EDC Science Weekly, Dec. 8-14, 2023

Post author:HEEDS
Post published:December 14, 2023
Post category:EDC Science Weekly

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week. View as a webpage.

Contents: Events, Regulations/Policy, Methods/Tools/Screening, Commentaries, Reviews/Meta-Analyses, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Highlights: PFAS and childhood cancer; PFOS and lower bone mineral density; arsenic, folate, and measles antibodies; EDCs and vitamin D; EDCs in the air.

More science highlights

Events

Course: Endocrine-Disrupting Chemicals: Hazards and Opportunities (ECHO) This two-week course in May at Woods Hole is accepting applications, due Jan. 15. Financial aid is available.

Webinar Dec. 14 (today, 2pm ET): Webinar on Proposed Revision to the Regulation of Persistent, Bioaccumulative, and Toxic Chemicals Under TSCA [EPA]

Webinar Jan. 9: Food Contact Materials: A Road Map to Improved Safety Testing [EDC Strategies Partnership]

More events

Regulations/Policy

An Approach to Assessing the Influence of Environmental and Occupational Cancer Hazard Identification on Policy Decision-Making and related Invited Perspective: Good Measure-Assessing the Impact of Cancer Hazard Identification on Policies for Cancer Prevention.

More EDC policy and regulations open for comment

Methods/Tools/Screening

Blurred lines: Crossing the boundaries between the chemical exposome and the metabolome. [review of tools and methods]

Computational modeling approaches for developing a synergistic effect prediction model of estrogen agonistic activity.

Review of machine learning and deep learning models for toxicity prediction.

In vitro screening of per- and polyfluorinated substances (PFAS) for interference with seven thyroid hormone system targets across nine assays.

Integrating climate model projections into environmental risk assessment: a probabilistic modeling approach.

Uncertainty in the results from oral repeated dose toxicity tests: Impact on regulatory classifications.

Comparing Transcriptomic Responses to Chemicals Across Six Species using the EcoToxChip RNASeq database.

An integrated in vitro approach to identifying chemically induced oxidative stress and toxicity in mitochondria.

More tools, reports, and resources

Commentaries

Synthetic Antioxidants as Contaminants of Emerging Concern in Indoor Environments: Knowns and Unknowns.

Time to integrate “One Health Approach” into nanoplastic research.

A fetus in the world: Physiology, epidemiology, and the making of fetal origins of adult disease.

Reviews/Meta-Analyses

Numerous Chemicals/Mixtures

Imprinting and Reproductive Health: A Toxicological Perspective.

A systematic review of the evaluation of endocrine-disrupting chemicals in the Japanese medaka (Oryzias latipes) fish.

BPA/Phenols

Research progress of the effects of bisphenol analogues on the intestine and its underlying mechanisms: A review.

Phthalates

Exposure to endocrine-disrupting plasticisers and lung function in children and adolescents: A systematic review and meta-analysis. [phthalates and bisphenols]

PFAS

Firefighters’ exposure to per-and polyfluoroalkyl substances (PFAS) as an occupational hazard: A review.

Flame Retardants

Research progress in cardiotoxicity of organophosphate esters.

Pesticides

Influence of pesticide exposure on farmers’ cognition: A systematic review.

Recent developments in fluorine-containing pesticides.

Microplastics/Nanomaterials

The potential impacts of micro-and-nano plastics on various organ systems in humans.

Soils in distress: The impacts and ecological risks of (micro)plastic pollution in the terrestrial environment.

Roadmap of environmental health research on emerging contaminants: Inspiration from the studies on engineered nanomaterials.

Air Pollution

Atmospheric endocrine disruptors: A systematic review on oestrogenic and androgenic activity of particulate matter.

Miscellaneous

Emerging organic contaminants of liquid crystal monomers: Environmental occurrence, recycling and removal technologies, toxicities and health risks.

Human Health Studies

Numerous Chemicals/Mixtures

Relationship between endocrine disrupting chemicals (phthalate metabolites, triclosan and bisphenols) and vitamin D in female subjects: An exploratory pilot study.

Paternal and maternal preconception and maternal pregnancy urinary phthalate metabolite and BPA concentrations in relation to child behavior.

BPA/Phenols

Placental transfer of bisphenol diglycidyl ethers (BDGEs) and its association with maternal health in a population in South of China.

Phthalates

Preconception Phthalate Exposure and Women’s Reproductive Health: Pregnancy, Pregnancy Loss, and Underlying Mechanisms.

