EDC Science Weekly, Mar. 29 – Apr. 4, 2024

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Events, Regulations/Policy, Methods/Tools/Screening, Commentaries, Reviews/Meta-Analyses, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Highlights: EDs and ED (endocrine disruptors and erectile dysfunction); phthalates in the NICU; PFAS contamination in Europe: “expert-reviewed” journalism.

More science highlights

Events

Apr. 9-16: Geneva Beat Plastic Pollution Dialogues [UNEP Geneva Environment Network]

Apr. 10 webinar: Petrochemicals, Plastics & Health: Will global treaty offer pathway to progress? [CHE-Alaska]

Apr. 17 conference: ICEDA Awardees [Intersectoral Centre for Endocrine Disruptor Analysis]

Apr. 18 webinar: Chemicals in plastics: Human health costs [EDC Strategies Partnership]

Apr. 24 workshop: Improved methods for assessment of metabolic effects of endocrine disruptors [EDCMET]

May 7 webinar: Endocrine disruptors and hormone levels during pregnancy [HEEDS Young EDC Scientists Showcase]

June 10-12: National PFAS Conference in Ann Arbor MI

June 23-28: Gordon Research Conference on EDCs June, in Tuscany Italy

More events

Regulations/Policy

Green finance reform and application intensity of chemical fertilizer and pesticide: policy evidence from China.

EAACI guidelines on environmental science for allergy and asthma: The impact of short-term exposure to outdoor air pollutants on asthma-related outcomes and recommendations for mitigation measures.

More EDC policy and regulations open for comment

Methods/Tools/Screening

PFAS Contamination in Europe: Generating Knowledge and Mapping Known and Likely Contamination with “Expert-Reviewed” Journalism.

New Approach Methodologies (NAMs) for ad hoc human health risk assessment of food and non-food products – Proceedings of a workshop.

A tool to assess risk of bias in non-randomized follow-up studies of exposure effects (ROBINS-E).

A 50-gene biomarker identifies estrogen receptor-modulating chemicals in a microarray compendium.

Species differences in specific ligand-binding affinity and activation of AHR: The biological basis for calculation of relative effective potencies and toxic equivalence factors.

Reflected generalized concentration addition and Bayesian hierarchical models to improve chemical mixture prediction.

A problem formulation framework for the application of in silico toxicology methods in chemical risk assessment.

Experimental data from the development of Lymnaea stagnalis embryo test for chemicals hazard assessment.

How neurobehavior and brain development in alternative whole-organism models can contribute to prediction of developmental neurotoxicity.

Perspectives on Chick Embryo Models in Developmental and Reproductive Toxicity Screening.

Micro- and nanoplastics concepts for particle and fibre toxicologists.

Development of Nontargeted Workflow of Occupational Exposure by Infrared Ion Spectroscopy and Silicone Wristbands’ Passive Sampling.

Intestinal carcinogenicity screening of environmental pollutants using organoid-based cell transformation assay.

The Chickahominy T.R.U.T.H. (Trust, Research, Understand, Teach, and Heal) Project-A Tribal Community-Academic Partnership for Understanding the Impact of Structural Factors on Perceived Cancer Risk in Rural Virginia.

Commentaries

Do We Need a New Unifying Theory for Obesity?

Editorial: Navigating Complex Chemical Mixtures in Risk Assessment

Commentary: Value of information case study strongly supports use of the Threshold of Toxicological Concern (TTC).

Environmental Epigenetics 2024 update.

Reviews/Meta-Analyses

Numerous Chemicals/Mixtures

Breast Cancer Exposomics.

Military environmental exposures and risk of breast cancer in active-duty personnel and veterans: a scoping review.

Environmental Pollution and Risk of Childhood Cancer: A Scoping Review of Evidence from the Last Decade.

Pollutants in Breast Milk: A Scoping Review of the Most Recent Data in 2024.

The impact of water pollution on the health of older people.

The research landscape concerning environmental factors in neurodevelopmental disorders: Endocrine disrupters and pesticides-A review.

