EDC Science Weekly, Feb. 2-8, 2024

Post author:HEEDS
Post published:February 8, 2024
Post category:EDC Science Weekly

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Events, Regulations/Policy, Methods/Tools/Screening, Commentaries, Reviews/Meta-Analyses, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

TL;DR Highlights: Comprehensive PFAS human health dashboard; air pollution particles in breast milk; The EU ban on microplastics includes artificial rurf crumb rubber infill; PFOA serum half-life; PFAS in contact lens users.

More science highlights

Events

Webinar February 13: Science for Prevention: Identifying breast carcinogens [EDC Strategies Partnership]

CME course Feb. 13: How Environmental Health Research Guides Clinical Care: PFAS, Obesity, and Bone Health [The Pediatric Environmental Health Center at Boston Children’s Hospital and the New England Region Pediatric Environmental Health Specialty Unit]

Webinar Feb. 20: How NY is Holding Pepsi Accountable for Its Plastic Pollution – & Your State Can, Too [Beyond Plastics]

Webinar Feb. 20: Prioritizing Five Chemicals for Risk Evaluation Under TSCA [EPA]

Webinar Feb. 21: Informational webinar on the Reach the Decision Makers program [UCSF EaRTH Center. Applications due Mar. 11]

Webinar Feb. 22: Tattoo Inks, Cancer and Other Chronic Diseases: Gaps in research and regulation [in Spanish and English, via CHE]

Conference Mar. 11-14: 10th Copenhagen Workshop on Endocrine Disruptors – COW2024.

Meeting March 22: HEEDS EDC- North Carolina annual meeting [free and open to anyone]

Gordon Research Conference on EDCs June 23-28, Tuscany Italy.

More events

Regulations/Policy

The European Union Ban on Microplastics Includes Artificial Turf Crumb Rubber Infill: Other Nations Should Follow Suit.

The ETA-ESE statement on the European Chemicals Agency opinion on iodine as an endocrine disruptor.

More EDC policy and regulations open for comment

Methods/Tools/Screening

Adverse effects in traditional and alternative toxicity tests.

Organoids and organoids-on-a-chip as the new testing strategies for environmental toxicology-applications & advantages.

Investigating the applicability domain of the hiPSC-based PluriLum assay: an embryotoxicity assessment of chemicals and drugs.

The Need to Include a Fluorine Mass Balance in the Development of Effective Technologies for PFAS Destruction.

Nominally identical microplastic models differ greatly in their particle-cell interactions.

More tools, reports, and resources

Commentaries

Editorial: Endocrine disruptors and diseases of brain and mind: past and prelude. [intro to a research topic in Frontiers in Endocrinology]

Estimated scale of costs to remove PFAS from the environment at current emission rates.

Marking Time: Epigenetic Aging May Partially Explain the Arsenic-Cardiovascular Disease Link.

Reviews/Meta-Analyses

Numerous Chemicals/Mixtures

Deleterious Biological Effects of Endocrine Disruptors: An Insight into Human Health Risks.

Disruption of the thyroid hormone system and patterns of altered thyroid hormones after gestational chemical exposures in rodents – a systematic review

Estrogens, Adipose Tissues, and Environmental Exposures Influence Obesity and Diabetes Across the Lifecycle.

The adverse role of endocrine disrupting chemicals in the reproductive system.

Special issue in Philos Trans R Soc Lond B Biol Sci on “Endocrine responses to environmental variation: conceptual approaches and recent developments” includes:

BPA/Phenols

Effects and mechanisms of bisphenols exposure on neurodegenerative diseases risk: A systemic review.

Bisphenol A in dairy products, amount, potential risks, and the various analytical methods, a systematic review.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Insights into Organochlorine Pesticides Exposure in the Development of Cardiovascular Diseases: A Systematic Review.

Polychlorinated biphenyls exposure and type 2 diabetes: Molecular mechanism that causes insulin resistance and islet damage.

Advances in polychlorinated biphenyls-induced female reproductive toxicity.

PFAS

Expanded Systematic Evidence Map for Hundreds of Per- and Polyfluoroalkyl Substances (PFAS) and Comprehensive PFAS Human Health Dashboard.

Metal-Organic Framework-Based Composites for the Adsorption Removal of Per- and Polyfluoroalkyl Substances from Water.

Occurrence, fate, and remediation for per-and polyfluoroalkyl substances (PFAS) in sewage sludge: A comprehensive review.

Pesticides

Novel protective aspects of dietary polyphenols against pesticidal toxicity and its prospective application in rice-fish mode: A Review.

Unlocking the interaction of organophosphorus pesticide residues with ecosystem: Toxicity and bioremediation.

