EDC Science Weekly, June 21-27, 2024

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Events, Methods/Tools/Screening, Commentaries, Reviews/Meta-Analyses, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Highlights: “Safe” dose of BPA given to healthy adults increased insulin resistance [abstract]; BPA linked to type 1 diabetes as well; BPA in semen linked to lower sperm count.

More science highlights

Events

July 2 webinar: Mapping Environmental Injustice: Disparities in chemical exposures and neurodevelopmental outcomes [CHE-Alaska]

July 12 and 31: Virtual symposium: Measuring Microplastics register for July 12; register for July 31 [NYU Langone Center for the Investigation of Environmental Hazards (CIEH)]

July 23 webinar: CHE Café: Protecting scientists from industry intimidation [Collaborative for Health and Environment (CHE)]

July 24 webinar: 3M’s decades-long cover-up of the “forever chemicals” in your blood [Beyond Plastics]

Sept. 23-24: Plastics and Human Health Symposium [NYU Center for the Investigation of Environmental Hazards (CIEH), save the date]

Oct. 14-16: 8th Annual meeting of the U.S. DOHaD Society: exploring translational DOHaD science: from cells to communities in Chapel Hill, NC [abstracts due Aug. 1]

Oct. 28: Swiss Symposium on Endocrine Disrupting Chemicals [Food Packaging Forum and ETH Zurich, save the date]

More events

Methods/Tools/Screening

Rapid identification of reproductive toxicants among environmental chemicals using an in vivo evaluation of gametogenesis in budding yeast Saccharomyces cerevisiae.

From molecular descriptors to the developmental toxicity prediction of pesticides/veterinary drugs/bio-pesticides against zebrafish embryo: Dual computational toxicological approaches for prioritization.

Integrated Approach for Testing and Assessment for Developmental Neurotoxicity (DNT) to Prioritize Aromatic Organophosphorus Flame Retardants.

Commentaries

Editorial: Linking environmental exposure to toxicants and chronic disease. [intro to a research topic in Frontiers in Toxicology]

PERHLs of Wisdom: Environmental Reproductive Health Literacy and Phthalates. [Science Selection in EHP]

Microplastics and Metabolism: Physiological Responses in Mice Following Ingestion. [Science Selection in EHP]

Structured expert judgement approach of the health impact of various chemicals and classes of chemicals.

Reviews/Meta-Analyses

Numerous Chemicals/Mixtures

Endocrine disruption and male reproductive disorders: unanswered questions.

Diverse mechanisms by which chemical pollutant exposure alters gut microbiota metabolism and inflammation.

PFAS

Per- and polyfluoroalkyl substances (PFAS) as contaminants in groundwater resources – A comprehensive review of subsurface transport processes.

Flame Retardants

Global Trends and Hotspots in Research on the Health Risks of Organophosphate Flame Retardants: A Bibliometric and Visual Analysis.

Pesticides

Advances in understanding and mitigating Atrazine’s environmental and health impact: A comprehensive review.

Is exposure to pesticides associated with biological aging? A systematic review and meta-analysis.

Does pyrethroid exposure lower human semen quality? a systematic review and meta-analysis

Microplastics/Nanomaterials

Review of microplastics and chemical risk posed by plastic packaging on the marine environment to inform the Global Plastic Treaty.

Microplastics in the human body: A comprehensive review of exposure, distribution, migration mechanisms, and toxicity.

Effects of microplastics on the kidneys: A narrative review.

Microplastics in water resources: Global pollution circle, possible technological solutions, legislations, and future horizon.

Impact of Microplastics on Pregnancy and Fetal Development: A Systematic Review.

Microplastic pollution in the Amazon Basin: Current scenario, advances and perspectives.

Microplastics and climate change; the global impacts of a tiny driver.

Environmental impact of microplastics and potential health hazards.

Miscellaneous

Tire and road wear particles in the aquatic organisms – A review of source, properties, exposure routes, and biological effects.

A Review of N-(1,3-Dimethylbutyl)-N‘-phenyl-p-Phenylenediamine (6PPD) and Its Derivative 6PPD-Quinone in the Environment.

Human Health Studies

Numerous Chemicals/Mixtures

Associations of co-exposure to polycyclic aromatic hydrocarbons and lead (Pb) with IGF1 methylation in peripheral blood of preschool children from an e-waste recycling area.

Association of Prenatal Dietary Toxicants and Inorganic Arsenic Exposure with Children’s Emotional and Behavioral Problems: ECLIPSES Study.

BPA/Phenols

ADA Presidents’ Select Abstract: Oral Bisphenol A Administration Decreased Peripheral Insulin Sensitivity in Healthy Adults [Not published as an article yet but the abstract was presented at American Diabetes Association Scientific Sessions last week and is getting a lot of press]

The potential Association of Bisphenol A exposure and type 1 diabetes mellitus among Dakahlia Governorate’s children sample, Egypt.

High seminal BPA in IVF patients correlates with lower sperm count and up-regulated miR-21 and miR-130a.

