EDC Science Weekly, May 10-16, 2024

Post author:HEEDS
Post published:May 16, 2024
Post category:EDC Science Weekly

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Events, Regulations/Policy, Methods/Tools/Screening, Commentaries, Reviews/Meta-Analyses, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Highlights: Using PFAS and chemical waste to store data; impacts of heat and wildfire on preterm birth; first reported microplastics in prostate; microplastics in human and dog testes and fertility.

More science highlights

Events

May-June webinars: FREIA end-of-project webinar series [Female Reproductive toxicity of EDCs: a human evidence-based screening and Identification Approach (FREIA) Project]

May 20 symposium: Brain and environment [Univ of Rochester/in Washington DC]

May 20-21 Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM) Public Forum, plus a May 22 training session on NTP’s Integrated Chemical Environment.

May 21 seminar: Silent Spring 2.0: Adverse impacts of neonicotinoid pesticides on human and wildlife health [CACHET and EHS/HEEDS. Virtual and in-person in Chicago. See the ChicAgo Center for Health and EnvironmentT (CACHET) website for additional seminars.]

May 21: ISCHE Research to Action project showcase [International Society for Children’s Health and the Environment (ISCHE) R2A Project]

May 23 webinar: ECOTOXicology Knowledgebase: Update with Ecologically Relevant Data for Emerging Contaminants [EPA]

May 29: Webinaire dédié au rassemblement de la communauté française sur les perturbateurs endocriniens [in French]

June 2 webinar: Greenwashing 2.0: Debunking recycling myths [Plastic Pollution Coalition]

June 10-11 workshop: Complementary and integrative interventions to prevent and mitigate the effects of endocrine-disrupting chemicals [NCCIH]

June 10-12: National PFAS Conference in Ann Arbor, MI

June 18 webinar: Research needs for protecting human health and the environment – an EU agencies’ perspective [ECHA]

June 23-28: Gordon Research Conference on EDCs in Tuscany, Italy

Aug. 5-8: DOHaD summer course in Portland, OR [OHSU Center for Developmental Health]

Oct. 14-16: 8th Annual meeting of the U.S. DOHaD Society: exploring translational DOHaD science: from cells to communities in Chapel Hill, NC [abstracts due Aug. 1]

More events

Regulations/Policy

Statement on the assessment of quality of data available to EFSA to derive the health-based guidance values for carbendazim.

More EDC policy and regulations open for comment

Methods/Tools/Screening

New approach methods to assess developmental and adult neurotoxicity for regulatory use: a PARC work package 5 project.

Ensemble multiclassification model for predicting developmental toxicity in zebrafish.

Smartphone microscopic method for imaging and quantification of microplastics in drinking water.

Comparing Transcriptomic Points of Departure to Apical Effect Concentrations For Larval Fathead Minnow Exposed to Chemicals with Four Different Modes Of Action.

Screening and characterization of 133 physiologically-relevant environmental chemicals for reproductive toxicity.

Commentaries

Editorial: Hazardous pollutants in agricultural soil and environment. [intro to a research topic in Frontiers in Microbiology]

Letter to the editor regarding Hall et al. (2023): Fluoride exposure and hypothyroidism in a Canadian pregnancy cohort.

Reviews/Meta-Analyses

Numerous Chemicals/Mixtures

The Impact of the Aryl Hydrocarbon Receptor on Antenatal Chemical Exposure-Induced Cardiovascular-Kidney-Metabolic Programming.

Environmental exposure and child health in China.

BPA/Phenols

A prioritization strategy for functional alternatives to bisphenol A in food contact materials.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Global trends of dioxin and dioxin-like PCBs in animal-origin foods: a systematic review and gap areas.

PFAS

Systematic review and meta-analysis of birth weight and perfluorohexane sulfonate exposures: examination of sample timing and study confidence.

Effects of PFAS on human liver transporters: implications for health outcomes.

Systematic evidence mapping of potential correlates of exposure for per- and poly-fluoroalkyl substances (PFAS) based on measured occurrence in biomatrices and surveys of dietary consumption and product use.

The perils of poly- and perfluorinated chemicals on the reproductive health of humans, livestock, and wildlife.

Pesticides

Was the Massive Increase in Use of Teratogenic Agrichemicals in Western States (USA) Associated with Declines in Wild Ruminant Populations between 1994 and 2013?

