EDC Science Weekly, Jan. 17-23, 2025

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Events, Methods/Tools/Screening, Commentaries, Reviews/Meta-Analyses, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Highlights: HBM4EU E-waste study: metabolic changes during E-waste recycling; drinking water disinfection by-products and cancer.

Science summaries and highlights

Events

Jan. 29 webinar: NAM-based strategies for systemic toxicity assessment [EPA, PETA, and EPIC]

Jan. 30 webinar: Product data for public health: Clearya case studies [CHE]

Jan. 30 and Feb. 13 webinars: EDC exposure and gonadal function: consequences and interventions [Endocrine Society EDC Special Interest Group]

Feb. 10-13: Childhood cancer prevention symposium, in person in Houston TX [CEHN and others]

Feb. 13-14 workshops: How to conduct systematic reviews and meta-analyses to improve environmental health policy and decision-making, free and in person at UCSF [UCSF EaRTH Center]

Feb. 19 webinar: Ultrashort-chain PFAS: The global threat of trifluoracetic acid [EDC Strategies Partnership]

Mar. 14-15: Lou Guillette Jr. Symposium, in person at the University of Florida in Gainesville [HEEDS]

Apr. 27-29, 2025 conference: Break the cycle of children’s environmental health disparities

More events, EDC policy, and regulations open for comment

Methods/Tools/Screening

Challenges and opportunities for validation of AI-based new approach methods.

Analytical Quality Evaluation of the Tox21 Compound Library.

Machine learning outperforms humans in microplastic characterization and reveals human labelling errors in FTIR data.

The long way from raw data to NAM-based information: Overview on data layers and processing steps.

AOPs to connect food additives’ effects on gut microbiota to health outcomes.

Effect-based analysis of endocrine effects in surface and ground water with focus on progestagenicity using Arxula yeast-based reporter gene assays.

High-throughput screening to identify endocrine disruptors: Contribution of low-resolution tandem MS and high-resolution MS.

Observational studies on per- and polyfluoroalkyl substance toxicity in marine species: hints for the extrapolation of a screening value.

Commentaries

Ending pollution and health harms from plastics.

Environmental Issues in Global Pediatric Health: Policy Statement and Environmental Issues in Global Pediatric Health: Technical Report.

Cancer incidence associated with PFAS contamination of drinking water in the USA. [News item in The Lancet Oncology]

Microplastics block blood flow in the brain, mice study reveals. [News item in Nature]

Reviews/Meta-Analyses

Numerous Chemicals/Mixtures

Nutritional Changes to Improve Female Fertility: Role of Obesity, Hormones, Dietary Patterns and Endocrine Disrupting Chemicals.

Pollution, stress response, and obesity: A systematic review.

How do lifestyle and environmental factors influence the sperm epigenome? Effects on sperm fertilising ability, embryo development, and offspring health.

The Role of Environmental Endocrine Disruptors on Leydig Cell Death and Senescence.

Phthalates

Association of diethylhexyl phthalate exposure with serum thyroid hormone levels: a systematic review and meta-analysis.

PFAS

Current understanding of human bioaccumulation patterns and health effects of exposure to perfluorooctane sulfonate (PFOS).

Metals/Metalloids

Exploring pathological targets and advancing pharmacotherapy in autism spectrum disorder: Contributions of glial cells and heavy metals.

The gut microbiota: A key player in cadmium toxicity – implications for disease, interventions, and combined toxicant exposures.

Microplastics/Nanomaterials

Impact of microplastics on female reproductive health: insights from animal and human experimental studies: a systematic review.

Microplastic Migration and Transformation Pathways and Exposure Health Risks.

The ant that may well destroy a whole dam: a systematic review of the health implication of nanoplastics/microplastics through gut microbiota.

A brief history of microplastics effect testing: Guidance and prospect.

Pharmaceuticals/Personal Care Products

Systematic Review of the Epidemiology of Hair Relaxer Use and Hormone-Sensitive Reproductive Outcomes Among Black Adult Women in the United States.

Plastics in dermatology: A review and solutions.

Miscellaneous

Exposure to Drinking Water Trihalomethanes and Risk of Cancer: A Systematic Review of the Epidemiologic Evidence and Dose-Response Meta-Analysis and related Invited Perspective: Drinking Water Disinfection By-Products and Cancer-A Historical Perspective.

