EDC Science Weekly, Aug. 9-15, 2024

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Events, Regulations/Policy, Methods/Tools/Screening, Commentaries, Reviews/Meta-Analyses, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Highlights: Dioxins vs. PFAS: Science and Policy Challenges; Clinical Implications of New Drinking Water Regulation for “Forever Chemicals”.

We are now accepting applications for the Lou Guillette, Jr Outstanding Young Investigator Award, due Sept. 30!

Science summaries and highlights

Events

Aug. 21 webinar: Innovations in Health Assessments: New Approach Methods and EPA’s Transcriptomics Assessment Product [EPA]

Aug. 28 webinar: The CATMoS Model for Acute Oral Toxicity and Evaluation of its Potential Use in a Regulatory Context for Pesticide Hazard and Risk Assessment [EPIC webinar series]

Sept. 18 webinar: Artificial Turf: Research on Plastic Pollution, PFAS, and Health Concerns [CHE]

Sept. 23-24: Plastics and Human Health Symposium [NYU Langone Health Center for the Investigation of Environmental Hazards]

Oct. 14-16: 8th Annual meeting of the U.S. DOHaD Society: exploring translational DOHaD science: from cells to communities in Chapel Hill, NC.

Oct. 28: Swiss Symposium on Endocrine Disrupting Chemicals [Food Packaging Forum and ETH Zurich]

Nov. 5-6 conference: State of the science on development and use of NAMs for chemical safety testing [U.S. EPA]

More events

Regulations/Policy

Dioxins vs. PFAS: Science and Policy Challenges.

Clinical Implications of New Drinking Water Regulation for “Forever Chemicals”.

A Systematic Workflow for Compliance Testing of Emerging International Classwide Restrictions on PFAS.

Utilizing Omics Data for Chemical Grouping.

Pesticide water pollution, human health risks, and regulatory evaluation: A nationwide analysis in Ethiopia.

More EDC policy and regulations open for comment

Methods/Tools/Screening

Large-Scale Screening of Per- and Polyfluoroalkyl Substance Binding Interactions and Their Mixtures with Nuclear Receptors.

Characterization of a human thyroid microtissue model for testing thyroid disrupting chemicals.

Identification of Key Toxic Substances Considering Metabolic Activation: A Combination of Transcriptome and Nontarget Analysis.

Identifying long-term health risks associated with environmental chemical incidents.

Screening persistent organic pollutants for effects on testosterone and estrogen synthesis at human-relevant concentrations using H295R cells in 96-well plates.

Endeavours made by trade associations, pharmaceutical companies and regulators in the replacement, reduction and refinement of animal experimentation in safety testing of pharmaceuticals.

Machine Learning-Driven QSAR Models for Predicting the Cytotoxicity of Five Common Microplastics.

Commentaries

Endocrine-Disrupting Chemicals: A Looming Threat to Current and Future Generations. [intro to a special issue of Int J Mol Sci, Endocrine Disruption and Human Diseases 2.0]

The great puberty shift [World Report in The Lancet]

Perspective on the Development of Monomer Recovery Technologies from Plastics Designed to Last.

Continuing the Conversation About Arsenic.

Hypothesis: 2 Major Environmental and Pharmaceutical Factors-Acetaminophen Exposure and Gastrointestinal Overgrowth of Clostridia Bacteria Induced By Ingestion of Glyphosate-Contaminated Foods-Dysregulate the Developmental Protein Sonic Hedgehog and Are Major Causes of Autism.

Emerging risks of microplastics and nanoplastics (MNPs): Is a silent threat for cardiovascular disease?

Reviews/Meta-Analyses

Numerous Chemicals/Mixtures

Intersecting planetary health: Exploring the impacts of environmental stressors on wildlife and human health.

A brief review on models for birds exposed to chemicals.

BPA/Phenols

Bisphenol A exposure and thyroid dysfunction during pregnancy: A Systematic Review.

Parabens/Triclosan/Antimicrobials

Toxicity evolution of triclosan during environmental transformation and human metabolism: Misgivings in the post-pandemic era.

Pesticides

Maternal Lifestyle and Prenatal Risk Factors for Childhood Leukemia: A Review of the Existing Evidence.

An evidence based comprehensive review on Thiacloprid, a pesticide residue, induced toxicity: Unveiling hazard to human health.

A review on toxic effects of pesticides in Zebrafish, Danio rerio and common carp, Cyprinus carpio, emphasising Atrazine herbicide.

