A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.
Contents: Events, Regulations/Policy, Methods/Tools/Screening, Commentaries, Reviews/Meta-Analyses, Human Health Studies, Laboratory Studies, Exposure/Environment Studies
TL;DR Highlights: COVID lockdown impacted microplastics in air; kids with higher chlorpyrifos exposure had higher risk of dyslexia; chasing “emerging” contaminants: an endless journey; EDCs and PFAS in meconium; DES and transgender identity; nanoplastics induce miscarriage in mice.
More science highlights
Events
Webinar February 13: Science for Prevention: Identifying breast carcinogens [EDC Strategies Partnership]
CME course Feb. 13: How Environmental Health Research Guides Clinical Care: PFAS, Obesity, and Bone Health [The Pediatric Environmental Health Center at Boston Children’s Hospital and the New England Region Pediatric Environmental Health Specialty Unit]
Webinar Feb. 20: How NY is Holding Pepsi Accountable for Its Plastic Pollution – & Your State Can, Too [Beyond Plastics]
Webinar Feb. 22: Tattoo Inks, Cancer and Other Chronic Diseases: Gaps in research and regulation [in Spanish and English, via CHE]
Conference Mar. 11-14: 10th Copenhagen Workshop on Endocrine Disruptors – COW2024. Abstracts are due Feb. 1.
Meeting March 22: HEEDS EDC- North Carolina annual meeting [free and open to anyone] [The date was incorrect in last week’s newsletter, it is Friday, March 22]
Gordon Research Conference on EDCs June 23-28, Tuscany Italy.
More events
Regulations/Policy
Can “Hazard-Cost-effectiveness Analysis” improve the risk management of chemicals under REACH?
Global environmental and toxicological impacts of polybrominated diphenyl ethers versus organophosphate esters: A comparative analysis and regrettable substitution dilemma.
Evidence evaluated by EFSA does not support lowering the temporary tolerable daily intake for bisphenol A.
More EDC policy and regulations open for comment
Methods/Tools/Screening
Report of the First ONTOX Stakeholder Network Meeting: Digging Under the Surface of ONTOX Together With the Stakeholders.
Artificial intelligence (AI)-it’s the end of the tox as we know it (and I feel fine).
A systems toxicology approach for identification of disruptions in cholesterol homeostasis after aggregated exposure to mixtures of perfluorinated compounds (PFAS) in humans.
Validation of a zebrafish developmental defects assay as a qualified alternative test for its regulatory use following the ICH S5(R3) guideline.
Utility of in vivo metabolomics to support read-across for UVCB substances under REACH.
The posterity of Zebrafish in paradigm of in vivo molecular toxicological profiling.
The Latest Sensor Detection Methods for per- and Polyfluoroalkyl Substances.
Systematic update to the mammalian relative potency estimate database and development of best estimate toxic equivalency factors for dioxin-like compounds.
Missing Genomic Resources for the Next Generation of Environmental Risk Assessment.
Towards safer pesticide management: A quantitative structure-activity relationship based hazard prediction model.
Proposing Effective Ecotoxicity Test Species for Chemical Safety Assessment in East Asia: A Review.
Computational Nanotoxicology Models for Environmental Risk Assessment of Engineered Nanomaterials.
More tools, reports, and resources
Commentaries
Editorial – Special issue on Developmental Origins of Health and Disease (DOHaD): Early developmental toxicology and reproductive effects.
Chasing “Emerging” Contaminants: An Endless Journey toward Environmental Health.
Per- and polyfluoroalkyl substances (PFAS) exposure might be a risk factor for thyroid cancer.
Racism as a public health issue in environmental health disparities and environmental justice: working toward solutions.
Asking the Right Questions: Untargeted Metabolomics for Studying Early Pregnancy Paraben Exposures.
Sustainability Claims of Nanoenabled Pesticides Require a More Thorough Evaluation.
Reviews/Meta-Analyses
Numerous Chemicals/Mixtures
Assessing the impact and mechanisms of environmental pollutants (heavy metals and pesticides) on the male reproductive system: a comprehensive review.
