EDC Science Weekly, Sept. 13 – 19, 2024

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Events, Methods/Tools/Screening, Commentaries, Reviews/Meta-Analyses, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Highlights:

Evidence for widespread human exposure to food contact chemicals
Identification of transformation products from fluorinated lithium-ion battery additives TPFPB and TPFPP: forever chemicals of tomorrow?
Microplastics in the olfactory bulb of the human brain.
Microplastics and cardiovascular diseases: Importance of coexisting environmental pollutants.

Science summaries and highlights

Events

Sept. 23-24: Plastics and Human Health Symposium [NYU Langone Health Center for the Investigation of Environmental Hazards]

Sept. 25: Public Meeting on the Development of an Enhanced Systematic Process for FDA’s Post-Market Assessment of Chemicals in Food [US FDA]

Sept. 30 and Oct. 1: Webinar on Next Round of Chemical Substances Being Considered for Prioritization Under TSCA [US EPA]

Oct. 1 webinar: Proposed Priorities for the Next U.S. President to Reduce Plastic Pollution [Beyond Plastics]

Oct. 7-8: Workshop on Advancing Quantitative Analysis in Human Health Assessments through Probabilistic Methods [US EPA]

Oct. 8: PFAS and Child Development: A Children’s Environmental Health Day Event (virtual) [Philadelphia Regional Center for Children’s Environmental Health]

Oct. 10: Children’s Environmental Health Day [Children’s Environmental Health Network]

Oct. 14-16: 8th Annual meeting of the U.S. DOHaD Society: exploring translational DOHaD science: from cells to communities in Chapel Hill, NC.

Oct. 28: Swiss Symposium on Endocrine Disrupting Chemicals [Food Packaging Forum and ETH Zurich]

Oct. 29-30: 6th Annual Forum on Endocrine Disruptors [European Commission]

Nov. 5-6 conference: State of the science on development and use of NAMs for chemical safety testing [U.S. EPA]

More events

Methods/Tools/Screening

Community-Engaged Research and the Use of Open Access ToxVal/ToxRef In Vivo Databases and New Approach Methodologies (NAM) to Address Human Health Risks From Environmental Contaminants.

Does residential address-based exposure assessment for outdoor air pollution lead to bias in epidemiological studies?

Is Seven Days Enough? Comparing A 7-Day Exposure to the Classical 21-Day OECD TG 229 Fish Short-Term Reproduction Assay in Fathead Minnow.

Exploring the environmental contamination toxicity and potential carcinogenic pathways of perfluorinated and polyfluoroalkyl substances (PFAS): An integrated network toxicology and molecular docking strategy.

Identification of Optimal Machine Learning Algorithms and Molecular Fingerprints for Explainable Toxicity Prediction Models Using ToxCast/Tox21 Bioassay Data.

vivoBodySeg: Machine learning-based analysis of C. elegans immobilized in vivoChip for automated developmental toxicity testing.

Advances and future directions of environmental risk research: A bibliometric review.

Commentaries

TORPP – Turtles, One Health Research & Plastic Pollution: A multidisciplinary consortium to evaluate the environmental and health impact of Micro/NanoPlastics (MNPs) pollution.

Editorial: Endocrine disrupting chemicals in reproductive health, fertility, and early development. [intro to a research topic in Frontiers in Endocrinology]

Editorial: Environmental racism: consideration of structural racism in environmental epidemiology. [intro to a research topic in Frontiers in Epidemiology]

Commentary: Building Knowledge of NAMs through Risk Science.

The passing of the creator of dolly and other pioneers, endocrine disruptors, metabolic syndrome, and more.

Reviews/Meta-Analyses

Numerous Chemicals/Mixtures

Evidence for widespread human exposure to food contact chemicals

Prenatal environmental risk factors for autism spectrum disorder and their potential mechanisms.

Development and child health in a world of synthetic chemicals.

Endocrine disruption assessment in aquatic vertebrates – Identification of substance-induced thyroid-mediated effect patterns.

Emerging hazardous chemicals and biological pollutants in Canadian aquatic systems and remediation approaches: A comprehensive status report.

Unravelling the Influence of Endocrine-Disrupting Chemicals on Obesity Pathophysiology Pathways.

BPA/Phenols

Impact of Bisphenol A and its alternatives on oocyte health: a scoping review.

The risk of prenatal bisphenol A exposure in early life neurodevelopment: Insights from epigenetic regulation.

Phthalates

Natural products modulate phthalate-associated miRNAs and targets.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Persistent Organic Pollutants and Metabolic Diseases: From the Perspective of Lipid Droplets.

PFAS

Emergency of per- and polyfluoroalkyl substances in drinking water: Status, regulation, and mitigation strategies in developing countries.

