EDC Science Weekly, Dec. 15-21, 2023

Post author:HEEDS
Post published:December 21, 2023
Post category:EDC Science Weekly

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Happy holidays from HEEDS, and see you in January!

Contents: Events, Regulations/Policy, Methods/Tools/Screening, Reviews/Meta-Analyses, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Highlights: Prebiotics lower arsenic levels in people; chemicals and ADHD, mental health in children; racial/ethnic disparities, phthalates, and preterm birth.

More science highlights

Events

Course: Endocrine-Disrupting Chemicals: Hazards and Opportunities (ECHO) This two-week course in May at Woods Hole is accepting applications, due Jan. 15. Financial aid is available.

Webinar Jan. 9: Food Contact Materials: A Road Map to Improved Safety Testing [EDC Strategies Partnership]

Webinar Jan. 10: Meet the Editors [of EHP, JHP, and JESEE; sponsored by NIEHS Partnerships for Environmental Public Health (PEHP)]

Symposium Jan. 22-24: USA Exposome Symposium: Children’s Health, Environmental Justice, and the Exposome [Mt Sinai and Meharry Medical College]

Webinar Jan. 25: CHE Café: Multisolving for climate, chemicals & health [CHE and the New School at Commonweal]

More events

Regulations/Policy

The global plastics treaty: why is it needed?

From research to policy: still a long way to go [not chemicals but perhaps relevant]

More EDC policy and regulations open for comment

Methods/Tools/Screening

Moving Forward with Reporting Back Individual Environmental Health Research Results.

A Deep-Learning Approach for Identifying Prospective Chemical Hazards.

Building a predictive model for hypertension related to environmental chemicals using machine learning.

Computational Risk Assessment of Persistence, Bioaccumulation, and Toxicity of Novel Flame-Retardant Chemicals.

Towards improved screening of toxins for Parkinson’s risk.

More tools, reports, and resources

Reviews/Meta-Analyses

Numerous Chemicals/Mixtures

A Systematic Review and Meta-analysis of Chemical Exposures and Attention-Deficit/Hyperactivity Disorder in Children.

Environmental chemical exposures and mental health outcomes in children: a narrative review of recent literature.

Inheritance of environment-induced phenotypic changes through epigenetic mechanisms.

Toxic Ingredients in Personal Care Products: A Dermatological Perspective.

Chronic kidney disease of unknown aetiology in Africa: A review of the literature.

PFAS

Current state of knowledge of environmental occurrence, toxic effects, and advanced treatment of PFOS and PFOA.

Unveiling nano-empowered catalytic mechanisms for PFAS sensing, removal and destruction in water.

Progress in the application of ionic liquids and deep eutectic solvents for the separation and quantification of per- and polyfluoroalkyl substances.

Flame Retardants

20 years of polybrominated diphenyl ethers on toxicity assessments.

Global patterns of human exposure to flame retardants indoors.

Pesticides

Impact of glyphosate (Roundup^TM) on the composition and functionality of the gut microbiome.

Exposure to pesticides during pregnancy and the risk of neural tube defects: A systematic review.

Toxic effects of organophosphate pesticide monocrotophos in aquatic organisms: A review of challenges, regulations and future perspectives.

An overview of ATP synthase, inhibitors, and their toxicity.

Metals/Metalloids

The relationship between cadmium exposure and preeclampsia: a systematic review and meta-analysis.

Microplastics/Nanomaterials

Neurotoxicity of Titanium Dioxide Nanoparticles: A Comprehensive Review.

Review on fate, transport, toxicity and health risk of nanoparticles in natural ecosystems: Emerging challenges in the modern age and solutions toward a sustainable environment.

Microplastisphere antibiotic resistance genes: A bird’s-eye view on the plastic-specific diversity and enrichment.

Organic pollutants adsorbed on microplastics: Potential indicators for source appointment of microplastics.

Air Pollution

Correlation between COVID-19 and air pollution: the effects of PM2.5 and PM10 on COVID-19 outcomes.

Pharmaceuticals/Personal Care Products

A review on the antibiotic florfenicol: Occurrence, environmental fate, effects, and health risks.

Miscellaneous

Perspectives and understanding on the occurrence, toxicity and abatement technologies of disinfection by-products in drinking water.

Human Health Studies

Numerous Chemicals/Mixtures

Urinary concentrations of bisphenol A, parabens and benzophenone-type ultra violet light filters in relation to sperm DNA fragmentation in young men: A chemical mixtures approach.

