EDC Science Weekly, Apr. 5-11, 2024

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Events, Regulations/Policy, Methods/Tools/Screening, Commentaries, Reviews/Meta-Analyses, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Highlights: The Conflict between Regulatory Agencies over the 20,000-Fold Lowering of the Tolerable Daily Intake (TDI) for Bisphenol A (BPA) by the European Food Safety Authority (EFSA)

More science highlights

Events

Apr. 15-16 conference: Break the Cycle of Health Disparities [virtual and in-person at Emory]

Apr. 17 conference: ICEDA Awardees [Intersectoral Centre for Endocrine Disruptor Analysis]

Apr. 18 webinar: Chemicals in plastics: Human health costs [EDC Strategies Partnership]

Apr. 24 workshop: Improved methods for assessment of metabolic effects of endocrine disruptors [EDCMET]

May 7 webinar: Endocrine disruptors and hormone levels during pregnancy [HEEDS Young EDC Scientists Showcase]

June 10-11 workshop: Complementary and Integrative Interventions To Prevent and Mitigate the Effects of Endocrine-Disrupting Chemicals [NCCIH and NIEHS]

June 10-12: National PFAS Conference in Ann Arbor MI

June 23-28: Gordon Research Conference on EDCs in Tuscany, Italy

More events

Regulations/Policy

The Conflict between Regulatory Agencies over the 20,000-Fold Lowering of the Tolerable Daily Intake (TDI) for Bisphenol A (BPA) by the European Food Safety Authority (EFSA).

Evidence evaluated by European Food Safety Authority does not support lowering the temporary tolerable daily intake for bisphenol A

Inconsistencies in the EU regulatory risk assessment of PFAS call for readjustment.

Sediment Toxicity Tests: A Critical Review of Their use in Environmental Regulations.

More EDC policy and regulations open for comment

Methods/Tools/Screening

Evaluation of in silico model predictions for mammalian acute oral toxicity and regulatory application in pesticide hazard and risk assessment.

Exploring a mechanism-based approach for the identification of endocrine disruptors using Adverse Outcome Pathways and New Approach Methodologies: A perfluorooctane sulfonic acid case study.

Revolutionizing developmental neurotoxicity testing – a journey from animal models to advanced in vitro systems.

Metabolomics in human SGBS cells as new approach method for studying adipogenic effects: Analysis of the effects of DINCH and MINCH on central carbon metabolism.

MetSim: Integrated Programmatic Access and Pathway Management for Xenobiotic Metabolism Simulators.

Commentaries

Impact of microplastics and nanoplastics on liver health: Current understanding and future research directions.

Evolutionary obstacles and not C-F bond strength make PFAS persistent.

Reviews/Meta-Analyses

Numerous Chemicals/Mixtures

Association of maternal exposure to endocrine disruptor chemicals with cardio-metabolic risk factors in children during childhood: a systematic review and meta-analysis of cohort studies.

Occupational risks associated with chronic kidney disease of non-traditional origin (CKDnt) in Brazil: it is time to dig deeper into a neglected problem.

BPA/Phenols

Effects and mechanisms of endocrine disruptor bisphenol AF on male reproductive health: A mini review.

Deciphering the molecular mechanism of NLRP3 in BPA-mediated toxicity: Implications for targeted therapies.

Phthalates

Recent advances in toxicological research of di-(2-ethylhexyl)-phthalate: Focus on endoplasmic reticulum stress pathway.

Phthalate Exposure and Neurotoxicity in Children: A Systematic Review and Meta-analysis.

PFAS

Understanding PFAS toxicity through cell culture metabolomics: Current applications and future perspectives.

Exposure to per- and polyfluoroalkyl substances and bone health: a systematic review and meta-analysis.

Per- and poly-fluoroalkyl substances in agricultural contexts and mitigation of their impacts using biochar: A review.

Flame Retardants

Organophosphate esters in water and air: A minireview of their sources, occurrence, and air-water exchange.

Metals/Metalloids

Toxic metals and pediatric clinical immune dysfunction: A systematic review of the epidemiologic evidence.