Phthalate metabolites in urine and follicular fluid in relation to menstrual cycle characteristics in women seeking fertility assistance.

Parabens/Triclosan/Antimicrobials

Expression Profiles of Genes Related to Development and Progression of Endometriosis and Their Association with Paraben and Benzophenone Exposure.

PFAS

Exposure to perfluoroalkyl substances and longitudinal changes in bone mineral density in adolescents and young adults: A multi-cohort study.

Case-Cohort Study of the Association between PFAS and Selected Cancers among Participants in the American Cancer Society’s Cancer Prevention Study II LifeLink Cohort.

The association between prenatal per-and polyfluoroalkyl substance levels and Kawasaki disease among children of up to 4 years of age: A prospective birth cohort of the Japan Environment and Children’s study.

Associations of a Prenatal Serum Per- and Polyfluoroalkyl Substance Mixture with the Cord Serum Metabolome in the HOME Study.

Maternal serum concentrations of per- and polyfluoroalkyl substances and childhood acute lymphoblastic leukemia.

Flame Retardants

Prenatal exposures to organophosphate ester metabolites and early motor development in the MADRES cohort.

Pesticides

Urinary neonicotinoids and metabolites are associated with obesity risk in Chinese school children.

Association between urinary glyphosate exposure and bone mineral density in adults.

Sex-specific effects of organophosphate ester exposure on child growth trajectories in the first two years.

Metals/Metalloids

Association of arsenic exposure with measles antibody titers in US children: Influence of sex and serum folate levels.

Prenatal fluoride exposure, offspring visual acuity and autonomic nervous system function in 6-month-old infants.

Association between Urinary Lead and Female Breast Cancer: A Population-Based Cross-Sectional Study.

Exploring the association between two groups of metals with potentially opposing renal effects and renal function in middle-aged and older adults: Evidence from an explainable machine learning method.

Air Pollution

Fluctuating risk of acute kidney injury-related mortality for four weeks after exposure to air pollution: A multi-country time-series study in 6 countries.

Long-term exposure to ambient air pollution and risk of leukemia and lymphoma in a pooled European cohort.

Ambient ozone pollution impairs glucose homeostasis and contributes to renal function decline: Population-based evidence.

Effects of in-utero personal exposure to PM_2.5 sources and components on birthweight.

Association of Air Pollution with a Urinary Biomarker of Biological Aging and Effect Modification by Vitamin K in the FLEMENGHO Prospective Population Study.

Associations between Short-Term Exposure to Ambient Air Pollution and Influenza: An Individual-Level Case-Crossover Study in Guangzhou, China. and Short-Term Exposure to Ambient Air Pollution and Influenza: A Multicity Study in China. are accompanied by Invited Perspective: On Air Pollution, Epidemics, Pandemics, and Planetary Health.

Miscellaneous

The urinary level of 2,4,5-trichlorophenol was positively associated with both all-cause and cause-specific mortalities in general adult residents of United States.

Laboratory Studies

Numerous Chemicals/Mixtures

Preconceptional and in utero exposure of sheep to a real-life environmental chemical mixture disrupts key markers of energy metabolism in male offspring.

Study on the combined toxicity of DEHP and lead on the blood system of rats.

Machine learning identifies phenotypic profile alterations of human dopaminergic neurons exposed to bisphenols and perfluoroalkyls.

Assessment of endocrine disruptor impacts on lipid metabolism in a fatty acid-supplemented HepaRG human hepatic cell line.

Transcriptional Response of Vitellogenin Gene in Flatfish to Environmental Pollutants from Two Regions of the Gulf of Mexico.

BPA/Phenols

The effects of bisphenol S exposure on the growth, physiological and biochemical indices, and ecdysteroid receptor gene expression in red swamp crayfish, Procambarus clarkii.

Bisphenol A Effects on Neurons’ Neurochemical Character in the Urinary Bladder Intramural Ganglia of Domestic Pigs.

The Effects of Acute Bisphenol A Toxicity on the Hematological Parameters, Hematopoiesis, and Kidney Histology of Zebrafish (Danio rerio).

Environmental bisphenol A exposure triggers trained immunity-related pathways in monocytes.

A comprehensive transcriptomic analysis of the bisphenol A affected kidney in mice.

Bisphenol B induces developmental toxicity in zebrafish via oxidative stress.

PPARα Senses Bisphenol S to Trigger EP300-Mediated Autophagy Blockage and Hepatic Steatosis.