Emerging Contaminants: An Emerging Risk Factor for Diabetes Mellitus.
Sex and Gender Differences on the Impact of Metabolism-Disrupting Chemicals on Obesity: A Systematic Review.
Chemical contaminants in blood and their implications in chronic diseases.
The epidemiology of Parkinson’s disease.
BPA/Phenols
The association between prenatal exposure to bisphenol A and offspring obesity: A systematic review.
Adverse effects of bisphenol A and its analogues on male fertility: An epigenetic perspective.
Phthalates
Phthalates contamination in sediments: A review of sources, influencing factors, benthic toxicity, and removal strategies.
Persistent Organic Pollutants: PCBs, Dioxin, OCPs
Is Physical Activity an Efficient Strategy to Control the Adverse Effects of Persistent Organic Pollutants in the Context of Obesity? A Narrative Review.
PFAS
Interaction between Per- and Polyfluorinated Substances (PFAS) and Acetaminophen in Disease Exacerbation-Focusing on Autism and the Gut-Liver-Brain Axis.
Association between per- and polyfluoroalkyl substances and sex hormone levels in males based on human studies.
Emergence of per- and poly-fluoroalkyl substances (PFAS) and advances in the remediation strategies.
Pesticides
Toxicology of chemical biocides: Anticoagulant rodenticides – Beyond hemostasis disturbance.
Occurrence, ecological risk, and advanced removal methods of herbicides in waters: a timely review.
2,4-D Herbicide-Induced Hepatotoxicity: Unveiling Disrupted Liver Functions and Associated Biomarkers.
The molecular determinants of pesticide sensitivity in bee pollinators.
Glyphosate: Impact on the microbiota-gut-brain axis and the immune-nervous system, and clinical cases of multiorgan toxicity.
Updated Intrinsic Role of Phytochemicals against Glyphosate-induced Neurotoxicity: Systematic Review.
Immunoassays and Emerging Analytical Techniques of Fipronil and its Metabolites for Food Safety: A Review.
A review of chitosan nanoparticles: Nature’s gift for transforming agriculture through smart and effective delivery mechanisms.
Metals/Metalloids
Heavy Metal Exposure: Molecular Pathways, Clinical Implications, and Protective Strategies.
Microplastics/Nanomaterials
Microplastics exposure: implications for human fertility, pregnancy and child health.
Unraveling the micro- and nanoplastic predicament: A human-centric insight.
Microplastic contamination in wastewater: Sources, distribution, detection and remediation through physical and chemical-biological methods.
Air Pollution
Emerging Stroke Risk Factors: A Focus on Infectious and Environmental Determinants.
Pharmaceuticals/Personal Care Products
An extensive review on phenolic compounds and their potential estrogenic properties on skin physiology.
Microalgae: A potential bioagent for treatment of emerging contaminants from domestic wastewater.
PAHs
Dietary Polycyclic Aromatic Hydrocarbon (PAH) Consumption and Risk of Adverse Birth Outcomes: A Systematic Review and Meta-Analysis.
A State-of-the-Science Review of Alcoholic Beverages and Polycyclic Aromatic Hydrocarbons. [see related Invited Perspective: Polyaromatic Hydrocarbons in Alcohol-An Unappreciated Carcinogenic Mechanism?]
Environmental impact and human health effects of polycyclic aromatic hydrocarbons and remedial strategies: A detailed review.
Human Health Studies
Numerous Chemicals/Mixtures
Association between mixed exposure to endocrine-disrupting chemicals and cognitive function in elderly Americans.
Association between multiple sclerosis and urinary levels of toxic metals and organophosphates: A cross-sectional study in Israel.
The mixed effect of Endocrine-Disrupting chemicals on biological age Acceleration: Unveiling the mechanism and potential intervention target.
Quantitative identification of the co-exposure effects of e-waste pollutants on human oxidative stress by explainable machine learning.
