EDC Science Weekly, Feb. 9-15, 2024

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Events, Methods/Tools/Screening, Commentaries, Reviews/Meta-Analyses, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Highlights: Prenatal phthalate exposure and adverse birth outcomes: burden and costs; personal care products, socioeconomic status, and EDCs in Black women; EDCs and child eating behaviors.

More science highlights

Events

Webinar Feb. 15 (today!): From the Frontline: Petrochemicals, Plastics, and Cancer Alley [Plastic Pollution Coalition]

Webinar Feb. 20: How NY is Holding Pepsi Accountable for Its Plastic Pollution – & Your State Can, Too [Beyond Plastics]

Webinar Feb. 20: Prioritizing Five Chemicals for Risk Evaluation Under TSCA [EPA]

Webinar Feb. 21: Informational webinar on the Reach the Decision Makers program [UCSF EaRTH Center. Applications due Mar. 11]

Webinar Feb. 22: Tattoo Inks, Cancer and Other Chronic Diseases: Gaps in research and regulation [in Spanish and English, via CHE]

Conference Mar. 11-14: 10th Copenhagen Workshop on Endocrine Disruptors – COW2024.

Meeting March 22: HEEDS EDC- North Carolina annual meeting [free and open to anyone]

Gordon Research Conference on EDCs June 23-28, Tuscany Italy.

More events

Methods/Tools/Screening

Protecting Human and Animal Health: The Road from Animal Models to New Approach Methods.

Human biomonitoring and toxicokinetics as key building blocks for next generation risk assessment.

Fish Physiologically Based Toxicokinetic Modeling Approach for In Vitro-In Vivo and Cross-Species Extrapolation of Endocrine-Disrupting Chemicals in Risk Assessment.

HESI workshop summary: Interpretation of developmental and reproductive toxicity endpoints and the impact on data interpretation of adverse events.

Endocrine-disrupting compounds and their impact on human placental function: evidence from placenta organ-on-chip studies.

Predicting the Metal Mixture Toxicity with a Toxicokinetic-Toxicodynamic Model Considering the Time-Dependent Adverse Outcome Pathways.

Fluorinated Pharmaceutical and Pesticide Photolysis: Investigating Reactivity and Identifying Fluorinated Products by Combining Computational Chemistry,¹⁹F NMR, and Mass Spectrometry.

More tools, reports, and resources

Commentaries

The “Microplastome” – A Holistic Perspective to Capture the Real-World Ecology of Microplastics.

Food Pesticide Residues Monitoring and Health Risk Assessment. [intro to a special issue in Foods]

Exploring Obesity Risk, Prevention, and Research Innovation in the First 2000 Days of Life: Volume II [intro to a special issue in Frontiers in Endocrinology; doesn’t include EDCs]

Reviews/Meta-Analyses

Numerous Chemicals/Mixtures

Thyroid dysfunction caused by exposure to environmental endocrine disruptors and the underlying mechanism: A review.

A systematic review and meta-analysis of human population studies on the association between exposure to toxic environmental chemicals and left ventricular dysfunction (LVD). [metals and air pollution]

BPA/Phenols

Nonylphenol and its derivatives: Environmental distribution, treatment strategy, management and future perspectives.

Parabens/Triclosan/Antimicrobials

Toxic effects of triclosan in aquatic organisms: A review focusing on single and combined exposure to environmental conditions and pollutants.

Flame Retardants

Uptake, translocation, and metabolism of organophosphate esters (OPEs) in plants and health perspective for human: A review.

Pesticides

Exposure to pesticides and risk of colorectal cancer: A systematic review and meta-analysis.

Exploring environmental exposomes and the gut-brain nexus: Unveiling the impact of pesticide exposure.

Metals/Metalloids

Heavy metals in biological samples of cancer patients: a systematic literature review.

Critical period of exposure to mercury and the diagnostic of autism spectrum disorder: A systematic review.

The Toxicity of Mercury and Its Chemical Compounds: Molecular Mechanisms and Environmental and Human Health Implications: A Comprehensive Review.

