EDC Science Weekly, May 31 – June 6, 2024

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Events, Regulations/Policy, Methods/Tools/Screening, Commentaries, Reviews/Meta-Analyses, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Highlights: Phthalates and hormones during perimenopause; including drinking water source and testing questions into electronic medical records; migration of EDCs from plastic food packaging … and from plant-based food packaging.

More science highlights

Events

June 6 webinar: PFAS: federal drinking water standards & opportunities for nursing action [Alliance of Nurses for Healthy Environments (ANHE) Policy & Advocacy Committee]

June 10 webinar: Exploring the impact of endocrine disruptors on human health [International Society of Endocrinology (ISE) and the European Society of Endocrinology (ESE)]

June 10-11 workshop: Complementary and integrative interventions to prevent and mitigate the effects of endocrine-disrupting chemicals [NCCIH]

June 10-12: National PFAS Conference in Ann Arbor, MI

June 12: Endocrine disruptors interactive workshop [In Brussels and online. EndocRine Guideline Optimisation (ERGO)]

June 13-14: EURION final event [In Brussels and online. European Cluster to Improve Identification of Endocrine Disruptors (EURION)]

June 18 webinar: Research needs for protecting human health and the environment – an EU agencies’ perspective [ECHA]

June 23-28: Gordon Research Conference on EDCs in Tuscany, Italy

June 25 webinar: Micro- and Nanoplastics and Public Health: EU research findings [EDC Strategies Partnership]

July 2 webinar: Mapping Environmental Injustice: Disparities in chemical exposures and neurodevelopmental outcomes [CHE-Alaska]

July 12 and 31: Virtual symposium: Measuring Microplastics register for July 12; register for July 31 [NYU Langone Center for the Investigation of Environmental Hazards (CIEH)]

Aug. 5-8: DOHaD summer course in Portland, OR [OHSU Center for Developmental Health]

Sept. 23-24: Plastics and Human Health Symposium [NYU Center for the Investigation of Environmental Hazards (CIEH), save the date]

Oct. 14-16: 8th Annual meeting of the U.S. DOHaD Society: exploring translational DOHaD science: from cells to communities in Chapel Hill, NC [abstracts due Aug. 1]

More events

Regulations/Policy

A UK Framework for the Assessment and Integration of Different Scientific Evidence Streams in Chemical Risk Assessment.

Battling Environmental Racism in Cancer Alley: A Legislative Approach.

More EDC policy and regulations open for comment

Methods/Tools/Screening

Inclusion of Drinking Water Source and Testing Questions into Electronic Medical Records: Advancing Environmental Medicine and Public Health Outreach in New Jersey.

Creation of an international laboratory network towards global microplastics monitoring harmonisation.

The generation gap in endocrine disruption: Can the integrated fish endocrine disruptor test (iFEDT) bridge the gap by assessing intergenerational effects of thyroid hormone system disruption?

Biological variability hampers the use of skeletal staining methods in zebrafish embryo developmental toxicity assays.

Advancing Nanomaterial Toxicology Screening Through Efficient and Cost-Effective Quantitative Proteomics.

The use of effect biomarkers in chemical mixtures risk assessment – Are they still important?

Determination of OTNE-Induced Thyroid Effects within an Adverse Outcome Pathway (AOP) Network.

Suspension of micro- and nanoplastic test materials: liquid compatibility, (bio)surfactants, toxicity and environmental relevance.

ChemFREE: a one-stop comprehensive platform for ecological and environmental risk evaluation of chemicals in one health world.

Zebrafish and nematodes as whole organism models to measure developmental neurotoxicity.

A workflow to practically apply true dose considerations to in vitro testing for next generation risk assessment

Commentaries

Synergy under the Sun? Nanoplastics Enhance Estrogenicity of Common UV-Blocker. [Science Selection in EHP]

Microplastics: An orthodontic concern!

Reviews/Meta-Analyses

Numerous Chemicals/Mixtures

The Known and Unknown: Investigating the Carcinogenic Potential of Plastic Additives.

Estrogenic compounds in drinking water: A systematic review and risk analysis.

Hazard identification of endocrine-disrupting carcinogens (EDCs) in relation to cancers in humans.

