EDC Science Weekly, Mar. 22-28, 2024

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Events, Regulations/Policy, Methods/Tools/Screening, Commentaries, Reviews/Meta-Analyses, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Highlights: Public Health Risks of PFAS-Related Immunotoxicity Are Real; PFAS alters placental arterial vasculature in term human placentae

More science highlights

Events

Apr. 3 webinar: A Global Plastics Treaty That Protects Endocrine Health [Endocrine Society EDC Special Interest Group]

Apr. 4 symposium: Environmental exposures and kidney health [Duke Integrated Toxicology and Environmental Health Program]

Apr. 5: NIEHS Biomedical Career Symposium [EPA campus in Research Triangle Park, NC]

Apr. 18 webinar: Chemicals in plastics: Human health costs [EDC Strategies Partnership]

May 7 webinar: Endocrine disruptors and hormone levels during pregnancy [HEEDS Young EDC Scientists Showcase]

June 10-12: National PFAS Conference in Ann Arbor MI

June 23-28: Gordon Research Conference on EDCs June, in Tuscany Italy

More events

Regulations/Policy

Public Health Risks of PFAS-Related Immunotoxicity Are Real.

Pesticide risk assessment in European agriculture: Distribution patterns, ban-substitution effects and regulatory implications.

Agri-environmental policies from 1960 to 2022.

More EDC policy and regulations open for comment

Methods/Tools/Screening

Advancing Endocrine Disruptors via In Vitro Evaluation: Recognizing the Significance of the Organization for Economic Co-Operation and Development and United States Environmental Protection Agency Guidelines, Embracing New Assessment Methods, and the Urgent Need for a Comprehensive Battery of Tests.

New approach methodologies (NAMs): identifying and overcoming hurdles to accelerated adoption.

Predicting the Activity of Unidentified Chemicals in Complementary Bioassays from the HRMS Data to Pinpoint Potential Endocrine Disruptors.

Innovative analytical methodologies for characterizing chemical exposure with a view to next-generation risk assessment.

Preparation of synthetic micro- and nano plastics for method validation studies.

How many microplastics do you need to (sub)sample?

Commentaries

Plastics in the environment in the context of UV radiation, climate change and the Montreal Protocol: UNEP Environmental Effects Assessment Panel, Update 2023.

2024 United States Elections: Air Pollution, Neurodegeneration, Neuropsychiatric, and Neurodevelopmental Disorders. Who Cares?

Editorial: 2024 – A Promising Start for Regulatory Toxicology and Pharmacology.

Hazardous Effects of Pesticides on Human Health. [intro to a special issue in Toxics]

Thawing Permafrost Releases Industrial Contaminants into Arctic Communities. [News item in EHP]

Reviews/Meta-Analyses

Numerous Chemicals/Mixtures

Exposure to endocrine disrupting chemicals (bisphenols, parabens, and triclosan) and their associations with preterm birth in humans.

Assessing preconception exposure to environmental chemicals and fecundity: strategies, challenges, and research priorities.

Environmental Toxicants and Nephrotoxicity: Implications on Mechanisms and Therapeutic Strategies.

A review of endocrine disrupting chemicals migration from food contact materials into beverages.

BPA/Phenols

Health risks of Bisphenol-A exposure: From Wnt signaling perspective.

Toxicological Impact of Bisphenol A on Females’ Reproductive System: Review Based on Experimental and Epidemiological Studies.

PFAS

Changing the structure of PFOA and PFOS: a chemical industry strategy or a solution to avoid thyroid-disrupting effects?

A review of the occurrence and microbial transformation of per- and polyfluoroalkyl substances (PFAS) in aqueous film-forming foams (AFFFs)-impacted environments.

Pesticides

Parkinson’s Disease in Sub-Saharan Africa: Pesticides as a Double-Edged Sword.

Integrated Assessment for the Estrogenic Effects of Pyrethroid Compounds: Defining the Molecular Initiating Events and Key Events for the Adverse Outcome Pathway.

Pesticides: Unintended Impact on the Hidden World of Gut Microbiota.

Metals/Metalloids

Systematic review of studies on exposure to arsenic in drinking water and cognitive and neurobehavioral effects.

Microplastics/Nanomaterials

The possible impacts of nano and microplastics on human health: lessons from experimental models across multiple organs.

Microplastics in drinking water: A review on methods, occurrence, sources, and potential risks assessment.

Behavioral Studies of Zebrafish Reveal a New Perspective on the Reproductive Toxicity of Micro- and Nanoplastics.

Micro(nano)plastics and Their Potential Impact on Human Gut Health: A Narrative Review.

