EDC Science Weekly, Jan. 12-18, 2024

Post author:HEEDS
Post published:January 18, 2024
Post category:EDC Science Weekly

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Events, Regulations/Policy, Methods/Tools/Screening, Commentaries, Reviews/Meta-Analyses, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Highlights: The costs of plastic chemicals; microplastics in human tissues; EDCs and hormone levels during pregnancy; cicadas and mortality; low-dose BPA accelerates puberty; lower lead means lower blood pressure; can plastic pollution drive new zoonotic diseases?

More science highlights

Events

Webinar Jan. 25: CHE Café: Multisolving for climate, chemicals & health [CHE and the New School at Commonweal]

CME course Feb. 13: How Environmental Health Research Guides Clinical Care: PFAS, Obesity, and Bone Health [The Pediatric Environmental Health Center at Boston Children’s Hospital and the New England Region Pediatric Environmental Health Specialty Unit]

Webinar Feb. 20: How NY is Holding Pepsi Accountable for Its Plastic Pollution – & Your State Can, Too [Beyond Plastics]

Webinar Feb. 22: Tattoo Inks, Cancer and Other Chronic Diseases: Gaps in research and regulation [in Spanish and English, via CHE]

Conference Mar. 11-14: 10th Copenhagen Workshop on Endocrine Disruptors – COW2024. Abstracts are due Feb. 1.

Meeting March 22: HEEDS EDC- North Carolina annual meeting [free and open to anyone]

Gordon Research Conference on EDCs June 23-28, Tuscany Italy.

More events

Regulations/Policy

Chemicals Used in Plastic Materials: An Estimate of the Attributable Disease Burden and Costs in the United States

Trends in flame retardant levels in upholstered furniture and children’s consumer products after regulatory action in California.

More EDC policy and regulations open for comment

Methods/Tools/Screening

Applying a modified systematic review and integrated assessment framework (SYRINA) – a case study on triphenyl phosphate.

Application of the Key Characteristics of Carcinogens to Bisphenol A.

Exploring the Mixture Assessment or Allocation Factor (MAF): a brief overview of the current discourse

The probable future of toxicology – probabilistic risk assessment.

Efficiency of pharmaceutical toxicity prediction in computational toxicology.

Systems bioengineering approaches for developmental toxicology.

Assessing background contamination of sample tubes used in human biomonitoring by non-targeted liquid chromatography-high resolution mass spectrometry.

Using in vitro data to derive acceptable exposure levels: A case study on PBDE developmental neurotoxicity.

Comparison of PM2.5 Air Pollution Exposures and Health Effects Associations Using 11 Different Modeling Approaches in the Women’s Health Initiative Memory Study (WHIMS).

How can contamination be prevented during laboratory analysis of atmospheric samples for microplastics?

Prioritization of chemicals in personal care products based on persistent, bioaccumulative and toxic (PBT) potential: An Indian perspective.

More tools, reports, and resources

Commentaries

Environmental Toxicology and Human Health.

Parkinson’s Disease Is Predominantly an Environmental Disease.

Broadening the Environmental Lens to Include Social and Structural Determinants of Women’s Health Disparities.

Stress and human health in diabetes: A report from the 19^th Chicago Biomedical Consortium symposium.

Reviews/Meta-Analyses

Numerous Chemicals/Mixtures

Obesogens: a unifying theory for the global rise in obesity.

The Role of Endocrine Disruptors Bisphenols and Phthalates in Obesity: Current Evidence, Perspectives and Controversies.

Environmental Risk Factors in Autism Spectrum Disorder: A Narrative Review.

Phthalates

Unpacking Phthalates from Obscurity in the Environment.

Parabens/Triclosan/Antimicrobials

Conceptualizing the Role of the Microbiome as a Mediator and Modifier in Environmental Health Studies: A Scoping Review of Studies of Triclosan and the Microbiome.

PFAS

Association of prenatal exposure to perfluorinated and polyfluoroalkyl substances with childhood neurodevelopment: A systematic review and meta-analysis.

Effect of Per and Poly-Fluoroalkyl Substances on Pregnancy and Child Development.

Respiratory Exposure to Highly Fluorinated Chemicals via Application of Ski Wax and Related Health Effects.

Progress and perspectives on carbon-based materials for adsorptive removal and photocatalytic degradation of perfluoroalkyl and polyfluoroalkyl substances (PFAS).

