EDC Science Weekly, Apr. 26 – May 2, 2024

Post author:HEEDS
Post published:May 2, 2024
Post category:EDC Science Weekly

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Events, Regulations/Policy, Methods/Tools/Screening, Commentaries, Reviews/Meta-Analyses, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Highlights: How Washington State will identify hazardous chemicals and safer alternatives; prenatal chemical exposure and autoimmune disease in children; altered sex ratio in Vietnamese infants; prenatal PFAS and markers of adverse birth outcomes; paternal exposures to EDCs and intergenerational epigenetic influences on offspring.

More science highlights

Events

May 2 webinar (7pm ET): Plastics and your health [Beyond Plastics]

May 7 webinar: Endocrine disruptors and hormone levels during pregnancy [HEEDS Young EDC Scientists Showcase and EDC Strategies Partnership]

May 8 webinar: Reducing PFAS in products: progress and challenges [EPA]

May 20 symposium: Brain and environment [Univ of Rochester/in Washington DC]

May 21 seminar: Silent Spring 2.0: Adverse impacts of neonicotinoid pesticides on human and wildlife health [CACHET and HEEDS. Virtual and in-person in Chicago. See the ChicAgo Center for Health and EnvironmentT (CACHET) website for additional seminars.]

May 29: Webinaire dédié au rassemblement de la communauté française sur les perturbateurs endocriniens [in French]

June 10-11 workshop: Complementary and integrative interventions to prevent and mitigate the effects of endocrine-disrupting chemicals [NCCIH]

June 10-12: National PFAS Conference in Ann Arbor, MI

June 23-28: Gordon Research Conference on EDCs in Tuscany, Italy

Oct. 14-16: 8th Annual meeting of the U.S. DOHaD Society: exploring translational DOHaD science: from cells to communities in Chapel Hill, NC [abstracts due Aug. 1]

More events

Regulations/Policy

A Hazard-Based Framework for Identifying Safer Alternatives to Classes of Chemicals: A Case Study on Phthalates in Consumer Products

More EDC policy and regulations open for comment

Methods/Tools/Screening

Development of a Phthalate Environmental Reproductive Health Literacy (PERHL) Scale.

A Comparison of In Vitro Points of Departure with Human Blood Levels for Per- and Polyfluoroalkyl Substances (PFAS).

Enhanced Detection of Estrogen-like Compounds by Genetically Engineered Yeast Sensor Strains.

Identification of sensitive endpoints for the assessment of phthalates-induced reproductive and developmental toxicity: a literature mining study.

Evaluation of a Proportional Response Addition Approach to Mixture Risk Assessment and Predictive Toxicology Using Data on Four Trihalomethanes from the U.S. EPA’s Multiple-Purpose Design Study.

Identification of new endocrine disruptive transthyretin ligands in polluted waters using pull-down assay coupled to non-target mass spectrometry.

A quantitative weight-of-evidence method for confidence assessment of adverse outcome pathway networks: a case study on chemical-induced liver steatosis.

Hybrid non-animal modeling: A mechanistic approach to predict chemical hepatotoxicity.

Avoiding a reproducibility crisis in regulatory toxicology-on the fundamental role of ring trials.

Commentaries

Microplastics and microbiota: Unraveling the hidden environmental challenge.

A Delicate Balance: Water Disinfection and By-Product Immunotoxicity. [Science Selection in EHP]

Reviews/Meta-Analyses

Numerous Chemicals/Mixtures

The Interplay between Endocrine-Disrupting Chemicals and the Epigenome towards Metabolic Dysfunction-Associated Steatotic Liver Disease: A Comprehensive Review.

Paternal exposures to endocrine-disrupting chemicals induce intergenerational epigenetic influences on offspring: A review.

Endocrine disrupting chemicals: gestational diabetes and beyond.

Literature review and meta-analysis of environmental toxins associated with increased risk of Parkinson’s disease.

Assessing the contribution of the chemical exposome to neurodegenerative disease

Multi- and transgenerational effects of environmental chemicals on mollusks: An underexplored experimental design in aquatic (eco)toxicological studies.

Plastic additives in the ocean: Use of a comprehensive dataset for meta-analysis and method development.

