EDC Science Weekly, July 12-18, 2024

Post author:HEEDS
Post published:July 18, 2024
Post category:EDC Science Weekly

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Note: Next week I’ll be on vacation so will publish a two-week summary the week after.

Contents: Events, Regulations/Policy, Methods/Tools/Screening, Commentaries, Reviews/Meta-Analyses, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Events

July 16 roundtable: Understanding of Environmental Exposures in Cancer by Strengthening Clinical, Government, and Community Partnerships [Biden Cancer Moonshot/CDC/ATSDR]

July 23 webinar: CHE Café: Protecting scientists from industry intimidation [Collaborative for Health and Environment (CHE)]

July 22 meeting: State-of-the-Science and the Future of Cumulative Impact Assessment [National Academies]

July 24 webinar: 3M’s decades-long cover-up of the “forever chemicals” in your blood [Beyond Plastics]

July 31 virtual symposium: Measuring Microplastics register for July 31 [NYU Langone Center for the Investigation of Environmental Hazards (CIEH)]

Aug 6 webinar: Protecting Children’s Developing Brains: Hazards of Plastics and Chemicals in Plastics [CHE-Alaska]

Sept. 23-24: Plastics and Human Health Symposium [NYU Langone Health Center for the Investigation of Environmental Hazards]

Oct. 28: Swiss Symposium on Endocrine Disrupting Chemicals [Food Packaging Forum and ETH Zurich]

More events

Regulations/Policy

Update of the scientific opinion on tetrabromobisphenol A (TBBPA) and its derivatives in food. [EFSA]

ACPM Position Statement: Air Pollution & Environmental Justice.

“Ad hoc policy decisions” in the news: Media framing analysis of a pesticide import ban in Sri Lanka.

More EDC policy and regulations open for comment

Methods/Tools/Screening

A systematic analysis of read-across within REACH registration dossiers.

NAMs: beta testing needed

Addressing chemically-induced obesogenic metabolic disruption: selection of chemicals for in vitro human PPARα, PPARγ transactivation, and adipogenesis test methods

An introduction to environmental neurotoxicology: Lessons from a clinical perspective.

Screening (ant)agonistic activities of xenobiotics on the retinoic acid receptor alpha (RARα) using in vitro and in silico analysis

Brief guidelines for zebrafish embryotoxicity tests

Advances in Genomic Toxicology: In vitro Developmental Toxicity Test based on Signal Network Disruption Dynamics

AOP-Anchored Transcriptome Analysis Catalogue Accelerates the Discovery of Environmental Toxicants in Zebrafish.

Understanding Human Health Impacts Following Microplastic Exposure Necessitates Standardized Protocols.

The Implementation Moonshot Project for Alternative Chemical Testing (IMPACT) toward a Human Exposome Project.

Commentaries

Microplastics in the penis.

The Surgical Pathologist’s (Potential) Role in Placental Microplastic Detection.

Editorial: The placenta: the origin of chronic diseases in adults [intro to a research topic in Frontiers in Endocrinology]

Editorial: Next generation chemical risk assessment: integration of advances in toxicology, biology and computation.

Reviews/Meta-Analyses

Numerous Chemicals/Mixtures

Prenatal endocrine-disrupting chemicals exposure and impact on offspring neurodevelopment: A systematic review and meta-analysis.

Liver and Pancreatic Toxicity of Endocrine-Disruptive Chemicals: Focus on Mitochondrial Dysfunction and Oxidative Stress.

The impact of endocrine-disrupting chemicals on stem cells: Mechanisms and implications for human health.

Effect of emerging pollutants on the gut microbiota of freshwater animals: Focusing on microplastics and pesticides.

Regrettable Substitutes and the Brain: What Animal Models and Human Studies Tell Us about the Neurodevelopmental Effects of Bisphenol, Per- and Polyfluoroalkyl Substances, and Phthalate Replacements.

Effects of Endocrine-Disrupting Chemicals on Bone Health.

BPA/Phenols

Maternal bisphenols exposure and thyroid function in children: a systematic review and meta-analysis.

Bisphenol a: Epigenetic effects on the male reproductive system and male offspring.

PFAS

Bacterial degradation of perfluoroalkyl acids.

Flame Retardants

Distribution, transformation, and toxic effects of the flame retardant tetrabromobisphenol S and its derivatives in the environment: A review.