Ovarian follicular fluid levels of phthalates and benzophenones in relation to fertility outcomes.

[Associations of a mixture of eleven endocrine disruptors in human urine with the risk of papillary thyroid cancer]. [in Chinese]

Phthalates

Racial and Ethnic Disparities in Phthalate Exposure and Preterm Birth: A Pooled Study of Sixteen U.S. Cohorts.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Exposure to persistent organic pollutants in newborn dried blood spots and childhood acute myeloid leukemia.

Organochlorine pesticides disrupt T helper cell regulation and reduce IL-2 and IFN-γ favoring infection and production of autoantibodies among pemphigus patients.

Association between combined exposure to dioxins and arthritis among US adults: a cross-sectional study.

PFAS

Distribution of per- and polyfluoroalkyl substances in blood, serum, and urine of patients with liver cancer and associations with liver function biomarkers.

Altered Transcriptome Response in PBMCs of Czech Adults Linked to Multiple PFAS Exposure: B Cell Development as a Target of PFAS Immunotoxicity.

Pesticides

Associations of maternal exposure to 2,4-dichlorophenoxyacetic acid during early pregnancy with steroid hormones among one-month-old infants.

Gene-environment interactions for Parkinson’s disease.

Metals/Metalloids

Preterm Birth and Metal Mixture Exposure among Pregnant Women from the Navajo Birth Cohort Study.

The arsenic-lowering effect of inulin-type prebiotics in end-stage renal disease: a randomized crossover trial.

Association between blood arsenic concentration and dyslipidemia: Mediating effect of lipid peroxidation in the elderly.

Construction of an adverse outcome pathway framework based on integrated data to evaluate arsenic-induced non-alcoholic fatty liver disease.

Fish consumption and omega-3 polyunsaturated fatty acids from diet are positively associated with cognitive function in older adults even in the presence of exposure to lead, cadmium, selenium, and methylmercury: a cross-sectional study using NHANES 2011 – 2014 data.

Association Between Combined Polymetallic Exposure and Osteoporosis.

Blood Concentrations of Lead, Cadmium, and Mercury Are Associated With Alcohol-Related Liver Disease.

Associations of multiple toxic metal exposures with metabolic dysfunction-associated fatty liver disease: NHANES 2011-2018.

Associations between metal(loid) exposure with overweight and obesity and abdominal obesity in the general population: A cross-sectional study in China.

Air Pollution

Ambient traffic related air pollution in relation to ovarian reserve and oocyte quality in young, healthy oocyte donors.

Identifying interactions among air pollutant emissions on diabetes prevalence in Northeast China using a complex network.

Pharmaceuticals/Personal Care Products

Pre- and postnatal maternal hair dye use and risk of wheeze and asthma in 5-year-old Japanese children: the Kyushu Okinawa Maternal and Child Health Study.

Miscellaneous

Maternal and newborn metabolomic changes associated with urinary polycyclic aromatic hydrocarbon metabolite concentrations at delivery: an untargeted approach.

Associations of dichlorophenol with metabolic syndrome based on multivariate-adjusted logistic regression: a U.S. nationwide population-based study 2003-2016.

Laboratory Studies

Numerous Chemicals/Mixtures

Transcriptomic and behavioral analyses reveal unique target tissues and molecular pathways associated with embryonic exposure to low level glyphosate and metal mixtures in zebrafish.

Disrupting Development: Unraveling the Interplay of Aryl Hydrocarbon Receptor (AHR) and Wnt/β-Catenin Pathways in Kidney Development Under the Influence of Environmental Pollutants.

BPA/Phenols

Influence of UV light, ultrasound, and heat treatment on the migration of bisphenol A from polyethylene terephthalate bottle into the food simulant.

Bisphenol A induces placental ferroptosis and fetal growth restriction via the YAP/TAZ-ferritinophagy axis.

Fluorene-9-bisphenol exposure damages the testis in mice through a novel mechanism of ferroptosis.

Phthalates

Exploring the potential of a new marine bacterium associated with plastisphere to metabolize dibutyl phthalate and bis(2-ethylhexyl) phthalate by enrichment cultures combined with multi-omics analysis.

Responses of Peritubular Macrophages and the Testis Transcriptome Profiles of Peripubertal and Adult Rodents Exposed to an Acute Dose of MEHP.

Diisobutyl phthalate (DiBP)-induced male germ cell toxicity and its alleviation approach.

