EDC Science Weekly, Dec. 20, 2024 – Jan. 2, 2025

Post author:HEEDS
Post published:January 2, 2025
Post category:EDC Science Weekly

Happy New Year!

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed over the past two weeks.

Contents: Events, Regulations/Policy, Methods/Tools/Screening, Commentaries, Reviews/Meta-Analyses, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Highlights:

Studies link autism to prenatal PFAS and PCBs
microplastics and the gut microbiome
contaminants in private, public, and bottled drinking water
anxiety from two hits of EDCs three generations apart in female and male rats

Science summaries and highlights

Events

Jan. 15 symposium: Strategies for Change: Turning Your Science into Action [PRHE’s Science Action Network]

Jan. 22 webinar: Gamechanger: California sues ExxonMobil over plastic recycling lies [Beyond Plastics]

Jan. 30 and Feb. 13 webinars: EDC exposure and gonadal function: consequences and interventions [Endocrine Society EDC Special Interest Group]

Mar. 14-15: Lou Guillette Jr. Symposium, in person at the University of Florida in Gainesville [HEEDS]

Apr. 27-29, 2025 conference: Break the Cycle of Children’s Environmental Health Disparities

May 21 – June 4, 2025 course: Endocrine-Disrupting Chemicals: Hazards and Opportunities (ECHO) [applications due Jan 10, financial aid is available]

More events

Regulations/Policy

The European legislation on the restriction on intentionally added microplastics. Commentary.

Regulatory preparedness for multicomponent nanomaterials: Current state, gaps and challenges of REACH.

More EDC policy and regulations open for comment

Methods/Tools/Screening

Endocrine disruptor identification and multitoxicity level assessment of organic chemicals: An example of multiple machine learning models.

Pooling Biospecimens for Efficient Exposure Assessment When Using Case-Cohort Analysis in Cohort Studies.

Advancements in the Developmental Zebrafish Model for Predictive Human Toxicology

NeuTox 2.0: A hybrid deep learning architecture for screening potential neurotoxicity of chemicals based on multimodal feature fusion.

QSAR Classification Modeling Using Machine Learning with a Consensus-Based Approach for Multivariate Chemical Hazard End Points.

Commentaries

The Key Characteristics Concept

Editorial: Endocrine disruptors in gut endocrinology. [intro to a research topic in Frontiers in Endocrinology]

Toxic Cargo: How Rail Transport of Vinyl Chloride Puts Millions at Risk, an Analysis One Year After the Ohio Train Derailment.

ACMT Position Statement: No Evidence that Tampons Cause Metal Poisoning.

Reviews/Meta-Analyses

Numerous Chemicals/Mixtures

Exploring the Human Health Impact of Artificial Turf Worldwide: A Systematic Review.

Adipose tissue as target of environmental toxicants: focus on mitochondrial dysfunction and oxidative inflammation in metabolic dysfunction-associated steatotic liver disease.

A systematic review of evidence that environmental contaminant exposure impedes weight loss and glycemic control during calorie-restricted diets in humans.

Intercontinental insights into autism spectrum disorder: a synthesis of environmental influences and DNA methylation.

Role of the Endocannabinoid System in Gonadal Development: Implications for Endocrine Disruption and Reproductive Toxicity.

The Relationship Between Maternal Exposure to Endocrine-Disrupting Chemicals and the Incidence of Congenital Heart Diseases: A Systematic Review and Meta-Analysis.

Impact of Endocrine Disruptors on the Genitourinary Tract.

Endocrine disruptor chemicals exposure and female fertility declining: from pathophysiology to epigenetic risks.

BPA/Phenols

Damage mechanisms of bisphenols on the quality of mammalian oocytes.

Bisphenol A and its potential mechanism of action for reproductive toxicity.

Phthalates

Prenatal Exposure to Dibutyl Phthalate and Its Negative Health Effects on Offspring: In Vivo and Epidemiological Studies.

The impact of exposure to phthalates in thyroid function of children and adolescents: a systematic review.

The potential mechanisms underlying phthalate-induced hypospadias: a systematic review of rodent model studies.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

The impact of persistent organic pollutants on fertility: exposure to the environmental toxicant 2,3,7,8-tetrachlorodibenzo-p-dioxin alters reproductive tract immune responses.

PFAS

Per- And Poly-Fluoroalkyl Substances (PFAS) Exposure and Risk of Breast, and Female Genital Cancers: A Systematic Review and Meta-Analysis.