Metals/Metalloids

Association between heavy metals exposure and risk of attention deficit hyperactivity disorder (ADHD) in children: a systematic review and meta-analysis.

Polyamines: Rising stars against metal and metalloid toxicity.

Toxic and essential metals: metabolic interactions with the gut microbiota and health implications.

Microplastics/Nanomaterials

Plastic particle impacts on the cardiovascular system and angiogenesis potential.

Human Health Studies

Numerous Chemicals/Mixtures

Associations of environmental chemical exposures measured in personal silicone wristbands with sociodemographic factors, COVID-19 restrictions, and child respiratory health.

Association of Phenols, Parabens, and Their Mixture with Maternal Blood Pressure Measurements in the PROTECT Cohort.

Associations of bisphenol and phthalate exposure and anti-Müllerian hormone levels in women of reproductive age.

Multiple Environmental Exposures and the Development of Hypertension in a Prospective US-Based Cohort of Female Nurses: A Mixture Analysis.

BPA/Phenols

Associations of prenatal and concurrent exposure to phenols mixture with anthropometric measures and blood pressure during childhood: a time-varying mixture approach.

Bisphenol-A and pentachlorophenol sodium levels in patients with rosacea.

Phthalates

Urinary concentrations of phthalate/DINCH metabolites and body mass index among European children and adolescents in the HBM4EU Aligned Studies: A cross-sectional multi-country study.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

The Relationship Between Polychlorinated and Polybrominated Biphenyls and Glycated Hemoglobin among Electronics Workers.

Association between pancreatic adenocarcinoma risk and concentration of organochlorine pesticides in adipose tissue and urine: A targeted-screening analysis case-control study (PESTIPAC).

PFAS

Per- and polyfluoroalkyl substances exposure is associated with polycystic ovary syndrome risk among women attending a fertility clinic.

Examining a Decade-Long Trend in Exposure to Per- and Polyfluoroalkyl Substances and Their Correlation with Lipid Profiles: Insights from a Prospective Cohort Study on the Young Taiwanese Population.

Flame Retardants

Exposure to organophosphate esters and early menopause: a population-based cross-sectional study.

Pesticides

Prenatal organophosphate pesticide exposure and sex-specific estimated Fetal size.

Oxidative stress and renal status of farmers exposed to pesticides in Seville (Spain).

Association between blood lipid levels in early pregnancy and urinary organophosphate metabolites in the Japan Environment and Children’s Study.

Metals/Metalloids

Edetate Disodium–Based Chelation for Patients With a Previous Myocardial Infarction and Diabetes and related Chelation Therapy Following Myocardial Infarction.

Biochemical study of the effect of lead exposure in nonobese gasoline station workers and risk of hyperglycemia: A retrospective case-control study.

Integrating Multi-Omics with environmental data for precision health: A novel analytic framework and case study on prenatal mercury induced childhood fatty liver disease.

Prenatal mercury exposure and the secondary sex ratio: The Japan Environment and Children’s Study.

Air Pollution

Multi-pollutant exposure profiles associated with breast cancer risk: A Bayesian profile regression analysis in the French E3N cohort.

Long-term ambient air pollution exposure and renal function and biomarkers of renal disease.

Associations between long-term ambient PM_2.5 exposure and the incidence of cardiopulmonary diseases and diabetes, attributable years lived with disability, and policy implication.

Miscellaneous

Urinary polycyclic aromatic hydrocarbon metabolites and their association with oxidative stress among pregnant women in Los Angeles.

Laboratory Studies

Numerous Chemicals/Mixtures

Combining transcriptomics and metabolomics to assess neurodevelopmental alteration caused by in utero exposure of mice to three putative thyroid hormone system disruptors.

Human skin absorption of three plasticizers: diisononyl-1,2-cyclohexanedicarboxylate (DINCH), di(2-ethylhexyl) terephthalate (DEHTP), and di(2-ethylhexyl) adipate (DEHA).

In silico analysis of endocrine-disrupting potential of triclosan, bisphenol A, and their analogs and derivatives.

Mechanistic insights into cadmium exacerbating 2-Ethylhexyl diphenyl phosphate-induced human keratinocyte toxicity: Oxidative damage, cell apoptosis, and tight junction disruption.

BPA/Phenols

Comparative in silico and in vitro evaluation of possible toxic effects of bisphenol derivatives in HepG2 cells.