BPA/Phenols

Bisphenol A Exposure Interferes with Reproductive Hormones and Decreases Sperm Counts: A Systematic Review and Meta-Analysis of Epidemiological Studies.

Phthalates

Association between urinary phthalates and phthalate metabolites and cancer risk: A systematic review and meta-analysis.

Phthalate exposure and subclinical carotid atherosclerosis: A systematic review and meta-analysis.

A systematic review of global distribution, sources and exposure risk of phthalate esters (PAEs) in indoor dust.

PFAS

Perfluoroalkyl/Polyfluoroalkyl Substances: Links to Cardiovascular Disease Risk.

Regeneration of exhausted adsorbents after PFAS adsorption: A critical review.

A Review of Sample Collection and Analytical Methods for Detecting Per- and Polyfluoroalkyl Substances in Indoor and Outdoor Air.

Pesticides

Assessing pesticides in the atmosphere: A global study on pollution, human health effects, monitoring network and regulatory performance.

Mechanisms of female reproductive toxicity in pigs induced by exposure to environmental pollutants.

Metals/Metalloids

Heavy Metal Exposure and Cardiovascular Disease.

Intestinal toxicity of Pb: Structural and functional damages, effects on distal organs and preventive strategies.

Microplastics/Nanomaterials

Micro(nano)plastics: invisible compounds with a visible impact.

Vertebrate Response to Microplastics, Nanoplastics and Co-exposed Contaminants: Assessing Accumulation, Toxicity, Behaviour, Physiology, and Molecular Changes.

Air Pollution

A review of air pollution as a driver of cardiovascular disease risk across the diabetes spectrum.

Pharmaceuticals/Personal Care Products

The research progress on the impact of antibiotics on the male reproductive system.

Miscellaneous

Toxicological Effects of Naturally Occurring Endocrine Disruptors on Various Human Health Targets: A Rapid Review.

Environmental profiles, hazard identification, and toxicological hallmarks of emerging tire rubber-related contaminants 6PPD and 6PPD-quinone.

Human Health Studies

Numerous Chemicals/Mixtures

Prenatal exposure to environmental contaminants and cord serum metabolite profiles in future immune-mediated diseases.

The associations between maternal and fetal exposure to endocrine-disrupting chemicals and asymmetric fetal growth restriction: a prospective cohort study.

Multiple xenoestrogen air pollutants and breast cancer risk: statistical approaches to investigate combined exposures effect.

Association of Combined Per- and Polyfluoroalkyl Substances and Metals with Chronic Kidney Disease.

Bisphenols/Phthalates

Associations between synthetic phenols, phthalates, and placental growth/function: a longitudinal cohort with exposure assessment in early pregnancy.

Early childhood exposures to phthalates in association with attention-deficit/hyperactivity disorder behaviors in middle childhood and adolescence in the ReCHARGE study.

Association of Di(2-ethylhexyl) Terephthalate and Its Metabolites with Nonalcoholic Fatty Liver Disease: An Epidemiology and Toxicology Study.

Parabens/Triclosan/Antimicrobials

Cholesterol mediates the effects of single and multiple environmental phenols in urine on obesity

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Altered Sex Ratio at Birth with Maternal Exposure to Dioxins in Vietnamese Infants.

Changes in Adipose Tissue and Circulating Concentrations of Persistent Organic Pollutants in Midlife Women.

Environmental Exposure to Persistent Organic Pollutants and Its Association with Endometriosis Risk: Implications in the Epithelial-Mesenchymal Transition Process.

Associations of pentachlorophenol exposure during pregnancy with maternal and infant reproductive hormones in a birth cohort.

PFAS

Changes in plasma concentrations of per- and Polyfluoroalkyl substances after bariatric surgery in adolescents from the Teen-Longitudinal Assessment of Bariatric Surgery (Teen-LABS) study.

Cross-Sectional Associations between Prenatal Per- and Poly-Fluoroalkyl Substances and Bioactive Lipids in Three Environmental Influences on Child Health Outcomes (ECHO) Cohorts.

Associations between serum perfluoroalkyl and polyfluoroalkyl concentrations and diabetes mellitus in the Korean general population: Insights from the Korean National Environmental Health Survey 2018-2020.