Bisphenol A promote the cell proliferation and invasion ability of prostate cancer cells via regulating the androgen receptor.

Phthalates

Inhibitory effects of phthalate esters (PAEs) and phthalate monoesters towards human carboxylesterases (CESs).

Prenatal to peripubertal exposure to Di(2-ethylhexyl) phthalate induced endometrial atrophy and fibrosis in female mice.

Parabens/Triclosan/Antimicrobials

Acute and chronic effects of triclosan on the behavior, physiology, and multigenerational characteristics of the water flea Moina macrocopa.

Toxicity of benzyl paraben on aquatic as well as terrestrial life.

Interference of gut-brain-gonad axis originating from triclocarban exposure to parent zebrafish induces offspring embryonic development abnormality by up-regulation of maternal circSGOL1.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Predicted Versus Observed Activity of PCB Mixtures Toward the Ryanodine Receptor.

Congener Variation of Genetic Dependent-Developmental Toxicology in Two Emerging Classes of Dioxin-like Compounds.

Features of Spleen Development in Newborn Rats Exposed to Endocrine Disrupter Dichlorodiphenyltrichloroethane during the Prenatal Period.

DNA methylation reprogramming mediates transgenerational diabetogenic effect induced by early-life p,p’-DDE exposure.

PFAS

Evaluating the toxicokinetics of some metabolites of a C6 polyfluorinated compound, 6:2 fluorotelomer alcohol in pregnant and nonpregnant rats after oral exposure to the parent compound.

Adverse effects of gestational exposure to hexafluoropropylene oxide trimer acid (HFPO-TA) homologs on maternal, fetal, and placental health in mice.

(-)-Epigallocatechin-3-Gallate Reduces Perfluorodecanoic Acid-Exacerbated Adiposity and Hepatic Lipid Accumulation in High-Fat Diet-Fed Male C57BL/6J Mice.

Inulin alleviates perfluorooctanoic acid-induced intestinal injury in mice by modulating the PI3K/AKT/mTOR signaling pathway.

PFOS-elicited metabolic perturbation in liver and fatty acid metabolites in testis of adult mice.

Perfluorooctanesulfonic Acid and Perfluorooctanoic Acid Promote Migration of Three-Dimensional Colorectal Cancer Spheroids.

Exploring Route-Specific Pharmacokinetics of PFAS in Mice by Coupling in Vivo Tests and Physiologically Based Toxicokinetic Models.

Flame Retardants

Tetrabromobisphenol A induces neuronal cytotoxicity by inhibiting PINK1-Parkin-mediated mitophagy via upregulating ATF3 expression.

Triphenyl phosphate exposure impairs colorectal health by altering host immunity and colorectal microbiota.

Perturbation of lipid metabolism in 3T3-L1 at different stages of preadipocyte differentiation and new insights into the association between changed metabolites and adipogenesis promoted by TBBPA or TBBPS.

Multigenerational effects and mutagenicity of three flame retardants on germ cells in Caenorhabditis elegans.

Pesticides

In vivo estrogenicity of glyphosate, its formulations, and AMPA on transgenic zebrafish (Danio rerio) embryos.

Toxicity assessment of a tebuconazole-based fungicide on the embryo-larval development of the common south American toad Rhinella arenarum.

Sub-chronic exposure to hexaconazole affects the lipid metabolism of rats through mTOR-PPAR-γ/SREBP1 signaling pathway mediated by oxidative stress.

Cross species extrapolation of the disruption of thyroid hormone synthesis by oxyfluorfen using in vitro data, physiologically based pharmacokinetic (PBPK), and thyroid hormone kinetics models.

The amelioration of ovarian dysfunction by hesperidin in malathion-treated mice through the overexpression of PCNA and FSHR proteins.

The Protective effects of Vitamin E against alterations of rat testis structure induced by deltamethrin; histological, ultrastructure, and biochemical study.

Impact of exposure to glyphosate-based herbicide on morphological and physiological parameters in embryonic and larval development of zebrafish.

Reproductive toxicity in birds predicted by physiologically-based kinetics and bioenergetics modelling.

Metals/Metalloids

Arsenic-Induced Thyroid Hormonal Alterations and Their Putative Influence on Ovarian Follicles in Balb/c Mice.

Effects of cadmium exposure during pregnancy on genome-wide DNA methylation and the CREB/CREM pathway in the testes of male offspring rats.

Lead aggravates Alzheimer’s disease pathology via mitochondrial copper accumulation regulated by COX17.