Maternal exposure to low-dose bisphenol A and its potential neurotoxic impact on male pups: A histological, immunohistochemical, and ultrastructural study.

Bisphenol S exposure induces cardiac remodeling and aggravates high-fat diet-induced cardiac hypertrophy in mice.

Procyanidine Alleviates Bisphenol A-Induced Apoptosis in TM3 Cells via the Nrf2 Signaling Pathway.

Thyroid-disrupting effects of bisphenol S in male Wistar albino rats: Histopathological lesions, follicle cell proliferation and apoptosis, and biochemical changes.

Resorcinol as “Endocrine Disrupting Chemical”: Are thyroid-related adverse effects adequately documented in reptiles? In vivo experimentation in lizard Podarcis siculus.

Fluorene-9-bisphenol impaired male fertility through disrupting the testicular function and local microenvironment.

Phthalates

Effects of Glycine on epigenetic modification and early embryonic development in porcine oocytes exposed to monobutyl phthalate.

Portulaca Oleracea L. Phenolic Amide Methyl (3,4,5-Trimethoxybenzoyl) Valylprolinate Attenuates Diethylhexyl Phthalate-Induced Human Umbilical Vein Endothelial Cells’ Inflammation Through NLRP3 and NF-κB Pathways.

Alterations in neurotransmitters, steroid hormones, vitellogenin, and antioxidant system induced by di-n-butyl phthalate and di-isopentyl phthalate on catfish Rhamdia quelen.

Smart RNA Sequencing Reveals the Toxicological Effects of Diisobutyl Phthalate (DiBP) in Porcine Oocytes.

Low doses of acetyl trihexyl citrate plasticizer promote adipogenesis in hepatocytes and mice. [phthalate replacement]

Parabens/Triclosan/Antimicrobials

Sex-Specific Effects of Environmental Exposure to the Antimicrobial Agents Benzalkonium Chloride and Triclosan on the Gut Microbiota and Health of Zebrafish (Danio rerio).

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Effects of Early Life Exposures to the Aryl Hydrocarbon Receptor Ligand TCDF on Gut Microbiota and Host Metabolic Homeostasis in C57BL/6J Mice. [This one made Newsweek, “Babies Exposed to Common Chemical May Face Higher Risk of Diabetes, Obesity.”]

Long-term exposure to polychlorinated biphenyl 126 induces liver fibrosis and upregulates miR-155 and miR-34a in C57BL/6 mice.

PFAS

Assessment of cardiotoxicity induced by PFOS exposure and mechanism research via untarget metabolomics.

Adolescent exposure to a mixture of per- and polyfluoroalkyl substances (PFAS) depletes the ovarian reserve, increases ovarian fibrosis, and alters the hippo pathway in adult female mice.

Perfluorooctanoic acid (PFOA) and its alternative perfluorobutanoic acid (PFBA) alter hepatic bile acid profiles via different pathways.

Reproductive toxicity and gene expression alterations in aquatic environments: Expanding the insights of the recent guppy study on PFAS exposure.

Flame Retardants

Phenotypic and Functional Outcomes in Macrophages Exposed to an Environmentally Relevant Mixture of Organophosphate Esters in Vitro.

Life-time exposure to decabromodiphenyl ethane (DBDPE) caused transgenerational epigenetic alterations of thyroid endocrine system in zebrafish.

Physiological and transcriptomic changes of zebrafish (Danio rerio) in response to Isopropylate Triphenyl Phosphate (IPPP) exposure.

Pesticides

Neonicotinoid Pesticides Affect Developing Neurons in Experimental Mouse Models and in Human Induced Pluripotent Stem Cell (iPSC)-Derived Neural Cultures and Organoids.

Increased Levels of Phosphorylated-P38α Induce WNT/β-Catenin and NGF/P75NTR/TrkA Pathways Disruption and SN56 Cell Death following Single and Repeated Chlorpyrifos Treatment.

Imidacloprid affects human cells through mitochondrial dysfunction and oxidative stress.

Embryonic exposure to flubendiamide induces hepatotoxicity in domestic chicks by altering drug-metabolizing enzymes, antioxidant status, and liver function.

Sublethal Imidacloprid Administration to Honey Bee Workers is More Lethal to the Queen Larvae.

Metals/Metalloids

Prolonged exposure to NaAsO₂ induces thyroid dysfunction and inflammatory injury in Sprague‒Dawley rats, involvement of NLRP3 inflammasome‒mediated pyroptosis.