Miscellaneous

A systematic review of polycyclic aromatic hydrocarbon pollution: A combined bibliometric and mechanistic analysis of research trend toward an environmentally friendly solution.

Human Health Studies

Numerous Chemicals/Mixtures

Association of Environmental Injustice and Cardiovascular Diseases and Risk Factors in the United States.

Exposure to environmental toxicants is associated with gut microbiome dysbiosis, insulin resistance and obesity. [including PFAS]

Glucocorticoid hormones in relation to environmental exposure to bisphenols and multiclass pesticides among middle aged-women: Results from hair analysis.

An Exploratory Investigation of Organic Chemicals Detected in Baby Teeth: Differences in Children with and without Autism.

Phthalates

Analyzing the impact of phthalate and DINCH exposure on fetal growth in a cohort with repeated urine collection.

Phthalate metabolites and sex steroid hormones in relation to obesity in US adults: NHANES 2013-2016.

Phthalate exposure and blood pressure in U.S. children aged 8-17 years (NHANES 2013-2018).

Associations between mixed exposure to phthalates and latent tuberculosis infection among the general U.S. population from NHANES 2011-2012.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Exposure to 4,4′-DDE in visceral adipose tissue and weight loss in adolescents from the Teen-LABS cohort.

Level of polychlorinated biphenyls in tumor and blood serum of breast cancer patients and control subjects from Punjab, Pakistan.

PFAS

PFAS alters placental arterial vasculature in term human placentae: A prospective pregnancy cohort study.

Plasma per- and polyfluoroalkyl substance mixtures during pregnancy and duration of breastfeeding in the New Hampshire birth cohort study.

Exploring the impact of prenatal perfluoroalkyl and polyfluoroalkyl substances exposure on blood pressure in early childhood: A longitudinal analysis.

Exposure to per- and polyfluoroalkyl substances and high-throughput proteomics in Hispanic youth.

Impact of Gestational Exposure to Individual and Combined Per- and Polyfluoroalkyl Substances on a Placental Structure and Efficiency: Findings from the Ma’anshan Birth Cohort.

Firefighting, per- and polyfluoroalkyl substances, and DNA methylation of genes associated with prostate cancer risk.

Flame Retardants

Association between organophosphate flame retardant exposure and lipid metabolism: data from the 2013-2014 National Health and Nutrition Examination Survey.

Metals/Metalloids

Reduction of haemoglobin is related to metal mixtures exposure in Chinese preschoolers: Joint effect models.

Heavy metals and metalloids exposure and liver function in Chinese adults – A nationally representative cross-sectional study.

Analysis of relationship between mixed heavy metal exposure and early renal damage based on a weighted quantile sum regression and Bayesian kernel machine regression model.

Long-Term Environmental Methylmercury Exposure Is Associated with Peripheral Neuropathy and Cognitive Impairment among an Amazon Indigenous Population.

Clinical, Laboratory and Neurodevelopmental Findings in Children from the Yanomami-Ninam Population Chronically Exposed to Methylmercury.

Associations between Urinary Mercury/Cadmium Concentrations and Anthropometric Features in Korean Children.

Air Pollution

Pregnancy exposure to PM_2.5 from wildland fire smoke and preterm birth in California.

The role of liver enzymes in the association between ozone exposure and diabetes risk: a cross-sectional study of Zhuang adults in China.

Laboratory Studies

Numerous Chemicals/Mixtures

Revealing chemical release from plastic debris in animals’ digestive systems using nontarget and suspect screening and simulating digestive fluids.

Di (2-ethylhexyl) phthalate and polystyrene microplastics co-exposure caused oxidative stress to activate NF-κB/NLRP3 pathway aggravated pyroptosis and inflammation in mouse kidney.

Mixture toxicity of 6PPD-quinone and polystyrene nanoplastics in zebrafish.

The Cocktail Effects on the Acute Cytotoxicity of Pesticides and Pharmaceuticals Frequently Detected in the Environment.

BPA/Phenols

Molecular Insights into the Antioxidative and Anti-inflammatory Effects of P-Coumaric Acid against Bisphenol A-Induced Testicular Injury: In Vivo and In Silico Studies.

Syringin alleviates bisphenol A-induced spermatogenic defects and testicular injury by suppressing oxidative stress and inflammation in male zebrafish.

Efficacy of epigallocatechin gallate (EGCG) and its underlying mechanism in preventing bisphenol-A-induced metabolic disorders in mice.

Evaluation of the chronic toxicity of bisphenol A and bisphenol AF to sea cucumber Apostichopus japonicus after long-term single and combined exposure at environmental relevant concentration.