An Overview on Recent Advances in Biomimetic Sensors for the Detection of Perfluoroalkyl Substances.

Flame Retardants

Bringing the emerging organophosphate flame retardants (eOPFRs) into view: A hidden ecological and human health threat.

Pesticides

Nano-Pesticides and Fertilizers: Solutions for Global Food Security.

Pesticides: An alarming detrimental to health and environment.

Metals/Metalloids

Is Environmental Cadmium Exposure Causally Related to Diabetes and Obesity?

Cadmium-induced Carcinogenesis in Respiratory Organs and the Prostate: Insights from Three Perspectives on Toxicogenomic Approach.

Arsenic in drinking water and lung cancer: A systematic review of 35 years of evidence.

Plastics/Microplastics/Nanomaterials

Can plastic pollution drive the emergence and dissemination of novel zoonotic diseases?

A systematic review of antibiotic resistance driven by metal-based nanoparticles: Mechanisms and a call for risk mitigation.

Microplastics in dermatology: Potential effects on skin homeostasis.

Micro- and nano-plastics in the atmosphere: A review of occurrence, properties and human health risks.

The invisible Threat: Assessing the reproductive and transgenerational impacts of micro- and nanoplastics on fish.

Air Pollution

Exposure to air pollutants and rheumatoid arthritis biomarkers: A scoping review.

Miscellaneous

Emerging trends in biomaterials for sustainable food packaging: A comprehensive review.

Human Health Studies

Numerous Chemicals/Mixtures

Associations of urinary non-persistent endocrine disrupting chemical biomarkers with early-to-mid pregnancy plasma sex-steroid and thyroid hormones. (parabens, phthalates, phenols)

Effects of endocrine disrupting chemicals and their interactions with genetic risk scores on cardiometabolic traits. (parabens, bisphenols, and phthalates)

Association of serum bisphenols, parabens, and triclosan concentrations with Sjögren Syndrome in the Hangzhou, China population.

BPA/Phenols

Association of bisphenol A with cognitive functions and functionality in adult attention deficit hyperactivity disorder.

Phthalates

The association between phthalate exposure and pubertal development.

The impact of follicular fluid phthalate metabolites on the ovarian reserve and ovarian function in Indian women undergoing intracytoplasmic sperm injection.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Occupational Exposure to Polychlorinated Biphenyls: Development of Neuropsychological Functions Over Time.

PFAS

The U.S. PFAS exposure burden calculator for 2017-2018: Application to the HOME Study, with comparison of epidemiological findings from NHANES.

Prenatal exposure to per-and polyfluoroalkyl substances and child executive function: Evidence from the Shanghai birth cohort study.

Pesticides

Gestational glyphosate exposure and early childhood neurodevelopment in a Puerto Rico birth cohort.

The Siren Song of Cicadas: Early-Life Pesticide Exposure and Later-Life Male Mortality.

Associations of chronic exposure to a mixture of pesticides and type 2 diabetes mellitus in a Chinese elderly population.

Association of pesticide exposure with neurobehavioral outcomes among avocado farmworkers in Mexico.

Metals/Metalloids

Association between serum heavy metal levels and diabetic retinopathy in NHANES 2011-2020.

Association between environmental mercury exposure and allergic disorders in Korean children: Korean National Environmental Health Survey (KoNEHS) cycles 3-4 (2015-2020).

The Contribution of Declines in Blood Lead Levels to Reductions in Blood Pressure Levels: Longitudinal Evidence in the Strong Heart Family Study.

Examining carcinogenic and noncarcinogenic health risks related to arsenic exposure in Ethiopia: A longitudinal study.

Air Pollution

Exposure to PM_2.5 and its five constituents is associated with the incidence of type 2 diabetes mellitus: a prospective cohort study in northwest China.

Miscellaneous

Independent and combined associations of polycyclic aromatic hydrocarbons exposure and sleep disorders among adults in the U.S. adult population.

Association between 6PPD-quinone exposure and BMI, influenza, and diarrhea in children.

Laboratory Studies

Numerous Chemicals/Mixtures

Developmental effects of zebrafish (Danio rerio) embryos after exposure to glyphosate and lead mixtures.

Responses of multifunctional immune complement component 1q (C1q) and apoptosis-related genes in Macrophthalmus japonicus tissues and human cells following exposure to environmental pollutants. [DEHP and HBCDs]

BPA/Phenols

Maternal oral exposure to low-dose BPA accelerates the onset of puberty by promoting prepubertal Kiss1 expression in the AVPV nucleus of female offspring.