Flame Retardants

Molecular Mechanism of Indoor Exposure to Airborne Halogenated Flame Retardants TCIPP (Tris(1,3-Dichloro-2-Propyl) Phosphate) and TCEP Tris(2-chloroethyl) Phosphate and Their Hazardous Effects on Biological Systems.

Pesticides

Exploring the endocrine-disrupting potential of atrazine for male reproduction: A systematic review and meta-analysis.

Pesticides and human health.

A systematic review of pesticide exposure, associated risks, and long-term human health impacts.

What immunology has to say about pesticide safety.

Sudden deaths in infancy and pesticide exposure: a systematic review.

Metals/Metalloids

Which prenatal biomarker is most appropriate for methylmercury dose-response for neurodevelopmental effects?

A Comprehensive Review of Arsenic-Induced Neurotoxicity: Exploring the Role of Glial Cell Pathways and Mechanisms.

Silent threats of lead-based paints in toys and households to children’s health and development.

Microplastics/Nanomaterials

Biotransport and toxic effects of micro- and nanoplastics in fish model and their potential risk to humans: A review.

From food-to-human microplastics and nanoplastics exposure and health effects: a review on food, animal and human monitoring data.

Exploring micro(nano)plastics toxicity from an environmental management perspective: Zebrafish as a vital bridge for assessing potential human health risks.

Miscellaneous

Chronic Kidney Disease of Unknown Etiology: A Global Health Threat in Rural Agricultural Communities-Prevalence, Suspected Causes, Mechanisms, and Prevention Strategies.

Human Health Studies

Numerous Chemicals/Mixtures

Comprehensive analysis of transplacental transfer of environmental pollutants detected in paired maternal and cord serums.

Prenatal exposure to endocrine disrupting chemicals and the association with behavioural difficulties in 7-year-old children in the SELMA study.

Exposure to Multiple Endocrine-Disrupting Chemicals and Associations with Female Infertility: A Case-Control Study.

Typical endocrine disrupting chemicals in newborns with congenital hypothyroidism: Concentrations, exposure assessment, and potential risks.

Prenatal exposure to a mixture of organophosphate ester and organophosphorus pesticides in relation to child neurodevelopment in the Shanghai Birth Cohort.

Joint association of polycyclic aromatic hydrocarbon and heavy metal exposures with sex steroid hormones in children and adolescents aged 6-19 years in NHANES 2013-2016.

BPA/Phthalates

Engraftment After Pediatric Hematopoietic Stem Cell Transplantation and Its Association with Recipient and Donor Phthalate and Bisphenol A Exposure Levels: A Cohort Study.

Associations between phthalate metabolites and body composition in children aged 8-19 years.

Association between prenatal exposure to phthalate esters and blood pressure in children aged 3-7 years: A prospective cohort study.

Endocrine disruptors and bladder function: the role of phthalates in overactive bladder.

Inflammation mediates the adverse effects of urinary phthalate exposure on metabolic disease risk: Results from NHANES 2005-2016.

Diisooctyl phthalate (DIOP) exposure leads to cell apoptosis to HUVEC cells and toxicity to Caenorhabditis elegans through increasing the oxidative stress.

Exploring the application of machine learning to identify the correlations between phthalate esters and disease: enhancing nursing assessments.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Persistent organic pollutants and endogenous sex-related hormones in Hispanic/Latino adults: The Hispanic Community Health Study/Study of Latinos (HCHS/SOL).

Risk of autism spectrum disorder at 18 months of age is associated with prenatal level of polychlorinated biphenyls exposure in a Japanese birth cohort.

Chlorinated paraffins in particulate matter associated with asthma and its relative symptoms in school-aged children and adolescents: A cross-sectional survey in South China.

Influence of prenatal hexachlorobenzene, PCB and selenium levels on growth trajectories in the first year of life: Findings from the NEHO birth cohort.

Pesticide exposure promotes disease activity by decreasing lymphoproliferative activity and increasing IL-4 production in systemic sclerosis patients.

PFAS

Associations of Cord Blood Concentrations of Perfluoroalkyl Substances with Autistic Traits in Singaporean Children: The Growing Up in Singapore Towards Healthy Outcomes Study.

Associations of early life per- and polyfluoroalkyl substances (PFAS) exposure with body mass index and risk of overweight or obesity at age 2-18 years: Mixture analysis in the prospective Boston Birth Cohort.

Effects of mixed exposure to PFAS on adolescent non-alcoholic fatty liver disease: Integrating evidence from human cohorts, toxicogenomics, and animal models to uncover mechanisms and potential target sites.