BPA/Phthalates
Evaluation of novel biomarkers for early diagnosis of bisphenol A-induced coronary artery disease.
Prenatal exposures to phthalates and bisphenols in relation to oxidative stress: single pollutant and mixtures analyses.
Associations between urinary phthalate concentrations and antral follicle count among women undergoing in vitro fertilization.
Phthalate exposure increases interferon-γ during pregnancy: The Atlanta African American Maternal-Child Cohort.
Persistent Organic Pollutants: PCBs, Dioxin, OCPs
Dioxins and furans maternal transfer: A study of breast milk and cord serum levels among Lebanese mothers and associations with newborn anthropometric measurements.
PFAS
Impact of Environmental Exposures on Human Breast Milk Lipidome in Future Immune-Mediated Diseases.
An investigation of 3M Cordova, IL production worker’s per- and polyfluoroalkyl substances biomonitoring results and mortality experience.
Relationship of single and co-exposure of per-and polyfluoroalkyl substances and their alternatives with uric acid: A community-based study in China.
Flame Retardants
Associations of Organophosphate Ester Flame Retardant Exposures during Pregnancy with Gestational Duration and Fetal Growth: The Environmental influences on Child Health Outcomes (ECHO) Program.
Racial and ethnic disparities in preterm birth: a mediation analysis incorporating mixtures of polybrominated diphenyl ethers.
Pesticides
Exposure to organophosphate, pyrethroid, and neonicotinoid insecticides and dyslexia: Association with oxidative stress.
Occupational exposure to pesticides deregulates systemic cortisol levels in women with breast cancer and correlates with poor prognosis features.
Metals/Metalloids
Fluoride exposure and thyroid hormone levels in pregnancy: The MIREC cohort.
Maternal exposure to metals and time-to-pregnancy: The MIREC cohort study.
Associations between prenatal metal exposure and growth rate in children: Based on Hangzhou Birth Cohort Study.
Association of exposure to multiple heavy metals during pregnancy with the risk of gestational diabetes mellitus and insulin secretion phase after glucose stimulation.
Influence of perinatal and childhood exposure to tobacco and mercury in children’s gut microbiota.
Associations between plasma metal/metalloid mixtures and the risk of central obesity: A prospective cohort study of Chinese adults.
Air Pollution
The Influence of Airborne Particulate Matter on the Risk of Gestational Diabetes Mellitus: A Large Retrospective Study in Chongqing, China.
The short-term effect of air pollution on the incidence of pulmonary tuberculosis in Chongqing, China, 2014-2020.
Causal Relationships between Air Pollutant Exposure and Bone Mineral Density and the Risk of Bone Fractures: Evidence from a Two-Stage Mendelian Randomization Analysis.
Pharmaceuticals/Personal Care Products
Early Female Transgender Identity after Prenatal Exposure to Diethylstilbestrol: Report from a French National Diethylstilbestrol (DES) Cohort.
Miscellaneous
Association between Urinary Haloacetic Acid Concentrations and Liver Injury among Women: Results from the Tongji Reproductive and Environmental (TREE) Study.
Association between exposure to polycyclic aromatic hydrocarbons and endometriosis: data from the NHANES 2001-2006.
Laboratory Studies
BPA/Phenols
Developmental Programming: Impact of Prenatal Exposure to Bisphenol A on Senescence and Circadian Mediators in the Liver of Sheep.
Environmental bisphenol A disrupts methylation of steroidogenic genes in the ovary of paradise threadfin Polynemus paradiseus via abnormal DNA methylation: Implications for human exposure and health risk assessment.
Bisphenol A triggers apoptosis in mouse pre-antral follicle granulosa cells via oxidative stress.
Food grade plastics and Bisphenol A: Associated risks, toxicity, and bioremediation approaches.
Bisphenol F exposure induces depression-like changes: Roles of the kynurenine metabolic pathway along the “liver-brain” axis.
Glutamine attenuates bisphenol A-induced intestinal inflammation by regulating gut microbiota and TLR4-p38/MAPK-NF-κB pathway in piglets.