Understanding the Selective Removal of Perfluoroalkyl and Polyfluoroalkyl Substances via Fluorine-Fluorine Interactions: A Critical Review.

Exploring the Prospects and Challenges of Fluorine-Free Firefighting Foams (F3) as Alternatives to Aqueous Film-Forming Foams (AFFF): A Review.

Pesticides

Pesticide exposure and spontaneous abortion risk: A comprehensive systematic review and meta-analysis.

A review of the potential adverse health impacts of atrazine in humans.

Metals/Metalloids

Environmental arsenic exposure and reproductive system toxicity in male and female and mitigatory strategies: a review.

Impact of arsenic on male and female reproductive function: a review of the pathophysiology and potential therapeutic strategies.

Changes in Energy Dynamics in Arsenic Exposure Based Neurotoxicity: A Comprehensive Review.

Leveraging the One Health concept for arsenic sustainability.

Microplastics/Nanomaterials

Microplastics and Cardiovascular Diseases: Importance of Coexisting Environmental Pollutants.

Micro- and nano-plastics, intestinal inflammation, and inflammatory bowel disease: A review of the literature.

Global distribution, drivers, and potential hazards of microplastics in groundwater: A review.

Deciphering the cytotoxicity of micro- and nanoplastics in Caco-2 cells through meta-analysis and machine learning.

Pharmaceuticals/Personal Care Products

Epilepsy and Anti-Seizure Medications: Secret Agents for Endocrine Disruption.

Miscellaneous

A bibliometric analysis of global research hotspots and progress on emerging environmental pollutants 6PPD and 6PPD-quinone from 2004 to 2024.

Human Health Studies

Numerous Chemicals/Mixtures

Environmental toxicants modulate disease severity in pediatric metabolic dysfunction-associated steatohepatitis.

Phthalates

Thyroid Hormones and Oxidative Stress Moderated the Association between Urinary Phthalate Metabolites and Cardiovascular Risk Factors.

Prenatal exposure to phthalates and childhood wheeze and asthma in the progress cohort.

Parabens/Triclosan/Antimicrobials

Associations of prenatal maternal urinary concentrations of triclosan and benzophenone-3 with cognition in 7.5-month-old infants.

PFAS

PFAS Levels, Early Life Factors, and Mammographic Breast Density in Premenopausal Women.

Decreases in serum PFAS are associated with decreases in serum lipids: A longitudinal study on a highly exposed population.

Prenatal exposure to perfluoroalkyl and polyfluoroalkyl substances and childhood bone mineral density: A prospective birth cohort study.

Associations between co-exposure to per- and polyfluoroalkyl substances and metabolic diseases: The mediating roles of inflammation and oxidative stress.

Exposure to per- and polyfluoroalkyl substances is associated with impaired cardiovascular health: a cross-sectional study.

Perfluoroalkyl substances and metabolic syndrome: A cross-sectional study using data from the US national health and nutrition examination survey.

Pesticides

Gestational urinary concentrations of glyphosate and aminomethylphosphonic acid in relation to preterm birth: the MIREC study.

Metals/Metalloids

Accelerated Longitudinal Glycemic Changes in Relation to Urinary Toxic/Essential Metals and Metal Mixtures Among Mexican Americans Living in Starr County, Texas.

Historical exposure to metals in contaminated areas and its impact on cardio- and cerebrovascular health.

Joint effects of tobacco smoke exposure and heavy metals on serum sex hormones in adult males.

Air Pollution

Prenatal and early life exposure to fine particulate matter and telomere length in early childhood.

Gestational exposure to wildfire PM_2.5 and its specific components and the risk of gestational hypertension and eclampsia in the southwestern United States.

Short-term effects of wildfire-specific fine particulate matter and its carbonaceous components on perinatal outcomes: A multicentre cohort study in New South Wales, Australia.

Laboratory Studies

BPA/Phenols

Subchronic toxic effects of bisphenol A on the gut-liver-hormone axis in rats via intestinal flora and metabolism.

Short-Term Exposure to Foodborne Xenoestrogens Affects Breast Cancer Cell Morphology and Motility Relevant for Metastatic Behavior In Vitro.

Effects of maternal nonylphenol exposure on the proliferation of glial cells in the brain of male offspring mice.

Phthalates

Exposure to environmental doses of DEHP causes phenotypes of polycystic ovary syndrome.

In Utero Exposure to Di-n-butyl Phthalate Causes Modulation in Neurotransmitter System of Wistar Rats: A Multigenerational Assessment.

Dimethyl phthalate exposure induces cognitive impairment via COX2-mediated neuroinflammation.

Novel Insight into the mechanism of di (2-ethylhexyl) phthalate (DEHP) impairing early follicle development.