Microplastics/Nanomaterials

Interactive impacts of photoaged micro(nano)plastics and co-occurring chemicals in the environment.

Are we eating plastic? Science mapping of microplastic pollution in the aquatic food chain.

The Plasticene era: Current uncertainties in estimates of the hazards posed by tiny plastic particles on soils and terrestrial invertebrates.

Association of tetrabromobisphenol A (TBBPA) with micro/nano-plastics: A review of recent findings on ecotoxicological and health impacts.

Exploring the potential and challenges of developing physiologically-based toxicokinetic models to support human health risk assessment of microplastic and nanoplastic particles.

Miscellaneous

Current Insights into the Neurotoxicity of Melamine: A Comprehensive Review.

Unpacking Neighborhood Socioeconomic Status in Children’s Health Research from an Environmental Justice Perspective: A Scoping Review.

Human Health Studies

Numerous Chemicals/Mixtures

Environmental Justice Index and adverse pregnancy outcomes.

Case-control study of environmental toxins and risk of amyotrophic lateral sclerosis involving the national ALS registry.

BPA/Phenols

Endocrine disrupting chemical Bisphenol A and its association with cancer mortality: a prospective cohort study of NHANES.

Phthalates

Phthalate and DINCH exposure and ovarian reserve markers among women seeking infertility care.

Gender associations between phthalate exposure and biomarkers of oxidative stress: A prospective cohort study.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Blood and Tissue Levels of Persistent Organic Pollutants and Genetic Susceptibility in Patients with Breast Cancer.

Positive association between chlorinated paraffins and the risk of allergic diseases in children and adolescents.

PFAS

First trimester plasma PER- AND Polyfluoroalkyl Substances (PFAS) and blood pressure trajectories across the second and third trimesters of pregnanacy.

Dietary intake of Perfluorooctanesulfonic acid (PFOS) and glucose homeostasis parameters in a non-diabetic senior population.

Per- and polyfluoroalkyl substances and bone mineral content in early adolescence: Modification by diet and physical activity.

Pesticides

Organophosphate Pesticide Exposure: Effect on Farmers’ Sperm Quality in the Mekong Delta, Vietnam.

Metals/Metalloids

Effects of multiple metals exposure on abnormal liver function: The mediating role of low-density lipoprotein cholesterol.

Arsenic Exposure-Related Hypertension in Bangladesh and Reduced Circulating Nitric Oxide Bioavailability.

Relationship between blood cadmium levels and bone mineral density in adults: a cross-sectional study.

Prevalence rates of neurodegenerative diseases versus human exposures to heavy metals across the United States.

Air Pollution

Persistent DNA Methylation Changes across the First Year of Life and Prenatal NO2 Exposure in a Canadian Prospective Birth Study.

Exposure to ambient air pollution and cognitive function: an analysis of the English Longitudinal Study of Ageing cohort.

Exposure to outdoor ambient air toxics and risk of breast cancer: The multiethnic cohort.

Exploring the impact of lifestyle and environmental exposures on appetite hormone levels in children and adolescents: An observational study.

Air pollution and diabetes mellitus: Association and validation in a desert area in China.

Association Between Individual Air Pollution (PM₁₀, PM_2.5) Exposure and Adverse Pregnancy Outcomes in Korea: A Multicenter Prospective Cohort, Air Pollution on Pregnancy Outcome (APPO) Study.

COVID-19 fatality and DALYs, and associated metabolic disorders and ambient air pollutants in pre-Omicron era of the pandemic: an international comparative study.

Laboratory Studies

Numerous Chemicals/Mixtures

Impact of endocrine-active compounds on adrenal androgen production in pigs during neonatal period.

BPA/Phenols

Long-term Bisphenol S exposure induced gut microbiota dysbiosis, obesity, hepatic lipid accumulation, intestinal lesions and dyslipidemia in mice.

Centella asiatica mitigates the detrimental effects of Bisphenol-A (BPA) on pancreatic islets.