Toxic Effects of Bisphenol AF Exposure on the Reproduction and Liver of Female Marine Medaka (Oryzias melastigma).
Effect of 4-Nonylphenol (4-NP) on Sperm Function: Insights into the PI3K/PDK1/AKT Signaling Pathway during Capacitation.
Sex differences in 4-tert-octylphenol toxicokinetics: Exploration of sex as an effective covariate through an in vivo modeling approach.
Phthalates
Regulation of BTB (POZ) Structural Domain 6b by MicroRNA-222b in Zebrafish Embryos after Exposure to Di(2-ethylhexyl)phthalate at Low Concentrations.
Dibutyl phthalate disrupts glycogen synthase kinase 3α essential for sperm motility.
Genistein prevents the production of hypospadias induced by Di-(2-ethylhexyl) phthalate through androgen signaling and antioxidant response in rats.
Melatonin alleviates di-butyl phthalate (DBP)-induced ferroptosis of mouse leydig cells via inhibiting Sp2/VDAC2 signals.
Alleviative effect of quercetin against reproductive toxicity induced by chronic exposure to the mixture of phthalates in male rats.
Parabens/Triclosan/Antimicrobials
Chronic exposure to parabens promotes non-alcoholic fatty liver disease in association with the changes of the gut microbiota and lipid metabolism.
Methylparaben induces hepatic glycolipid metabolism disorder by activating the IRE1α-XBP1 signaling pathway in male mice.
Persistent Organic Pollutants: PCBs, Dioxin, OCPs
Theoretical Studies on the Quantitative Structure-Toxicity Relationship of Polychlorinated Biphenyl Congeners Reveal High Affinity Binding to Multiple Human Nuclear Receptors.
Paternal p,p’-DDE exposure and pre-pubertal high-fat diet increases the susceptibility to fertility impairment and sperm Igf2 DMR2 hypo-methylation in male offspring.
Transgenerational Transmission of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) Effects in Human Granulosa Cells: The Role of MicroRNAs.
PFAS
Maternal F-53B exposure during pregnancy and lactation induced glucolipid metabolism disorders and adverse pregnancy outcomes by disturbing gut microbiota in mice.
Perfluorooctanoate (PFOA) cell-autonomously promotes thermogenic and adipogenic differentiation of brown and white adipocytes.
Toxicity Assessment of Mixed Exposure of Nine Perfluoroalkyl Substances at Concentrations Relevant to Daily Intake.
Interspecies comparison of metabolism of two novel prototype PFAS.
In Vitro and In Silico Analysis of the Bindings between Legacy and Novel Per- and Polyfluoroalkyl Substances and Human Serum Albumin.
Binding Affinity and Mechanism of Six PFAS with Human Serum Albumin: Insights from Multi-Spectroscopy, DFT and Molecular Dynamics Approaches.
PFHxS Exposure and the Risk of Non-Alcoholic Fatty Liver Disease.
Flame Retardants
Differential effects of ocean warming and BDE-47 on mussels with various personalities.
Neurotoxic effects of 2-ethylhexyl diphenyl phosphate exposure on zebrafish larvae: Insight into inflammation-driven changes in early motor behavior.
Pesticides
The epoxiconazole and tebuconazole fungicides impair granulosa cells functions partly through the aryl hydrocarbon receptor (AHR) signalling with contrasted effects in obese, normo-weight and polycystic ovarian syndrome (PCOS) patients.
Developmental exposure to pesticides that disrupt retinoic acid signaling cause persistent retinoid and behavioral dysfunction in zebrafish.
Glyphosate exposure affected longevity-related pathways and reduced survival in asian honey bees (Apis cerana).
Elucidating the effects of pure glyphosate and a commercial formulation on early life stages of zebrafish using a complete biomarker approach: All-or-nothing!
Metabolomic Changes in Rat Serum after Chronic Exposure to Glyphosate-Based Herbicide.