Individual and joint associations of per- and polyfluoroalkyl substances (PFAS) with gallstone disease in adults: A cross-sectional study.

Flame Retardants

Gestational PBDE Concentrations, Persistent Externalizing, and Emerging Internalizing Behaviors in Adolescents: The HOME Study.

Pesticides

A prospective cohort study of exposure to household pesticide with cardiovascular diseases mortality in older adults.

New findings on the risk of hypertension from organophosphorus exposure under different glycemic statuses: The key role of lipids?

Metals/Metalloids

A Cross-Sectional Analysis Investigating Pregnant Women’s Renal Function and Its Association with Lead and Cadmium Exposures-The DSAN Birth Cohort Study in Recôncavo Baiano, Brazil.

Association between maternal heavy metal exposure and Kawasaki Disease, the Japan Environment and Children’s Study (JECS).

The relationship between heavy metals and metabolic syndrome using machine learning.

Air Pollution

Association between particulate air pollution and hypertensive disorders in pregnancy: A retrospective cohort study.

Prenatal exposure to air pollutant mixtures and birthweight in the upstate KIDS cohort.

Large-scale genome-wide association studies reveal the genetic causal etiology between air pollutants and autoimmune diseases.

Laboratory Studies

Numerous Chemicals/Mixtures

An Integrated Approach of Bioassays and Non-Target Screening for the Assessment of Endocrine-Disrupting Activities in Tap Water and Identification of Novel Endocrine-Disrupting Chemicals. [re boiling tap water]

A System Biology Approach Reveals New Targets for Human Thyroid Gland Toxicity in Embryos and Adult Individuals.

Integrative Bioinformatics-Gene Network Approach Reveals Linkage between Estrogenic Endocrine Disruptors and Vascular Remodeling in Peripheral Arterial Disease.

BPA/Phenols

Multi-omics approach characterizes the role of Bisphenol F in disrupting hepatic lipid metabolism

Phthalates

Effect of MEHP on testosterone synthesis via Sirt1/Foxo1/Rab7 signaling pathway inhibition of lipophagy in TM3 cells.

Mitochondrial DNA Stress-Mediated Health Risk to Dibutyl Phthalate Contamination on Zebrafish (Danio rerio) at Early Life Stage.

Prenatal diethylhexylphthalate exposure disturbs adult Leydig cell function via epigenetic downregulation of METTL4 expression in male rats.

Exposure to the phthalate metabolite MEHP impacts survival and growth of human ovarian follicles in vitro.

Lactiplantibacillus plantarum RS20D Alleviates Male Reproductive Toxicity Induced by Pubertal Exposure to Di-n-butyl Phthalate and Mono-n-butyl Phthalate

Parabens/Triclosan/Antimicrobials

Triclocarban and triclosan promote breast cancer progression in vitro and in vivo via activating G protein-coupled estrogen receptor signaling pathways.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

New Perspectives on the Risks of Hydroxylated Polychlorinated Biphenyl (OH-PCB) Exposure: Intestinal Flora α-Glucosidase Inhibition.

Breast milk-mediated exposure to dioxins and antigen in infancy enhances antigen-specific antibody production capacity in adulthood in mice.

PFAS

Comparative steroidogenic effects of hexafluoropropylene oxide trimer acid (HFPO-TA) and perfluorooctanoic acid (PFOA): Regulation of histone modifications.

Assessment and Comparison of Early Developmental Toxicity of Six Per- and Polyfluoroalkyl Substances with Human Embryonic Stem Cell Models.

Exposure to hexafluoropropylene oxide trimer acid (HFPO-TA) impairs 5-HT metabolism by impacting the brain-gut axis in mice.

Effects of Temperature and Salinity on Perfluorooctane Sulfonate (PFOS) Toxicity in Larval Estuarine Organisms.

Species-Specific Unbound Fraction Differences in Highly Bound PFAS: A Comparative Study across Human, Rat, and Mouse Plasma and Albumin.

Perfluorooctanesulfonic Acid Alters Pro-Cancer Phenotypes and Metabolic and Transcriptional Signatures in Testicular Germ Cell Tumors.