Are the BPA analogues an alternative to classical BPA? Comparison between 2D and alternative 3D in vitro neuron model to assess cytotoxic and genotoxic effects.

Bisphenol A exposure stimulates prostatic fibrosis via exosome-triggered epithelium changes.

Bisphenol A triggers apoptosis in mouse pre-antral follicle granulosa cells via oxidative stress.

Formation of halogenated forms of bisphenol A (BPA) in water: Resolving isomers with ion mobility – mass spectrometry and the role of halogenation position in cellular toxicity.

Alkylphenols disrupt estrogen homeostasis via diradical cross-coupling reactions: A novel pathway of endocrine disruption.

Nonylphenol induces depressive behavior in rats and affects gut microbiota: A dose-dependent effect.

Phthalates

Long-term exposure to the mixture of phthalates induced male reproductive toxicity in rats and the alleviative effects of quercetin.

Protective effect of gomisin N on benzyl butyl phthalate-induced dysfunction of testosterone production in TM3 Leydig cells.

Parabens/Triclosan/Antimicrobials

Molecular interactions of paraben family of pollutants with embryonic neuronal proteins of Danio rerio: A step ahead in computational toxicity towards adverse outcome pathway.

Comparative study on estrogen receptor alpha dimerization and transcriptional activity of parabens.

PFAS

Perfluorooctane sulfonate (PFOS) induces apoptosis and autophagy by inhibition of PI3K/AKT/mTOR pathway in human granulosa cell line KGN.

Perfluorooctanoic Acid (PFOA) Exposure Compromises Fertility by Affecting Ovarian and Oocyte Development.

Perfluorotetradecanoic acid exposure to adult male rats stimulates corticosterone biosynthesis but inhibits aldosterone production.

Insight into the differential toxicity of PFOA and PFBA based on a 3D-cultured MDA-MB-231 cell model.

GenX analogs exposure induced greater hepatotoxicity than GenX mainly via activation of PPARα pathway while caused hepatomegaly in the absence of PPARα in female mice.

Degradation and mechanism of PFOA by peroxymonosulfate activated by nitrogen-doped carbon foam-anchored nZVI in aqueous solutions.

Kynurenic Acid Plays a Protective Role in Hepatotoxicity Induced by HFPO-DA in Male Mice.

Perfluorooctane sulfonate causes pyroptosis and lipid metabolism disorders through ROS-mediated NLRP3 inflammasome activation in grass carp hepatocyte.

Characterization and dermal bioaccessibility of residual- and listed PFAS ingredients in cosmetic products.

Flame Retardants

A universal eco-friendly flame retardant strategy for polylactic acid fabrics and other polymer substrates.

BDE-47 induces metabolic dysfunction-associated steatotic liver disease (MASLD) through CD36-mediated increased fatty acid uptake and PPARα-induced abnormal fatty acid oxidation in BALB/c mice.

Pharmacokinetic characterisation of a valproate Autism Spectrum Disorder rat model in a context of co-exposure to α-Hexabromocyclododecane.

Physiologically based toxicokinetic modelling of Tri(2-chloroethyl) phosphate (TCEP) in mice accounting for multiple exposure routes.

Organotins

Exposure to triphenyltin impairs gut integrity, disturbs gut microbiota, and alters fecal metabolites.

TMT-based quantitative proteomics analysis of Sprague-Dawley rats liver reveals Triphenyltin induced liver damage and lipid metabolism disorders.

Pesticides

Peripubertal exposure of atrazine cause decrease in exploratory activity, deficits in sociability and few alterations on brain monoaminergic systems of rats.

Evaluation of the diphenyl herbicide, oxyfluorfen, for effects on thyroid hormones in the juvenile rat.

d-Tetramethrin causes zebrafish hepatotoxicity by inducing oxidative stress and inhibiting cell proliferation.

Ancestors’ Gift: Parental Early Exposure to the Environmentally Realistic Pesticide Mixture Drives Offspring Phenotype in a Larger Extent Than Direct Exposure in the Pacific Oyster, Crassostrea gigas.

2,4-D-based herbicide underdoses cause mortality, malformations, and nuclear abnormalities in Physalaemus cuvieri tadpoles.

Interactive transgenerational effects of parental co-exposure to prochloraz and chlorpyrifos: Disruption in multiple biological processes and induction of genotoxicity.