Human Health Studies

Numerous Chemicals/Mixtures

HBM4EU E-waste study – An untargeted metabolomics approach to characterize metabolic changes during E-waste recycling.

Exposome-Wide Association Study of Thyroid Function Using U.S. National Health and Nutrition Examination Survey Data.

BPA/Phenols

Repeated measurements of urinary bisphenol A and its analogues in relation to sperm DNA damage.

Synergistic effect of synthetic phenolic antioxidant exposure and overweight/obesity on altered sex hormone levels: normoglycemic rural Chinese population.

Phthalates

Effect of Fasting Status on Association between Exposure to Phthalate and Phenolics, and Thyroid Hormones in Adult Women of Reproductive Age.

Flame Retardants

Associations of prenatal organophosphate esters exposure with risk of eczema in early childhood, mediating role of gut microbiota.

Pesticides

Preconception and first trimester exposure to pesticides and associations with stillbirth.

Association between exposure to pyrethroids and chlorpyrifos at age 5 years and IQ at age 7 years among children from the Odense Child Cohort, a prospective birth cohort study.

Association of Organophosphorus Pesticide and Glyphosate Exposure with Nasal Flora and Total IgE in Solar Greenhouse Workers: A Unique Farmer Group.

Metals/Metalloids

Combined effects of global DNA methylation, blood lead and total urinary arsenic levels on developmental delay in preschool children.

Metal mixtures and adiposity indicators in women from Northern Mexico.

The correlation between heavy metal ions in blood and metabolic dysfunction-associated steatotic liver disease from 1999 to 2018 based on NHANES data.

Cadmium levels in maternal blood, placenta, and cord blood in relation to preeclampsia and fetal growth: a case-control study in China.

Air Pollution

Gestational exposure to PM_2.5, NO₂, and sex steroid hormones: Identifying critical windows of exposure in the Rochester UPSIDE Cohort.

Laboratory Studies

Numerous Chemicals/Mixtures

Prenatal bisphenol A and/or diethylhexyl phthalate exposure followed by adult estradiol treatment affects behavior and brain monoamines in female rat offspring.

BPA/Bisphenols

Sex-specific effects of prenatal bisphenol A exposure on transcriptome-interactome profiles of autism candidate genes in neural stem cells from offspring hippocampus.

Taurine protection attenuates bisphenol-A-induced behavioral, neurochemical, and histopathological alterations in male rats.

Perinatal exposure to bisphenol A or S alters differently sexual behavior and kisspeptin system in mice.

The obesogenic effects of Bisphenol A and its analogues are differentially regulated via PPARγ transactivation in mouse 3T3-L1 cells.

Nonylphenol

Nonylphenol promotes epithelial-mesenchymal transition in colorectal cancer cells by upregulating miR-151a-3p.

Nonylphenol exposure increases the risk of Hirschsprung’s disease by inducing macrophage M1 polarization.

Maternal exposure to chronic, low-dose nonylphenol in zebrafish: Disruption of ovarian health, reproductive function, and embryogenesis.

Phthalates

Discovery of phloridzin as a new antagonist for Di(2-ethylhexyl) phthalate-induced male reproductive toxicity based on the adverse outcome pathway network and drug-target gene set enrichment analysis.

Investigating the link between microplastic exposure (benzyl butyl phthalate) and neurodegenerative diseases using high-performance computational toxicology.

Impact of 17-alpha ethinyl estradiol (EE2) and diethyl phthalate (DEP) exposure on microRNAs expression and their target genes in differentiated SH-SY5Y cells.

Phthalate exposure induces microRNA-5010/Nrf2-EGR1/GDF15 signaling expression in prostate cancer.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Multi-omics analysis reveals toxicity and gut-liver axis disruption induced by polychlorinated biphenyls exposure in Yellowfin Seabream (Acanthopagrus latus).

PFAS

Perfluorohexane Sulfonic Acid Disrupts the Immune Microenvironment for Spermatogenesis by Damaging the Structure of the Blood-Testis Barrier in Mice.

Bone cell differentiation and mineralization in wild-type and osteogenesis imperfecta zebrafish are compromised by per- and poly-fluoroalkyl substances (PFAS).

Research on the PFAS release and migration behavior of multi-layer outdoor jacket fabrics.