Metals/Metalloids

Guardians of the Gut: Harnessing the Power of Probiotic Microbiota and Their Exopolysaccharides to Mitigate Heavy Metal Toxicity in Human for Better Health.

The Impact of Thallium Exposure in Public Health and Molecular Toxicology: A Comprehensive Review.

Microplastics/Nanomaterials

Important Factors Affecting Induction of Cell Death, Oxidative Stress and DNA Damage by Nano- and Microplastic Particles In Vitro.

Immunotoxicity of microplastics in fish.

Understanding the links between micro/nanoplastics-induced gut microbes dysbiosis and potential diseases in fish: A review.

Microplastics and PAHs mixed contamination: An in-depth review on the sources, co-occurrence, and fate in marine ecosystems.

A systematic review of microplastics emissions in kitchens: Understanding the links with diseases in daily life.

Miscellaneous

What is driving the global decline of human fertility? Need for a multidisciplinary approach to the underlying mechanisms.

Human Health Studies

Numerous Chemicals/Mixtures

Environmental Pollutant Risk Factors for Worse COVID-19 Related Clinical Outcomes in Predominately Hispanic and Latino Populations. [PFAS and metals]

Fetal and Infancy Exposure to Phenols, Parabens, and Phthalates and Anthropometric Measurements up to 36 Months, in the Longitudinal SEPAGES Cohort.

Fetal bisphenol and phthalate exposure and early childhood growth in a New York City birth cohort.

Vitamin D Deficiency Exacerbates Poor Sleep Outcomes with Endocrine-Disrupting Chemicals Exposure: A Large American Population Study.

Individual and mixture analyses of the associations of phenols and phthalates with lung function among US adults.

BPA/Phenols

Environmental triggers of autoimmunity: The association between bisphenol analogues and systemic lupus erythematosus.

Interference of Bisphenol A on Cumulus Cells Development and Number of Retrieved Mature Oocytes in Unexpected Poor Ovarian Response Women: A Prospective Cohort Study.

Phthalates

Phthalate exposure and subfecundity in preconception couples: A nested case-control study.

Associations between exposure to phthalates and liver function among women undergoing assisted reproductive technology.

Associations of phthalates with accelerated aging and the mitigating role of physical activity.

Extracellular Vesicles in Environmental Toxicological Studies: Association between Urinary Concentrations of Phthalate Metabolites and Exosomal miRNA Expression Profiles.

Association of phthalate metabolites with periodontitis: a population-based study.

Parabens

Association between parabens exposure and neurodevelopment in children.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Impacts of dioxin exposure on brain connectivity estimated by DTI analysis of MRI images in men residing in contaminated areas of Vietnam.

PFAS

Per- and polyfluoroalkyl substances (PFAS) and fetal growth: A nation-wide register-based study on PFAS in drinking water.

Pesticides

Malathion exposure may increase infertility risk among US Adults: Results from the 2015-2016 NHANES.

Metals/Metalloids

Associations between plasma metabolites and heavy metal exposure in residents of environmentally polluted areas.

A comparative study of urinary levels of multiple metals and neurotransmitter correlations between GDM and T2DM populations.

Associations among neighborhood walkability, metal exposure, and sex steroid hormone levels: Results from Hangzhou Birth Cohort Study Ⅱ.

Early life exposure to mercury and relationships with telomere length and mitochondrial DNA content in European children.

Influence of folic acid and vitamin B12 supplementation on arsenic methylation: A double-blinded, placebo-controlled trial in Bangladeshi children.

Microplastics/Nanomaterials

Microplastic presence in dog and human testis and its potential association with sperm count and weights of testis and epididymis.

Air Pollution

Impacts of heat and wildfire on preterm birth.

Gestational and Postpartum Exposure to PM_2.5 Components and Glucose Metabolism in Chinese Women: A Prospective Cohort Study.

Associations of Ambient Particulate Matter with Maternal Thyroid Autoimmunity and Thyroid Function in Early Pregnancy.

Relationship of long-term exposure to air pollutant mixture with metabolic-associated fatty liver disease and subtypes: A retrospective cohort study of the employed population of Southwest China.

Laboratory Studies

Numerous Chemicals/Mixtures

Repurposing Waste Chemicals for Sustainable and Durable Molecular Data Storage.

Effects of Environmental Enrichment on Exposure to Human-Relevant Mixtures of Endocrine Disrupting Chemicals in Zebrafish.