Atrazine exposure promotes cardiomyocyte pyroptosis to exacerbate cardiotoxicity by activating NF-κB pathway.

Cajanus cajan (L) Millsp seeds extract prevents rotenone-induced motor- and non-motor features of Parkinson disease in mice: Insight into mechanisms of neuroprotection.

Imazalil resulted in glucolipid metabolism disturbance and abnormal m⁶A RNA methylation in the liver of dam and offspring mice.

Metals/Metalloids

Assessment of thimerosal effects in sublethal doses on zebrafish (Danio rerio) embryos exploring NMR-based metabolomics profile.

Melatonin attenuates liver injury in arsenic-treated rats: The potential role of the Nrf2/HO-1, apoptosis, and miR-34a/Sirt1/autophagy pathways.

Analysis of Prussian carp (Carassius gibelio B.) oocytes under the influence of Roundup^® herbicide.

Microplastics/Nanomaterials

Polystyrene microplastics enhanced the effect of PFOA on Chlorella sorokiniana: Perspective from the cellular and molecular levels.

Exposure of Mytilus galloprovincialis to Microplastics: Accumulation, Depuration and Evaluation of the Expression Levels of a Selection of Molecular Biomarkers.

Size-dependent vector effect of microplastics on the bioaccumulation of polychlorinated biphenyls in tilapia: A tissue-specific study.

Polyethylene microplastics induced inflammation via the miR-21/IRAK4/NF-κB axis resulting to endoplasmic reticulum stress and apoptosis in muscle of carp.

Microplastics induced apoptosis in macrophages by promoting ROS generation and altering metabolic profiles.

Impact of nanoplastics on Alzheimer ‘s disease: Enhanced amyloid-β peptide aggregation and augmented neurotoxicity.

Exposure/Environment Studies

Numerous Chemicals/Mixtures

How do mothers with young children perceive endocrine-disrupting chemicals?: an exploratory qualitative study.

Cocktails of endocrine disruptors in the different diets of French consumers.

Pollution characteristics and health risk of sixty-five organics in one drinking water system: PAEs should be prioritized for control.

Implementation of simple and effective fine droplet formation-based spray-assisted liquid phase microextraction for the simultaneous determination of twenty-nine endocrine disruptor compounds and pesticides in rock, soil, water, moss, and feces samples from antarctica using gas chromatography-mass spectrometry.

BPA/Phenols

Broad-Spectrum Antibody-Based Immunochromatographic Strip Assay for Rapid Screening of Bisphenol A Diglycidyl Ether and Its Derivatives in Canned Foods.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Polychlorinated alkanes in paired blood serum and breast milk in a Swedish cohort study: Matrix dependent partitioning differences compared to legacy POPs.

Persistent organic pollutants in the olive ridley turtle (Lepidochelys olivacea) during the nesting stage in the “La Escobilla” Sanctuary, Oaxaca, Mexico.

PFAS

Profile of per- and polyfluoroalkyl substances, source appointment, and determinants in Argentinean postpartum women.

Tree barks for retrospective measurement and source appointment of airborne perfluoroalkyl and polyfluoroalkyl substances.

Unveiling the hidden threat: spatiotemporal trends and source apportionments of per-and polyfluorinated alkyl substances in wastewater treatment plants in South Africa.

Uptake and distribution of perfluoroalkyl substances by grafted tomato plants cultivated in a contaminated site in northern Italy.

Unregulated Active and Closed Textile Mills Represent a Significant Vector of PFAS Contamination into Coastal Rivers.

Concentrations of 45 Per- and Polyfluoroalkyl Substances in North American River Otters (Lontra canadensis) from West Virginia, USA.

Flame Retardants

Quantifying the removal of polybrominated diphenyl ethers (PBDEs) in physical, chemical, and biological sludge treatment systems.

Influence of watershed characteristics and human activities on the occurrence of organophosphate esters related to dissolved organic matter in estuarine surface water.

A Review of Distribution and Profiles of HBCD in Different Environmental Media of China.

The influence of emerging atmospheric organophosphorus flame retardants from land source emissions on the East China Sea.

Insights into the occurrence, spatial distribution, and ecological implications of organophosphate triesters in surface sediments from polluted urban rivers across China.

[Spatiotemporal Occurrence of Organophosphate Esters in the Surface Water and Sediment of Taihu Lake and Relevant Risk Assessment].