Microplastics/Nanomaterials

Transcriptome and proteome analyses reveal the mechanisms involved in polystyrene nanoplastics disrupt spermatogenesis in mice.

Microplastics cause hepatotoxicity in diabetic mice by disrupting glucolipid metabolism via PP2A/AMPK/HNF4A and promoting fibrosis via the Wnt/β-catenin pathway.

Nanoplastic propels diet-induced NAFL to NASH via ER-mitochondrial tether-controlled redox switch.

Micro(nano)plastics in marine medaka: Entry pathways and cardiotoxicity with triphenyltin.

Chronic exposure to polystyrene microplastics increased the chemosensitivity of normal human liver cells via ABC transporter inhibition.

Polystyrene microplastics mediate cell cycle arrest, apoptosis, and autophagy in the G2/M phase through ROS in grass carp kidney cells.

Effects of the adsorption behavior of polyamide microplastics on male reproductive health by reduction of testosterone bioavailability.

Effects of combined exposure to polystyrene microplastics and 17α-Methyltestosterone on the reproductive system of zebrafish.

Air Pollution

Epigenetic transgenerational effects of PM2.5 collected from southern Taiwan on sperm functions and DNA methylation in mouse offspring.

Pharmaceuticals/Personal Care Products

Transcriptomic profiles of brains in juvenile Atlantic cod (Gadus morhua) exposed to pharmaceuticals and personal care products from a wastewater treatment plant discharge.

Cashmeran as a potential endocrine disrupting chemical: What does the weight-of-the-evidence indicate?

Miscellaneous

Sex-specific perturbation of systemic lipidomic profile in newborn lambs impacted by prenatal testosterone excess.

Bypassing the Brain Barriers: Upregulation of Serum miR-495 and miR-543-3p Reflects Thyroid-Mediated Developmental Neurotoxicity in the Rat.

Non-regulated haloaromatic water disinfection byproducts act as endocrine and lipid disrupters in human placenta cells.

Evaluating the in vitro developmental toxicity potency of a series of petroleum substance extracts using new approach methodologies (NAMs).

Exposure/Environment Studies

Numerous Chemicals/Mixtures

Urinary concentrations and elimination half-lives of parabens, benzophenones, bisphenol and triclosan in Japanese young adults.

BPA/Phenols

Urinary concentrations of environmental phenol among pregnant women in the Japan Environment and Children’s Study.

Phthalates

Predictors of Phthalate Metabolites Exposure among Healthy Pregnant Women in the United States, 2010-2015.

High-throughput analytical methodology of monoalkyl phthalate esters and the composite risk assessment with their parent phthalate esters in aquatic organisms and seawater.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

PCB concentrations in riparian spiders (Tetragnathidae) consistently reflect concentrations in water and aquatic macroinvertebrates, but not sediment: Analysis of a seven-year field study.

Exposure to POPs in Australian Waterbirds.

Legacy contaminant trends in the Great lakes uncovered by the wildlife environmental quality index.

PFAS

Novel PFAS-specific monitoring approach for highly impacted surface waters.

Factors affecting the occurrence and accumulation of perfluoroalkyl acids in indoor dust in Tainan, Taiwan.

Assessing the trophic ecology and migration on the exposure of cape petrels and Wilson’s storm petrels from Antarctica to perfluoroalkylated substances, trace and major elements.

Metabolic and Microbial Profiling of Soil Microbial Community under Per- and Polyfluoroalkyl Substance (PFAS) Stress.

Flame Retardants

Occurrence, distribution, potential sources, and risks of organophosphate esters in fresh snow on Urumqi Glacier No. 1, eastern Tien Shan, China.

Pesticides

Quantitation of glyphosate, glufosinate, and AMPA in drinking water and surface waters using direct injection and charged-surface chromatography coupled to ultra-high performance liquid chromatography-tandem mass spectrometry.

Metals/Metalloids

Concentrations of Lead and Arsenic in Mother’s Milk and Children’s Blood in Peruvian Breastfeeding Dyads.

Prenatal arsenic and mercury levels among women practicing geophagy in areas with artisanal and small-scale gold mining activities, Northwestern Tanzania.

Microplastics/Nanomaterials

Microplastics in oral healthcare products (OHPs) and their environmental health risks and mitigation measures.

Airborne microplastics in urban, rural and wildland environments on the Tibetan Plateau.

