EDC Science Weekly, Nov. 17-22, 2023

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week. Sending a day early due to U.S. Thanksgiving!

Contents: Events, Regulations/Policy, Methods/Tools/Screening, Commentaries, Reviews/Meta-Analyses, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Highlights: How regulators have assessed BPA incorrectly; PFAS and early menarche, hyperactivity.

More science highlights

Events

Webinar Nov. 28: Chemical Recycling: A Dangerous Deception [Beyond Plastics and IPEN]

Webinar Nov. 29: Shades of Pink: Breast Cancer, Pinkwashing, and the Importance of Prevention [CHE-Alaska Partnership]

Webinar Nov. 29: Development and Application of NAMs Workflows and Tools [EPA, PETA, Institute for In Vitro Sciences, California Department of Pesticide Regulation]

Webinar Dec. 12: Neuroendocrine disruptors and brain development: Lessons from PCBs [EDC Strategies Partnership]

More events

Regulations/Policy

Drivers of divergent assessments of bisphenol-A hazards to semen quality by various European agencies, regulators and scientists.

Safety Assessment of Polyfluorinated Polymers as Used in Cosmetics.

EU allows use of controversial weedkiller glyphosate for 10 more years. [News item in Nature]

More EDC policy and regulations open for comment

Methods/Tools/Screening

In silico bioavailability triggers applied to direct and indirect thyroid hormone disruptors.

Reporting and reproducibility: Proteomics of fish models in environmental toxicology and ecotoxicology.

Beyond chemicals: Opportunities and challenges of integrating non-chemical stressors in adverse outcome pathways.

Multi-tissue proteogenomic analysis for mechanistic toxicology studies in non-model species.

Recovery of 400 Chemicals with Three Extraction Methods for Low Volumes of Human Plasma Quantified by Instrumental Analysis and In Vitro Bioassays.

ROB-ME: a tool for assessing risk of bias due to missing evidence in systematic reviews with meta-analysis. [see related, Will the ROB-ME checklist prevent omission bias in meta-analyses?]

More tools, reports, and resources

Commentaries

Endocrine disrupting chemicals: New risk factors for embryonic neurodevelopment.

Reviews/Meta-Analyses

Numerous Chemicals/Mixtures

Sex difference of pre- and post-natal exposure to six developmental neurotoxicants on intellectual abilities: a systematic review and meta-analysis of human studies.

Association of prenatal and postnatal exposure to some endocrine-disrupting chemicals with birth and neurodevelopmental outcomes: an extensive review.

Asthma and Environmental Exposures to Phenols, Polycyclic Aromatic Hydrocarbons, and Phthalates in Children.

Pollutant exposure and myocardial injury: Protocol and progress report for a toxicological systematic mapping review.

Phthalates

Prenatal phthalate exposure and birth size: a systematic review and meta-analysis.

PFAS

Polyfluoroalkyl phosphate esters (PAPs) as PFAS substitutes and precursors: An overview.

Environmental impacts, exposure pathways, and health effects of PFOA and PFOS.

Pesticides

Ecotoxicology of the herbicide paraquat: effects on wildlife and knowledge gaps.

Metals/Metalloids

Mercury and cadmium-induced inflammatory cytokines activation and its effect on the risk of preeclampsia: a review.

Bioaccessibility data of potentially toxic elements in complementary foods for infants: A review.

Microplastics/Nanomaterials

Review on impacts of micro- and nano-plastic on aquatic ecosystems and mitigation strategies.

Indoor microplastics: a comprehensive review and bibliometric analysis.

Micro (nano) plastics uptake, toxicity and detoxification in plants: Challenges and prospects.

Micro and nano plastics in food: A review on the strategies for identification, isolation, and mitigation through photocatalysis, and health risk assessment.

Air Pollution

Association of air pollution exposure with overweight or obesity in children and adolescents: A systematic review and meta-analysis.

Pharmaceuticals/Personal Care Products

A systematic review of pharmaceutical and personal care products as emerging contaminants in waters: The panorama of West Africa.

Human Health Studies

Numerous Chemicals/Mixtures

Role of inflammatory lipid and fatty acid metabolic abnormalities induced by plastic additives exposure in childhood asthma.

BPA/Phthalates

Bisphenol A analogues and metabolic syndrome in women with polycystic ovary syndrome.

Urinary Bisphenol-A (BPA) and Bis(2-ethylhexyl)phthalate (DEHP) metabolite concentrations in children with obesity: A case-control study.

Associations Between Phthalate, Eosinophil, and Aeroallergen Sensitization in Schoolchildren.

BMI-specific inflammatory response to phthalate exposure in early pregnancy: findings from the TMCHESC study.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Placental concentrations of xenoestrogenic organochlorine pesticides and polychlorinated biphenyls and assessment of their xenoestrogenicity in the PA-MAMI mother-child cohort.