Cadmium as a male reproductive toxicant and natural and non-natural ways to tackle it: a review.

Neurotoxic effects of heavy metal pollutants in the environment: Focusing on epigenetic mechanisms.

Could the gut microbiota be capable of making individuals more or less susceptible to environmental toxicants?

Microplastics/Nanomaterials

A Latest Review on Micro- and Nanoplastics in the Aquatic Environment: The Comparative Impact of Size on Environmental Behavior and Toxic Effect.

Air Pollution

A comprehensive review on endocrine toxicity of gaseous components and particulate matter in smog.

Human Health Studies

Numerous Chemicals/Mixtures

Associations of parental preconception and maternal pregnancy urinary phthalate biomarker and bisphenol-a concentrations with child eating behaviors.

Adherence to the EAT-Lancet diet in relation to mortality and exposure to food contaminants in population-based cohorts of Swedish men and women.

BPA/Phenols

Urinary concentrations of bisphenol A and its alternatives: Potential predictors of and associations with antral follicle count among women from an infertility clinic in Northern China.

Epigenetic Methylation Changes in Pregnant Women: Bisphenol Exposure and Atopic Dermatitis.

Phthalates

Prenatal phthalate exposure and adverse birth outcomes in the USA: a prospective analysis of births and estimates of attributable burden and costs.

Exposure to di-2-ethylhexyl phthalate (DEHP) increases the risk of cancer.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Association of UGT1A1 gene variants, expression levels, and enzyme concentrations with 2,3,7,8-TCDD exposure in individuals exposed to Agent Orange/Dioxin.

PFAS

Association between per- and polyfluoroalkyl substances exposure and thyroid function biomarkers among females attending a fertility clinic.

Associations between per- and polyfluoroalkyl substances exposure and thyroid hormone levels in the elderly.

Associations of per- and polyfluoroalkyl substances with maternal metabolic and inflammatory biomarkers in early-to-mid-pregnancy.

Evaluating the association between longitudinal exposure to a PFAS mixture and adolescent cardiometabolic risk in the HOME Study.

Associations of per- and polyfluoroalkyl substances and nonalcoholic fatty liver disease in the United States adult population, 2003-2018.

The interaction of perfluoroalkyl acids and a family history of diabetes on arthritis: analyses of 2011-2018 NHANES.

Mortality and cancer incidence in perfluorooctanesulfonyl fluoride production workers.

Pesticides

Association between dietary pesticide exposure profiles and body weight change in French adults: Results from the NutriNet-Santé cohort.

Pesticide use and inflammatory bowel disease in licensed pesticide applicators and spouses in the Agricultural Health Study.

Metals/Metalloids

Metabolic and Environmental Biomarkers in Mild Cognitive Impairment and Dementia: An Exploratory Study.

Association between maternal blood or cord blood metal concentrations and catch-up growth in children born small for gestational age: an analysis by the Japan environment and children’s study.

Association of blood metals with anxiety among adults: A nationally representative cross-sectional study.

Air Pollution

Outdoor air pollution exposure and uterine cancer incidence in the sister study.

Pharmaceuticals/Personal Care Products

Associations of personal care products use with reproductive outcomes of IVF/ICSI treatment.

Miscellaneous

Diabetes: a potential mediator of associations between polycyclic aromatic hydrocarbon exposure and stroke.

Dyslexia is associated with polycyclic aromatic hydrocarbon metabolite concentrations in the urine of children from China: Data from the READ program.

Laboratory Studies

BPA/Phenols

A biochemical and histological evaluation of in vivo exposure of bisphenol P for multi-organ toxicity and pathology in rats.

Structural insight into the mechanisms and interacting features of endocrine disruptor Bisphenol A and its analogs with human estrogen-related receptor gamma.

Multiphase Ozonolysis of Bisphenol A: Chemical Transformations on Surfaces in the Environment.

18β-Glycyrrhetinic acid exerts cardioprotective effects against BPA-induced cardiotoxicity through antiapoptotic and antioxidant mechanisms.

Biochemical responses and antioxidant defense mechanisms in Channa Striatus exposed to Bisphenol S.

