 years.

Association between Organochlorine Exposures and Lung Functions Modified by Thyroid Hormones and Mediated by Inflammatory Factors among Healthy Older Adults.

Breast adipose tissue level of organochlorine pesticides as a risk factor in breast cancer: A cross sectional study in North Indian females.

PFAS

Evaluating PFAS-Induced modulation of peripheral blood mononuclear cells (PBMCs) immune response to SARS-CoV-2 spike in COVID-19 Vaccinees.

Association of Per- and Polyfluoroalkyl Substance Exposure with Coronary Stenosis and Prognosis in Acute Coronary Syndrome.

Association Between Per- and Polyfluoroalkyl Substances and All-Cause Mortality in Diabetic Patients: Insights from a National Cohort Study and Toxicogenomic Analysis

Plasma perfluoroalkyl substances and breast cancer risk in Brazilian women: a case-control study.

Associations of exposure to individual polyfluoroalkyl substances and their mixtures with vitamin D biomarkers in postmenopausal women.

Assessing the impact of per- and polyfluoroalkyl substances on pregnancy loss: An environmental-wide association study in Northwest China.

Serum concentrations of per- and poly-fluoroalkyl substances (PFAS) in Danish pregnant women-temporal trends during pregnancy, correlations with partners, associations with physical activity, and blood lipid concentrations.

Pesticides

Pre- and Postnatal Exposures to Residential Pesticides and Survival of Childhood Acute Lymphoblastic Leukemia.

Serum testosterone partially mediates the adverse effects of organophosphate pesticides exposure on growth indicators of children and adolescents.

Environmental pesticide exposure and its association with hematological parameters and inflammation indices among school-aged children in Mexico.

The relationship between urinary glyphosate and all-cause and specific-cause mortality: a prospective study.

Association of glyphosate exposure with frailty and all-cause mortality in general adults: A population-based cohort study.

Associations between Pesticide Metabolites and Decreased Estimated Glomerular Filtration Rate Among Solar Greenhouse Workers: A Specialized Farmer Group.

Metals/Metalloids

Associations of Environmental Pollutant Mixtures and Red Blood Cell Folate Concentrations: A Mixture Analysis of the U.S. Adult Population Based on NHANES Data, 2007-2016

Evaluation of Heavy Metals and Essential Minerals in the Hair of Children with Autism Spectrum Disorder and Their Association with Symptom Severity.

Metallic trace elements in pancreatic tissue are associated with higher risk of pancreatic adenocarcinoma – METAPANDA study.

A prospective study of early pregnancy metal concentrations and gestational diabetes mellitus based on a birth cohort in Northwest China.

The association between low-concentration heavy metal exposure and chronic kidney disease risk through α-klotho.

Association of arsenic exposure with PDGF-BB in vitro and in a South Texas population exposed through drinking water.

Microplastics/Nanomaterials

Exposure to microplastics during pregnancy and fetal liver function.

The silent invasion of microplastics polyvinyl chloride and polyethylene terephthalate: Potential impact on osteoporosis.

Air Pollution

Maternal metabolomics linking prenatal exposure to fine particulate matter and birth weight: a cross-sectional analysis of the MADRES cohort.

Pharmaceuticals/Personal Care Products

Associations of personal care product use during pregnancy and the postpartum period with markers of postpartum glycemic control – Results from the ERGO Study.

Association of Personal Care and Consumer Product Chemicals with Long-Term Amenorrhea: Insights into Serum Globulin and STAT3.

Miscellaneous

Associations of Human Exposure to 6PPD and 6PPDQ with Colorectal Cancer: A Mixture Analysis.

Associations between urinary polycyclic aromatic hydrocarbon biomarker concentrations and birth outcomes in the LIFECODES cohort.

Laboratory Studies

Numerous Chemicals/Mixtures

In Vitro Hazard Characterization of Contaminants Migrating from Recycled Paper Food Contact Materials.

Modulation of immune gene expression profile in Labeo catla with chronic toxicity to emerging endocrine disruptors through a multiorgan approach.

BPA/Phenols

Effects and regulatory mechanisms of bisphenol a on the increases apoptosis and decreases differentiation potential in mouse embryonic stem cells.

Puerarin Attenuates the Cytotoxicity Effects of Bisphenol S in HT22 Cells by Regulating the BDNF/TrkB/CREB Signaling Pathway

Protective role of Cocos nucifera L. water on BPA-mediated oxidative stress and reproductive damage in male rats.

Apigenin Regulates Bisphenol-A Induced Polycystic Ovarian Syndrome (PCOS) Symptoms In-Vivo Zebrafish.

Mechanistic insights into the P-coumaric acid protection against bisphenol A-induced hepatotoxicity in in vivo and in silico models.

Chronic exposure to bisphenol S is associated with antagonistic neurobehavioral transformation and cleaved caspase 3 induced neurodegeneration in zebrafish brain.

Phthalates

Paternal DEHP Exposure Triggers Reproductive Toxicity in Offspring via Epigenetic Modification of H3K27me3

Dicyclohexyl Phthalate derails trophoblast function and lipid metabolism through NDRG1 by targeting PPARα: RXRα.