Exploring the mechanism of nonylphenol-induced ovarian developmental delay of manila clams, Ruditapes philippinarum: Applying RNAi to toxicological analysis.

Neurodevelopmental Effects of Prenatal Bisphenol A Exposure on the Role of MicroRNA Regulating NMDA Receptor Subunits in the Male Rat Hippocampus.

Perinatal bisphenol S exposure exacerbates the oxidative burden and apoptosis in neonatal ovaries by suppressing the mTOR/autophagy axis.

Inhibition of reactive oxygen species generation by N-Acetyl Cysteine can mitigate male germ cell toxicity induced by bisphenol analogs.

Molecular docking and molecular dynamics simulation decoding molecular mechanism of EDCs binding to hERRγ.

Phthalates

Nanoparticles for Augmenting Therapeutic Potential and Alleviating the Effect of Di(2-ethylhexyl) Phthalate on Gastric Cancer.

Prenatal DEHP exposure induces lifelong testicular toxicity by continuously interfering with steroidogenic gene expression.

Role of formyl peptide receptor 2 in steatosis of L02 cells exposed to Mono-(2-ethylhexyl) phthalate.

Di (2-ethylhexyl) phthalate effects on the growth, development, and reproduction of Moina macrocopa (Crustacea: Cladocera).

PFAS

Carbon-chain length determines the binding affinity and inhibitory strength of per- and polyfluoroalkyl substances on human and rat steroid 5α-reductase 1 activity.

Comparison of transcriptomic profiles between HFPO-DA and prototypical PPARα, PPARγ, and cytotoxic agents in wild-type and PPARα knockout mouse hepatocytes.

Transcriptome and Metabolome analysis reveal HFPO-TA induced disorders of hepatic glucose and lipid metabolism in rat by interfering with PPAR signaling pathway.

Differential impact of perfluorooctanoic acid and fluorotelomer ethoxylates on placental metabolism in mice.

A novel method to derive a human safety limit for PFOA by gene expression profiling and modelling.

Adsorption of per- and poly-fluoroalkyl substances (PFAS) on Ni: A DFT investigation.

Flame Retardants

Potential adverse outcome pathway of neurodevelopmental toxicity, inflammatory response, and oxidative stress induction mediated by three alkyl organophosphate flame retardants in zebrafish larvae.

Pesticides

The impact of the herbicide glyphosate and its metabolites AMPA and MPA on the metabolism and functions of human blood neutrophils and their sex-dependent effects on reactive oxygen species and CXCL8/IL-8 production.

Glyphosate-based herbicide worsens alterations induced by cafeteria diet on rat uterus.

A comparative study on targeted gene expression in zebrafish and its gill cell line exposed to chlorpyrifos.

Maternal exposure to beta-Cypermethrin disrupts placental development by dysfunction of trophoblast cells from oxidative stress.

Decreases in the number of microglia and neural circuit dysfunction elicited by developmental exposure to neonicotinoid pesticides in mice.

Early life stage exposure to fenbuconazole causes multigenerational cardiac developmental defects in zebrafish and potential reasons.

Mixture of pesticides based on dimethylamine and imidacloprid affects locomotion of adult zebrafish.

Exposure to atrazine stimulates progesterone secretion and induces oxidative stress, inflammation, and apoptosis in the ovary of pseudopregnant rats.

Effects of acute insecticide exposure on neuronal activity in vitro in rat cortical cultures.

GPR39-mediated ERK1/2 signaling reduces permethrin-induced proliferation of estrogen receptor α-negative cells.

Metals/Metalloids

Arsenic aggravates the progression of diabetic nephropathy through miRNA-mRNA-autophagy axis.

Transgenerational Effects of Arsenic Exposure on Learning and Memory in Rats: Crosstalk between Arsenic Methylation, Hippocampal Metabolism, and Histone Modifications.

Cadmium exposure activates mitophagy through downregulating thyroid hormone receptor/PGC1α signal in preeclampsia.

Microplastics/Nanomaterials

Developmental toxicity of pre-production plastic pellets affects a large swathe of invertebrate taxa.