The Role of Placental DNA Methylation at Reproduction-Related Genes in Associations between Prenatal Bisphenol Analogues Exposure and the Digit Ratio in Children at Age 4: A Birth Cohort Study.

Association between bisphenol A exposure and cardiometabolic outcomes: A longitudinal approach.

Phthalates

Association between environmental phthalates exposure and gut microbiota and metabolome in dementia with Lewy bodies.

Phthalate and gallstones: the mediation of insulin.

PFAS

Associations of per- and polyfluoroalkyl substances with uterine leiomyomata incidence and growth: a prospective ultrasound study.

Flame Retardants

Nephrotoxicity of organophosphate flame retardants in patients with chronic kidney disease: A 2-year longitudinal study.

Pesticides

Childhood exposure to organophosphate pesticides: functional connectivity and working memory in adolescents.

Relationship of urinary glyphosate concentrations with glycosylated hemoglobin and diabetes in US adults: a cross-sectional study.

Prenatal and childhood neonicotinoid exposure and neurodevelopment: A study in a young Taiwanese cohort.

Metals/Metalloids

Plasma metals, genetic risk, and rapid kidney function decline among type 2 diabetes.

Effects of exposure to multiple metallic elements in the first trimester of pregnancy on the risk of preterm birth.

Association of metals with early postnatal gut microbiota among infants admitted to the neonatal intensive care unit.

Interaction between depression and non-essential heavy metals (Cd, Pb, and Hg) on metabolic diseases.

Associations of Urinary Heavy Metal Mixtures with High Remnant Cholesterol among US Adults: Evidence from the National Health and Nutrition Examination Survey (1998-2018).

Air Pollution

Associations between weekly gestational exposure of fine particulate matter, ozone, and nitrogen dioxide and preterm birth in a North Carolina Birth Cohort, 2003-2015.

Miscellaneous

Inflammatory biomarkers mediate the association between polycyclic aromatic hydrocarbon exposure and dyslipidemia: a national population-based study.

Laboratory Studies

Numerous Chemicals/Mixtures

Investigating phenotypic plasticity due to toxicants with exposure disparities in primary human breast cells in vitro.

BPA/Phenols

Induction of fibrosis following exposure to bisphenol A and its analogues in 3D human uterine leiomyoma cultures.

The Olfactory Receptor Olfr25 Mediates Sperm Dysfunction Induced by Low-Dose Bisphenol A through the CatSper-Ca²⁺ Signaling Pathway.

Bisphenol S Exposure induces Intestinal Inflammation via altering Gut Microbiome.

A novel long non-coding RNA linc-93.2 participates in bisphenol induced oxidative stress and macrophage polarization in red common carp (Cyprinus carpio).

Phthalates

Developmental exposure to environmentally relevant doses of phthalates alters the neural control of male and female reproduction in mice.

DNMT inhibitor, 5-aza-2′-deoxycytidine mitigates di(2-ethylhexyl) phthalate-induced aggravation of psoriasiform inflammation in mice via reduction in global DNA methylation in dermal and peripheral compartments.

AQP1 Deficiency Drives Phthalate-Induced Epithelial Barrier Disruption through Intestinal Inflammation.

Macrophage polarization as a novel endpoint for assessing combined risk of phthalate esters.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Characterization of medaka (Oryzias latipes) AHRs and the comparison of two model fishes-Medaka vs. zebrafish: The subform-specific sensitivity to dioxin.

PFAS

Perinatal exposure to perfluorooctane sulfonate and the risk of hepatic inflammation in rat offspring: Perturbation of gut-liver crosstalk.

Metabolic and phenotypic changes induced by PFAS exposure in two human hepatocyte cell models.

Exposure to PFAS chemicals induces sex-dependent alterations in key rate-limiting steps of lipid metabolism in liver steatosis.

Emerging perfluoroalkyl substances retard skeletal growth by accelerating osteoblasts senescence via ferroptosis.

Exposure to PFAS contaminated urban wetland water causes similar metabolic alterations to laboratory-based exposures in the freshwater amphipod Austrochiltonia subtenuis.

N-glucuronidation and Excretion of Perfluoroalkyl Sulfonamides in Mice Following Ingestion of Aqueous Film-Forming Foam.

Flame Retardants

GC/MS-Based Metabolomic Analysis of A549 Cells Exposed to Emerging Organophosphate Flame Retardants.

Organotins

Responses of zebra and quagga mussels to copper and tribytiltin exposure: Bioconcentration, metabolic and cardiac biomarkers.

Pesticides

Simulated climate change and atrazine contamination can synergistically impair zebrafish testicular function.

The endocrine disruptor vinclozolin causes endothelial injury via eNOS/Nox4/IRE1α signaling.

Long-term exposure of metamifop affects sex differentiation and reproductive system of zebrafish (Danio rerio).

Ameliorative potentials of diosmin and hesperidin fractions on chlorpyriphos-induced changes in reproductive hormones, sperm characteristics, and testicular glycogen in male Wistar rats.