Perfluoroalkyl Substances (PFAS) Exposure and Preeclampsia Risk: Impaired Angiogenesis Through Suppression of VEGF Signaling.

Association between exposure to perfluoroalkyl and polyfluoroalkyl substances with estimated glomerular filtration rate: Mediating role of serum albumin.

Flame Retardants

Associations of gestational exposure to organophosphate esters with thyroid hormones in cord plasma and the safety threshold of exposure in pregnant women.

Individual and joint effects of exposure to multiple organophosphate esters and the risk of depression in adults: Differences in sex, age, and physical activity.

Pesticides

Exploring the Link: DNA Methylation and Kidney Injury Markers in Farmers Exposed to Glyphosate-Surfactant Herbicides.

Maternal pesticide exposure and risk of birth defects: a population-based cross-sectional study in China.

Associations of pesticide residue exposure from fruit and vegetable intake with ovarian reserve.

Metals/Metalloids

Prenatal Metals and Offspring Cognitive Development: Insights from a Large-Scale Placental Bioassay Study.

Effect of Arsenic Exposure on AS3MT Protein Levels in Serum of Type 2 Diabetic Patients Compared to Non-diabetics.

Urinary arsenic and depressive symptoms among adults: A moderated mediation analysis of folate and dietary inflammation index.

Dietary fiber intake moderates the impact of blood cadmium on depression: a nationally representative cross-sectional study.

Association between chronic ambient heavy metal exposure and mental health in Korean adult patients with asthma and the general population.

The interplay of gut microbiota and heavy metals in Multiple Sclerosis patients.

Biochemical study of the risk of diabetes, prediabetic and insulin resistance in car painters and its association with mercury exposure: a retrospective case-control study.

Microplastics/Nanomaterials

Association between microplastics and the functionalities of human gut microbiome.

Air Pollution

Air pollution exposure is associated with gene expression in children.

Longitudinal associations between air pollution and incident dementia as mediated by MRI-measured brain volumes in the UK Biobank.

Miscellaneous

Associations of prenatal urinary melamine, melamine analogues, and aromatic amines with gestational duration and fetal growth in the ECHO Cohort.

Laboratory Studies

Numerous Chemicals/Mixtures

Bioactivity Profiling of Chemical Mixtures for Hazard Characterization.

Estrogenic-like compounds severely disturb germ cell formation in Japanese quail.

BPA/Phenols

Comprehensive assessment of the safety of bisphenol A and its analogs based on multi-toxicity tests in vitro.

A comprehensive atlas of multi-tissue metabolome and microbiome shifts: Exploring obesity and insulin resistance induced by perinatal bisphenol S exposure in high-fat diet-fed offspring.

Bisphenol S impairs oocyte quality by inducing gut microbiota dysbiosis.

Integrated Metagenomic and Metabolomic Analysis of In Vitro Murine Gut Microbial Cultures upon Bisphenol S Exposure.

Effect of Bisphenol F on Reproductive Function in F1 Generation Male Mice and its Potential Mechanisms.

Exposure to Bisphenol A jeopardizes decidualization and consequently triggers preeclampsia by up-regulating CYP1B1.

Bisphenol A induces sex-dependent alterations in the neuroendocrine response of Djungarian hamsters to photoperiod.

Short-Term Exposure of Bisphenol A Deteriorates the Quality of Rabbit Milk by Impairing Milk Fat Synthesis.

Toxicological investigation of bisphenol A and its derivates on human breast epithelial (MCF-10A) cells.

Bisphenol S exposure interrupted human embryonic stem cell derived cardiomyocytes differentiation through ER-NF-κB/ERK signaling pathway.

Bisphenol A exposure during gestation and lactation in mice: sex-specific consequences on oligodendrocytes and myelination.

Cleome arabica L mitigates bisphenol A-induced ovarian dysfunction and inflammation in Wistar rats: biochemical, histopathological, pharmacokinetic, and in silico studies.

Ameliorative effects of Ganoderma lucidum (Reishi) on testicular tissue of rats exposed to bisphenol A.

Phthalates

Tetrahydrocurcumin alleviates di-(2-ethylhexyl) phthalate-induced adipose tissue dysfunction and testicular toxicity in adult mice: possible involvement of adiponectin-adipoR signaling in the testis.

A pathway-based genetic score for inflammation: An indicator of vulnerability to phthalate-induced adverse neurodevelopment outcomes.