Cuscuta chinensis flavonoids alleviate ovarian damage in offspring female mice induced by BPA exposure during pregnancy by regulating the central carbon metabolism pathway.

Melatonin Alleviates BPA-Induced Testicular Apoptosis and Endoplasmic Reticulum Stress.

Effects of Acute and Developmental Exposure to Bisphenol S on Chinese Medaka (Oryzias sinensis).

Phthalates

Mitigating phthalate toxicity: The protective role of humic acid and clay in zebrafish larvae.

Molecular insights into the catabolism of dibutyl phthalate in Pseudomonas aeruginosa PS1 based on biochemical and multi-omics approaches.

Biotoxicity responses of Zebrafish in environmentally relevant concentration of Di (2-ethylhexyl) phthalate.

Dimethyl phthalate induced cardiovascular developmental toxicity in zebrafish embryos by regulating MAPK and calcium signaling pathways.

Differential Disruption of Glucose and Lipid Metabolism Induced by Phthalates in Human Hepatocytes and White Adipocytes.

Exposure to Plasticiser DEHP Affects Eggs Spawned by Blue Mussels: A Possible Risk to Fertilisation?

Parabens/Triclosan/Antimicrobials

Triclosan, an antimicrobial drug, induced reproductive impairment in the freshwater fish, Anabas testudineus (Bloch, 1792).

The Potential for Genotoxicity, Mutagenicity and Endocrine Disruption in Triclosan and Triclocarban Assessed through a Combination of In Vitro Methods.

Long-Term Triclocarban Exposure Induced Enterotoxicity by Triggering Intestinal AhR-Mediated Inflammation and Disrupting Microbial Community in Mice.

PFAS

Evidence of promoting effects of 6:2 Cl-PFESA on hepatocellular carcinoma proliferation in humans: An ideal alternative for PFOS in terms of environmental health?

Perfluorooctanoic acid inhibits cell proliferation through mitochondrial damage.

Mixtures of per- and polyfluoroalkyl substances (PFAS) alter sperm methylation and long-term reprogramming of offspring liver and fat transcriptome.

Quantitative Cross-Species comparison of serum albumin binding of per- and polyfluoroalkyl substances from five structural classes.

Roles of varying carbon chains and functional groups of legacy and emerging per-/polyfluoroalkyl substances in adsorption on metal-organic framework: Insights into mechanism and adsorption prediction.

Role of ABCB1 and ABCB4 in renal and biliary excretion of perfluorooctanoic acid in mice.

Evaluating potential developmental toxicity of perfluoroalkyl and polyfluoroalkyl substances in Xenopus laevis embryos and larvae.

Analysis of per- and polyfluoroalkyl substances (PFAS) in raw materials intended for the production of paper-based food contact materials – evaluating LC-MS/MS versus total fluorine and extractable organic fluorine.

Exploring the molecular mechanisms by which per- and polyfluoroalkyl substances induce polycystic ovary syndrome through in silico toxicogenomic data mining.

Per- and Polyfluoroalkyl Substances: Impacts on Morphology, Behavior and Lipid Levels in Zebrafish Embryos.

PFAS Modulate Osmotic Signaling Independent of Gravimetric Changes in the Rat Uterus.

Flame Retardants

Organophosphate ester flame retardants and plasticizers affect the phenotype and function of HepG2 liver cells.

Bioactivity assessment of organophosphate flame retardants via a dose-dependent yeast functional genomics approach.

Tetrabromobisphenol A exerts thyroid disrupting effects but has little overt impact on postnatal brain development and neurobehaviors in mice.

Pesticides

Exploring the Relationship Among Lipid Profile Changes, Growth, and Reproduction in Folsomia candida Exposed to Teflubenzuron Over Time.

Chlorpyrifos impairs sperm parameters and number of Sertoli and Leydig cells in rats after exposure during the peripubertal period.

Transcriptomic profile in carbendazim-induced developmental defects in zebrafish (Danio rerio) embryos/larvae.

Melatonin alleviates glyphosate-induced testosterone synthesis inhibition via targeting mitochondrial function in roosters.

Long-term exposure to aryl hydrocarbon receptor agonist neburon induces reproductive toxicity in male zebrafish (Danio rerio).

Glyphosate and aminomethylphosphonic acid metabolite (AMPA) modulate the phenotype of murine melanoma B16-F1 cells.

n-Acetylcysteine protects against diazinon-induced histopathological damage and apoptosis in renal tissue of rats.