Maternal PFOS exposure affects offspring development in Nrf2-dependent and independent ways in zebrafish (Danio rerio).

In-Vitro Effects of Perfluorooctanoic Acid on Human Sperm Function: What Are the Clinical Consequences?

Evidences for the influence from key chemical structures of per- and polyfluoroalkyl substances on their environmental behaviors.

Lipid responses to perfluorooctane sulfonate exposure for multiple rat organs.

Per- and polyfluoroalkyl substances induce lipid metabolic impairment in fish: Integration on field investigation and laboratory study.

F-53B mediated ROS affects uterine development in rats during puberty by inducing apoptosis.

Flame Retardants

Acute exposure to tris(2,4-di-tert-butylphenyl)phosphate elicits cardiotoxicity in zebrafish (Danio rerio) larvae via inducing ferroptosis.

Organophosphorus Flame Retardant TPP-Induced Human Corneal Epithelial Cell Apoptosis through Caspase-Dependent Mitochondrial Pathway.

Protective Effects of Isoliquiritigenin and Licochalcone B on the Immunotoxicity of BDE-47: Antioxidant Effects Based on the Activation of the Nrf2 Pathway and Inhibition of the NF-κB Pathway.

Global responses to tris(1-chloro-2-propyl) phosphate and tris(2-butoxyethyl) phosphate in Escherichia coli: evidences from biomarkers, and metabolic disturbance using GC-MS and LC-MS metabolomics analyses.

ZLN005 alleviates PBDE-47 induced impairment of mitochondrial translation and neurotoxicity through PGC-1α/ERRα axis.

Organotins

Long-term tributyltin exposure alters behavior, oocyte maturation, and histomorphology of the ovary due to oxidative stress in adult zebrafish.

Tributyltin (TBT) toxicity: Effects on enteric neuronal plasticity and intestinal barrier of rats’ duodenum.

Pesticides

Chronic cypermethrin induced toxicity and molecular fate assessment within common carp (Cyprinus carpio) using multiple biomarkers approach and its novel therapeutic detoxification.

Stereo-selective cardiac toxicity induced by metconazole via oxidative stress and the Wnt/β-catenin signaling pathway in zebrafish embryos.

In Vitro Human Dermal Absorption Studies on Pesticides in Complex Mixtures: Investigation of Guidance Criteria and Possible Impact Parameters.

Microglial Exosomes in Paraquat-Induced Parkinson’s Disease: Neuroprotection and Biomarker Clues.

Next-Generation Neonicotinoid: The Impact of Cycloxaprid on the Crustacean Decapod Penaeus vannamei.

Contribution of Immune Responses to the Cardiotoxicity and Hepatotoxicity of Deltamethrin in Early Life Stage Zebrafish (Danio rerio).

Two thyroperoxidase-inhibiting chemicals induce shared transcriptional changes in hippocampus of developing rats.

Metals/Metalloids

Reproductive and Developmental Effects of Sex-Specific Chronic Exposure to Dietary Arsenic in Zebrafish (Danio rerio).

Chronic Exposure to Arsenic and Fluoride Starting at Gestation Alters Liver Mitochondrial Protein Expression and Induces Early Onset of Liver Fibrosis in Male Mouse Offspring.

Arsenic exposure causes decline in sperm motility accompanied by energy metabolism disorders in mouse testes.

Microplastics/Nanomaterials

Evaluating the potential of daily intake of polystyrene microplastics via drinking water in inducing PCOS and its ovarian fibrosis progression using female zebrafish.

Co-exposure of polystyrene nanoplastics and copper induces development toxicity and intestinal mitochondrial dysfunction in vivo and in vitro.

Co-exposure of arsenic and polystyrene-nanoplastics induced kidney injury by disrupting mitochondrial homeostasis and mtROS-mediated ferritinophagy and ferroptosis.

Polyethylene terephthalate (PET) micro- and nanoplastic particles affect the mitochondrial efficiency of human brain vascular pericytes without inducing oxidative stress.

Nano-titanium dioxide exacerbates the harmful effects of perfluorooctanoic acid on the health of mussels.

Exposure to Microplastics Made of Plasmix-Based Materials at Low Amounts Did Not Induce Adverse Effects on the Earthworm Eisenia foetida.