Parabens/Triclosan/Antimicrobials

Endocrine-disrupting chemical, methylparaben, in environmentally relevant exposure promotes hazardous effects on the hypothalamus-pituitary-thyroid axis.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Two Hits of EDCs Three Generations Apart: Evaluating Multigenerational Anxiety-Like Behavioral Phenotypes in Female Rats Exposed to Aroclor 1221 and Vinclozolin.

Two Hits of EDCs Three Generations Apart: Evaluating Multigenerational Anxiety-Like Behavioral Phenotypes in Male Rats Exposed to Aroclor 1221 and Vinclozolin.

Exposure to oxygenated polycyclic aromatic hydrocarbons and endocrine dysfunction: Multi-level study based on hormone receptor responses.

Effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on the immune system maternal-fetal interface during palatal development.

PFAS

Expanding PFAS Identification with Transformation Product Libraries: Nontargeted Analysis Reveals Biotransformation Products in Mice.

Nanomolar PFOA Concentrations Affect Lipid Membrane Structure: Consequences for Bioconcentration Mechanisms.

Perfluorobutanoic acid: A short-chain perfluoroalkyl substance exhibiting estrogenic effects through the estrogen-related receptor γ pathways.

Time-Course Strategy Reveals a Dual Potential of Perfluorooctanoic Acid and Its Alternative in Adipocyte Differentiation.

Comparison of the combined toxicity of PFOA and emerging alternatives: A comprehensive evaluation of oxidative damage, apoptosis and immunotoxicity in embryonic and adult zebrafish.

Lower toxicity of HFPO-DA compared to its predecessor PFOA to the earthworm Eisenia fetida: Evidence from oxidative stress and transcriptomic analysis.

PFOA substitute GenX at a sub-cytotoxic level exhibits thyroid-disrupting effects by inhibiting the expression of Thyroid Transcription Factor 1.

Perfluorodecanoic acid (PFDA) increases oxidative stress through inhibition of mitochondrial β-oxidation.

Flame Retardants

Rap1 and mTOR signaling pathways drive opposing immunotoxic effects of structurally similar aryl-OPFRs, TPHP and TOCP.

A Novel Organophosphate Ester, Tris(2,4-ditert-butylphenyl) Phosphate, Induced Reproductive Toxicity in Male Zebrafish at Environmentally Relevant Concentrations.

Integration of network toxicology and transcriptomics reveals the novel neurotoxic mechanisms of 2, 2′, 4, 4′-tetrabromodiphenyl ether.

Organotins

HMG-CoA reductase inhibitor simvastatin ameliorates trimethyltin neurotoxicity and cognitive impairment through reversal of Alzheimer’s-associated markers.

Pesticides

Environmental exposure to common pesticide induces synaptic deficit and social memory impairment driven by neurodevelopmental vulnerability of hippocampal parvalbumin interneurons.

Maternal neonicotinoid pesticide exposure impairs glucose metabolism by deteriorating brown fat thermogenesis.

Morphological and cellular effects in Boana faber tadpoles (Anura: Hylidae) exposed to atrazine-based herbicide and glyphosate-based herbicide and their mixtures.

Chlorpyrifos Influences Tadpole Development by Disrupting Thyroid Hormone Signaling Pathways.

Involvement of gut microbiota in chlorpyrifos-induced subchronic toxicity in mice.

Insights into organophosphorus insecticide malathion induced reproductive toxicity and intergenerational effect in zebrafish (Danio rerio).

Embryonic exposure to acetamiprid insecticide induces CD68-positive microglia and Purkinje cell arrangement abnormalities in the cerebellum of neonatal rats.

The fungicide propiconazole induces hepatic steatosis and activates PXR in a mouse model of diet-induced obesity.

Tetrachlorantraniliprole induces neurodevelopmental toxicity through oxidative stress-mediated apoptosis and dysregulation of Wnt signaling pathway.

Novel neonicotinoid insecticide cycloxaprid exhibits sublethal toxicity to honeybee (Apis mellifera L.) workers by disturbing olfactory sensitivity and energy metabolism.

Metals/Metalloids

Employment of a Newly Defined In Vitro Fertilization Protocol to Determine the Cytoskeletal Machinery, DNA Damage, and Subsequent DNA Repair Resulting from Endocrine Disruption by Hexavalent Chromium in Rat Metaphase II Oocytes.

Microplastics/Nanomaterials

Environmental release behavior, cell toxicity and intracellular distribution of novel biodegradable plastic materials.

A digestive system microphysiological platform for assessment of internal-exposure risks and metabolic disease mechanisms induced by multi-size nano-plastics.

