EDC Science Weekly, Nov. 15-21, 2024

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Note: Next week we won’t send a newsletter due to the Thanksgiving holiday.

Contents: Events, Regulations/Policy, Methods/Tools/Screening, Commentaries, Reviews/Meta-Analyses, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Highlights:

Scientists’ Declaration for the Global Plastics Treaty: read it here and sign it here. Due Nov. 22.
Microplastics accumulated in breast cancer patients

Science summaries and highlights

Events

Dec. 3 webinar: Fluoride, Neurodevelopment, and Cognition: A National Toxicology Program monograph [EDC Strategies Partnership]

Dec. 5 webinar: ECOTOX Knowledgebase and PFAS Updates [EPA]

Dec. 5 symposium: Scientific symposium and general meeting (hybrid) [Intersectoral Center for Endocrine Disruptor Analysis (ICEDA)]

Dec. 9 webinar: Behind the Scenes at EPA: What’s going wrong and what does it mean for our work? [CHE, Earthjustice, and UCSF’s EaRTH Center]

Mar. 14-15: Lou Guillette Jr. Symposium, in person at the University of Florida in Gainesville [HEEDS]

Apr. 27-29, 2025 conference: Break the Cycle of Children’s Environmental Health Disparities

May 21 – June 4, 2025 course: Endocrine-Disrupting Chemicals: Hazards and Opportunities (ECHO) [applications due Jan 10, financial aid is available]

More events

Regulations/Policy

Identifying non-essential uses to phase out substances of very high concern under REACH.

The definition of chemical contaminants in food: ambiguity and consequences

Scientists’ Declaration for the Global Plastics Treaty: read it here and sign it here. Due Nov. 22.

More EDC policy and regulations open for comment

Methods/Tools/Screening

LitChemPlast: An Open Database of Chemicals Measured in Plastics.

Influence of Talc in Polypropylene on Total Fluorine Measurements Used as an Indicator of Per- and Polyfluoroalkyl Substances (PFAS).

Nanoplastics measurements must have appropriate blanks.

Screening

Transcriptomic characterization of 2D and 3D human induced pluripotent stem cell-based in vitro models as New Approach Methodologies for developmental neurotoxicity testing.

Mechanism-based toxicity screening of organophosphate flame retardants using Tox21 assays and molecular docking analysis.

Characterization of AhR-mediated potency in sediments from Kongsfjorden, Svalbard: Application of effect-directed analysis and nontarget screening.

Zebrafish Larvae as a Predictive Model for the Risk of Chemical-Induced Cholestasis: Phenotypic Evaluation and Nomogram Formation.

Commentaries

Asking Why Is Necessary to Address Health Disparities: A Critical Approach for Solution-Oriented Environmental Epidemiological Research.

Air Toxics Matter to More than Just Air.

Plastics treaty: Address building materials.

Trump, health, science, and the next 4 years

Reviews/Meta-Analyses

Numerous Chemicals/Mixtures

Influence of exposure to endocrine disruptors and other environmental chemicals on breast development in girls: A systematic review of human studies.

Prenatal chemical exposures and the methylome: current evidence and opportunities for environmental epigenetics.

BPA/Phenols

Is exposure to Bisphenol A associated with Attention-Deficit Hyperactivity Disorder (ADHD) and associated executive or behavioral problems in children? A comprehensive systematic review.

Phthalates

Phthalates Disrupt Female Reproductive Health: A Call for Enhanced Investigation into Mixtures.

Exploring the Nephrotoxicity and Molecular Mechanisms of Di-2-ethylhexyl phthalate: A Comprehensive Review.

Bacterial Catabolism of Phthalates With Estrogenic Activity Used as Plasticisers in the Manufacture of Plastic Products.

PFAS

Clinical, histological, molecular, and toxicokinetic renal outcomes of per-/polyfluoroalkyl substances (PFAS) exposure: Systematic review and meta-analysis.

Exploring the sources, occurrence, transformation, toxicity, monitoring, and remediation strategies of per- and polyfluoroalkyl substances: a review.

Pesticides

Recent advances in the toxicological effects of difenoconazole: A focus on toxic mechanisms in fish and mammals.

Metals/Metalloids

Alpha-lipoic acid, as an effective agent against toxic elements: a review.

Heavy metals: toxicity and human health effects.

Microplastics/Nanomaterials

Microplastics and orthodontic aligners: The concerns arising from the modernization of practice through polymers and plastics.

Contribution of chemical toxicity to the overall toxicity of microplastic particles: A review.

Zooming in the plastisphere: the ecological interface for phytoplankton-plastic interactions in aquatic ecosystems.

Leveraging nanoparticle environmental health and safety research in the study of micro- and nano-plastics.

Microplastics: the hidden danger.

Air Pollution

Quantifying the association between PM_2.5 air pollution and IQ loss in children: a systematic review and meta-analysis.

Miscellaneous

Innovations in poly(3-hydroxybutyrate-co-3-hydroxyvalerate) and nanocomposites for sustainable food packaging via biochemical biorefinery platforms: A comprehensive review.