Parabens/Triclosan/Antimicrobials

Deciphering the molecular mediators of triclosan-induced lipid accumulation: Intervention via short-chain fatty acids and miR-101a.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

In ovo o,p’-DDT exposure induces malformation of reproductive organs and alters the expression of genes controlling sexual differentiation in Japanese quail embryo.

PFAS

Exposure to select PFAS and PFAS mixtures alters response to platinum-based chemotherapy in endometrial cancer cell lines.

Microbial defluorination of TFA, PFOA, and HFPO-DA by a native microbial consortium under anoxic conditions.

Hexafluoropropylene oxide trimer acid, a perfluorooctanoic acid alternative, induces cardiovascular toxicity in zebrafish embryos.

Metastatic effects of perfluorooctanoic acid (PFOA) on Drosophila melanogaster with metabolic reprogramming and dysrhythmia in a multigenerational exposure scenario.

Early life exposure to perfluorooctanesulfonate (PFOS) impacts vital biological processes in Xenopus laevis: Integrated morphometric and transcriptomic analyses.

Perturbation of IP3R-dependent endoplasmic reticulum calcium homeostasis by PPARδ-activated metabolic stress leads to mouse spermatocyte apoptosis: A direct mechanism for perfluorooctane sulfonic acid-induced spermatogenic disorders.

Impact of perfluoroalkyl substances (PFAS) and PFAS mixtures on lipid metabolism in differentiated HepaRG cells as a model for human hepatocytes.

Perfluorooctanoic acid (PFOA) exposure induces renal filtration and reabsorption disorders via downregulation of aquaporins.

Flame Retardants

Integrated Studies on Male Reproductive Toxicity of Bis(2-ethylhexyl)-tetrabromophthalate: in Silico, in Vitro, ex Vivo, and in Vivo.

Organophosphate ester cresyl diphenyl phosphate disrupts lipid homeostasis in zebrafish embryos.

BDE-209 exposure in murine melanoma (B16-F1) cells modulates tumor malignancy and progression in vivo.

BDE-47-mediated cytotoxicity via autophagy blockade in 3D HepaRG spheroids cultured in alginate microcapsules.

Pesticides

Long-term tralopyril exposure results in endocrinological and transgenerational toxicity: A two-generation study of marine medaka (Oryzias melastigma).

Deciphering the interplay between LPS/TLR4 pathways, neurotransmitter, and deltamethrin-induced depressive-like behavior: Perspectives from the gut-brain axis.

Hesperidin counteracts chlorpyrifos-induced neurotoxicity by regulating oxidative stress, inflammation, and apoptosis in rats.

Exogenous Melatonin Alleviates Atrazine-Induced Glucose Metabolism Disorders in Mice Liver via Suppressing Endoplasmic Reticulum Stress.

Toxicologic effect and transcriptome analysis for sub-chronic exposure to carbendazim, prochloraz, and their combination on the liver of mice.

Metals/Metalloids

TRPML1 contributes to antimony-induced nephrotoxicity by initiating ferroptosis via chaperone-mediated autophagy.

Environmental Cadmium Exposure Exacerbated Bone Loss in NAFLD Mice.

Arsenic-Induced Ferroptosis in Chicken Hepatocytes via the Mitochondrial ROS Pathway.

Ginkgo Biloba Extract Can Antagonize Subchronic Arsenite Exposure-Induced Hepatocyte Senescence by Inhibiting Oxidative Damage and Inflammation in Rats.

TFAM-mediated intercellular lipid droplet transfer promotes cadmium-induced mice nonalcoholic fatty liver disease.

Microplastics/Nanomaterials

Subacute toxicity and endocrine-disrupting effects of Fe₂O₃, ZnO, and CeO₂ nanoparticles on amphibian metamorphosis.

The effect of polystyrene nanoplastics on arsenic-induced apoptosis in HepG2 cells.

Toxic effects of polystyrene microbeads and benzo[α]pyrene on bioaccumulation, antioxidant response, and cell damage in goldfish Carassius auratus.

Concurrent impacts of polystyrene nanoplastic exposure and Aeromonas hydrophila infection on oxidative stress, immune response and intestinal microbiota of grass carp (Ctenopharyngodon idella).

Polystyrene micro- and nanoplastics induce gastric toxicity through ROS mediated oxidative stress and P62/Keap1/Nrf2 pathway.

Effects of partial reduction of polystyrene micro-nanoplastics on the immunity, gut microbiota and metabolome of mice.

Maternal exposure to nano-titanium dioxide impedes fetal development via endothelial-to-mesenchymal transition in the placental labyrinth in mice.