BPA/Phenols

Mechanistic Insights into Bisphenol A-Mediated Male Infertility: Potential Role of Panax Ginseng Extract.

Food contamination from packaging material with special focus on the Bisphenol-A.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Global dioxin research trends and focal points: A century-long visual and bibliometric analysis (1923-2022).

Flame Retardants

Reviewing the current state of legacy POP-brominated flame retardants in plastic childcare products and toys: a scoping review protocol.

Pesticides

Endocrine toxicity of atrazine and its underlying mechanisms.

Toxicological evaluation of microbial secondary metabolites in the context of European active substance approval for plant protection products.

Metals/Metalloids

Heavy metals toxicity on epigenetic modifications in the pathogenesis of Alzheimer’s disease (AD).

Microplastics/Nanomaterials

Advances of microplastics ingestion on the morphological and behavioral conditions of model zebrafish: A review.

Groundwater systems under siege: The silent invasion of microplastics and cock-tails worldwide.

Air Pollution

Prenatal exposure to ambient air pollution and risk of fetal overgrowth: Systematic review of cohort studies.

Miscellaneous

Navigating the environmental dynamics, toxicity to aquatic organisms and human associated risks of an emerging tire wear contaminant 6PPD quinone.

A raising alarm on the current global electronic waste situation through bibliometric analysis, life cycle, and techno-economic assessment: a review.

Narrative review of occupational exposures and noncommunicable diseases.

Human Health Studies

BPA/Phthalates

Phthalates and sex steroid hormones across the perimenopausal period: A longitudinal analysis of the Midlife Women’s Health Study.

Evaluating associations of bisphenol and phthalate exposure with time to pregnancy and subfecundity in a New York City pregnancy cohort.

Phthalate and phthalate replacement concentrations in relationship to adiposity in a multi-racial cohort of children.

Maternal pre-pregnancy BMI influences the associations between bisphenol and phthalate exposures and maternal weight changes and fat accumulation.

The relationship between bisphenol A and phthalates with precocious puberty in Vietnamese children.

Exploring the relationships between exposure levels of bisphenols and phthalates and prostate cancer occurrence.

Association of vitamin D and bisphenol A levels with cardiovascular risk in an elderly Italian population: results from the InCHIANTI study.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Potential lethality of organochlorine pesticides: Inducing fatality through inflammatory responses in the organism.

PFAS

Association of co-exposure to organophosphate esters and per- and polyfluoroalkyl substances and mixture with cardiovascular-kidney-liver-metabolic biomarkers among Chinese adults.

Metals/Metalloids

The evolution of symptoms of nervous system dysfunction in a First Nation community with a history of mercury exposure: a longitudinal study.

Microplastics/Nanomaterials

Features, Potential Invasion Pathways, and Reproductive Health Risks of Microplastics Detected in Human Uterus.

Air Pollution

Air pollution from biomass burning disrupts early adolescent cortical microarchitecture development.

Arachidonic Acid Metabolites in Self-collected Biospecimens Following Campfire Exposure: Exploring Non-invasive Biomarkers of Wildfire Health Effects.

Type 2 diabetes attributable to ambient particulate matter pollution: a global burden study from 1990 to 2019.

Pharmaceuticals/Personal Care Products

Maternal intake of paracetamol during pregnancy and biomarkers of male fecundity in young adult sons.

Prenatal exposure to benzophenone-type UV filters and the associations with neonatal birth outcomes and maternal health in south China.

Miscellaneous

Urinary haloacetic acid concentrations in relation to sex and thyroid hormones among reproductive-aged men.

Laboratory Studies

Numerous Chemicals/Mixtures

Time-course of oral toxicity to contaminated groundwater in male Sprague Dawley rats.

Chemical mixture effects on the simplified human intestinal microbiota: Assessing xenobiotics at environmentally realistic concentrations.

Effects of Developmental Lead and Phthalate Exposures on DNA Methylation in Adult Mouse Blood, Brain, and Liver: A Focus on Genomic Imprinting by Tissue and Sex.

Epigenetic footprints: Investigating placental DNA methylation in the context of prenatal exposure to phenols and phthalates.