Exposure to bisphenol A affects transcriptome-wide N6-methyladenine methylation in ovarian granulosa cells.

Phthalates

Are the new phthalates safe? Evaluation of Diisononilphtalate (DINP) effects in porcine ovarian cell cultures.

Maternal exposure to di-(2-ethylhexyl) phthalate impaired the social interaction via activating microglia in male pups.

Exposure to MEHP during Pregnancy and Lactation Impairs Offspring Growth and Development by Disrupting Thyroid Hormone Homeostasis.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Postnatal Exposure to the Endocrine Disruptor Dichlorodiphenyltrichloroethane Affects Adrenomedullary Chromaffin Cell Physiology and Alters the Balance of Mechanisms Underlying Cell Renewal.

Results of an international interlaboratory study on dioxin-like activities in drinking-, river surface- and wastewater using DR CALUX bioassay.

Environmentally relevant concentrations of 2,3,7,8-TCDD induced inhibition of multicellular alternative splicing and transcriptional dysregulation.

PFAS

Perinatal exposure to PFOS and sustained high-fat diet promote neurodevelopmental disorders via genomic reprogramming of pathways associated with neuromotor development.

Toxicity and bioaccumulation of the fluorosurfactant cC₆O₄ in the earthworm Eisenia foetida (Savigny, 1826).

Perfluorooctanesulfonic acid (PFOS) disrupts cadherin-16 in the developing rat thyroid gland.

Flame Retardants

New Insights into Decabromodiphenyl Ether-Induced Splenic Injury in Chickens: Involvement of ROS-Mediated Endoplasmic Reticulum Stress Pathway Triggering Autophagy and Apoptosis.

Highly impact toughened and excellent flame-retardant polylactide/poly(butylene adipate-co-terephthalate) blend foams with phosphorus-containing and food waste-derived flame retardants.

Organotins

Whole-Transcriptome Analysis Reveals the RNA Profiles in Mouse Bone Marrow Mesenchymal Stem Cells or Zebrafish Embryos After Exposure to Environmental Level of Tributyltin.

Pesticides

Chlorothalonil as a potential endocrine disruptor in male zebrafish (Danio rerio): Impact on the hypothalamus-pituitary-gonad axis and sperm quality.

Early and transitory hypoactivity and olfactory alterations after chronic atrazine exposure in female Sprague-Dawley rats.

Berberine alleviates chlorpyrifos-induced nephrotoxicity in rats via modulation of Nrf2/HO-1 axis.

Quantification of the tissue distribution and accumulation of the neonicotinoid pesticide clothianidin and its metabolites in maternal and fetal mice.

Oxidative stress and mitochondrial dysfunction in brain of vinclozolin exposed animals.

Induction of Paraquat-Mediated Parkinsonian Phenotype in Zebrafish.

Fungicide ingestion reduces net energy gain and microbiome diversity of the solitary mason bee.

Microplastics/Nanomaterials

Microplastics may induce food dilution and endocrine disrupting effects in fathead minnows (Pimephales promelas), and decrease offspring quality.

Are bioplastics safe? Hazardous effects of polylactic acid (PLA) nanoplastics in Drosophila.

Comparison of sulfide-induced transformation of biodegradable and conventional microplastics: Mechanism and environmental fate.

Independent and synergistic effects of microplastics and endocrine-disrupting chemicals on the reproductive social behavior of fathead minnows (Pimephales promelas).

Polystyrene nanoplastics inhibit beige fat function and exacerbate metabolic disorder in high-fat diet-fed mice.

Polyethylene nanoparticles at environmentally relevant concentrations enhances neurotoxicity and accumulation of 6-PPD quinone in Caenorhabditis elegans.

Polystyrene microplastics mitigate lead-induced neurotoxicity by reducing heavy metal uptake in zebrafish larvae.

Oxidative stress-activated Nrf2 remitted polystyrene nanoplastic-induced mitochondrial damage and inflammatory response in HepG2 cells.

Exposure to different surface-modified polystyrene nanoparticles caused anxiety, depression, and social deficit in mice via damaging mitochondria in neurons.