Polystyrene nanobeads exacerbate chronic colitis in mice involving in oxidative stress and hepatic lipid metabolism.

Miscellaneous

Untargeted metabolomics reveals potential health risks associated with chronic exposure to environmentally relevant concentrations of 2-Phenylphenol.

Tire additives: Evaluation of joint toxicity, design of new derivatives and mechanism analysis of free radical oxidation.

Stable isotope-assisted mass spectrometry reveals in vivo distribution, metabolism, and excretion of tire rubber-derived 6PPD-quinone in mice.

Study on epigenotoxicity, sex hormone synthesis, and DNA damage of benzo[a]pyrene in the testis of male Ruditapes philippinarum.

Exposure/Environment Studies

Numerous Chemicals/Mixtures

Target Analysis of Polychlorinated Naphthalenes and Nontarget Screening of Organic Chemicals in Bovine Milk, Infant Formula, and Adult Milk Powder by High-Resolution Mass Spectrometry. [plus phthalates]

Endocrine Disruptors and Estrogens in Human Prostatic Tissue.

Occurrence and removal of legacy plasticizers and flame retardants through a drinking water treatment plant.

Mitigating risks and maximizing sustainability of treated wastewater reuse for irrigation.

Mapping chemical footprints of organic micropollutants in European streams.

New analytical method for the determination of endocrine disruptors in human faeces using gas chromatography coupled to tandem mass spectrometry.

Evaluation of chemical contamination of crops produced in greenhouse by irrigation with reclaimed water.

Contrasted Antibiotics and Pesticides Impregnation in Fish Exposed in situ to Urban Effluents: A 20-Day Caging Experiment.

BPA/Phenols

Assessment of nonylphenol exposure based on global urinary concentration data and its risk analysis.

Alternatives Exert Higher Health Risks than Bisphenol A on Indo-Pacific Humpback Dolphins.

Phthalates

Comprehensive assessment of phthalates in indoor dust across China between 2007 and 2019: Benefits from regulatory restrictions.

Parabens/Triclosan/Antimicrobials

The occurrence and probabilistic risk of exposure to parabens from bottled and hand-shaken teas in the general adult population of Taiwan.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Varying temporal trends in the levels of six groups of legacy persistent organic pollutants (POPs) in liver of three gadoid species from the north sea.

Biomonitoring of PAHs and PCBs in industrial, suburban, and rural areas using snails as sentinel organisms.

One Health assessment of persistent organic chemicals and PFAS for consumption of restored anadromous fish.

Levels of persistent organic pollutants (PoPs) and the role of anthropic subsidies in the diet of avian scavengers tracked by stable isotopes.

PFAS

Identification and quantification of fluorinated polymers in consumer products by combustion ion chromatography and pyrolysis-gas chromatography-mass spectrometry.

Evaluation of fatty acids and carnitine as biomarkers of PFOS exposure in biota (fish and dolphin) from Galveston Bay and the northwestern Gulf of Mexico.

Emerging and legacy per- and polyfluoroalkyl substances (PFAS) in fluorochemical wastewater along full-scale treatment processes: Source, fate, and ecological risk.

Occurrence and transport of novel and legacy poly- and perfluoroalkyl substances in coastal rivers along the Laizhou Bay, northern China.

Assessment of perfluoroalkyl substances concentration levels in wild bat guano samples.

First insights into per-and polyfluoroalkyl substance contamination in edible fish species of the Indus water system of Pakistan.

Flame Retardants

Occurrence, distribution, sources, and risk assessment of organophosphate esters in typical coastal aquaculture waters of China.

Face mask as an indicator and shield of human exposure to traditional and novel organophosphate esters.

[Pollution Level and Risk Assessment of OPEs in Typical River Basins of China].

Pesticides

Risk assessment requires several bee species to address species-specific sensitivity to insecticides at field-realistic concentrations.

Metals/Metalloids

Environmental exposure to metallic pollution impairs honey bee brain development and cognition.

Biomonitoring of Exposures to Solvents and Metals in Electronics Manufacturing Facilities in Batam, Indonesia.

A review of heavy metal risks around e-waste sites and comparable municipal dumpsites in major African cities: Recommendations and future perspectives.

Microplastics/Nanomaterials

The threat of microplastics: Exploring pollution in coastal ecosystems and migratory shorebirds along the west coast of India.

Air Pollution

Community-driven research and capacity building to address environmental justice concerns with industrial air pollution in Curtis Bay, South Baltimore.