Environmental epigenetics: Exploring phenotypic plasticity and transgenerational adaptation in fish.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

The bioremediation of the typical persistent organic pollutants (POPs) by microalgae-bacteria consortia: A systematic review.

DDT contamination in water resources of some African countries and its impact on water quality and human health.

PFAS

Review of Recent Computational Research on the Adsorption of PFASs with a Variety of Substrates.

Poly- and perfluoroalkyl substances (PFASs) in amphibians and reptiles – exposure and health effects.

Metals/Metalloids

Toward a Mechanism-Driven Integrated Framework to Link Human Exposure to Multiple Toxic Metal(loid) Species with Environmental Diseases.

Exposure to potentially toxic elements (PTEs) and the risk of male infertility- A Systematic review and meta-analysis.

Arsenic’s shadowy influence: A systematic review of its carcinogenic role in gallbladder cancer.

Polysaccharides as Protective Agents against Heavy Metal Toxicity.

Neurogenic Effects of Inorganic Arsenic and Cdk5 Knockdown in Zebrafish Embryos: A Perspective on Modeling Autism.

Emerging insights into the impacts of heavy metals exposure on health, reproductive and productive performance of livestock.

Microplastics/Nanomaterials

PLASTAMINATION: Outcomes on the Central Nervous System and Reproduction.

Exploring the hidden environmental pollution of microplastics derived from bioplastics: A review.

Science-based evidence on pathways and effects of human exposure to micro- and nanoplastics.

Understanding the impact of Nanoplastics on Reproductive Health: Exposure Pathways, Mechanisms, and implications.

Harnessing photosynthetic microorganisms for enhanced bioremediation of microplastics: A comprehensive review.

Microorganism-mediated biodegradation for effective management and/or removal of micro-plastics from the environment: a comprehensive review.

A critical review on male-female reproductive and developmental toxicity induced by micro-plastics and nano-plastics through different signaling pathways.

Microplastics as an emerging threat to amphibians: Current status and future perspectives.

Global analysis of the adverse effects of micro- and nanoplastics on intestinal health and microbiota of fish.

Assessing the current state of plastic pollution research in Antarctica: Knowledge gaps and recommendations.

Air Pollution

Breath of Danger: Unveiling PM2.5’s Stealthy Impact on Cancer Risks.

Human Health Studies

Numerous Chemicals/Mixtures

Association between multipollutant exposure and thyroid hormones in elderly people: A cross-sectional study in China.

BPA/Phenols/Phthalates

Endocrine-disrupting chemical concentrations in follicular fluid and follicular reproductive hormone levels.

Association of exposure to phthalates and phthalate alternatives with dyslexia in Chinese primary school children.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Associations of polychlorinated biphenyls exposure, lifestyle, and genetic susceptibility with dyslipidemias: Evidence from a general Chinese population.

PFAS

Early life poly- and perfluoroalkyl substances (PFAS) levels and adiposity in the first 2 years of life.

PFOA and testis cancer in the Veneto Region (Italy).

Association of per- and polyfluoroalkyl substances with constipation: The National Health and Nutrition Examination Survey (2005-2010).

Flame Retardants

Exposure to Polybrominated Diphenyl Ethers and Risk of All-Cause and Cause-Specific Mortality.

Pesticides

Associations of glyphosate exposure and serum sex steroid hormones among 6-19-year-old children and adolescents.

Exposure to Environmental Pesticides and the Risk of Autism Spectrum Disorders: A Population-Based Case-Control Study.

Environmental Exposure to Pesticides and the Risk of Child Neurodevelopmental Disorders.

Placental transcriptome variation associated with season, location, and urinary prenatal pyrethroid metabolites of Thai farm-working women.

Association between glyphosate exposure and osteoarthritis in US adults: Especially in people who are obese and inactive in leisure time physical activity.

Metals/Metalloids

Physical activity modified association of urinary metals mixture and fasting blood glucose in children: From two panel studies.

Heavy metal association with chronic kidney disease of unknown cause in central India-results from a case-control study.

Air Pollution

In-Utero exposure to potential sources of indoor air pollution and umbilical cord blood leukocyte telomere length.