Epidemiology and Risk Factors for Testicular Cancer: A Systematic Review.

Society for Birth Defects Research and Prevention Symposium: Health Disparities Within Communities of Color.

Dietary interventions in mitigating the impact of environmental pollutants on Alzheimer’s disease – A review.

Environmental public health research at the U.S. Environmental Protection Agency: A blueprint for exposure science in a connected world.

Human Health Studies

BPA/Phenols

Serum bisphenol S levels are associated with decreased ovarian reserve function: a single-center study.

Preconception exposure to bisphenol A and its alternatives: Effects on female fecundity mediated by oxidative stress and ovarian reserve.

Phthalates

Phthalate exposure increases oxidative stress, early renal injury, and the risk of calcium urolithiasis: A case-control study.

Combined effects and potential mechanisms of phthalate metabolites on serum sex hormones among reproductive-aged women: An integrated epidemiology and computational toxicology study.

Associating prenatal phthalate exposure with childhood autistic traits: Investigating potential adverse outcome pathways and the modifying effects of maternal vitamin D.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Evidence of a positive association between dietary exposure to polychlorinated biphenyl (PCB) and weight gain among women in the E3N prospective cohort.

Exploring the impact of polychlorinated biphenyls on comorbidity and potential mitigation strategies.

PFAS

The impact of high exposure to perfluoroalkyl substances and risk for hormone receptor-positive breast cancer – A Swedish cohort study.

The T cell response to SARS-CoV-2 mRNA vaccine in adults with high exposure to perfluoroalkyl substances from Ronneby, Sweden.

Sex-specific association of per- and polyfluoroalkyl substances (PFAS) exposure with vitamin D concentrations in older adults in the USA: an observational study.

Prenatal exposure to per- and polyfluoroalkyl substances (PFAS) and their influence on inflammatory biomarkers in pregnancy: Findings from the LIFECODES cohort.

Association between Exposure to Per- and Polyfluoroalkyl Substances and Missed Miscarriage: A Hospital-Based Case-Control Study in Shanghai, China.

Association between per- and polyfluoroalkyl substance exposures and thyroid homeostasis parameters.

Associations of pre- and postnatal per- and polyfluoroalkyl substance exposure with adolescents’ eating behaviors.

Pesticides

High serum pesticide levels are associated with increased odds of inflammatory bowel disease in a nested case-control study.

Correlation between environmental DEET exposure and the mortality rate of cancer survivors: a large-sample cross-sectional investigation.

Association between pesticide exposure and end-stage renal disease: A case-control study from Morocco based on the STROBE guidelines.

Metals/Metalloids

Maternal and Cord Blood Levels of Metals and Fetal Liver Function.

Gut heavy metal and antibiotic resistome of humans living in the high Arctic.

Microplastics/Nanomaterials

Microplastics accumulated in breast cancer patients lead to mitophagy via ANXA2-mediated endocytosis and IL-17 signaling pathway.

Air Pollution

Exposure to air pollutants and breast cancer risk: mediating effects of metabolic health biomarkers in a nested case-control study within the E3N-Generations cohort.

Air pollution exposure in vitrified oocyte donors and male recipient partners in relation to fertilization and embryo quality.

Miscellaneous

Association between fish consumption and mortality in the E3N French women’s cohort.

Laboratory Studies

Numerous Chemicals/Mixtures

Additive effect of Bisphenol A and Pefluoro-sulphoctanoic acid exposure at subacute toxic levels, on a murine model of sertoli cell.

Target Organ Toxicity in Sprague Dawley Rats Following Oral Exposure to Complex Groundwater Mixture: Assessment of Dose-Response Relationships Using Histopathological and Biochemical Alterations

BPA/Phenols

Environmental triggers and future risk of developing autoimmune diseases: Molecular mechanism and network toxicology analysis of bisphenol A.

A computational assay for identifying millet-derived compounds that antagonize the interaction between bisphenols and estrogen-related receptor gamma.

Bisphenol A-induced polycystic ovary syndrome (PCOS) with hormonal and metabolic implications in rats.

Selenium ameliorates oxidized phospholipid-mediated testicular dysfunction and epididymal sperm abnormalities following Bisphenol A exposure in adult Wistar rats.

Folic acid mitigates the developmental and neurotoxic effects of bisphenol A in zebrafish by inhibiting the oxidative stress/JNK signaling pathway.

Altered Mammary Gland Development and Pro-Tumorigenic Changes in Young Female Mice Following Prenatal BPAF Exposure.

Assessment of toxicity and endocrine-disrupting activity of bisphenol analogues during ozone and UV treatments in zebrafish eleutheroembryos.

Metabolic status is a key factor influencing proteomic changes in ewe granulosa cells induced by chronic BPS exposure.

Evaluating the Toxicity Induced by Bisphenol F in Labeo rohita Fish Using Multiple Biomarker Approach.