In Vitro Effects of Cypermethrin and Glyphosate on LPS-Induced Immune Cell Activation.
Mitochondrial impairment related to the immunotoxicity of the herbicides clomazone, glyphosate and sulfentrazone in THP-1 cells.
Bupropion and varenicline administration reversed depressive behavior induced by acetamiprid exposure in mice: the role of nAChRs in depression.
Neurotoxic pesticides change respiratory parameters in early gill-breathing, but not in skin-breathing life-stages of zebrafish (Danio rerio).
Chronic and acute exposure to rotenone reveals distinct Parkinson’s disease-related phenotypes in human iPSC-derived peripheral neurons.
Biological-based techniques for real-time water-quality studies: Assessment of non-invasive (swimming consistency and respiration) and toxicity (antioxidants) biomarkers of zebrafish. [atrazine]
Bifenthrin Diminishes Male Fertility Potential by Inducing Protein Defects in Mouse Sperm.
Effects of exposure to the neonicotinoid pesticide clothianidin on α-defensin secretion and gut microbiota in mice.
Olfactory Learning Behavior and Mortality of the Honey Bee Apis mellifera jemenitica in Response to Pyrethroid Insecticide (Deltamethrin).
Early-Life Sublethal Thiacloprid Exposure to Honey Bee Larvae: Enduring Effects on Adult Bee Cognitive Abilities.
Metals/Metalloids
Lead exposure induced transgenerational developmental neurotoxicity by altering genome methylation in Drosophila melanogaster.
Chronic arsenic exposure-provoked biotoxicity involved in liver-microbiota-gut axis disruption in chickens based on multi-omics technologies.
Microplastics/Nanomaterials
Polystyrene Nanoplastics Activate Autophagy and Suppress Trophoblast Cell Migration/Invasion and Migrasome Formation to Induce Miscarriage.
Combined exposure of nano-titanium dioxide and polystyrene nanoplastics exacerbate oxidative stress-induced liver injury in mice by regulating the Keap-1/Nrf2/ARE pathway.
Subacute toxicity and endocrine-disrupting effects of Fe2O3, ZnO, and CeO2 nanoparticles on amphibian metamorphosis.
Comparison of reproductive toxicity between pristine and aged polylactic acid microplastics in Caenorhabditis elegans.
Polystyrene microplastics effects on zebrafish embryological development: comparison of two different sizes.
The Exploration of Joint Toxicity and Associated Mechanisms of Primary Microplastics and Methamphetamine in Zebrafish Larvae.
Amitriptyline ecotoxicity in Danio rerio (Hamilton, 1822) embryos – similar toxicity profile in the presence of nanoplastics.
Accumulation of polyethylene microplastics in river biofilms and effect on the uptake, biotransformation and toxicity of the antimicrobial triclosan.
The weakened physiological functions of human serum albumin in presence of polystyrene nanoplastics.
Air Pollution
Adverse effects of exposure to petrol-generator exhaust fumes on the reproductive hormones, testis and spermatozoa in male dogs.
Miscellaneous
Dichloroacetic acid and trichloroacetic acid as disinfection by-products in drinking water are endocrine-disrupting chemicals.
Tire particles and their leachates reduce the filtration rate of the mussel Mytilus edulis.
Evaluation of the Mechanisms Involved in the Development of Bladder Toxicity following Exposure to Occupational Bladder Cancer Causative Chemicals Using DNA Adductome Analysis.
Exposure/Environment Studies
Numerous Chemicals/Mixtures
Multiclass Determination of Endocrine-Disrupting Chemicals in Meconium: First Evidence of Perfluoroalkyl Substances in This Biological Compartment.
De facto Water Reuse: Investigating the Fate and Transport of Chemicals of Emerging Concern from Wastewater Discharge through Drinking Water Treatment Using Non-targeted Analysis and Suspect Screening.
Measurement of persistent organic pollutants, perfluorinated compounds, and toxic metals in the blood of humboldt penguins (spheniscus humboldti) at punta san juan, peru using dried blood spots.
