1956-1960 Birth control pills tested in a clinical trial on Puerto Rican women in 1956. Available commercially for “menstrual disorders” in 1957 and FDA approved for contraception in 1960.
Garcia, C. R., Pincus, G., and Rock, J. (1956). Effects of certain 19-nor steroids on the normal human menstrual cycle. Science (New York, N.Y.), 124(3227), 891–893.
Pincus, G., Rock, J., Garcia, C. R., et al. (1958). Fertility control with oral medication. American journal of obstetrics and gynecology, 75(6), 1333–1346.
1959 FDA banned DES for chickens after high DES levels in poultry produced side effects, such as male breast growth in humans.
Source: DES Action timeline