Association between Fine Particulate Matter Exposure and Cerebrospinal Fluid Biomarkers of Alzheimer’s Disease among a Cognitively Healthy Population-Based Cohort.

Multiple dietary patterns and the association between long-term air pollution exposure with type 2 diabetes risk: Findings from UK Biobank cohort study.

An ecological analysis of associations between ambient air pollution and cancer incidence rates in Taiwan.

Particulate polycyclic aromatic hydrocarbons and metals, DNA methylation and DNA methyltransferase among middle-school students in China.

Miscellaneous

Environmental exposure to melamine and its derivatives and kidney outcomes in children.

Laboratory Studies

Numerous Chemicals/Mixtures

High-Throughput Transcriptomics of Nontumorigenic Breast Cells Exposed to Environmentally Relevant Chemicals.

BPA/Phenols

Developmental programming: An exploratory analysis of pancreatic islet compromise in female sheep resulting from gestational BPA exposure.

Developmental exposure to Bisphenol F and Bisphenol S induces autism-like endophenotypes in adult Drosophila melanogaster.

Bisphenols can promote antibiotic resistance by inducing metabolic adaptations and natural transformation.

Integrated In-Silico and In Vitro Analysis to Decipher the Contribution of Bisphenol-A in Cervical Cancer.

Phthalates

Dibutyl phthalate exposure induced mitochondria-dependent ferroptosis by enhancing VDAC2 in zebrafish ZF4 cells.

Phthalate exposure aggravates periodontitis by activating NFκB pathway.

The Blood-Testis barrier disruption is a prerequisite for Toxicant-Induced peritubular macrophage increases in the testis of peripubertal rats.

Parabens/Triclosan/Antimicrobials

Parabens promotes invasive properties of multiple human cells: A potential cancer-associated adverse outcome pathway.

Butylparaben induced zebrafish (Danio rerio) kidney injury by down-regulating the PI3K-AKT pathway.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Paternal DDT exposure induces sex-specific programming of fetal growth, placenta development and offspring’s health phenotypes in a mouse model.

A realistic mixture of ubiquitous persistent organic pollutants affects bone and cartilage development in zebrafish by interaction with nuclear receptor signaling.

Chronic Aroclor 1260 Exposure Alters the Mouse Liver Proteome, Selenoproteins, and Metals in Steatotic Liver Disease.

Germ-free Status but Not Subacute Polychlorinated Biphenyl (PCB) Exposure Altered Hepatic Phosphatidylcholine and Ether-Phosphatidylcholine Levels in Mice.

PFAS

Life in the PFAS lane: The impact of perfluoroalkyl substances on photosynthesis, cellular exudates, nutrient cycling, and composition of a marine microbial community.

Determination of in vitro immunotoxic potencies of a series of perfluoralkylsubstances (PFASs) in human Namalwa B lymphocyte and human Jurkat T lymphocyte cells.

Proteomic and cardiac dysregulation by representative perfluoroalkyl acids of different chemical speciation during early embryogenesis of zebrafish.

Maternal PFOS exposure in mice induces hepatic lipid accumulation and inflammation in adult female offspring: Involvement of microbiome-gut-liver axis and autophagy.

Effects of developmental exposure to individual and combined PFAS on development and behavioral stress responses in larval zebrafish.

Flame Retardants

Mechanistic insight into biotransformation of novel triazine-based flame retardant 1,3,5-Tris(2,3-Dibromopropyl)-1,3,5-triazinane-2,4,6-trione by human cytochrome P450s.

Combined exposure to decabromodiphenyl ether and nano zero-valent iron aggravated oxidative stress and interfered with metabolism in earthworms.

Organotins

Tributyltin-induced oxidative stress causes developmental damage in the cardiovascular system of zebrafish (Danio rerio).

Pesticides

Bifenthrin induces changes in clinical poisoning symptoms, oxidative stress, DNA damage, histological characteristics, and transcriptome in Chinese giant salamander (Andrias davidianus) larvae.

Protective Effects of Curcumin and Nanomicelle Curcumin on Chlorpyrifos-induced Oxidative Damage and Inflammation in the Uterus, Ovary and Brain of Rats.