Microplastics/Nanomaterials

Tissue accumulation of microplastics and potential health risks in human.

Are volatile methylsiloxanes in downcycled tire microplastics? Levels and human exposure estimation in synthetic turf football fields.

Microplastics in Qinghai-Tibet Plateau and Yunnan-Guizhou Plateau lakes, China.

Air Pollution

Occurrence of high production volume chemicals and polycyclic aromatic hydrocarbons in urban sites close to industrial areas. Human exposure and risk assessment.

An environmental justice analysis of air pollution emissions in the United States from 1970 to 2010.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. The searchable archives are at https://groups.google.com/d/forum/edc_research or online at https://heeds.org/category/edc-science-weekly/. Compiled by Sarah Howard of Healthy Environment and Endocrine Disruptor Strategies (HEEDS), a program of Environmental Health Sciences.

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EHN EHN

Webinar: Fluoride, neurodevelopment, and cognition: a National Toxicology Program monograph
by Sarah Howard on November 19, 2024 at 5:00 pm
This Dec. 3 webinar features Dr. Kyla Taylor of NIEHS who will discuss the results of a National Toxicology Program monograph review that concluded there is "moderate confidence" in the scientific evidence that showed an association between higher levels of fluoride exposure and lower IQ in children.
Webinar: Behind the scenes at EPA: What's gone wrong and what does it mean for our work?
by Sarah Howard on November 19, 2024 at 3:56 pm
This Dec. 9 webinar, Behind the scenes at EPA: what's gone wrong and what does it mean for our work? is part 2 of a series on the future of EPA decision-making. Sponsored by the Collaborative for Health and Environment (CHE), Earthjustice, and UCSF's Earth Center.
Endocrine-disrupting chemicals: hazards and opportunities (ECHO) course
by Sarah Howard on October 31, 2024 at 2:50 pm
This course focuses on the chemical, biological, and societal challenges of endocrine-disrupting chemicals (EDCs) and new opportunities for moving forward. ECHO is a two-week intensive bootcamp-style career development course for graduate students, postdoctoral fellows, and professionals in the field. It is held at Woods Hole, Massachusetts.

EHN EHN

“We have enough evidence” to act on toxic plastic exposure now
by Katherine McMahon,Sarah Howard on November 22, 2024 at 3:31 pm
In a recent commentary published in The Lancet, Dr. Leonardo Trasande of NYU’s Grossman School of Medicine emphasizes the need to address the well-established health harms from exposure to chemical additives used in plastics. “Only through a serious and concerted effort to turn off the plastic tap will we apply the lessons learned from plastic use… and avoid the invisible chemicals used in plastic materials from becoming visible in the form of a larger global pandemic of chronic disease.”
Kids who adopt a gluten-free diet have increased arsenic levels
by Katherine McMahon,Sarah Howard on November 20, 2024 at 1:32 pm
A recent study published in The American Journal of Gastroenterology found that children who adopted a gluten-free (GF) diet after being diagnosed with celiac disease had significantly increased arsenic exposure after only six months. “More research needs to be done to determine whether there are long-term effects of this bump, but overall, I think it speaks to the importance of diversifying the grains in the gluten-free diet.”
NIEHS publishes new strategic plan
by Sarah Howard on November 19, 2024 at 6:03 pm
The National Institute of Environmental Health Sciences (NIEHS) published a 2025-2029 strategic plan, "Health at the Intersection of People and Their Environments."

EHN EHN

Nations push for global treaty to limit plastic pollution
by EHN Curators on November 26, 2024 at 12:56 pm
Global talks in South Korea aim to create the first treaty to curb plastic waste, but opposition from oil-producing nations and shifting U.S. leadership complicates the effort. Hiroko Tabuchi reports for The New York Times.
Louisiana plastics plants discharge high levels of pollution due to weak EPA regulations
by EHN Curators on November 26, 2024 at 12:01 pm
U.S. plastics plants, including 22 in Louisiana, release significant wastewater pollutants into rivers due to outdated federal regulations, according to an Environmental Integrity Project report. Elise Plunk reports for Louisiana Illuminator.
Trump’s second term could mean fewer protections for drinking water
by EHN Curators on November 21, 2024 at 12:30 pm
Donald Trump’s plans for the Environmental Protection Agency may include rolling back protections against PFAS and other drinking water threats, worrying public health advocates. Hiroko Tabuchi reports for The New York Times.