BPA/Phenols

Sex-specific impacts of prenatal bisphenol A exposure on genes associated with cortical development, social behaviors, and autism in the offspring’s prefrontal cortex.

VD₃/VDR attenuates bisphenol A-induced impairment in mouse Leydig cells via regulation of autophagy.

Comparative toxicological assessment of two bisphenols using a systems approach: Evaluation of the behavioral and transcriptomic responses of Danio rerio to Bisphenol A and Tetrabromobisphenol A.

Experimental Model Exposed to Bisphenol and Submitted to a High-Fat Diet and Related Morphologic Testicular Parameters Alterations Analysis.

Phthalates

Protective Effects of Polysaccharide of Atractylodes Macrocephala Koidz against Porcine Aortic Valve Endothelial Cells Damage Induced by di (2-ethylhexyl) Phthalate.

Single-Cell Insights into Mouse Testicular Toxicity under Peripubertal Exposure to Di(2-ethylhexyl) phthalate.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Transcriptomic analysis of AHR wildtype and Knock-out rat livers supports TCDD’s role in AHR/ARNT-mediated circadian disruption and hepatotoxicity.

Proinflammatory microglial response is a common mechanism of Aroclor 1254- and Tetrabromobisphenol-A-induced neurotoxicity in immature chronically exposed rats.

PFAS

Can Bees Detect Perfluorooctane Sulfonate (PFOS)?

Regulating the absorption and excretion of perfluorooctane sulfonate and its alternatives through influencing enterohepatic circulation.

Unveiling the intricate connection between per- and polyfluoroalkyl substances and prostate hyperplasia.

Multi-omics reveal disturbance of glucose homeostasis in pregnant rats exposed to short-chain perfluorobutanesulfonic acid.

Do PFCAs drive the establishment of thyroid cancer microenvironment? Effects of C6O4, PFOA and PFHxA exposure in two models of human thyroid cells in primary culture.

Pesticides

Linking pesticide exposure to neurodegenerative diseases: An in vitro investigation with human neuroblastoma cells.

Ameliorative impacts of astaxanthin against atrazine-induced renal toxicity through the modulation of ionic homeostasis and Nrf2 signaling pathways in mice.

Vitamin E alleviates chlorpyrifos induced glutathione depletion, lipid peroxidation and iron accumulation to inhibit ferroptosis in hepatocytes and mitigate toxicity in Zebrafish.

Metabolic perturbations in zebrafish (Danio rerio) larvae exposed to sulfentrazone and imidacloprid.

VGluT2 neuron subtypes in the paraventricular thalamic nucleus regulate depression in paraquat-induced Parkinson’s disease.

Prenatal exposure to ethion caused maternal and foetal toxicity in rats.

Beta-cyfluthrin impairs implantation process by inducing mitochondrial defects and changes in reactive oxygen species-mediated signaling pathways in porcine trophectoderm and uterine luminal epithelial cells.

Life cycle assessment of hepatotoxicity induced by cyhalofop-butyl in environmental concentrations on zebrafish in light of gut-liver axis.

Prenatal exposure to fenvalerate causes depressive-like behavior in adulthood by inhibiting brain-derived 5-HT synthesis.

Exposure to atrazine and endosulfan alters oviductal adenogenesis in the broad-snouted caiman (Caiman latirostris).

Uncovering hidden dangers: The combined toxicity of abamectin and lambda-cyhalothrin on honey bees.

Metals/Metalloids

Down-regulation of O-GlcNAcylation alleviates insulin signaling pathway impairment following arsenic exposure via suppressing the AMPK/mTOR-autophagy pathway.

Microplastics/Nanomaterials

Interfacial Interactions between Nanoplastics and Biological Systems: toward an Atomic and Molecular Understanding of Plastics-Driven Biological Dyshomeostasis.

Polystyrene microplastics induce male reproductive toxicity in mice by activating spermatogonium mitochondrial oxidative stress and apoptosis.

Ferroptosis: First evidence in premature duck ovary induced by polyvinyl chloride microplastics.

Impact of the Oral Administration of Polystyrene Microplastics on Hepatic Lipid, Glucose, and Amino Acid Metabolism in C57BL/6Korl and C57BL/6-Lep^em1hwl/Korl Mice.

Nanoplastics Penetrate Human Bronchial Smooth Muscle and Small Airway Epithelial Cells and Affect Mitochondrial Metabolism.

Exposure to polystyrene nanoplastics induces hepatotoxicity involving NRF2-NLRP3 signaling pathway in mice.