BPA/Phenols

Exploring the mechanisms underlying effects of bisphenol a on cardiovascular disease by network toxicology and molecular docking.

Exposure to BPA and BPS during pregnancy disrupts the bone mineralization in the offspring.

Analysis of environmental pollutant Bisphenol F elicited prostate injury targets and underlying mechanisms through network toxicology, molecular docking, and multi-level bioinformatics data integration.

Rsad2 mediates Bisphenol A-induced actin cytoskeletal disruption in mouse spermatocytes.

Upregulation of GOLPH3 mediated by Bisphenol a promotes colorectal cancer proliferation and migration: evidence based on integrated analysis.

Lignin-Derivable Alternatives to Bisphenol A with Potentially Undetectable Estrogenic Activity and Minimal Developmental Toxicity.

Phthalates

Maternal Di-(2-ethylhexyl)-Phthalate exposure during pregnancy altered energy metabolism in immature offspring and caused hyperglycemia.

Toxicity assessment of di(2-ethylhexyl) phthalate using zebrafish embryos: Cardiotoxic potential.

Oxidative damage to mitochondrial DNA in maternal zebrafish (Danio rerio) exposed to dibutyl phthalate at environmentally relevant level.

Mitigation of benzyl butyl phthalate toxicity in male germ cells with combined treatment of parthenolide, N-acetylcysteine, and 3-methyladenine.

Parabens/Triclosan/Antimicrobials

Neurotoxic effects of triclosan in adolescent mice: Pyruvate kinase M2 dimer regulated signal transducer and activator of transcription 3 phosphorylation mediated microglia activation and neuroinflammation.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

TCDD (2,3,7,8–p-dioxin) induces depression-like phenotype.

PFAS

Thyroid disrupting effects and the developmental toxicity of hexafluoropropylene oxide oligomer acids in zebrafish during early development.

Multi-omics reveals the molecular mechanism of the combined toxic effects of PFOA and 4-HBP exposure in MCF-7 cells and the key player: mTORC1.

Caspase-8 promotes NLRP3 inflammasome activation mediates eye development defects in zebrafish larvae exposed to perfulorooctane sulfonate (PFOS).

Single-cell transcriptomics reveal the microenvironment landscape of perfluorooctane sulfonate-induced liver injury in female mice.

Perfluorooctanoic acid triggers premature ovarian insufficiency by impairing NAD+ synthesis and mitochondrial function in adult zebrafish.

Developmental PFOS exposure alters lung inflammation and barrier integrity in juvenile mice.

Flame Retardants

Characterizing the effects of Dechlorane Plus on β-cells: a comparative study across models and species.

An in Silico Study on Human Carcinogenicity Mechanism of Polybrominated Biphenyls Exposure.

Toxicity comparison and risk assessment of two chlorinated organophosphate flame retardants (TCEP and TCPP) on Polypedates megacephalus tadpoles.

Specific human CYP enzymes-dependent mutagenicity of tris(2-butoxyethyl) phosphate (an organophosphorus flame retardant) in human and hamster cell lines.

Pesticides

Assessing the impact of imidacloprid, glyphosate, and their mixtures on multiple biomarkers in Corbicula largillierti.

Effects of the glyphosate-based herbicide Roundup on C. elegans and S. cerevisiae mortality, reproduction, and transcription fidelity.

Metals/Metalloids

Resveratrol Alleviates Arsenic Exposure-Induced Liver Fibrosis in Rats by Inhibiting Hepatocyte Senescence.

Effects of developmental exposure to arsenic species on behavioral stress responses in larval zebrafish and implications for stress-related disorders.

Microplastics/Nanomaterials

Bisphenol A sorption on commercial polyvinyl chloride microplastics: Effects of UV-aging, biofilm colonization and additives on plastic behavior in the environment.

Probing Long-Term Impacts: Low-Dose Polystyrene Nanoplastics Exacerbate Mitochondrial Health and Evoke Secondary Glycolysis via Repeated and Single Dosing.

Generation and Fate of Nanoplastics in the Intestine of Plastic-Degrading Insect (Tenebrio molitor Larvae) during Polystyrene Microplastic Biodegradation.