Oral exposure of polystyrene microplastics and doxycycline affects mice neurological function via gut microbiota disruption: The orchestrating role of fecal microbiota transplantation.

Transcriptomic and metabolomic analysis unveils nanoplastic-induced gut barrier dysfunction via STAT1/6 and ERK pathways.

Polyethylene microplastics induced lipidomic responses in Chironomus tepperi: A two-generational exploration.

Can Microplastics Accumulate Toxic dye in Water? An adsorption-desorption Study under Different Experimental Conditions.

Miscellaneous

In vitro assessment of potential endocrine disrupting activities of chlorinated paraffins of various chain lengths.

Environmental chemical TCPOBOP exposure alters milk liposomes and offspring growth trajectories in mice.

In vitro metabolism of the emerging contaminant 6PPD-quinone in human and rat liver microsomes: Kinetics, pathways, and mechanism.

Chronic exposure to 3,6-dichlorocarbazole exacerbates non-alcoholic fatty liver disease in zebrafish by disrupting lipid metabolism and inducing special lipid biomarker accumulation.

Exposure/Environment Studies

Numerous Chemicals/Mixtures

Exploring additives beyond phthalates: Release from plastic mulching films, biodegradation and occurrence in agricultural soils.

BPA/Phenols

‘Occurrence of Chlorinated Derivatives of Bisphenol S in Paper Products and Their Potential Health Risks through Dermal Exposure.

Phthalates

Dust-phase phthalates in university dormitories in Beijing, China: pollution characteristics, potential sources, and non-dietary oral exposure.

Assessment of baby disposable diapers application for urine collection and determination of phthalate metabolites.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Comprehensive characterization and prioritization of halogenated organic compounds in fish and their implications for exposure.

PFAS

Per- and Polyfluoroalkyl Substances (PFAS) in Serum of 2 to 5 year-Old Children: Temporal Trends, Determinants, and Correlations with Maternal PFAS Concentrations.

Short-term mass loads of per- and polyfluoroalkyl substances in a wastewater treatment plant from South China.

Occurrence, source apportionment and risk assessment of perfluorinated compounds in sediments from the longest river in Asia.

High-Resolution Mass Spectrometry Non-Targeted Detection of Per- and Polyfluoroalkyl Substances in Roe Deer (Capreolus capreolus).

Occurrence of antibiotics, hormones and PFAs in surface water from a Nile tilapia aquaculture facility in a Brazilian hydroelectric reservoir.

Uptake and cellular responses of Microcystis aeruginosa to PFOS in various environmental conditions.

Flame Retardants

Indoor environment, physiological factors, and diet as predictors of halogenated flame retardant levels in stool and plasma of children from a Canadian cohort.

Organophosphate flame retardants and their metabolites in the Pearl River Estuary: Occurrence, influencing factors, and ecological risk control strategies based on a mass balance model.

Organophosphate esters in edible marine fish: Tissue-specific distribution, species-specific bioaccumulation, and human exposure.

Pesticides

Child exposure to organophosphate and pyrethroid insecticides measured in urine, wristbands, and household dust and its implications for child health in South Africa: A panel study.

Pesticide exposure in greenspaces: Comparing field measurement of dermal contamination with values predicted by registration models.

Metals/Metalloids

Urinary biomarkers of exposure to toxic and essential elements: A comparison of infants fed with human milk or formula.

Microplastics/Nanomaterials

Plastic webs, the new food: Dynamics of microplastics in a Mediterranean food web, key species as pollution sources and receptors.

Plastic does not simply flow into the sea: River transport dynamics affected by tides and floating plants.

Pharmaceuticals/Personal Care Products

Personal Care Products, Socioeconomic Status, and Endocrine-Disrupting Chemical Mixtures in Black Women.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me and ask to join the EDC Science Weekly group EDC_re…@googlegroups.com. The searchable archives are at https://groups.google.com/d/forum/edc_research or online at https://heeds.org/category/edc-science-weekly/. Compiled by Sarah Howard of Healthy Environment and Endocrine Disruptor Strategies (HEEDS), a program of Environmental Health Sciences.

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