Hepatotoxicity, developmental toxicity, and neurotoxicity risks associated with co-exposure of zebrafish to fluoroquinolone antibiotics and tire microplastics: An in silico study.

Polystyrene microplastics induce depression-like behavior in zebrafish via neuroinflammation and circadian rhythm disruption.

Microplastics Aggravate the Adverse Effects of Methylmercury than Inorganic Mercury on Zebrafish (Danio rerio).

Microbial diversity and metabolomics analysis of colon contents exposed to cadmium and polystyrene microplastics.

The released micro/nano-plastics from plastic containers amplified the toxic response of disinfection by-products in human cells.

The underestimated environmental risk of tris (2-chloroethyl) phosphate photodegradation in aqueous environment induced by polystyrene microplastics.

Nano-sized polystyrene plastics toxicity: Necroptosis pathway caused by autophagy blockade and lysosomal dysfunction.

Pharmaceuticals/Personal Care Products

Prenatal exposure to diethylstilbestrol has multigenerational effects on folliculogenesis.

Miscellaneous

Crude Oil-Induced Reproductive Disorders in Male Goldfish: Testicular Histopathology, Sex Steroid Hormones, and Sperm Swimming Kinematics.

Multigenerational toxic effects in Daphnia pulex are induced by environmental concentrations of tire wear particle leachate.

Exposure/Environment Studies

Numerous Chemicals/Mixtures

The characteristics of phthalate acid esters and bisphenol A in PM_2.5 of a petrochemical city: Concentrations, compositions, and health risk assessment in Dongying.

Private, public, and bottled drinking water: Shared contaminant-mixture exposures and effects challenge.

Phthalates

Risk assessment of food contact materials. [DEHP]

Parabens/Triclosan/Antimicrobials

Triclosan in the urine of Chinese youth: concentration, temporal variability, sources of exposure and predictive ability.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Human exposure to polychlorinated alkanes (C_8-36) in soil and dust from Nigerian e-waste sites: Occurrence, homologue pattern and health risk assessment.

Evaluation of the Body Burden of Short- and Medium-Chain Chlorinated Paraffins in the Blood Serum of Residents of the Czech Republic.

Association of Hepatic Gene Expression with Chemical Concentrations in Wild-Collected Double-Crested Cormorant Embryos using an EcoToxChip Gene Array.

Persistent organic pollutants and fatty acids in humpback whales: Antarctic and Chilean feeding and Brazilian breeding sites.

PFAS

An extended PFAS profiling of a Swedish subpopulation and mixture risk assessments using multiple approaches.

Evalu ating Dermal Absorption of Perfluorooctanoic Acid (PFOA) and Implications for Other Per- and Polyfluoroalkyl Substances (PFAS).

Evaluation of the validity of a perfluorooctane sulfonic acid exposure reconstruction using a measured serum concentration among workers with a wide range of exposure.

Cleaner cuts: Farmed fish and skin-off fillets are lower in per- and polyfluoroalkyl substances (PFAS).

PFAS in agroecosystems: Sources, impacts, and opportunities for mitigating risks to human and ecosystem health.

Modelling PFAS Transport in Lake Ekoln: Implications for Drinking Water Safety in the Stockholm Region.

Evaluation of the exposure to perfluorooctane sulfonic acid (PFOS) and perfluorooctanoic acid (PFOA) through drinking water and human risk assessment.

Occurrence, bioaccumulation and trophodynamics of per- and polyfluoroalkyl substances (PFAS) in terrestrial and marine ecosystems of Svalbard, Arctic.

Per- and polyfluoroalkylated substances (PFAS) in the feathers and excreta of Gentoo penguins (Pygoscelis papua) from the Antarctic Peninsula.

Interpretable machine learning models reveal the partnership of microplastics and perfluoroalkyl substances in sediments at a century scale.

Flame Retardants

Declining trends and regional variations of organophosphate ester contamination in indoor dust from mainland China: Insights from a filed study and meta-analysis.

Novel Flame Retardants (NFRs) in E-waste: Environmental burdens, health implications, and recommendations for safety assessment and sustainable management.

Besides Traditional Organophosphate Esters: The Ecological Risks of Emerging Organophosphate Esters in the Yangtze River Basin Cannot Be Ignored.

Pesticides

Automatic magnetic solid phase extraction for rapid and high-throughput determination of neonicotinoid insecticides and their metabolites in serum, breast milk and urine samples.

QuEChERS methodology and Gas Chromatography-mass spectrometry for detection of 345 pesticide residues in Egyptian poultry feed: a comprehensive study.