Perfluorooctane sulfonate attenuates IgE/Ag-stimulated mast cell activation and anaphylactic responses via activating SHP-1 pathway.

Toxicological effects of the environmental pollutant perfluoronanoic acid on the ground-dwelling arthropod Solenopsis invicta.

Flame Retardants

Environmentally relevant concentrations of DBDPE (decabromodiphenyl ethane) induce intestinal toxicity in silkworms (Bombyx mori L.).

Analysis of potential human accumulation differences and mechanisms of environmental new flame retardants: Based on in vitro experiments and theoretical calculations.

Pesticides

Maternal exposure to deltamethrin during pregnancy and lactation impairs hippocampal learning and memory function of male offspring by ferroptosis.

Effects of cypermethrin exposure on learning and memory functions and anxiety-like behavior in rats.

Metals/Metalloids

Effects of cadmium on female Drosophila melanogaster and its transgenerational inheritance effects.

Arsenic-Induced Inflammatory Response via ROS-Dependent Activation of ERK/NF-kB Signaling Pathways: Protective Role of Natural Polyphenol Tannic Acid.

Microplastics/Nanomaterials

Exposure to nano-polystyrene during pregnancy leads to Alzheimer’s disease-related pathological changes in adult offspring.

Cardiotoxicity of polystyrene nanoplastics and associated mechanism of myocardial cell injury in mice.

Mechanisms Underlying the Size-Dependent Neurotoxicity of Polystyrene Nanoplastics in Zebrafish.

Can biodegradable plastics mitigate plastamination? Feedbacks from marine organisms.

Polystyrene microplastics induce liver fibrosis and lipid deposition in mice through three hub genes revealed by the RNA-seq.

Assessing the impact of sub-chronic polyethylene terephthalate nanoplastic exposure on male reproductive health in mice.

Microplastics in the bloodstream can induce cerebral thrombosis by causing cell obstruction and lead to neurobehavioral abnormalities.

Pharmaceuticals/Personal Care Products

Gabapentin impairs visual development in zebrafish via retinal apoptosis and thyroid disruption.

Tire Wear Particles

Tire rubber-derived contaminants 6PPD and 6PPD-quinone reduce attachment and outgrowth of trophoblast spheroids onto endometrial epithelial cells.

Bioactivity of the ubiquitous tire preservative 6PPD and degradant, 6PPD-quinone in fish and mammalian-based assays.

Size-dependent ecotoxicological impacts of tire wear particles on zebrafish physiology and gut microbiota: Implications for aquatic ecosystem health.

Miscellaneous

Sustainable, biodegradable, and recyclable bioplastics derived from renewable carboxymethyl cellulose and waste walnut shell.

Exposure/Environment Studies

Numerous Chemicals/Mixtures

Contamination levels and distribution of persistent and non-persistent pollutants in paired hair, urine and serum samples from a Belgian non-occupationally exposed population.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Persistent pollutant exposure impacts metabolomic profiles in polar bears and ringed seals from the High Arctic and Hudson Bay, Canada.

PFAS

PFAS concentrations in the blood of Danish surfers.

Comprehensive Screening of per- and Polyfluoroalkyl Substances (PFAS) in Food Contact Materials: Utilizing Combustion Ion Chromatography for Total Organic Fluorine (TOF) Analysis.

Occurrence levels of perfluoroalkyl carboxylic acids (PFCA) and perfluoroalkyl sulfonic acids (PFSA) in European perch (Perca fluviatilis) samples collected from inland waters in Latvia: component profiles, spatial distribution and dietary exposure to consumers.

Unveiling the emerging concern of per- and polyfluoroalkyl substances (PFAS) and their potential impacts on estuarine ecosystems.

Flame Retardants

Integrated risk assessment of dietary exposure and body burden of three brominated flame retardants in childbearing-aged Chinese women and breastfeeding infants.

Microplastics/Nanomaterials

Assessing microplastic and nanoplastic contamination in bird lungs: evidence of ecological risks and bioindicator potential.

Toxic tuna tales: Tracing microplastic pathways in mackerel tuna (Euthynnus affinis), longtail tuna (Thunnus tonggol), and bullet tuna (Auxis rochei).

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Industry-funded articles are included without notation. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. There are searchable archives. Compiled by Sarah Howard of Healthy Environment and Endocrine Disruptor Strategies (HEEDS), a program of Environmental Health Sciences.

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