Polycyclic Aromatic Hydrocarbons (PAHs) in Wildfire Smoke Accumulate on Indoor Materials and Create Postsmoke Event Exposure Pathways.

Pharmaceuticals/Personal Care Products

Increasing exposure to the UV filters octocrylene and 2-ethylhexyl salicylate in Germany from 1996 to 2020: Human biomonitoring in 24-h urine samples of the German Environmental Specimen Bank (ESB).

Miscellaneous

Polycyclic aromatic hydrocarbon (PAH) source identification and a maternal transfer case study in threatened killer whales (Orcinus orca) of British Columbia, Canada.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. The searchable archives are at https://groups.google.com/d/forum/edc_research or online at https://heeds.org/category/edc-science-weekly/. Feel free to forward this email. Compiled by Sarah Howard of Healthy Environment and Endocrine Disruptor Strategies (HEEDS), a program of Environmental Health Sciences.

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EHN EHN

Webinar: Fluoride, neurodevelopment, and cognition: a National Toxicology Program monograph
by Sarah Howard on November 19, 2024 at 5:00 pm
This Dec. 3 webinar features Dr. Kyla Taylor of NIEHS who will discuss the results of a National Toxicology Program monograph review that concluded there is "moderate confidence" in the scientific evidence that showed an association between higher levels of fluoride exposure and lower IQ in children.
Webinar: Behind the scenes at EPA: What's gone wrong and what does it mean for our work?
by Sarah Howard on November 19, 2024 at 3:56 pm
This Dec. 9 webinar, Behind the scenes at EPA: what's gone wrong and what does it mean for our work? is part 2 of a series on the future of EPA decision-making. Sponsored by the Collaborative for Health and Environment (CHE), Earthjustice, and UCSF's Earth Center.
Endocrine-disrupting chemicals: hazards and opportunities (ECHO) course
by Sarah Howard on October 31, 2024 at 2:50 pm
This course focuses on the chemical, biological, and societal challenges of endocrine-disrupting chemicals (EDCs) and new opportunities for moving forward. ECHO is a two-week intensive bootcamp-style career development course for graduate students, postdoctoral fellows, and professionals in the field. It is held at Woods Hole, Massachusetts.

EHN EHN

“We have enough evidence” to act on toxic plastic exposure now
by Katherine McMahon,Sarah Howard on November 22, 2024 at 3:31 pm
In a recent commentary published in The Lancet, Dr. Leonardo Trasande of NYU’s Grossman School of Medicine emphasizes the need to address the well-established health harms from exposure to chemical additives used in plastics. “Only through a serious and concerted effort to turn off the plastic tap will we apply the lessons learned from plastic use… and avoid the invisible chemicals used in plastic materials from becoming visible in the form of a larger global pandemic of chronic disease.”
Kids who adopt a gluten-free diet have increased arsenic levels
by Katherine McMahon,Sarah Howard on November 20, 2024 at 1:32 pm
A recent study published in The American Journal of Gastroenterology found that children who adopted a gluten-free (GF) diet after being diagnosed with celiac disease had significantly increased arsenic exposure after only six months. “More research needs to be done to determine whether there are long-term effects of this bump, but overall, I think it speaks to the importance of diversifying the grains in the gluten-free diet.”
NIEHS publishes new strategic plan
by Sarah Howard on November 19, 2024 at 6:03 pm
The National Institute of Environmental Health Sciences (NIEHS) published a 2025-2029 strategic plan, "Health at the Intersection of People and Their Environments."

EHN EHN

Trump’s second term could mean fewer protections for drinking water
by EHN Curators on November 21, 2024 at 12:30 pm
Donald Trump’s plans for the Environmental Protection Agency may include rolling back protections against PFAS and other drinking water threats, worrying public health advocates. Hiroko Tabuchi reports for The New York Times.
Kennedy’s fluoride policy faces obstacles
by EHN Curators on November 19, 2024 at 8:28 pm
President-elect Trump’s selection of Robert F. Kennedy Jr. to lead the Department of Health and Human Services won’t give him direct control over water fluoridation policies, though his influence could sway public and local debates. Miranda Willson reports for E&E News.
Scientists' Declaration for the Global Plastics Treaty
by Sarah Howard on November 19, 2024 at 5:54 pm
The signatories of this declaration are independent scientists with expertise on plastics, and who are free of conflicts of interest associated with the life cycle of plastics. Read it here and sign it here. Due Nov. 22, 2024.