Neurotoxicity of glyphosate: focus on molecular mechanisms probably associated with alterations in cognition and behavior.

Metals/Metalloids

Metalloestrogens exposure and risk of gestational diabetes mellitus: Evidence emerging from the systematic review and meta-analysis.

Non-essential heavy metal effects in cardiovascular diseases: an overview of systematic reviews.

Microplastics/Nanomaterials

Are you drowned in microplastic pollution? A brief insight on the current knowledge for early career researchers developing novel remediation strategies.

Integrating aggregate exposure pathway and adverse outcome pathway for micro/nanoplastics: A review on exposure, toxicokinetics, and toxicity studies.

From organic fertilizer to the soils: What happens to the microplastics? A critical review.

Microplastics in the Asia-Pacific Region in the Plasticene Era: Exposures and Health Risks.

Chemical methods to remove microplastics from wastewater: A review.

Air Pollution

Air pollution exposure and cardiometabolic risk.

Pharmaceuticals/Personal Care Products

Long-term dietary exposure to the non-steroidal anti-inflammatory drugs diclofenac and ibuprofen can affect the physiology of common carp (Cyprinus carpio) on multiple levels, even at “environmentally relevant” concentrations.

Human Health Studies

Numerous Chemicals/Mixtures

Long-term Impacts of Endocrine-Disrupting Chemicals Exposure on Kidney Function: A Community-Based Cohort Study. [phenols, phthalates, parabens, etc.]

BPA/Phenols

Bisphenol chemicals in colostrum from Shanghai, China during 2006-2019: Concentration, temporal variation, and potential influence on birth parameters.

Cross sectional study on exposure to BPA and its analogues and semen parameters in Czech men.

Bisphenol S, bisphenol F, bisphenol a exposure and body composition in US adults.

Bisphenol A and its alternatives bisphenol S and F exposure with serum uric acid levels, hyperuricemia, and gout prevalence among US adults: a nationally representative cross-sectional study.

Relationship between Bisphenol A and Autoimmune thyroid disease in Women of Reproductive Age

Phthalates

The effect of low-level phthalate mixture on the prevalence of type 2 diabetes mellitus among adults in the US.

Association between phthalate metabolite mixture in neonatal cord serum and birth outcomes.

PFAS

Associations of prenatal exposure to per- and polyfluoroalkyl substances and fetal sex hormones in the Guangxi Zhuang Birth Cohort Study: Greater effect of long-chain PFAS.

The association between per- and polyfluoroalkyl substances (PFASs) and brain, esophageal, melanomatous skin, prostate, and lung cancer using the 2003-2018 US National Health and Nutrition Examination Survey (NHANES) datasets.

Association among serum per- and polyfluoroalkyl substances, lipid profile and metabolic syndrome in Czech adults, HBM-EHES survey 2019.

Associations between serum per- and polyfluoroalkyl substances and thyroid hormones in Chinese adults: A nationally representative cross-sectional study.

Pesticides

Agricultural paraquat dichloride use and Parkinson’s disease in California’s Central Valley.

A comprehensive multiplatform metabolomic analysis reveals alterations of 2-hydroxybutyric acid among women with deep endometriosis related to the pesticide trans-nonachlor.

Metals/Metalloids

Effects of chronic low-level lead (Pb) exposure on cognitive function and hippocampal neuronal ferroptosis: An integrative approach using bioinformatics analysis, machine learning, and experimental validation. [human and lab study]

Evaluation of Environmental Contamination by Heavy Metals and Relationship with Cardiovascular Risk in a Population of Barcarena-PA.

Prenatal Metal Exposures and Child Social Responsiveness Scale Scores in 2 Prospective Studies.

Air Pollution

Exposure to particulate matter may affect semen quality via trace metals: Evidence from a retrospective cohort study on fertile males.

Secular trends in type 2 diabetes mellitus attributable to PM_2.5 exposure in China from 1990 to 2019: an age-period-cohort analysis.

Pharmaceuticals/Personal Care Products

Personal Care Product Use during Puberty and Incident Breast Cancer among Black, Hispanic/Latina, and White Women in a Prospective US-Wide Cohort. [and related Invited Perspective: Deciphering the Role of Endocrine Disruptors in Cancer-Challenges and Opportunities for Epidemiological Research.]

Laboratory Studies

BPA/Phenols

Effects of Bisphenol A and Its Substitute, Bisphenol F, on the Gut Microbiota in Mice.

Bisphenol F affects neurodevelopmental gene expression, mushroom body development and behavior in Drosophila melanogaster.