Metals/Metalloids

Investigation of the protective effect of chitosan against arsenic-induced nephrotoxicity and oxidative damage in rat kidney tissue.

Activated fibroblasts modify keratinocyte stem niche through TET1 and IL-6 to promote their rapid transformation in a mouse model of prenatal arsenic exposure.

Cumulative effect of arsenic on the number of mouse offspring and the female reproductive hormones in mice.

Microplastics/Nanomaterials/Plastics

Harmful effects of true-to-life nanoplastics derived from PET water bottles in human alveolar macrophages.

ROS-dependent degeneration of human neurons induced by environmentally relevant levels of micro- and nanoplastics of diverse shapes and forms.

Dynamics of leaching of POPs and additives from plastic in a Procellariiform gastric model: Diet- and polymer-dependent effects and implications for long-term exposure.

Polystyrene microplastics with absorbed nonylphenol induce intestinal dysfunction in human Caco-2 cells.

Combined effects of polyethylene microplastics and carbendazim on Eisenia fetida: A comprehensive ecotoxicological study.

Miscellaneous

Trichloroethylene metabolite modulates DNA methylation-dependent gene expression in Th1 polarized CD4+ T cells from autoimmune-prone mice.

Indications of Endocrine Disruptor Effects of JP-5 Jet Fuel Using a Rat-Model Reproductive Study and an In Vitro Human Hormone Receptor Assay.

Exposure/Environment Studies

BPA/Phenols

Feasibility of sulfated BPA and BPS as wastewater-based epidemiology biomarkers: Insights from wastewater and reported human urine analysis.

Parabens/Triclosan/Antimicrobials

A large-scale survey of urinary parabens and triclocarban in the Chinese population as well as the influencing factors and health risks.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Germany’s first Total Diet Study – Occurrence of non-dioxin-like polychlorinated biphenyls and polybrominated diphenyl ethers in foods.

Concentration of polychlorinated biphenyls and risk assessment in finless porpoises from the East China Sea.

PFAS

Crowdsourcing citizens for statewide mapping of per- and polyfluoroalkyl substances (PFAS) in Florida drinking water.

Evaluation of per- and polyfluoroalkyl substances (PFAS) in landfill liquids from Pennsylvania, Colorado, and Wisconsin.

Evaluation of ecological impacts with ferrous iron addition in constructed wetland under perfluorooctanoic acid stress.

Species-specific profiles of per- and polyfluoroalkyl substances (PFAS) in small coastal sharks along the South Atlantic Bight of the United States.

Non-target and target screening and risk assessment of per- and polyfluoroalkyl substances in textile wastewater and receiving river.

Exploring Perfluoroalkyl Substances (PFASs) in Aquatic Fauna of Lake Trasimeno (Italy): Insights from a Low-Anthropized Area.

Pesticides

Exposure of Male Farmers and Nonfarmers to Neonicotinoid Pesticides in the South-West and Littoral Regions of Cameroon: A Comparative Study.

Simultaneous determination of diquat, paraquat, glufosinate, and glyphosate in plasma by liquid chromatography/tandem mass spectrometry: from method development to clinical application.

Organochlorine, organophosphorus, and carbamate pesticide residues in an Ethiopian Rift Valley Lake Hawassa: occurrences and possible ecological risks.

Metals/Metalloids

Effect of an Arsenic Mitigation Program on Arsenic Exposure in American Indian Communities: A Cluster Randomized Controlled Trial of the Community-Led Strong Heart Water Study Program. [see related Invited Perspective: The Importance of Community Involvement in Interventions to Reduce Arsenic Exposure and Improve Health Outcomes in Indigenous Communities.]

Maternal and Umbilical Cord Blood Lead Levels in Selected Informal Settlements in Nairobi, Kenya: A Cross-Sectional Study.

Bioaccumulation of trace metals in the plastisphere: Awareness of environmental risk from a European perspective.

Microplastics/Nanomaterials

Microplastics contamination in water supply system and treatment processes.

Disposable surgical/medical face masks and filtering face pieces: Source of microplastics and chemical additives in the environment.

Birds as bioindicators of plastic pollution in terrestrial and freshwater environments: A 30-year review.

Air Pollution

Assessing the 2023 Canadian wildfire smoke impact in Northeastern US: Air quality, exposure and environmental justice.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. The searchable archives are at https://groups.google.com/d/forum/edc_research or online at https://heeds.org/category/edc-science-weekly/. Feel free to forward this email. Compiled by Sarah Howard of Healthy Environment and Endocrine Disruptor Strategies (HEEDS), a program of Environmental Health Sciences.

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