In situ profiling reveals spatially metabolic injury in the initiation of polystyrene nanoplastic-derived intestinal epithelial injury in mice.

Adsorption of PFAS onto secondary microplastics: A mechanistic study.

Comparison of gut toxicity and microbiome effects in zebrafish exposed to polypropylene microplastics: Interesting effects of UV-weathering on microbiome.

Impact of Micro- and Nano-Plastics on Human Intestinal Organoid-Derived Epithelium.

Nanoplastics aggravated TDCIPP-induced transgenerational developmental neurotoxicity in zebrafish depending on the involvement of the dopamine signaling pathway.

The release, degradation, and distribution of PVC microplastic-originated phthalate and non-phthalate plasticizers in sediments.

Pharmaceuticals/Personal Care Products

Exposure to topiramate and acetazolamide causes endocrine disrupting effects in female rats during estrus.

Miscellaneous

Chronic exposure to tire rubber-derived contaminant 6PPD-quinone impairs sperm quality and induces the damage of reproductive capacity in male mice.

Evaluation of Sub-Chronic Toxicity of Melamine via Systematic or Oral Delivery in Adult Zebrafish Based on Behavioral Endpoints.

Developmental programming: Testosterone excess masculinizes female pancreatic transcriptome and function in sheep.

Exposure/Environment Studies

Numerous Chemicals/Mixtures

Socio-demographic inequalities influence differences in the chemical exposome among Swedish adolescents.

Chemical uptake into silicone wristbands over a five-day period.

Personal environmental exposure to plasticizers and organophosphate flame retardants using silicone wristbands and urine: Patterns, comparisons, and correlations.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Quantifying 209 Polychlorinated Biphenyl Congeners in Silicone Wristbands to Evaluate Differences in Exposure among Demolition Workers.

Evaluation of hexabromocyclododecane (HBCD), polybrominated dibenzo-p-dioxins/furans (PBDD/Fs) and polychlorinated dibenzo-p-dioxins/furans (PCDD/Fs) outflows during the destruction of HBCD wastes in a hazardous waste incinerator.

PFAS

Estimating the dynamic early life exposure to PFOA and PFOS of the HELIX children: Emerging profiles via prenatal exposure, breastfeeding, and diet.

Per- and polyfluoroalkyl substances (PFAS) in senior care facilities and older adult residents.

Peril in the Pipeline: Unraveling the threads of PFAS contamination in U.S. drinking water systems.

Per- and polyfluoroalkyls used as cosmetic ingredients – Qualitative study of 765 cosmetic products.

Nationwide occurrence and discharge mass load of per- and polyfluoroalkyl substances in effluent and biosolids: A snapshot from 75 wastewater treatment plants across Australia.

Accumulation features and temporal trends (2002-2015) for legacy and emerging per- and polyfluoroalkyl substances (PFASs) in finless porpoises bycaught off Korean coasts.

Flame Retardants

Exposure of Peregrine Falcons to Halogenated Flame Retardants: A 30 Year Retrospective Biomonitoring Study across North America.

Pesticides

Simultaneous detection of mycotoxins and pesticides in human urine samples: A 24-h diet intervention study comparing conventional and organic diets in Spain.

Metals/Metalloids

Predictors of urinary heavy metal concentrations among pregnant women in Jinan, China.

Essential and non-essential element concentrations in human milk samples and the assessment of infants’ exposure.

Multistress Interplay: Time and Duration of Ocean Acidification Modulate the Toxicity of Mercury and Other Metals.

Microplastics/Nanomaterials

Influence of microplastic contamination on the dissipation of endocrine disrupting chemicals in soil environment.

Plastic waste management in recycling facilities: Intentionally generated MPs as an emerging contaminant.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. The searchable archives are at https://groups.google.com/d/forum/edc_research or online at https://heeds.org/category/edc-science-weekly/. Feel free to forward this email. Compiled by Sarah Howard of Healthy Environment and Endocrine Disruptor Strategies (HEEDS), a program of Environmental Health Sciences.

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