Gut microbiota combined with metabolome dissects Fluorene-9-bisphenol exposure-induced male reproductive toxicity.

Phthalates

A common phthalate replacement disrupts ovarian function in young adult mice.

Assessing male reproductive toxicity of environmental pollutant di-ethylhexyl phthalate with network toxicology and molecular docking strategy.

Developmental toxicity and mechanism of dibutyl phthalate on the development of subintestinal vessels in zebrafish.

Toxic effects of DEHP and MEHP on gut-liver axis in rats via intestinal flora and metabolomics.

Multi-omics analysis of the toxic effects on gill tissues of crucian carp (Carassius auratus) from chronic exposure to environmentally relevant concentrations of Di(2-ethylhexyl) phthalate (DEHP).

The Aloe vera acemannan polysaccharides inhibit phthalate-induced cell viability, metastasis, and stemness in colorectal cancer cells.

Protective effects of black ginseng on testicular toxicity induced by Di-n-butyl phthalate in rats.

Parabens/Triclosan/Antimicrobials

Effects of Parabens on Human and Rat Placental 3β-Hydroxysteroid Dehydrogenase Isoforms: Structure Activity Relationship and Docking Analysis.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

The potential role of AhR/NR4A1 in androgen-dependent prostate cancer: Focus on TCDD-induced ferroptosis.

PFAS

Exposure to perfluorodecanoic acid impairs follicular development via inducing granulosa cell necroptosis.

Perfluorooctane sulfonate causes HK-2 cell injury through ferroptosis and endoplasmic reticulum stress pathways.

Flame Retardants

Effects of dechlorane plus on hepatic pathology, metabolic health and gut microbiota in male mice.

Sex-specific neurotoxicity and transgenerational effects of an emerging pollutant, tris(1,3-dichloro-2-propyl)phosphate (TDCIPP).

Pesticides

Organophosphate Insecticide Malathion Induces Alzheimer’s Disease-Like Cognitive Impairment in Mice: Evidence of the Microbiota-Gut-Brain Axis.

Co-Administration of a Plantain-Based Diet and Quercetin Modulates Atrazine-Induced Testicular Dysfunction in Rats via Testicular Steroidogenesis and Redox-Inflammatory Processes.

Life stage dependent effects of neonicotinoid exposure on honey bee hypopharyngeal gland development.

Metals/Metalloids

Effect of fluoride-induced testicular alteration in rats fed a high-fat diet.

Melatonin Ameliorates Cadmium-Induced Liver Fibrosis Via Modulating Gut Microbiota and Bile Acid Metabolism.

Microplastics/Nanomaterials

Anti-oxidant and anti-apoptotic effects of royal jelly against polystyrene microplastic-induced testicular injury in mice.

Proteomics reveals that nanoplastics with different sizes induce hepatocyte apoptosis in mice through distinct mechanisms involving mitophagy dysregulation and cell cycle arrest.

Nanoplastics and bisphenol A exposure alone or in combination induce hepatopancreatic damage and disturbances in carbohydrate metabolism in the Portunus trituberculatus.

Identification of a PET hydrolytic enzyme from the human gut microbiome unveils potential plastic biodegradation in human digestive tract.

Exposure to polystyrene nanoplastics promotes premature cellular senescence through mitochondrial ROS production and dysfunction in pre-differentiated skeletal myoblasts.

Short-term polystyrene nanoplastic exposure alters zebrafish male and female germline and reproductive outcomes, unveiling pollutant-impacted molecular pathways.

Exposure/Environment Studies

Numerous Chemicals/Mixtures

Pregnant women’s lifestyles and exposure to endocrine-disrupting chemicals: a machine learning approach.

Chemical migration from reusable plastic bottles: Silicone, polyethylene, and polypropylene show highest hazard potential in LC-HRMS analysis.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Lower chlorinated PCBs accumulate in demolition workers while working on a contaminated worksite.

Factors affecting the polychlorinated biphenyl signatures in serum of adults living in a highly polluted area in eastern Slovakia.

PFAS

Examining Disparities in PFAS Plasma Concentrations: Impact of Drinking Water Contamination, Food Access, Proximity to Industrial Facilities and Superfund Sites.

Residential Garden Produce Harvested Near a Fluorochemical Manufacturer in North Carolina Can Be An Important Fluoroether Exposure Pathway.

Practical limits of current technologies in removing per- and polyfluoroalkyl substances from fire suppression systems.

Pesticides

Quantitative measures of recent and lifetime agricultural pesticide use are associated with increased pesticide concentrations in house dust.

Glyphosate losses through various stages of coffee production and consequences for human exposure.

Metals/Metalloids

Trace element contaminants and endocrine status of European brown bears assessed using blood as a matrix.

Microplastics/Nanomaterials

Pavement wear generates microplastics in stormwater runoff.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. There are searchable archives. Compiled by Sarah Howard of Healthy Environment and Endocrine Disruptor Strategies (HEEDS), a program of Environmental Health Sciences.

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