In vitro digestion of microplastics in human digestive system: Insights into particle morphological changes and chemical leaching.

Microplastic exposure is associated with epigenomic effects in the model organism Pimephales promelas (fathead minnow).

Correspondence on “Assessing the Release of Microplastics and Nanoplastics from Plastic Containers and Reusable Food Pouches: Implications for Human Health”. and the response.

Miscellaneous

The lethal and sublethal impacts of two tire rubber-derived chemicals on Brook trout (Salvelinus fontinalis) fry and fingerlings.

Exposure to 6-PPD quinone causes damage on mitochondrial complex I/II associated with lifespan reduction in Caenorhabditis elegans.

In Vitro and In Vivo Biotransformation Profiling of 6PPD-Quinone toward Their Detection in Human Urine.

Exposure/Environment Studies

Parabens/Triclosan/Antimicrobials

Parabens and triclosan in red swamp crayfish (Procambarus clarkii) from China: Concentrations, tissue distribution and related human dietary intake risk.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Pesticide contamination of lactating mothers’ milk in Latin America: a systematic review.

Accumulation of typical persistent organic pollutants and heavy metals in bioretention facilities: distribution, risk assessment, and microbial community impact.

Biochemical and molecular biomarkers and their association with anthropogenic chemicals in wintering Manx shearwaters (Puffinus puffinus).

Alps at risk: High-mountain lakes as reservoirs of persistent and emerging contaminants.

What potential do mosses have as biomonitors of POPs? A comparative study of hexachlorocyclohexane sorption.

PFAS

Association of diet with per- and polyfluoroalkyl substances in plasma and human milk in the New Hampshire Birth Cohort Study.

Determination of total extractable organofluorine (EOF) in food contact materials and target and non-target analysis of per- and polyfluoroalkyl substances using LC-MS/MS and LC-HRMS simultaneously coupled to ICP-MS.

Population exposure to emerging perfluoroalkyl acids (PFAAs) via drinking water resources: Application of multivariate statistics and risk assessment models.

Unique hepatic maternal transfer pattern of trace metals and perfluoroalkyl substances (PFAS) in a bluntnose sixgill shark (Hexanchus griseus).

Investigation of the Link between Per- and Polyfluoroalkyl Substances and Stress Biomarkers in Bottlenose Dolphins (Tursiops truncatus).

Per- and polyfluoroalkyl substances (PFASs) in bivalve molluscs from Shandong Province, China: Occurrence, distribution, and implications for human consumption.

Passive biomonitoring for per- and polyfluoroalkyl substances using invasive clams, C. fluminea.

Per- and polyfluoroalkyl substances (PFAS) in construction and demolition debris (CDD): discerning sources and fate during waste management.

Effects of perfluorooctanoic acid on the nutritional quality of Mytilus edulis.

Are Geotextiles Silent Contributors of Ultrashort Chain PFASs to the Environment?

No evidence of an association between size and levels of four per- and polyfluorinated substances (PFAS) in perch (Perca fluviatilis).

Flame Retardants

Children’s Exposure to Brominated Flame Retardants in the Home: The TESIE Study.

Occurrence and seasonal variations of organophosphate flame retardants in air and dust from college microenvironments at Qingdao, China: Implications for student’s exposure and risk assessment.

Levels, Distribution and Ecological Risk Assessment of PBDEs in Soils and Plants Around the Engineering Plastics Factory.

Species-specific and habitat-dependent bioaccumulation of halogenated flame retardants in marine organisms from estuary to coastal seas.

Hexabromocyclododecanes in soils, plants, and sediments from Svalbard, Arctic: Levels, isomer profiles, chiral signatures, and potential sources.

Metals/Metalloids

Sea-level rise and arsenic-rich soils: A toxic relationship.

Plastics/Microplastics/Nanomaterials

The first reported values of microplastics in prostate.

Plastic breath: Quantification of microplastics and polymer additives in airborne particles.

Probabilistic Estimation of Airborne Micro- and Nanoplastic Intake in Humans.

Human exposure to microplastics via the consumption of nonalcoholic beverages in various packaging materials: The case of Hong Kong.

Severe Microplastic Pollution Risks in Urban Freshwater System Post-Landfill Fire: A Case Study from Brahmapuram, India.

Geographical and ecological factors affect microplastic body burden in marine fish at global scale.

Point-source tracking of microplastics in sewerage systems. Finding the culprit.