Exploring Microbiota-Gut-Brain Axis Biomarkers Linked to Autism Spectrum Disorder in Prenatally Chlorpyrifos-Exposed Fmr1 Knock-Out and Wild-Type Male Rats.

Roundup^® induces premature senescence of mouse granulosa cells via mitochondrial ROS-triggered NLRP3 inflammasome activation.

Evaluation of behavioral and neurochemical changes induced by carbofuran in zebrafish (Danio rerio).

Metals/Metalloids

Trace elements alone or in mixtures associated with unconventional natural gas exploitation affect rat fetal steroidogenesis and testicular development in vitro.

Arsenic exposure at environmentally relevant levels induced metabolic toxicity in development mice: Mechanistic insights from integrated transcriptome and metabolome.

Zn(II)-curcumin prevents cadmium-aggravated diabetic nephropathy by regulating gut microbiota and zinc homeostasis.

Subchronic intake of arsenic at environmentally relevant concentrations causes histological lesions and oxidative stress in the prostate of adult Wistar rats.

The response of gut microbiota to arsenic metabolism is involved in arsenic-induced liver injury, which is influenced by the interaction between arsenic and methionine synthase.

Microplastics/Nanomaterials

Thyroid and parathyroid function disorders induced by short-term exposure of microplastics and nanoplastics: Exploration of toxic mechanisms and early warning biomarkers.

Neonatal Exposure to Polystyrene Nanoplastics Impairs Microglia-Mediated Synaptic Pruning and Causes Social Behavioral Defects in Adulthood.

Evidence that microplastics at environmentally relevant concentration and size interfere with energy metabolism of microalgal community.

Nanoplastic-Induced Liver Damage Was Alleviated by Maltol via Enhancing Autophagic Flow: An In Vivo and In Vitro Study.

Polystyrene Nanoplastics Induce Lipid Metabolism Disorder by Activating the PERK-ATF4 Signaling Pathway in Mice.

Nanoplastics trigger the aging and inflammation of porcine kidney cells.

Miscellaneous

The potential impact of 6PPD and its oxidation product 6PPD-quinone on human health: A case study on their interaction with human serum albumin.

Effects of 6PPD-Quinone on Human Liver Cell Lines as Revealed with Cell Viability Assay and Metabolomics Analysis.

Benzo[a]pyrene exposure disrupts the organelle distribution and function of mouse oocytes.

Exposure/Environment Studies

Numerous Chemicals/Mixtures

Emerging investigator series: nontargeted screening of aryl hydrocarbon receptor agonists in endangered beluga whales from the St. Lawrence Estuary: beyond legacy contaminants.

Nontarget and suspect screening reveals the presence of multiple plastic related compounds in polar bear, killer whale, narwhal and long-finned pilot whale blubber from East Greenland.

Polyamide 6 microplastics as carriers led to changes in the fate of bisphenol A and dibutyl phthalate in drinking water distribution systems: The role of adsorption and interfacial partitioning.

BPA/Phenols

Assessing dietary bisphenol A exposure among Koreans: comprehensive database construction and analysis using the Korea National Health and Nutrition Examination Survey.

Phthalates

Silicone wristbands reveal ubiquitous human exposure to ortho-phthalates and non-ortho-phthalate plasticizers in Southern California.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Blood levels of persistent organic pollutants among women in France in the 90’s: main profiles and individual determinants.

Human biomonitoring of PCDDs, PCDFs, and PCBs in women living in a Northern Italy industrial area.

PFAS

Machine learning predicts the serum PFOA and PFOS levels in pregnant women: Enhancement of fatty acid status on model performance.

Measuring short-chain per- and polyfluoroalkyl substances in Central New Jersey air using chemical ionization mass spectrometry.

PFAS-Contaminated Pesticides Applied near Public Supply Wells Disproportionately Impact Communities of Color in California.

Non-Targeted PFAS Suspect Screening and Quantification of Drinking Water Samples Collected through Community Engaged Research in North Carolina’s Cape Fear River Basin.

Pesticides

Reassuring Quantitative Analysis of Glyphosate and Aminomethylphosphonic Acid Levels in Breast Milk Using Liquid Chromatography Mass Spectrometry.

Widespread occurrence of pesticides in low-income housing.

A global assessment of glyphosate and AMPA inputs into rivers: Over half of the pollutants are from corn and soybean production.

Metals/Metalloids

Residential proximity to toxic metal-emitting industrial sites and toenail metal concentrations in a United States-wide prospective cohort.

Microplastics/Nanomaterials

Microplastics in feed affect the toxicokinetics of persistent halogenated pollutants in Atlantic salmon.

Miscellaneous

Emerging N-(1,3-dimethylbutyl)-N’-phenyl-p-phenylenediamine (6PPD) and 6PPD quinone in paired human plasma and urine from Tianjin, China: Preliminary assessment with demographic factors.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. The searchable archives are at https://groups.google.com/d/forum/edc_research or online at https://heeds.org/category/edc-science-weekly/. Compiled by Sarah Howard of Healthy Environment and Endocrine Disruptor Strategies (HEEDS), a program of Environmental Health Sciences.

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