Mode of action exploration of reproductive toxicity induced by bisphenol S using human normal ovarian epithelial cells through ERβ-MAPK signaling pathway.

The Possible Protective Effect of Taurine on Bisphenol: Induced Structural Changes on the Cerebral Cortex of Rats: Histological and Immunohistochemical Study.

Ginger volatile oil inhibits the growth of MDA-MB-231 in the bisphenol A environment by altering gut microbial diversity.

Comparative cardiotoxicity assessment of bisphenol chemicals and estradiol using human induced pluripotent stem cell-derived cardiomyocytes.

BPA and low-Se exacerbate apoptosis and mitophagy in chicken pancreatic cells by regulating the PTEN/PI3K/AKT/mTOR pathway.

Widely targeted quantitative lipidomics reveal lipid remodeling in adipose tissue after long term of the combined exposure to bisphenol A and fructose.

Bombesin-like receptor 3 expression induced by bisphenol A is likely associated with reduced cell proliferation by inhibiting DNA synthesis and inducing inflammation in liver cells.

Bisphenol A induces placental ferroptosis and fetal growth restriction via the YAP/TAZ-ferritinophagy axis.

Phthalates

The Impact of Chronic Phthalate Exposure on Rodent Anxiety and Cognition.

Di (2-ethylhexyl) phthalate induced lipophagy-related renal ferroptosis in quail (Coturnix japonica).

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

The aryl hydrocarbon receptor in β-cells mediates the effects of TCDD on glucose homeostasis in mice.

Agent Orange Herbicidal Toxin-Initiation of Alzheimer-Type Neurodegeneration.

Differential eigengene network analysis reveals benzo[a]pyrene and 2,3,7,8-tetrachlorodibenzo-p-dioxin consensus regulatory network in human liver cell line HepG2.

Proteomic insight towards key modulating proteins regulated by the aryl hydrocarbon receptor involved in ovarian Cancer carcinogenesis and Chemoresistance.

PFAS

Hepatic injury and ileitis associated with gut microbiota dysbiosis in mice upon F-53B exposure.

When polyethylene terephthalate microplastics meet Perfluorooctane sulfonate in thermophilic biogas upgrading system: Their effect on methanogenesis.

Differential regulations of neural activity and survival in primary cortical neurons by PFOA or PFHpA.

The effects of two short-chain perfluoroalkyl carboxylic acids (PFCAs) on northern leopard frog (Rana pipiens) tadpole development.

Nanoplastics Affect the Bioaccumulation and Gut Toxicity of Emerging Perfluoroalkyl Acid Alternatives to Aquatic Insects (Chironomus kiinensis): Importance of Plastic Surface Charge.

Hormetic effect of a short-chain PFBS on Microcystis aeruginosa and its molecular mechanism.

Flame Retardants

A molecularly engineered fully bio-derived phosphorylated furan-based flame retardant for biomass-based fabrics.

Tris(1,3-dichloro-2-propyl) phosphate disrupts cellular metabolism within human embryonic kidney (HEK293) cells.

Chronic exposure to tris (2-chloroethyl) phosphate (TCEP) induces brain structural and functional changes in zebrafish (Danio rerio): A comparative study on the environmental and LC50 concentrations of TCEP.

Deciphering the impact of decabromodiphenyl ether (BDE-209) on benthic foraminiferal communities: Insights from Cell-Tracker Green staining and eDNA metabarcoding.

Pesticides

Pubertal glyphosate-based herbicide exposure aggravates high-fat diet-induced obesity in female mice.

Continuous low-level dietary exposure to glyphosate elicits dose and sex-dependent synaptic and microglial adaptations in the rodent brain.

Effect of glyphosate, its metabolite AMPA, and the glyphosate formulation Roundup^® on brown trout (Salmo trutta f. fario) gut microbiome diversity.

Polyoxyethylene tallow amine and glyphosate exert different developmental toxicities on human pluripotent stem cells-derived heart organoid model.

Effects of atrazine and curcumin exposure on TCMK-1 cells: Oxidative damage, pyroptosis and cell cycle arrest.

No-observed-adverse-effect-level (NOAEL) clothianidin, a neonicotinoid pesticide, impairs hippocampal memory and motor learning associated with alteration of gene expression in cerebellum.

Effect of clothianidin exposure at the no-observed-adverse-effect level (NOAEL) in a mouse model of atopic dermatitis.

Metals/Metalloids

Chronic arsenic exposure affects stromal cells and signaling in the small intestine in a sex-specific manner.

Role of an interdependent Wnt, GSK3-β/β-catenin and HB-EGF/EGFR mechanism in arsenic-induced hippocampal neurotoxicity in adult mice.