Pubertal progression in relation to peripubertal exposure to organochlorine chemicals in a cohort of Russian boys.

Dietary intakes of dioxins and polychlorobiphenyls (PCBs) and mortality: EPIC cohort study in 9 European countries.

PFAS

Prenatal Exposure to Perfluoroalkyl Substances and Child Behavior at Age 12: A PELAGIE Mother-Child Cohort Study.

Early menarche and other endocrine disrupting effects of per- and polyfluoroalkyl substances (PFAS) in adolescents from Northern Norway. The Fit Futures study.

Flame Retardants

Co-occurrence of tetrabromobisphenol a and debromination products in human hair across China: Implications for exposure sources and health effects on metabolic syndrome.

Association of organophosphate flame retardants with all-cause and cause-specific mortality among adults aged 40 years and older.

Pesticides

Exposure to chlorpyrifos and pyrethroid insecticides and symptoms of Attention Deficit Hyperactivity Disorder (ADHD) in preschool children from the Odense Child Cohort.

Metals/Metalloids

Integrating Data Across Multiple Sites in the Northeastern United States to Examine Associations Between a Prenatal Metal Mixture and Child Cognition.

The Relationship Between Heavy Metals and Missed Abortion: Using Mediation of Serum Hormones.

Arsenic-Induced Cardiovascular Diseases and their Correlation with Mitochondrial DNA Copy Number, Deletion, and Telomere Length in Bangladeshi Population.

Male reproductive hormone disorders among copper smelter workers.

Miscellaneous

Association between polycyclic aromatic hydrocarbon exposure and blood lipid levels: the indirect effects of inflammation and oxidative stress.

Laboratory Studies

Numerous Chemicals/Mixtures

Evaluation of precopulatory pairing behaviour and male fertility in a marine amphipod exposed to plastic additives.

BPA/Phenols

Transcriptomic Integration Analyses Uncover Common Bisphenol A Effects Across Species and Tissues Primarily Mediated by Disruption of JUN/FOS, EGFR, ER, PPARG, and P53 Pathways.

Bisphenol A exposure decreases sperm production and male fertility through inhibition PCBP2 expression.

Phthalates

DEHP and DBP, common phthalates, induce glucose metabolism disorders in rats via oxidative damage of PI3K/Akt/GLUT4 signaling.

Protective effects of melatonin on DEHP-induced apoptosis and oxidative stress in prepubertal testes via the PI3K/AKT pathway.

Quercetin alleviates DEHP exposure-induced pyroptosis and cytokine expression changes in grass carp L8824 cell line by inhibiting ROS/MAPK/NF-κB pathway.

Mitochondrial dysfunction and endoplasmic reticulum stress induced by activation of PPARα leaded testicular to apoptosis in SD rats explored to di-(2-ethylhexyl) phthalate (DEHP).

Isomers are more likely to cause collapse of Daphnia magna populations than Di-(2-ethylhexyl) phthalate (DEHP).

Combined Astragalus, vitamin C, and vitamin E alleviate DEHP-induced oxidative stress and the decreased of insulin synthesis and secretion in INS-1 cells.

Butyl benzyl phthalate induced reproductive toxicity in the endoplasmic reticulum and oxidative stress in Brachionus plicatilis Müller, 1786.

Effects of two alternative plasticizers on the growth hormone-related endocrine system, neurodevelopment, and oxidative stress of zebrafish larvae. [phthalate alternatives]

Parabens/Triclosan/Antimicrobials

Cardio- and neuro-toxic effects of four parabens on Daphnia magna.

Systolic heart failure induced by butylparaben in zebrafish is caused through oxidative stress and immunosuppression.

Chronic administration of triclosan leads to liver fibrosis through hepcidin-ferroportin axis-mediated iron overload.

Transcriptome analysis reveals differences in developmental neurotoxicity mechanism of methyl-, ethyl-, and propyl- parabens in zebrafish embryos.

PFAS

Adverse impacts of environmentally relevant PFOS alternatives on mice pancreatic tissues.

Perfluorinated iodine alkanes promote the differentiation of mouse embryonic stem cells by regulating estrogen receptor signaling.

Unraveling the mechanism of quercetin alleviating perfluorooctane sulfonate-induced apoptosis in grass carp (Ctenopharyngodon idellus) hepatocytes: AMPK/mTOR-mediated mitophagy.

Perfluorinated iodine alkanes promote the differentiation of mouse embryonic stem cells by regulating estrogen receptor signaling.

Evidence for neurotoxicity and oxidative stress in zebrafish embryos/larvae treated with HFPO-DA ammonium salt (GenX).

Flame Retardants

Toxicity assessment of organophosphate flame retardant triphenyl phosphate (TPHP) on intestines in mice.

Japanese medaka (Oryzias latipes) exposed via maternal transfer to the brominated flame retardant, 1,2,5,6-tetrabromocyclooctane (TBCO), experience decreased fecundity and impaired oocyte maturation.