Parabens/Triclosan/Antimicrobials

Triclosan Caused Oocyte Meiotic Arrest by Modulating Oxidative Stress, Organelle Dysfunctions, Autophagy, and Apoptosis in Pigs.

Triclosan exposure induces liver fibrosis in mice: The heterogeneous nuclear ribonucleoprotein A1/pyruvate kinase M2 axis drives hepatic stellate cell activation.

Investigating methylparaben’s oxidative stress effects on rainbow trout blood, liver, and kidney toxicity.

PFAS

Impacts of Gestational F-53B Exposure on Fetal Neurodevelopment: Insights from Placental and Thyroid Hormone Disruption.

Effects of Perfluorooctane Sulfonic Acid Exposure on Intestinal Microbial Community, Lipid Metabolism, and Liver Lesions in Mice.

Developmental perfluorooctanesulfonic acid (PFOS) exposure impairs exocrine pancreas function in zebrafish (Danio rerio).

An Analytical Screening Platform to Differentiate Acute and Prolonged Exposures of PFAS on Invasive Cellular Phenotypes.

Dose-response modeling of effects in mice after exposure to a polyfluoroalkyl substance (Nafion byproduct 2).

Lipid metabolism-mediated fertility decline in male mice exposed to Fluorene-9-bisphenol: An integrated DNA methylation and transcriptomics analysis.

Comparison of Transcriptomic Points of Departure (tPOD) with Apical Endpoints in Developing Zebrafish Exposed to PFOS, PFOA, or PFHxS.

Flame Retardants

The effect of Polybrominated diphenyl ethers at the fetal blood-brain-barrier: evaluation using a microphysiological system.

Flame-retardant Tris(2-chloroethyl) phosphate: Assessing the effects on microalgae, mussel hemocytes and human peripheral blood cells.

Pesticides

Fipronil Triggers Immunotoxicity Through Reactive Oxygen Species-Driven Mitochondrial Apoptosis in Thymocytes.

Dose-Dependent Effects of Chlorpyrifos on Liver Injury, Intestinal Dysbiosis, and Metabolic Perturbations in C57BL/6J Mice.

Effects of Glyphosate on Zebrafish (Danio rerio) Developmental Toxicity.

Exposure of Parental Zebrafish to Difenoconazole throughout Their Life Cycle May Lead to Developmental Toxicity in the F1 Generation through Epigenetic Changes in Gametes, Impaired Nutrient Supply from the Ovum, and Maternal Transfer of Difenoconazole.

Metals/Metalloids

Detrimental effects of chronic arsenic exposure through daily diet on hepatic and renal health: An animal model study.

Microplastics/Nanomaterials

Exposure to Nanoplastics During Pregnancy Induces Brown Adipose Tissue Whitening in Male Offspring

Synergistic endocrine disruption and cellular toxicity of polyethylene microplastics and bisphenol A in MLTC-1 cells and zebrafish.

Polyethylene terephthalate microplastics affect gut microbiota distribution and intestinal damage in mice.

Toxicological assays and metabolomic profiling to evaluate the effects of virgin and aged micro- and nano- polystyrene plastics in SH-SY5Y human neuroblastoma cells.

Microplastics and nanoplastics co-exposure modulates chromium bioaccumulation and physiological responses in rats.

Engineered Probiotics Mitigate Gut Barrier Dysfunction Induced by Nanoplastics.

Subchronic Exposure to Polystyrene Nanoplastics Disrupts Placental Development and Calcium Homeostasis: Insights from In Vivo and In Vitro Models.

Exposure/Environment Studies

Numerous Chemicals/Mixtures

UPLC-QTOF Mass Spectrometry Detection of Four Endocrine Disrupting Chemicals (Methyl Paraben, 2,4-Dichlorophenoxyacetic acid, Monobutyl Phthalate, and Bisphenol A) in Urine of Filipino Women.

Development and validation of a survey on reproductive health behaviors to reduce exposure to endocrine-disrupting chemicals in Koreans.

Phthalates

Occurrence, Characteristics, and Mixed Reproductive Exposure Risk Assessment of Traditional Phthalates and Their Novel Alternatives in Campus Indoor Dust.

Parabens/Triclosan/Antimicrobials

The utility of silicone wristbands in characterizing exposure to parabens found in commercial lotions.

PFAS

Determinants of plasma poly- and perfluoroalkyl substances during pregnancy: The Japan Environment and Children’s Study.

Serum biomonitoring of per- and polyfluoroalkyl substances (PFASs) in the adult population of Switzerland: Results from the pilot phase of the Swiss health study.

Per- and Polyfluoroalkyl Ether Acid (PFEA) Concentrations in Indoor Dust are Higher in Homes Closer to a Fluorochemical Manufacturing Facility.