PFAS

Identification of transformation products from fluorinated lithium-ion battery additives TPFPB and TPFPP: forever chemicals of tomorrow?

Effects of perfluoroalkyl sulfonic acids on developmental, physiological, and immunological measures in northern leopard frog tadpoles.

Reproductive and germ-cell mutagenic effects of poly-and perfluoroalkyl substances (PFAS) to Caenorhabditis elegans after multigenerational exposure.

Influence of perfluoroalkyl substances, with focus on perfluorobutanoic acid on the responding characteristics and molecular mechanisms of Thalassiosira pseudonana.

The Effects of Perfluorooctanoic Acid on Breast Cancer Metastasis Depend on the Phenotypes of the Cancer Cells: An in vivo Study with Zebrafish Xenograft Model.

Flame Retardants

Migration patterns of organophosphate esters from plastic food packaging simulants to foods: Donors, behaviours, and influencing factors.

Triphenyl Phosphate Alters Methyltransferase Expression and Induces Genome-Wide Aberrant DNA Methylation in Zebrafish Larvae.

Flame retardant, hexabromocyclododecane, increases production of pro-inflammatory cytokines, interleukin 1-beta and interleukin 6, in human immune cells.

Brominated Flame Retardant HBCD and Artificial Light at Night Synergically Caused Visual Disorder and Sleep Difficulty in Zebrafish Larvae.

Pesticides

Permethrin exposure primes neuroinflammatory stress response to drive depression-like behavior through microglial activation in a mouse model of Gulf War Illness.

Study on low concentration deltamethrin toxicity mediated by phospholipase D in Chinese mitten crab (Eriocheir sinensis) ovary.

Effects of diazinon on the ovarian tissue of rats: a histochemical and ultrastructural study.

Paraquat disrupts the blood-brain barrier by increasing IL-6 expression and oxidative stress through the activation of PI3K/AKT signaling pathway.

Metals/Metalloids

Dehydrozingerone ameliorates arsenic-induced reproductive toxicity in male Wistar rats.

Impaired learning and memory in male mice induced by sodium arsenite was associated with MMP-2/MMP-9-mediated blood-brain barrier disruption and neuronal apoptosis.

Microplastics/Nanomaterials

Bioaccessibility of plastic-related compounds from polymeric particles in marine settings: Are microplastics the principal vector of phthalate ester congeners and bisphenol A towards marine vertebrates?

Long-term exposure to polystyrene microplastics reduces macrophages and affects the microbiota-gut-brain axis in mice.

Effects of Microplastic Interaction with Persistent Organic Pollutants on the Activity of the Aryl Hydrocarbon and Estrogen Receptors.

Efficacy of DHA-enriched phosphatidylserine and its underlying mechanism in alleviating polystyrene nanoplastics-induced hepatotoxicity in mice.

Combined effects of polyvinyl chloride or polypropylene microplastics with cadmium on the intestine of zebrafish at environmentally relevant concentrations.

Exposure/Environment Studies

Numerous Chemicals/Mixtures

Storms mobilize organophosphate esters, bisphenols, PFASs, and vehicle-derived contaminants to San Francisco Bay watersheds.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Levels and trends of persistent organic pollutants in human populations living in the Arctic.

PFAS

Determination of regulated perfluoroalkyl substances (PFAS) in drinking water according to Directive 2020/2184/EU.

Legacy and alternative per- and polyfluoroalkyl substances spatiotemporal distribution in China: Human exposure, environmental media, and risk assessment.

Occurrence and health risk assessment of PFAS and possible precursors: a case study in a drinking water treatment plant and bottled water (south Catalonia, Spain).

Comparing occurrence of per- and polyfluoroalkyl substances (PFAS) in municipal biosolids and industrial wastewater sludge: A City of Los Angeles study.

Adsorption of Per- and Polyfluoroalkyl Substances on Biochar Derived from Municipal Sewage Sludge.

Flame Retardants

From e-waste to living space: flame retardants contaminating household items add to concern about plastic recycling.

Pesticides

Comparison of pesticide contamination between captive-reared and wild grey partridges: insights into environmental exposure disparities.

Microplastics/Nanomaterials

Microplastics in the Olfactory Bulb of the Human Brain.

Is intravenous infusion an unrecognized route for internal microplastic human exposure? A general assessment.

Microplastics pollution in sediments of the Thames and Medway estuaries, UK: Organic matter associations and predominance of polyethylene.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. The searchable archives are at https://groups.google.com/d/forum/edc_research or online at https://heeds.org/category/edc-science-weekly/. Compiled by Sarah Howard of Healthy Environment and Endocrine Disruptor Strategies (HEEDS), a program of Environmental Health Sciences.

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