Traded Plastic, Traded Impacts? Designing Counterfactual Scenarios to Assess Environmental Impacts of Global Plastic Waste Trade.

Microplastics in different tissues of historical and live samples of endangered mega-fish (Acipenser sinensis) and their potential relevance to exposure pathways.

Microplastic in an apex predator: evidence from Barn owl (Tyto alba) pellets in two sites with different levels of anthropization.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. The searchable archives are at https://groups.google.com/d/forum/edc_research or online at https://heeds.org/category/edc-science-weekly/. Feel free to forward this email. Compiled by Sarah Howard of Healthy Environment and Endocrine Disruptor Strategies (HEEDS), a program of Environmental Health Sciences.

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EHN EHN

Lou Guillette Jr. Memorial Symposium
by Sarah Howard on December 16, 2024 at 3:52 pm
On March 14-15, 2025, HEEDS is hosting the Lou Guillette Jr. Memorial Symposium on endocrine disrupting science at the University of Florida. It will celebrate the life and legacy of Dr. Guillette, gather together his trainees and colleagues, and focus on the research topics that Lou made famous. Information here.
Endocrine-disrupting chemicals: hazards and opportunities (ECHO) course
by Sarah Howard on December 16, 2024 at 3:50 pm
This course focuses on the chemical, biological, and societal challenges of endocrine-disrupting chemicals (EDCs) and new opportunities for moving forward. ECHO is a two-week intensive bootcamp-style career development course for graduate students, postdoctoral fellows, and professionals in the field. It is held at Woods Hole, Massachusetts.
Webinar: EDC exposure and gonadal function: consequences and interventions
by Sarah Howard on December 16, 2024 at 3:36 pm
This two part webinar series is sponsored by the Endocrine Society's Special Interest Group (SIG) on endocrine disrupting chemicals (EDCs). The first webinar is scheduled for Jan. 30, 2025, and the second for Feb. 13.

EHN EHN

The plastics crisis: A neuropsychiatric problem hidden in plain sight
by EHN Curators on December 18, 2024 at 7:47 pm
The impact of plastics on health is an area of increasing concern.
Scientists lay out new framework to identify toxics contributing to metabolic disorders
by Katherine McMahon,Sarah Howard on December 17, 2024 at 10:00 am
A new consensus statement published in Nature Reviews Endocrinology proposes a set of 12 characteristics that can be used to identify metabolic-disrupting agents - chemicals, pharmaceuticals, and environmental hazards that increase the risk of metabolic disorders like diabetes and obesity. “This approach will enable a more comprehensive mechanistic understanding of how environmental chemicals and other agents disrupt metabolism and cause adverse outcomes.”
2024 Lou Guillette Jr Outstanding Young Investigator Award Winner: Dr. Chris Kassotis
by Sarah Howard on December 16, 2024 at 4:00 pm
Chris Kassotis, Ph.D., is the 2024 winner of the Lou Guillette, Jr. Outstanding Young Investigator Award, sponsored by Healthy Environment and Endocrine Disruptor Strategies (HEEDS). The award, in honor of scientist and mentor Lou Guillette, Jr., is given to an early-career scientist working in some aspect of endocrine disruptor research. The Kassotis lab focuses on understanding endocrine disrupting chemicals (EDCs) and mixtures, and their potential impacts on human and animal health, with a particular focus on metabolic health. He takes on critical public health issues, such as the health effects of chemicals found in fracking fluids and in artificial turf.

EHN EHN

Pesticide industry fights state efforts to regulate PFAS in farming
by EHN Curators on December 19, 2024 at 11:21 am
Pesticide trade groups are using lobbyists and grassroots networks to delay state laws aimed at curbing PFAS contamination in food and water, citing economic concerns. Lisa Held reports for Civil Eats.
Safe drinking water law marks 50 years, but challenges persist
by EHN Curators on December 19, 2024 at 11:19 am
Fifty years after the Safe Drinking Water Act became law, millions still lack reliable access to clean water, particularly in marginalized communities and small towns. Brett Walton reports for Circle of Blue.
RFK Jr. plans to eliminate fluoride in water, but states hold the power
by EHN Curators on December 18, 2024 at 11:47 am
President-elect Donald Trump's health appointee, Robert F. Kennedy Jr., aims to end fluoride in drinking water nationwide, but many states maintain mandates that the federal government cannot override. Hannah Recht reports for The Washington Post.