Pharmaceuticals/Personal Care Products

Beauty Beware: Associations between Perceptions of Harm and Safer Hair-Product-Purchasing Behaviors in a Cross-Sectional Study of Adults Affiliated with a University in the Northeast.

Beauty Inside Out: Examining Beauty Product Use Among Diverse Women and Femme-Identifying Individuals in Northern Manhattan and South Bronx Through an Environmental Justice Framework.

Miscellaneous

Assessing the ecological impacts of polycyclic aromatic hydrocarbons petroleum pollutants using a network toxicity model.

Source, distribution, and risk assessment of polycyclic aromatic hydrocarbons in sediment and fish samples from River Owan, Edo State, Nigeria.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. The searchable archives are at https://groups.google.com/d/forum/edc_research or online at https://heeds.org/category/edc-science-weekly/. Feel free to forward this email. Compiled by Sarah Howard of Healthy Environment and Endocrine Disruptor Strategies (HEEDS), a program of Environmental Health Sciences.

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EHN EHN

Webinar: Fluoride, neurodevelopment, and cognition: a National Toxicology Program monograph
by Sarah Howard on November 19, 2024 at 5:00 pm
This Dec. 3 webinar features Dr. Kyla Taylor of NIEHS who will discuss the results of a National Toxicology Program monograph review that concluded there is "moderate confidence" in the scientific evidence that showed an association between higher levels of fluoride exposure and lower IQ in children.
Webinar: Behind the scenes at EPA: What's gone wrong and what does it mean for our work?
by Sarah Howard on November 19, 2024 at 3:56 pm
This Dec. 9 webinar, Behind the scenes at EPA: what's gone wrong and what does it mean for our work? is part 2 of a series on the future of EPA decision-making. Sponsored by the Collaborative for Health and Environment (CHE), Earthjustice, and UCSF's Earth Center.
Endocrine-disrupting chemicals: hazards and opportunities (ECHO) course
by Sarah Howard on October 31, 2024 at 2:50 pm
This course focuses on the chemical, biological, and societal challenges of endocrine-disrupting chemicals (EDCs) and new opportunities for moving forward. ECHO is a two-week intensive bootcamp-style career development course for graduate students, postdoctoral fellows, and professionals in the field. It is held at Woods Hole, Massachusetts.

EHN EHN

“We have enough evidence” to act on toxic plastic exposure now
by Katherine McMahon,Sarah Howard on November 22, 2024 at 3:31 pm
In a recent commentary published in The Lancet, Dr. Leonardo Trasande of NYU’s Grossman School of Medicine emphasizes the need to address the well-established health harms from exposure to chemical additives used in plastics. “Only through a serious and concerted effort to turn off the plastic tap will we apply the lessons learned from plastic use… and avoid the invisible chemicals used in plastic materials from becoming visible in the form of a larger global pandemic of chronic disease.”
Kids who adopt a gluten-free diet have increased arsenic levels
by Katherine McMahon,Sarah Howard on November 20, 2024 at 1:32 pm
A recent study published in The American Journal of Gastroenterology found that children who adopted a gluten-free (GF) diet after being diagnosed with celiac disease had significantly increased arsenic exposure after only six months. “More research needs to be done to determine whether there are long-term effects of this bump, but overall, I think it speaks to the importance of diversifying the grains in the gluten-free diet.”
NIEHS publishes new strategic plan
by Sarah Howard on November 19, 2024 at 6:03 pm
The National Institute of Environmental Health Sciences (NIEHS) published a 2025-2029 strategic plan, "Health at the Intersection of People and Their Environments."

EHN EHN

Trump’s second term could mean fewer protections for drinking water
by EHN Curators on November 21, 2024 at 12:30 pm
Donald Trump’s plans for the Environmental Protection Agency may include rolling back protections against PFAS and other drinking water threats, worrying public health advocates. Hiroko Tabuchi reports for The New York Times.
Kennedy’s fluoride policy faces obstacles
by EHN Curators on November 19, 2024 at 8:28 pm
President-elect Trump’s selection of Robert F. Kennedy Jr. to lead the Department of Health and Human Services won’t give him direct control over water fluoridation policies, though his influence could sway public and local debates. Miranda Willson reports for E&E News.
Scientists' Declaration for the Global Plastics Treaty
by Sarah Howard on November 19, 2024 at 5:54 pm
The signatories of this declaration are independent scientists with expertise on plastics, and who are free of conflicts of interest associated with the life cycle of plastics. Read it here and sign it here. Due Nov. 22, 2024.