In vitro effects of two environmental toxicants, beauvericin and glyphosate in Roundup, on cell numbers and steroidogenesis of bovine ovarian cells.

Exposure to chlorpyrifos interferes with intercellular communication in cumulus-oocyte complexes during porcine oocyte maturation.

Sublethal acetamiprid exposure induces immunity, suppresses pathways linked to juvenile hormone synthesis in queens and affects cycle-related signaling in emerging bees.

Metals/Metalloids

Environmental cadmium inhibits testicular testosterone synthesis via Parkin-dependent MFN1 degradation.

In vivo chronic exposure to inorganic mercury worsens hypercholesterolemia, oxidative stress and atherosclerosis in the LDL receptor knockout mice.

Neurotoxic effects of low dose ranges of environmental metal mixture in a rat model: The benchmark approach.

Metallomic mapping of gut and brain in heavy metal exposed earthworms: A novel paradigm in ecotoxicology.

Microplastics/Nanomaterials

Nanoplastics increase in vitro oestrogenic activity of neurotherapeutic drugs.

Effect of Biofilm Forming on the Migration of Di(2-ethylhexyl)phthalate from PVC Plastics.

Enhanced neurotoxic effect of PCB-153 when co-exposed with polystyrene nanoplastics in zebrafish larvae.

Physiological response of mussel to rayon microfibers and PCB’s exposure: Overlooked semi-synthetic micropollutant?

The silent threat: Nanopolystyrene and chrysene pollutants disrupt the intestinal mucosal barrier, new insights from juvenile Siniperca chuatsi.

Combined neurotoxicity of aged microplastics and thiamethoxam in the early developmental stages of zebrafish (Daniorerio).

Exposure to polystyrene nanoplastics induces abnormal activation of innate immunity via the cGAS-STING pathway.

Combined toxic effects of polystyrene nanoplastics and lead on Chlorella vulgaris growth, membrane lipid peroxidation, antioxidant capacity, and morphological alterations.

Pharmaceuticals/Personal Care Products

Estrogenic endocrine disruptor exposure directly impacts erectile function. [DES]

Exposure/Environment Studies

Numerous Chemicals/Mixtures

Prioritization and Risk Ranking of Regulated and Unregulated Chemicals in US Drinking Water.

Phthalates

Ongoing exposure to endocrine disrupting phthalates and alternative plasticizers in neonatal intensive care unit patients.

Biomonitoring and health risk assessment of exposure to phthalate esters in waste management workers.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Carcinogenic, non-carcinogenic risk, and attributable cases to organochlorine pesticide exposure in women from Northern Mexico.

PFAS

Concentrations of PFAS in vegetables from Sydney and Newcastle, Australia.

Investigating the sources and fate of per- and polyfluoroalkyl substances (PFAS) in food waste compost.

Global quantification of emerging and legacy per- and polyfluoroalkyl substances in indoor dust: Levels, profiles and human exposure.

Flame Retardants

Bioaccessibility of halogenated flame retardants and organophosphate esters in settled dust: Influences of specific dust matrices from informal e-waste and end-of-life vehicle processing areas in Vietnam.

Polybrominated diphenyl ether contamination in sediments from rivers in the western Niger Delta of Nigeria.

Pesticides

Human Pesticide Exposure in Bolivia: A Scoping Review of Current Knowledge, Future Challenges and Research Needs.

Leaching of unexpected cyazofamid degradation products into groundwater demonstrates gaps in current pesticide risk assessment.

Microplastics/Nanomaterials

An Overview of the Possible Exposure of Infants to Microplastics.

Global discharge of microplastics from mechanical recycling of plastic waste.

Micro and nano plastics in fruits and vegetables: A review.

Miscellaneous

The hidden diet: Synthetic antioxidants in packaged food and their impact on human exposure and health.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. The searchable archives are at https://groups.google.com/d/forum/edc_research or online at https://heeds.org/category/edc-science-weekly/. Feel free to forward this email. Compiled by Sarah Howard of Healthy Environment and Endocrine Disruptor Strategies (HEEDS), a program of Environmental Health Sciences.

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