Phthalates
Comparison of phthalate esters (PAEs) in freshwater and marine food webs: Occurrence, bioaccumulation, and trophodynamics.
Persistent Organic Pollutants: PCBs, Dioxin, OCPs
Temporal Trends of Great Lakes Legacy Contaminants: Ecological and Biological Considerations Applying the Age-Trend Model.
Feed materials – Levels and characteristic profiles of dioxins and PCBs.
PFAS
Profiles and transplacental transfer of per- and polyfluoroalkyl substances in maternal and umbilical cord blood: A birth cohort study in Zhoushan, Zhejiang Province, China.
Is it raining PFAS in France? An analysis of 52 PFAS at nanogram per liter levels in French rainwaters during autumn season.
Determination of Perfluorooctanoic Acid (PFOA) in the Indoor Dust Matter of the Sicily (Italy) Area: Analysis and Exposure Evaluations.
Transport of per-/polyfluoroalkyl substances from leachate to groundwater as affected by dissolved organic matter in landfills.
Per- and polyfluoroalkyl substances (PFASs) in Chinese surface water: Temporal trends and geographical distribution.
Contamination status, partitioning behavior, ecological risks assessment of legacy and emerging per- and polyfluoroalkyl substances in a typical heavily polluted semi-enclosed bay, China.
Evaluation of per- and polyfluoroalkyl substances (PFAS) released from two Florida landfills based on mass balance analyses.
Is removal and destruction of perfluoroalkyl and polyfluoroalkyl substances from wastewater effluent affordable?
Flame Retardants
Assessment of Human Exposure to Traditional and Novel Organophosphate Esters via Multiple Personal Matrices.
Polybrominated Diphenyl Ethers in Human Milk of Croatian First-Time Mothers: 2010 Versus 2020.
An Initial Survey on Occurrence, Fate, and Environmental Risk Assessment of Organophosphate Flame Retardants in Romanian Waterways.
Historical Occurrence and Composition of Novel Brominated Flame Retardants and Dechlorane Plus in Sediments from an Electronic Waste Recycling Site in South China.
Pesticides
Applicability of Food Monitoring Data for Assessing Relative Exposure Contributions of Pyrethroids in Retrospective Human Biomonitoring Risk Estimations.
The downside of copper pesticides: An earthworm’s perspective.
Distribution of organophosphorus pesticides and its potential connection with probiotics in sediments of a shallow freshwater lake.
Metals/Metalloids
Density and proximity of oil and gas wells and concentrations of trace elements in urine, hair, nails and tap water samples from pregnant individuals living in Northeastern British Columbia.
Micro-distribution of arsenic in toenail clippings using laser ablation inductively coupled plasma mass spectrometry: implications for biomonitoring.
Update of the risk assessment of inorganic arsenic in food and Plain Language Summary of the Update of the risk assessment of inorganic arsenic in food [EFSA]
Mortality and heavy metals environmental exposure: a study in dogs.
Tree foliage as a net accumulator of highly toxic methylmercury.
Sea level rise from climate change is expected to increase the release of arsenic into Bangladesh’s drinking well water by reduction and by the salt effect.
Microplastics/Nanomaterials
COVID lockdown significantly impacted microplastic bulk atmospheric deposition rates.
Phthalate esters and nonylphenol concentrations correspond with microplastic distribution in anthropogenically polluted river sediments.
Biodegradable microplastics reduce the effectiveness of biofertilizers by altering rhizospheric microecological functions.
Pharmaceuticals/Personal Care Products
Predicting environmental risks of pharmaceutical residues by wastewater surveillance: An analysis based on pharmaceutical sales and their excretion data.
——-
This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. The searchable archives are at https://groups.google.com/d/forum/edc_research or online at https://heeds.org/category/edc-science-weekly/. Compiled by Sarah Howard of Healthy Environment and Endocrine Disruptor Strategies (HEEDS), a program of Environmental Health Sciences.
If you enjoy this newsletter, please feel free to donate here! Thank you!