Pesticides

Assessing the Risks of Pesticide Exposure: Implications for Endocrine Disruption and Male Fertility.

Effects of glyphosate exposure on intestinal microbiota, metabolism and microstructure: a systematic review.

Metals/Metalloids

Lithium and endocrine disruption: A concern for human health?

Microplastics/Nanomaterials

Analytical methods, source, concentration, and human risks of microplastics: a review.

A review of the neurobehavioural, physiological, and reproductive toxicity of microplastics in fishes.

Dancing with danger-how honeybees are getting affected in the web of microplastics-a review.

Air Pollution

The association between air pollution and obesity: an umbrella review of meta-analyses and systematic reviews.

Miscellaneous

The effect of information about hazardous chemicals in consumer products on behaviour – A systematic review.

Human Health Studies

Numerous Chemicals/Mixtures

Endocrine-disrupting effects of bisphenol-A, thiamethoxam, and fipronil in hormone-naïve transmen compared to cis-women.

BPA/Phenols

Associations of exposure to bisphenol-A or parabens with markers of liver injury/function among US adults in NHANES 2011-2016.

Phthalates

Phthalate exposure during pregnancy and its association with thyroid hormones: A prospective cohort study.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Associations of serum persistent organic pollutant concentrations with incident diabetes in midlife women: the Study of Women’s Health Across the Nation Multi-Pollutant Study.

Persistent organic pollutants and cognitive decline among middle-aged or older adults in the Hispanic Community Health Study/Study of Latinos.

Effects of dioxin exposure on reproductive and thyroid hormone levels and male sexual function in airbase military workers in Vietnam.

Epigenetic link between Agent Orange exposure and type 2 diabetes in Korean veterans

PFAS

Exposure of women undergoing In-Vitro Fertilization to per-and polyfluoroalkyl substances: Evidence on negative effects on Fertilization and high-quality embryos.

Gene expression patterns associated with PFOA exposure in Czech young men and women.

Flame Retardants

Organophosphate Ester Flame Retardant Chemicals and Maternal Depression During Pregnancy.

Association between brominated flame retardants (PBDEs and PBB153) exposure and hypertension in U.S. adults: results from NHANES 2005-2016.

Individual and joint effects of organophosphate esters and hypertension or diabetes on renal injury among Chinese adults.

Pesticides

Unveiling the link: Neonicotinoids and elevated cardiometabolic risks in Chinese rural residents-from a prospective cohort study combing mendelian randomization study.

The association of isocarbophos and isofenphos with different types of glucose metabolism: The role of inflammatory cells.

Association between organophosphorus insecticides exposure and osteoarthritis in patients with arteriosclerotic cardiovascular disease.

Pre-Conception And First Trimester Exposure To Pesticides And Associations With Stillbirth.

Serum albumin and liver dysfunction mediate the associations between organophosphorus pesticide exposure and hypertension among US adults.

Metals/Metalloids

Dose-response relationship between arsenic in drinking water and mortality of urinary cancers in Taiwan.

Arsenic exposure and oxidative damage to lipid, DNA, and protein among general Chinese adults: A repeated-measures cross-sectional and longitudinal study.

Roles of serum uric acid on the association between arsenic exposure and incident metabolic syndrome in an older Chinese population.

Internal Flames: Metal(loid) Exposure Linked to Alteration of the Lipid Profile in Czech Male Firefighters (CELSPAC-FIREexpo Study).

Microplastics/Nanomaterials

Take-out food enhances the risk of MPs ingestion and obesity, altering the gut microbiome in young adults.

Air Pollution

Home and School Pollutant Exposure, Respiratory Outcomes, and Influence of Historical Redlining.

Long-term exposure to air pollution, road traffic noise and greenness, and incidence of myocardial infarction in women.

Using Parametric g-Computation for Time-to-Event Data and Distributed Lag Models to Identify Critical Exposure Windows for Preterm Birth: An Illustrative Example Using PM2.5 in a Retrospective Birth Cohort Based in Eastern Massachusetts (2011-2016).

Long-term exposure to air pollution, road traffic noise and greenness, and incidence of myocardial infarction in women.

Miscellaneous

Residential Proximity to Oil and Gas Development and Mental Health in a North American Preconception Cohort Study: 2013-2023.