Sex-Specific Effects of Polystyrene Microplastic and Lead(II) Co-Exposure on the Gut Microbiome and Fecal Metabolome in C57BL/6 Mice.

Polystyrene microplastics enhance microcystin-LR-induced cardiovascular toxicity and oxidative stress in zebrafish embryos.

Polystyrene nanoplastics cause reproductive toxicity in zebrafish: PPAR mediated lipid metabolism disorder.

Gender-specific effects of polystyrene nanoplastic exposure on triclosan-induced reproductive toxicity in zebrafish (Danio rerio).

Miscellaneous

Effects of crosstalk between steroid hormones mediated thyroid hormone in zebrafish exposed to 4-tert-octylphenol: Estrogenic and anti-androgenic effects.

Estetrol/drospirenone versus 17α-ethinylestradiol/drospirenone: An extended one generation test to evaluate the endocrine disruption potential on zebrafish (Danio rerio).

Cocktail effects of tire wear particles leachates on diverse biological models: A multilevel analysis.

Exposure/Environment Studies

Numerous Chemicals/Mixtures

Critical Environmental Injustice: A Case Study Approach to Understanding Disproportionate Exposure to Toxic Emissions.

Empowering Student Pharmacists to Counsel Patients on Endocrine Disrupting Chemicals through Interactive Role-Play.

Factors impacting human exposure to legacy and emerging contaminants in residential dust in Beijing, China: Characteristics of indoor microenvironment.

Temporal trends of plastic additive contents in sediment cores of three French rivers (Loire, Meuse and Moselle) over the last decades.

Parabens/Triclosan/Antimicrobials

Human intake assessment of triclosan associated with the daily use of polypropylene-made antimicrobial food packaging.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Systematic investigation of organochlorine pesticides and polychlorinated biphenyls blood levels in Greek children from the Rhea birth cohort suggests historical exposure to DDT and through diet to DDE.

A Comprehensive Evaluation of Dioxins and Furans Occurrence in River Sediments from a Secondary Steel Recycling Craft Village in Northern Vietnam.

Exposure of an endangered seabird species to persistent organic pollutants: Assessing levels in blood and link with reproductive parameters.

PFAS

Characterizing Important Dietary Exposure Sources of Perfluoroalkyl Acids in Inuit Youth and Adults in Nunavik Using a Feature Selection Tool

Crop Contamination and Human Exposure to Per- and Polyfluoroalkyl Substances around a Fluorochemical Industrial Park in China.

Distribution of Per- and Polyfluoroalkyl Substances (PFASs) in a Waste-to-Energy Plant─Tracking PFASs in Internal Residual Streams.

Spatial distribution, source, and fate of per- and polyfluoroalkyl substances in the surrounding environment of closed and converted fluorochemical factories in Fujian, China.

Characterization of Per- and Polyfluoroalkyl Substances (PFAS) and Other Constituents in MSW Landfill Leachate from Puerto Rico.

Perfluoroalkyl substances (PFAS) occurrence, concentrations and spatial distribution along the French Mediterranean coast and lagoons, based on active biomonitoring.

Evaluation and prediction of anthropogenic impacts on long-term multimedia fate and health risks of PFOS and PFOA in the Elbe River Basin.

Flame Retardants

Investigation of Urinary Metabolites of Organophosphate Esters in Hanoi, Vietnam: Assessment Exposure and Estimated Daily Intake.

Pesticides

Organic farming reduces pesticide load in a bird of prey.

Metals/Metalloids

Effect of Environmental and Socioeconomic Factors on Increased Early Childhood Blood Lead Levels: A Case Study in Chicago.

Essential and Toxic Elements in Infant Cereal in Brazil: Exposure Risk Assessment.

Microplastics/Nanomaterials

Toy building bricks as a potential source of microplastics and nanoplastics.

Airborne Transboundary Microplastics – A Swirl Around the Globe.

Influence of ongoing discharge from multiple wastewater treatment plants on microplastic patterns in small-scale receiving rivers.

Microplastic and other anthropogenic microparticles in Arctic char (Salvelinus alpinus) and their coastal habitat: A first-look at a central Canadian Arctic commercial fishery.