A re-assessment of archived (1989-2006) beluga liver from the North American Arctic with non-targeted analysis reveals brominated chemicals of emerging concern. [and PFAS]

Metals/Metalloids

Biomonitoring of Serum Inorganic Element Concentrations in Morbidly Obese Patients: Impact of Bariatric Surgery

Environmental pollution and health risks to informal workers: exposure to heavy metals in human hair at Indonesian landfills.

Microplastics/Nanomaterials

Microplastic release from coronary catheters: Insights from catheter analysis.

Inhalable microplastics and plastic additives in the indoor air of chemical laboratories.

Waste Dumps as Microplastic Hotspots: A Comparative Investigation at Urban, Suburban, and Rural Areas of Eastern India and Associated Risk Assessment.

Hormonal disruption from plastic ingestion in northern fulmars: activation and inhibition of estrogen receptors.

Long-term variations in size and polymer type of meso- and microplastics in seabirds and on beaches since the 1980s.

Half a century of caddisfly casings (Trichoptera) with microplastic from natural history collections.

Detection of microplastics in the feline placenta and fetus.

Pharmaceuticals/Personal Care Products

Occupational exposure to disinfectants and risk of incident cardiovascular disease among US nurses: the Nurses’ Health Study II.

——-

This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Industry-funded articles are included without notation. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. There are searchable archives. Compiled by Sarah Howard of Healthy Environment and Endocrine Disruptor Strategies (HEEDS), a program of Environmental Health Sciences.

If you enjoy this newsletter, please feel free to donate here! Thank you!

EHN EHN

POSTPONED: North Carolina EDC working group 5th annual meeting
by Sarah Howard on April 4, 2025 at 11:46 am
Previously scheduled for April 25, 2025, Healthy Environment and Endocrine Disruptor Strategies (HEEDS) has postponed its 5th Annual Meeting of EDC-NC, its North Carolina working group on endocrine disrupting chemicals (EDCs). More information. We hope to reschedule this fall.
Webinar: Changes at NIH: What do they mean for environmental health?
by Sarah Howard on April 3, 2025 at 3:34 pm
This May 8 webinar features Dr. Linda Birnbaum, who will discuss the implications of the Trump administration's changes for environmental health, and Dr. Scott Belcher who will discuss the effects on individual research efforts. Sponsored by the EDC Strategies Partnership.
Webinar: Children's health and the exposome
by Sarah Howard on March 12, 2025 at 7:02 pm
This April 15 webinar, Children's Health: Assessing impacts of the exposome, features Dr. Rémy Slama of the EU's ATHLETE research project. Dr. Slama will explore the environmental factors that are most likely to affect children’s health, and present approaches to rank the impact of these factors. The webinar is sponsored by the EDC Strategies Partnership.

EHN EHN

Gas stove emissions significantly increase cancer risks, especially in children
by Katherine McMahon,Sarah Howard on April 18, 2025 at 8:18 pm
In a recent study published in Journal of Hazardous Materials, researchers examined the impact of benzene exposure - a hazardous chemical emitted by natural gas and propane stoves - on cancer risk. “Our results should help facilitate prioritization of air toxins for potential environmental regulation and pollution control, and ultimately help to protect public health, especially for the people who are using gas stoves in their homes.”
Common pesticide harms fertility and reproduction in bees
by Katherine McMahon,Sarah Howard on April 16, 2025 at 5:59 pm
The pesticide sulfoxaflor - a common substitute for toxic neonicotinoid pesticides - harms bees’ reproductive health, according to a new study published in Chemosphere. “More accurate assessments of pesticide exposure, toxicity, and risks are urgent to fully grasp their potential harm, support science-based regulatory decisions, and finally minimize inadvertent negative effects on our ecosystems.”
Plastics may disrupt the body’s clock, raise risk of chronic disease, study finds
by Pamela Ferdinand on April 16, 2025 at 11:49 am
This article was originally published by U.S. Right To Know and is republished here with permission under a Creative Commons license. Chemicals found in common food packaging plastics like cling film and snack pouches may interfere with the body’s natural 24-hour sleep-wake cycle, increasing the risk of sleep disorders, diabetes, immune problems, and even cancer, new research shows.

EHN EHN

Iowa lawmakers reject bill shielding pesticide companies from cancer lawsuits
by EHN Curators on April 17, 2025 at 11:05 am
A bill that would have blocked lawsuits against pesticide companies over health warnings failed again in the Iowa legislature, despite a push from Bayer-backed lobbyists and support from Senate Republicans. Anika Jane Beamer reports for Inside Climate News.
Aggressive rollback of environmental rules raises legal and public health concerns
by EHN Curators on April 16, 2025 at 11:26 am
A sweeping new executive order from President Trump would force federal agencies to eliminate key environmental regulations unless they’re reapproved annually, a move legal scholars say is likely unlawful and could endanger public health. Kiley Bense reports for Inside Climate News.
EU moves to ban toxic ‘forever chemicals’ from children’s toys in online and in-store markets
by EHN Curators on April 14, 2025 at 10:47 am
A new European Union regulation bans PFAS and other hormone-disrupting chemicals in toys, aiming to curb health risks and tighten online toy safety. Richard Connor reports for Deutsche Welle.