Laboratory Studies

Numerous Chemicals/Mixtures

Impaired memory in Sprague-Dawley rats exposed to complex groundwater mixtures of contaminants is associated with reduced cranial blood flow and hippocampal neurotoxicity.

Synergistic risk in the gut and liver: Insights into the toxic mechanisms and molecular interactions of combined exposure to triazophos and fenvalerate in zebrafish

Developmental dyslexia genes are selectively targeted by diverse environmental pollutants.

BPA/Phenols

Gestational bisphenol A exposure alters energy homeostasis and adult hypothalamic neurogenesis in female mice.

Sexual dimorphism in neurobehavioural phenotype and gut microbial composition upon long-term exposure to structural analogues of bisphenol-A.

Co-occurrence of azorubine and bisphenol A in beverages increases the risk of developmental toxicity: A study in zebrafish model.

Comparison of the Influence of Bisphenol A and Bisphenol S on the Enteric Nervous System of the Mouse Jejunum.

FTO mediates bisphenol F-induced blood-testis barrier impairment through regulating ferroptosis via YTHDF1/TfRc and YTHDF2/SLC7A11 signal axis

Integrated analysis reveals the immunotoxicity mechanism of BPs on human lymphocytes.

Phthalates

Epidemiologically relevant phthalates affect human endometrial cells in vitro through cell specific gene expression changes related to the cytoskeleton and mitochondria.

Using targeted fetal rat testis genomic and endocrine alterations to predict the effects of a phthalate mixture on the male reproductive tract.

Diethyl phthalate and dibutyl phthalate disrupt sirtuins expression in the HepG2 cells.

Identification and Quantification of Acetyl Tributyl Citrate (ATBC) Metabolites Using Human Liver Microsomes and Human Urine.

Parabens/Triclosan/Antimicrobials

Triclosan impairs spermatocyte cell proliferation and induces autophagy by regulating MicroRNA-20a-5P by pargeting PTEN.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Developmental origins of parkinson’s disease risk: perinatal exposure to the organochlorine pesticide dieldrin leads to sex-specific DNA modifications in critical neurodevelopmental pathways in the mouse midbrain.

PFAS

General toxicity and screening of reproductive and developmental toxicity following bioaccumulation of oral-dosed perfluorooctanoic acid: Loss of the Golgi apparatus.

Stereoselective Bioconcentration and Neurotoxicity of Perfluoroethylcyclohexane Sulfonate in Marine Medaka.

Flame Retardants

Insights into Brominated Flame Retardant Neurotoxicity: Mechanisms of Hippocampal Neural Cell Death and Brain Region-Specific Transcriptomic Shifts in Mice.

2,2′,4,4′-Tetrabromodiphenyl ether exposure disrupts blood-testis barrier integrity through CMA-mediated ferroptosis.

Unraveling the anti-androgenic mechanism of tris(2,3-dibromopropyl) isocyanurate (TBC) via the non-classical testosterone pathway and steroidogenesis: potential human reproductive health implications

Elucidating the reproductive toxicity mechanisms in female zebrafish: A transcriptomic study of lifetime tris(2-chloroethyl) phosphate exposure.

Organophosphate flame retardants tris (2-butoxyethyl) phosphate (TBEP) and tris (2-chloroethyl) phosphate (TCEP) disrupt human motor neuron development by differentially affecting their survival and differentiation.

Pesticides

Permethrin exposure impacts zebrafish lipid metabolism via the KRAS-PPAR-GLUT signaling pathway, which is mediated by oxidative stress.

Increased spontaneous activity and progressive suppression of adult neurogenesis in the hippocampus of rat offspring after maternal exposure to imidacloprid.

Glyphosate Exposure Induces Cytotoxicity, Mitochondrial Dysfunction and Activation of ERα and ERβ Estrogen Receptors in Human Prostate PNT1A Cells.

Glyphosate effects on growth and biofilm formation in bee gut symbionts and diverse associated bacteria.

Acute effects of atrazine on the immunoexpressions of Sertoli and germ cells molecular markers, cytokines, chemokines, and sex hormones levels in mice testes and epididymides.

Pesticide exposure triggers sex-specific inter- and transgenerational effects conditioned by past sexual selection.

Microplastics/Nanomaterials

Detection of microplastics in zebrafish housing systems: Can microplastic background contamination affect the final results of microplastic-related toxicological tests?