Ellagic acid ameliorates arsenic-induced neuronal ferroptosis and cognitive impairment via Nrf2/GPX4 signaling pathway.

Roles of m⁶A modification in regulating PPER pathway in cadmium-induced pancreatic β cell death.

Microplastics/Nanomaterials

Identification of micro- and nanoplastic particles in postnatal sprague-dawley rat offspring after maternal inhalation exposure throughout gestation.

Protective effect of Cordycepin on blood-testis barrier against pre-puberty polystyrene nanoplastics exposure in male rats.

Do Microplastics Have Neurological Implications in Relation to Schizophrenia Zebrafish Models? A Brain Immunohistochemistry, Neurotoxicity Assessment, and Oxidative Stress Analysis.

Exposure to polystyrene microplastics during lactational period alters immune status in both male mice and their offspring.

Macrogenomes reveal microbial-mediated microplastic degradation pathways in the porcine gut: a hope for solving the environmental challenges of microplastics.

Air Pollution

Omega-3 Reverses the Metabolic and Epigenetically Regulated Placental Phenotype acquired from Pre-conceptional and Peri-conceptional Exposure to Air Pollutants.

Pharmaceuticals/Personal Care Products

Protective effect of Cordycepin on blood-testis barrier against pre-puberty polystyrene nanoplastics exposure in male rats.

Miscellaneous

Distinct Species-Specific and Toxigenic Metabolic Profiles for 6PPD and 6PPD Quinone by P450 Enzymes: Insights from In Vitro and In Silico Studies.

The potential toxic effects of estrogen exposure on neural and vascular development in zebrafish.

Sex-specific divergent responses of marine medaka (Oryzias melastigma) towards long-term benzo[a]pyrene exposure revealed stronger resilience and recoverability in female fish.

Effects of Naphtho[2,1-a]pyrene Exposure on CYP1A1 Expression: An in Vivo and in Vitro Mechanistic Study Exploring the Role of m6A Posttranscriptional Modification.

Exposure/Environment Studies

Numerous Chemicals/Mixtures

Lifestyle and Chemicals: Exploring Behavioral Habits Related to Endocrine Disruptor Exposure Among the General Population of Saudi Arabia.

Effect driven prioritization of contaminants in wastewater treatment plants across China: A data mining-based toxicity screening approach.

BPA/Phenols

Exposure to bisphenol A in European women from 2007 to 2014 using human biomonitoring data – The European Joint Programme HBM4EU.

Occurrence and health risks of multiple emerging bisphenol S analogues in pregnant women from South China.

Benzotriazoles and bisphenols in wastewater from the food processing industry and the quantitative changes during mechanical/biochemical treatment processes.

Phthalates

Temporal Trends in Phthalate Metabolite Exposure of Girls in the United States Across Sociodemographic Factors and Intersectional Social Identities: National Health and Nutrition Examination Survey 2001-2018.

Phthalates and fatty acid markers in free-ranging cetaceans from an insular oceanic region: ecological niches as drivers of contamination.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Intercorrelations of Chlorinated Paraffins, Dechloranes, and Legacy Persistent Organic Pollutants in 10 Species of Marine Mammals from Norway, in Light of Dietary Niche.

PFAS

Occurrence of short- and ultra-short chain PFAS in drinking water from Flanders (Belgium) and implications for human exposure.

Assessment of per- and poly-fluoroalkyl substances and physiological biomarkers in aquarium-based bottlenose dolphins and killer whales.

Pesticides

Occurrence, sources and transport of triazine herbicides in the Antarctic marginal seas.

Monitoring of current-use pesticides along a Europe-Arctic transect using ships of opportunity.

Metals/Metalloids

Blood Levels of 21 Metals and Metalloids in Riverside Villagers of the Brazilian Amazon: A Human Biomonitoring Study with Associations with Sociodemographic, Dietary, and Lifestyle Factors.

Association between Residential Distance to Airport and Blood Lead Levels in Children under 6 Living in North Carolina, 1992-2015.

Microplastics/Nanomaterials

First-of-Its-Kind: Nationwide Meta-Analysis of Microplastic Pollution and Risk Assessment in Thailand.

Little change in plastic loads in South Atlantic seabirds since the 1980s.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. The searchable archives are at https://groups.google.com/d/forum/edc_research or online at https://heeds.org/category/edc-science-weekly/. Compiled by Sarah Howard of Healthy Environment and Endocrine Disruptor Strategies (HEEDS), a program of Environmental Health Sciences.

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