Microplastics/Nanomaterials

Polystyrene microplastic-induced oxidative stress triggers intestinal barrier dysfunction via the NF-κB/NLRP3/IL-1β/MCLK pathway.

Polystyrene nanoparticles strengthen high glucose toxicity associated with alteration in insulin signaling pathway in C. elegans.

Simulated gastrointestinal digestion of two different sources of biodegradable microplastics and the influence on gut microbiota.

Long-term polystyrene nanoplastic exposure disrupt hepatic lipid metabolism and cause atherosclerosis in ApoE^-/- mice.

Abiotic weathering of plastic: Experimental contributions towards understanding the formation of microplastics and other plastic related particulate pollutants.

The in vitro gastrointestinal digestion-associated protein corona of polystyrene nano- and microplastics increases their uptake by human THP-1-derived macrophages.

Differences in toxicity induced by the various polymer types of nanoplastics on HepG2 cells.

Toxic effects of environmental-relevant exposure to polyethylene terephthalate (PET) micro and nanoparticles in zebrafish early development.

Airborne Nanoplastics Exposure Inducing Irreversible Glucose Increase and Complete Hepatic Insulin Resistance.

Association of specific gut microbiota with polyethylene microplastics caused gut dysbiosis and increased susceptibility to opportunistic pathogens in honeybees.

Miscellaneous

Environmentally realistic dose of tire-derived metabolite 6PPD-Q exposure causes intestinal jejunum and ileum damage in mice via cannabinoid receptor-activated inflammation.

Exposure/Environment Studies

Numerous Chemicals/Mixtures

A meta-analysis highlighting the increasing relevance of the hair matrix in exposure assessment to organic pollutants.

Coastal wastewater treatment plants as a source of endocrine disrupting micropollutants: a case study of Lithuania in the Baltic Sea.

Phthalates

Exposure assessment of plastics, phthalate plasticizers and their transformation products in diverse bio-based fertilizers.

Soil health hazards of di(2-ethylhexyl) phthalate: New perspectives on earthworms from different ecological niches DNA damage, gut microbial disruption and soil enzyme changes.

Parabens/Triclosan/Antimicrobials

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Investigating the levels of organochlorine pesticides in human milk at three lactational stages: an intensive Ghanaian study.

PFAS

Elevated levels of serum per- and poly-fluoroalkyl substances (PFAS) in contact lens users of U.S. young adults

Determinants of PFOA Serum Half-Life after End of Exposure: A Longitudinal Study on Highly Exposed Subjects in the Veneto Region.

Associations of dietary intake and longitudinal measures of per- and polyfluoroalkyl substances (PFAS) in predominantly Hispanic young Adults: A multicohort study.

Measurement of Hydro-EVE and 6:2 FTS in Blood from Wilmington, North Carolina, Residents, 2017-2018.

Reanalysis of PFO5DoA Levels in Blood from Wilmington, North Carolina, Residents, 2017-2018.

Extraordinary levels of per- and polyfluoroalkyl substances (PFAS) in vertebrate animals at a new Mexico desert oasis: Multiple pathways for wildlife and human exposure.

Examining changes in groundwater PFAS contamination from legacy landfills over a three-year period at Australia’s largest urban renewal site.

Distribution and release of PFAS from AFFF-impacted asphalt: How does it compare to concrete?

Application of Gaussian mixture models to quantify the upper background threshold for perfluorooctane sulfonate (PFOS) in U.S. surface soil.

Aquatic macroinvertebrate community responses to pollution of perfluoroalkyl substances (PFAS): Can we define threshold body burdens?

Occurrence, behaviors, and fate of per- and polyfluoroalkyl substances (PFASs) in typical municipal solid waste disposal sites.

PFAS occurrence and distribution in yard waste compost indicate potential volatile loss, downward migration, and transformation.

Industrial sources of per- and polyfluoroalkyl substances (PFAS) to a sewershed in Ontario, Canada.

A comprehensive trial on PFAS remediation: hemp phytoextraction and PFAS degradation in harvested plants.

Pesticides

Revealing the cascade of pesticide effects from gene to community.

Identification of key factors affecting neonicotinoid residues in crops and risk of dietary exposure.

Identifying opportunities for high resolution pesticide usage data to improve the efficiency of endangered species pesticide risk assessment.

Neonicotinoids Persisting in the Sea Pose a Potential Chronic Risk to Marine Organisms: A Case from Xiangshan Bay, China (2015-2019).

Widespread Pesticide Distribution in the European Atmosphere Questions their Degradability in Air.

Metals/Metalloids

Estimated mercury vapor exposure from amalgams among American pregnant women.