Integrated transcriptomic and metabolomic analysis reveals the underlying mechanisms for male reproductive toxicity of polystyrene nanoplastics in mouse spermatocyte-derived GC-2spd(ts) cells.

Impact of polystyrene nanoplastics on apoptosis and inflammation in zebrafish larvae: Insights from reactive oxygen species perspective.

Chronic exposure to polystyrene microplastics induced LHR reduction and decreased testosterone levels through NF-κB pathway.

Are recyclable plastics eco-friendly? Recycled PVC microplastics show higher toxicity than pristine PVC on Vallisneria natans, regardless of Cadmium.

Kinetics and toxicity of nanoplastics in ex vivo exposed human whole blood as a model to understand their impact on human health.

Polystyrene Microplastics Causes Diarrhea and Impairs Intestinal Angiogenesis through the ROS/METTL3 Pathway.

Air Pollution

Male-Biased Vulnerability of Mouse Brain Tryptophan/Kynurenine and Glutamate Systems to Adolescent Exposures to Concentrated Ambient Ultrafine Particle Air Pollution.

Gestational Exposure to Air Pollutants Perturbs Metabolic and Placenta-Fetal Phenotype.

Gut microbiota mediates ambient PM_2.5 exposure-induced abnormal glucose metabolism via short-chain fatty acids.

Miscellaneous

Induction of insulin resistance in female mice due to prolonged phenanthrene exposure: unveiling the low-dose effect and potential mechanisms.

Exposure/Environment Studies

Numerous Chemicals/Mixtures

Drinking water source and exposure to regulated water contaminants in the California Teachers Study cohort.

Exposure to pesticides, persistent and non – persistent pollutants in French 3.5-year-old children: Findings from comprehensive hair analysis in the ELFE national birth cohort.

Elimination of microplastics, PFAS, and PPCPs from biosolids via pyrolysis to produce biochar: Feasibility and techno-economic analysis.

BPA/Phenols

Phenolic endocrine-disrupting compounds in the Xiangjiang River: occurrence and risk assessment.

Phthalates

Exploring associations between the Phthalate Environmental Reproductive Health Literacy (PERHL) scale & biomarkers of phthalate exposure: A pilot study.

PFAS

Linear isomer but not branched isomers of perfluorooctane sulfonate in plasma is associated with eicosapentaenoic acid, a seafood consumption biomarker.

Winter Tracking Data Suggest that Migratory Seabirds Transport Per- and Polyfluoroalkyl Substances to Their Arctic Nesting Site.

Accumulation of Per- and Polyfluoroalkyl Substances (PFAS) in Coastal Sharks from Contrasting Marine Environments: The New York Bight and The Bahamas.

Low levels of per- and polyfluoroalkyl substances (PFAS) detected in drinking water in Norway, but elevated concentrations found near known sources.

Surveillance of PFAS in sludge and biosolids at 12 water resource recovery facilities.

Occurrence and potential ecological risks of PFAS in Pampulha Lake, Brazil, a UNESCO world heritage site

Understanding the role of atmospheric deposition on the environmental load of per- and polyfluoroalkyl substances: A case study in Three Gorges Reservoir, China

Deep eutectic solvent-functionalized amorphous UiO-66 for efficient extraction and ultrasensitive analysis of perfluoroalkyl substances in infant milk powder.

Nontarget Analysis of Legacy and Emerging PFAS in a Lithium-Ion Power Battery Recycling Park and Their Possible Toxicity Measured Using High-Throughput Phenotype Screening.

[Risk appraisal of dietary intake of per- and polyfluoroalkyl substances by the Veneto population living in the area with water contamination. Update based on EFSA 2020 limits. Food surveillance campaign 2016-2017]. [in Italian]

Flame Retardants

Understanding Human Health Impacts Following Microplastic Exposure Necessitates Standardized Protocols.

Metals/Metalloids

A Snapshot of Lead in Consumer Products Across Four US Jurisdictions. and related Invited Perspective: Why Aren’t We Doing More to Ensure Consumer Products Are Free of Lead?

Microplastics/Nanomaterials

Percutaneous coronary intervention leads to microplastics entering the blood: Interventional devices are a major source.

Remote Mountainous Area Inevitably Becomes Temporal Sink for Microplastics Driven by Atmospheric Transport.

Influence of agricultural activity in corn farming on airborne microplastic in surrounding elementary school.