Metals/Metalloids

The Effect of Physical Activity on Combined Cadmium, Lead, and Mercury Exposure.

Microplastics/Nanomaterials

Look before you leap: Are increased recycling efforts accelerating microplastic pollution?

The first report on emerged microplastics in deep-sea sediment: Insights from the Central Indian Ocean Basin.

Prevalence and characteristics of microplastic contamination in soft drinks and potential consumer exposure.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Industry-funded articles are included without notation. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. There are searchable archives. Compiled by Sarah Howard of Healthy Environment and Endocrine Disruptor Strategies (HEEDS), a program of Environmental Health Sciences.

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EHN EHN

Webinar: Ultrashort-chain PFAS: the global threat of trifluoroacetic acid
by Sarah Howard on January 16, 2025 at 3:35 pm
This Feb. 19, 2025 webinar features Dr. Hans Peter Arp discussing TFA, a degradation product of many refrigerants and a widespread contaminant in the environment. Shorter-chain PFAS have been assumed to be less hazardous than longer-chain PFAS, but widespread exposures have not been taken into account in making this assessment. Sponsored by the EDC Strategies Partnership.
Webinar: PFAS and cancer
by Sarah Howard on January 13, 2025 at 4:53 pm
This Jan. 23, 2025 webinar is sponsored by the Health and Environment Alliance and Association of European Cancer Leagues. It will explore links between PFAS and cancer in the context of the International Agency for Research on Cancer (IARC) evaluation and relevant epidemiological data, and features Dr. Tony Fletcher, an environmental epidemiologist and Associate Professor at the London School of Hygiene & Tropical Medicine.
Webinar: Product data for public health: Clearya case studies
by Sarah Howard on January 13, 2025 at 2:55 pm
A variety of tools have been created for collecting consumer product data and making it available for research. This Jan. 30, 2025 webinar will explore one such product. Sponsored by the Collaborative for Health and Environment (CHE).

EHN EHN

Wastewater treatment plants fail to remove most toxic PFAS from drinking water sources
by Katherine McMahon,Sarah Howard on January 17, 2025 at 5:14 pm
Wastewater treatment facilities with technology similar to the plants that serve 70% of the US population are ill-equipped to address contamination from organofluorine chemicals, a class of chemicals that include toxic PFAS, according to recent findings published in the Proceedings of the National Academy of Sciences. “The US Food and Drug Administration’s drug approval process does not consider the environmental persistence and secondary human and ecological exposures to pharmaceuticals….The potential public health consequences of ubiquitous low-level exposures to these compounds require urgent consideration.”
Exposure to common household chemicals linked to bladder cancer in dogs
by Katherine McMahon,Sarah Howard on January 16, 2025 at 6:53 pm
In a recent study published in Environmental Science & Technology, researchers compared levels of chemical exposures between healthy dogs and dogs displaying early signs of bladder cancer. “Our household pets share our daily domestic environment and thus offer opportunities for consideration as sentinel species for exposure related concerns.”
Exposure to BPA during pregnancy disrupts uterine development, increasing preeclampsia risk
by EHN Curators on January 16, 2025 at 5:03 pm
Recent research using mouse models shows that bisphenol A (BPA), a common chemical in plastics, impairs uterine development during pregnancy and increases the risk of preeclampsia, a life-threatening condition. Pamela Ferdinand reports for U.S. Right To Know.

EHN EHN

EU facing pressure over PFAS ban as chemical industry ramps up lobbying
by EHN Curators on January 16, 2025 at 12:37 pm
A cross-European investigation has revealed how the chemical industry is intensifying efforts to influence the EU’s proposed ban on PFAS chemicals, raising concerns about regulatory delays and environmental harm. Robert Hodgson reports for Euronews.
Industry pushback intensifies against EU proposal to regulate all PFAS chemicals
by EHN Curators on January 15, 2025 at 12:15 pm
A cross-border investigation reveals that industry lobbying efforts, including funded research and exaggerated economic claims, are slowing attempts to regulate PFAS chemicals linked to environmental contamination and health concerns. Rachel Salvidge and Leana Hosea report for The Guardian.
Chemical regulations leave children vulnerable to harmful exposure
by EHN Curators on January 10, 2025 at 7:01 pm
A New England Journal of Medicine article warns that weak U.S. chemical regulations have failed to protect children from exposure to harmful synthetic chemicals, contributing to rising rates of childhood cancers, asthma and obesity. Jim Morris reports for Public Health Watch.