Aged polystyrene microplastics cause reproductive impairment via DNA-damage induced apoptosis in Caenorhabditis elegans.

Understanding the Ecological Robustness and Adaptability of the Gut Microbiome in Plastic-Degrading Superworms (Zophobas atratus) in Response to Microplastics and Antibiotics.

The impact of microplastics polystyrene on the microscopic structure of mouse intestine, tight junction genes and gut microbiota.

Air Pollution

Fine particulate matter disrupts bile acid homeostasis in hepatocytes via binding to and activating farnesoid X receptor.

Episodic ozone exposure in Long-Evans rats has limited effects on cauda sperm motility and non-coding RNA populations.

Miscellaneous

Study of endocrine disruptor effects in AVP and OT mediated behavioral and reproductive processes in female rat models.

Exposure/Environment Studies

Numerous Chemicals/Mixtures

Migration of endocrine and metabolism disrupting chemicals from plastic food packaging.

Plant-based food contact materials: presence of hazardous substances.

Non-targeted identification and risk assessment of unknown substances in disposable plastic tableware by GC-Orbitrap HRMS.

Contaminant assessment of stranded and deceased beaked whales (Ziphiidae) on the New South Wales coast of Australia.

Spatiotemporal variations and risk assessment of estrogens in the water of the southern Bohai Sea: A comprehensive investigation spanning three years.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Environmental contaminants in Arctic human populations: Trends over 30 years.

Transcriptomic and developmental effects of persistent organic pollutants in sentinel fishes collected near an arctic formerly used defense site.

Atmospheric Concentrations and Potential Sources of Dioxin-Like Contaminants to Acadia National Park.

PFAS

Levels and spatial profile of per- and polyfluoroalkyl substances in edible shrimp products from Japan and neighboring countries; a potential source of dietary exposure to humans.

Impact of tightening environmental regulations against long-chain perfluoroalkyl acids on composition of durable water repellents containing side-chain fluorinated polymers.

Four Decades of Spatiotemporal Variability of Per- and Polyfluoroalkyl Substances (PFASs) in the Baltic Sea.

Analysis of Legacy and Novel Neutral Per- and Polyfluoroalkyl Substances in Soils from an Industrial Manufacturing Facility.

Legacy and emerging per- and polyfluoroalkyl substances (PFASs) in agricultural soils affected by fluorochemical manufacturing facilities, North China: Occurrence, region-specific distribution, substitution trend and source appointment.

Spatial and temporal distribution of perfluoroalkyl substances (PFAS) detected after an aqueous film forming foam (AFFF) spill.

Flame Retardants

Children’s exposure to halogenated flame retardants and organophosphate esters through dermal absorption and hand-to-mouth ingestion in Swedish preschools.

Organotins

Bioaccumulation of organotin compounds in the marbled electric ray (Torpedo marmorata) in the northern Adriatic Sea.

Pesticides

The mother-offspring transfer of chlorothalonil through human breast milk: A multi-city cross-sectional study.

Occurrence and distribution of pesticides and transformation products in ambient air in two European agricultural areas.

Results from the Danish monitoring programme on pesticide residues from the period 2012-2017 – frequencies and trends in detected pesticides.

Field agrochemical exposure impacts locomotor activity in wild bumblebees.

Metals/Metalloids

Comparison of carbon, nitrogen, and oxygen stable isotope ratios and mercury concentrations in muscle tissues of five beaked whale species and sperm whales stranded in Hokkaido, Japan.

Microplastics/Nanomaterials

Microplastics in Arctic waters of the Finnish Sámi area.

Kelp Forest Food Webs as Hot Spots for the Accumulation of Microplastic and Polybrominated Diphenyl Ether Pollutants.

Miscellaneous

Assessing the aging and environmental implications of polyethylene mulch films in agricultural land.

——-

This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. The searchable archives are at https://groups.google.com/d/forum/edc_research or online at https://heeds.org/category/edc-science-weekly/. Compiled by Sarah Howard of Healthy Environment and Endocrine Disruptor Strategies (HEEDS), a program of Environmental Health Sciences.

If you enjoy this newsletter, please feel free to donate here! Thank you!