Microplastics and Anthropogenic Particles in Recreationally Caught Freshwater Fish from an Urbanized Region of the North American Great Lakes.

Miscellaneous

Tire-derived contaminants 6PPD and 6PPD-Q: analysis, sample handling, and reconnaissance of United States stream exposures.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. The searchable archives are at https://groups.google.com/d/forum/edc_research or online at https://heeds.org/category/edc-science-weekly/. Compiled by Sarah Howard of Healthy Environment and Endocrine Disruptor Strategies (HEEDS), a program of Environmental Health Sciences.

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EHN EHN

Webinar: Ultrashort-chain PFAS: the global threat of trifluoroacetic acid
by Sarah Howard on January 16, 2025 at 3:35 pm
This Feb. 19, 2025 webinar features Dr. Hans Peter Arp discussing TFA, a degradation product of many refrigerants and a widespread contaminant in the environment. Shorter-chain PFAS have been assumed to be less hazardous than longer-chain PFAS, but widespread exposures have not been taken into account in making this assessment. Sponsored by the EDC Strategies Partnership.
Webinar: PFAS and cancer
by Sarah Howard on January 13, 2025 at 4:53 pm
This Jan. 23, 2025 webinar is sponsored by the Health and Environment Alliance and Association of European Cancer Leagues. It will explore links between PFAS and cancer in the context of the International Agency for Research on Cancer (IARC) evaluation and relevant epidemiological data, and features Dr. Tony Fletcher, an environmental epidemiologist and Associate Professor at the London School of Hygiene & Tropical Medicine.
Webinar: Product data for public health: Clearya case studies
by Sarah Howard on January 13, 2025 at 2:55 pm
A variety of tools have been created for collecting consumer product data and making it available for research. This Jan. 30, 2025 webinar will explore one such product. Sponsored by the Collaborative for Health and Environment (CHE).

EHN EHN

Glyphosate exposure linked to lower birth weights and preterm births in rural areas
by EHN Curators on January 21, 2025 at 11:45 am
A new study reveals that maternal exposure to glyphosate, the active ingredient in Roundup, is associated with lower birth weights and shorter pregnancies in rural U.S. communities, disproportionately impacting marginalized groups. Pamela Ferdinand reports for U.S. Right to Know.
Wastewater treatment plants fail to remove most toxic PFAS from drinking water sources
by Katherine McMahon,Sarah Howard on January 17, 2025 at 5:14 pm
Wastewater treatment facilities with technology similar to the plants that serve 70% of the US population are ill-equipped to address contamination from organofluorine chemicals, a class of chemicals that include toxic PFAS, according to recent findings published in the Proceedings of the National Academy of Sciences. “The US Food and Drug Administration’s drug approval process does not consider the environmental persistence and secondary human and ecological exposures to pharmaceuticals….The potential public health consequences of ubiquitous low-level exposures to these compounds require urgent consideration.”
Exposure to common household chemicals linked to bladder cancer in dogs
by Katherine McMahon,Sarah Howard on January 16, 2025 at 6:53 pm
In a recent study published in Environmental Science & Technology, researchers compared levels of chemical exposures between healthy dogs and dogs displaying early signs of bladder cancer. “Our household pets share our daily domestic environment and thus offer opportunities for consideration as sentinel species for exposure related concerns.”

EHN EHN

UK criticized for weak action on toxic PFAS chemicals
by EHN Curators on January 21, 2025 at 11:40 am
Scientists are urging the UK to align with the European Union in regulating PFAS chemicals, which persist in the environment and pose significant health risks. Rachel Salvidge and Leana Hosea report for The Guardian.
EU facing pressure over PFAS ban as chemical industry ramps up lobbying
by EHN Curators on January 16, 2025 at 12:37 pm
A cross-European investigation has revealed how the chemical industry is intensifying efforts to influence the EU’s proposed ban on PFAS chemicals, raising concerns about regulatory delays and environmental harm. Robert Hodgson reports for Euronews.
Industry pushback intensifies against EU proposal to regulate all PFAS chemicals
by EHN Curators on January 15, 2025 at 12:15 pm
A cross-border investigation reveals that industry lobbying efforts, including funded research and exaggerated economic claims, are slowing attempts to regulate PFAS chemicals linked to environmental contamination and health concerns. Rachel Salvidge and Leana Hosea report for The Guardian.