Miscellaneous

Toxicity threshold and ecological risk of nitrate in rivers based on endocrine-disrupting effects: A case study in the Luan River basin, China.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. The searchable archives are at https://groups.google.com/d/forum/edc_research or online at https://heeds.org/category/edc-science-weekly/. Feel free to forward this email. Compiled by Sarah Howard of Healthy Environment and Endocrine Disruptor Strategies (HEEDS), a program of Environmental Health Sciences.

If you enjoy this newsletter, please feel free to donate here! Thank you!

EHN EHN

Lou Guillette Jr. Memorial Symposium
by Sarah Howard on December 16, 2024 at 3:52 pm
On March 14-15, 2025, HEEDS is hosting the Lou Guillette Jr. Memorial Symposium on endocrine disrupting science at the University of Florida. It will celebrate the life and legacy of Dr. Guillette, gather together his trainees and colleagues, and focus on the research topics that Lou made famous. Information here.
Endocrine-disrupting chemicals: hazards and opportunities (ECHO) course
by Sarah Howard on December 16, 2024 at 3:50 pm
This course focuses on the chemical, biological, and societal challenges of endocrine-disrupting chemicals (EDCs) and new opportunities for moving forward. ECHO is a two-week intensive bootcamp-style career development course for graduate students, postdoctoral fellows, and professionals in the field. It is held at Woods Hole, Massachusetts.
Webinar: EDC exposure and gonadal function: consequences and interventions
by Sarah Howard on December 16, 2024 at 3:36 pm
This two part webinar series is sponsored by the Endocrine Society's Special Interest Group (SIG) on endocrine disrupting chemicals (EDCs). The first webinar is scheduled for Jan. 30, 2025, and the second for Feb. 13.

EHN EHN

The plastics crisis: A neuropsychiatric problem hidden in plain sight
by EHN Curators on December 18, 2024 at 7:47 pm
The impact of plastics on health is an area of increasing concern.
Scientists lay out new framework to identify toxics contributing to metabolic disorders
by Katherine McMahon,Sarah Howard on December 17, 2024 at 10:00 am
A new consensus statement published in Nature Reviews Endocrinology proposes a set of 12 characteristics that can be used to identify metabolic-disrupting agents - chemicals, pharmaceuticals, and environmental hazards that increase the risk of metabolic disorders like diabetes and obesity. “This approach will enable a more comprehensive mechanistic understanding of how environmental chemicals and other agents disrupt metabolism and cause adverse outcomes.”
2024 Lou Guillette Jr Outstanding Young Investigator Award Winner: Dr. Chris Kassotis
by Sarah Howard on December 16, 2024 at 4:00 pm
Chris Kassotis, Ph.D., is the 2024 winner of the Lou Guillette, Jr. Outstanding Young Investigator Award, sponsored by Healthy Environment and Endocrine Disruptor Strategies (HEEDS). The award, in honor of scientist and mentor Lou Guillette, Jr., is given to an early-career scientist working in some aspect of endocrine disruptor research. The Kassotis lab focuses on understanding endocrine disrupting chemicals (EDCs) and mixtures, and their potential impacts on human and animal health, with a particular focus on metabolic health. He takes on critical public health issues, such as the health effects of chemicals found in fracking fluids and in artificial turf.

EHN EHN

Pesticide industry fights state efforts to regulate PFAS in farming
by EHN Curators on December 19, 2024 at 11:21 am
Pesticide trade groups are using lobbyists and grassroots networks to delay state laws aimed at curbing PFAS contamination in food and water, citing economic concerns. Lisa Held reports for Civil Eats.
Safe drinking water law marks 50 years, but challenges persist
by EHN Curators on December 19, 2024 at 11:19 am
Fifty years after the Safe Drinking Water Act became law, millions still lack reliable access to clean water, particularly in marginalized communities and small towns. Brett Walton reports for Circle of Blue.
RFK Jr. plans to eliminate fluoride in water, but states hold the power
by EHN Curators on December 18, 2024 at 11:47 am
President-elect Donald Trump's health appointee, Robert F. Kennedy Jr., aims to end fluoride in drinking water nationwide, but many states maintain mandates that the federal government cannot override. Hannah Recht reports for The Washington Post.