Lead, cadmium, and mercury blood levels in schoolchildren in southern Sweden: Time trends over the last decades.

Plastics/Microplastics/Nanomaterials

A City-Wide Emissions Inventory of Plastic Pollution.

Identification and characterization of plastic debris in the gastrointestinal tract of Guiana dolphins (Sotalia guianensis) from Espírito Santo coast, Brazil.

Microplastics in aquatic ecosystems of Africa: A comprehensive review and meta-analysis.

Accumulation of microplastics in predatory birds near a densely populated urban area.

At second glance: The importance of strict quality control – A case study on microplastic in the Southern Ocean key species Antarctic krill, Euphausia superba.

Air Pollution

Black carbon particles in human breast milk: assessing infant’s exposure.

Pharmaceuticals/Personal Care Products

Defining the data gap: What do we know about environmental exposure, hazards and risks of pharmaceuticals in the European aquatic environment?

In-sewer stability assessment of 140 pharmaceuticals, personal care products, pesticides and their metabolites: Implications for wastewater-based epidemiology biomarker screening.

——-

This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. The searchable archives are at https://groups.google.com/d/forum/edc_research or online at https://heeds.org/category/edc-science-weekly/. Compiled by Sarah Howard of Healthy Environment and Endocrine Disruptor Strategies (HEEDS), a program of Environmental Health Sciences.

If you enjoy this newsletter, please feel free to donate here! Thank you!

EHN EHN

Webinar: Fluoride, neurodevelopment, and cognition: a National Toxicology Program monograph
by Sarah Howard on November 19, 2024 at 5:00 pm
This Dec. 3 webinar features Dr. Kyla Taylor of NIEHS who will discuss the results of a National Toxicology Program monograph review that concluded there is "moderate confidence" in the scientific evidence that showed an association between higher levels of fluoride exposure and lower IQ in children.
Webinar: Behind the scenes at EPA: What's gone wrong and what does it mean for our work?
by Sarah Howard on November 19, 2024 at 3:56 pm
This Dec. 9 webinar, Behind the scenes at EPA: what's gone wrong and what does it mean for our work? is part 2 of a series on the future of EPA decision-making. Sponsored by the Collaborative for Health and Environment (CHE), Earthjustice, and UCSF's Earth Center.
Endocrine-disrupting chemicals: hazards and opportunities (ECHO) course
by Sarah Howard on October 31, 2024 at 2:50 pm
This course focuses on the chemical, biological, and societal challenges of endocrine-disrupting chemicals (EDCs) and new opportunities for moving forward. ECHO is a two-week intensive bootcamp-style career development course for graduate students, postdoctoral fellows, and professionals in the field. It is held at Woods Hole, Massachusetts.

EHN EHN

NIEHS publishes new strategic plan
by Sarah Howard on November 19, 2024 at 6:03 pm
The National Institute of Environmental Health Sciences (NIEHS) published a 2025-2029 strategic plan, "Health at the Intersection of People and Their Environments."
Pesticide use linked to increased prostate cancer risk
by EHN Curators on November 18, 2024 at 11:22 am
A study finds 22 pesticides associated with prostate cancer risk in the U.S., with four also tied to higher death rates. Andrea Tamayo reports for Science News.
PFAS levels increase throughout pregnancy, study finds
by Katherine McMahon,Sarah Howard on November 15, 2024 at 9:32 pm
A recent study published in Environmental Health Perspectives examines trends in PFAS exposure in pregnant Black women and their newborns in Atlanta. “Investigating the changes in PFAS exposure levels throughout pregnancy… is crucial for identifying critical exposure periods and guiding public health policies to reduce PFAS exposure.”

EHN EHN

Trump’s second term could mean fewer protections for drinking water
by EHN Curators on November 21, 2024 at 12:30 pm
Donald Trump’s plans for the Environmental Protection Agency may include rolling back protections against PFAS and other drinking water threats, worrying public health advocates. Hiroko Tabuchi reports for The New York Times.
Kennedy’s fluoride policy faces obstacles
by EHN Curators on November 19, 2024 at 8:28 pm
President-elect Trump’s selection of Robert F. Kennedy Jr. to lead the Department of Health and Human Services won’t give him direct control over water fluoridation policies, though his influence could sway public and local debates. Miranda Willson reports for E&E News.
Scientists' Declaration for the Global Plastics Treaty
by Sarah Howard on November 19, 2024 at 5:54 pm
The signatories of this declaration are independent scientists with expertise on plastics, and who are free of conflicts of interest associated with the life cycle of plastics. Read it here and sign it here. Due Nov. 22, 2024.