Organotins

Tributyltin causes generational neurodevelopmental toxicity and the protective effect of folic acid in zebrafish.

Pesticides

Transgenerational epigenetic effects imposed by neonicotinoid thiacloprid exposure.

Effect of environmental level of methomyl on hatching, morphology, immunity and development related genes expression in zebrafish (Danio rerio) embryo.

Assessment of oxidative stress biomarkers in the threatened annual killifish Austrolebias charrua exposed to roundup.

Effects of environmentally relevant cypermethrin and sulfamethoxazole on intestinal health, microbiome, and liver metabolism in grass carp.

A Pediatric Rat Model of Organophosphate-Induced Refractory Status Epilepticus: Characterization of Long-term Epileptic Seizure Activity, Neurological Dysfunction and Neurodegeneration.

Exposure of embryos to fenbuconazole causes persistent neurotoxicity in adult zebrafish.

Developmental toxicity assessment of neonicotinoids and organophosphate esters with a human embryonic stem cell- and metabolism-based fast-screening model.

Combined exposure of beta-cypermethrin and emamectin benzoate interferes with the HPO axis through oxidative stress, causing an imbalance of hormone homeostasis in female rats.

Metals/Metalloids

Gene expression profiles to analyze the anticancer and carcinogenic effects of arsenic in bladder cancer.

The endocrine disruptor cadmium modulates the androgen-estrogen receptors ratio and induces inflammatory cytokines in luminal (A) cell models of breast cancer.

In vitro and in vivo approaches to assess atherosclerosis following exposure to low-dose mixtures of arsenic and cadmium.

Secondary Exposure to Heavy metal in Genetically susceptible Mice Leads to Acceleration of Autoimmune Response.

Microplastics/Nanomaterials

Fish microplastic ingestion may induce tipping points of aquatic ecosystems.

Environmentally persistent free radicals on photoaged microplastics from disposable plastic cups induce the oxidative stress-associated toxicity.

Fate and disposition of [¹⁴C]-polystyrene microplastic after oral administration to laying hens.

Microplastics exposure induced and exacerbated the development of systemic lupus erythematosus in mice.

Polystyrene nanoplastics induce glycolipid metabolism disorder via NF-κB and MAPK signaling pathway in mice.

Long-term exposure to polystyrene microplastics induces hepatotoxicity by altering lipid signatures in C57BL/6J mice.

Vitamin D modulates disordered lipid metabolism in zebrafish (Danio rerio) liver caused by exposure to polystyrene nanoplastics.

Titanium-doped PET nanoplastics, from opaque milk bottle degradation, as a model of environmental true-to-life nanoplastics. Hazardous effects on Drosophila.

Pharmaceuticals/Personal Care Products

Embryonic Exposure to the Benzotriazole UV Stabilizer, UV-P, Decreases Fertility of Adult Zebrafish (Danio rerio).

Early-life long-term ibuprofen exposure reduces reproductive capacity involved in spermatogenesis impairment and associated with the transcription factor DAF-5 in Caenorhabditis elegans.

Exposure/Environment Studies

Numerous Chemicals/Mixtures

Levels of organic pollutants and metals/metalloids in infant formula marketed in Brazil: Risks to early-life health.

Characterizing the marine mammal exposome by iceberg modeling, linking chemical analysis and in vitro bioassays.

BPA/Phenols

Bisphenol analogues in infant foods in south China and implications for infant exposure.

Phthalates

Phthalate metabolites in breast milk from mothers in Southern China: Occurrence, temporal trends, daily intake, and risk assessment.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

POPs in long-finned pilot whales mass stranded in Iceland as a proxy for their physiological condition.

PFAS

Per- and polyfluoroalkyl substances (PFAS) in Canadian municipal wastewater and biosolids: Recent patterns and time trends 2009 to 2021.

Tracing the Bioaccessibility of Per- and Polyfluoroalkyl Substances in Fish during Cooking Treatment.

Biomagnification and health risks of perflfluoroalkyl acids (PFAAs) in seafood from the Yangtze river estuary of China.

Per- and polyfluoroalkyl substances in a subtropical river-mangrove estuary-bay system.

Target and non-target analyses of neutral per- and polyfluoroalkyl substances from fluorochemical industries using GC-MS/MS and GC-TOF: Insights on their environmental fate.

Hunting the missing fluorine in aqueous film-forming foams containing per- and polyfluoroalkyl substances.

Are Chinese mitten crabs (Eriocheir sinensis) suitable as biomonitor or bioindicator of per- and polyfluoroalkyl substances (PFAS) pollution?

Flame Retardants

Indirect Emissions from Organophosphite Antioxidants Result in Significant Organophosphate Ester Contamination in China.

Organophosphorus flame retardants and their metabolites in paired human blood and urine.

Emerging and traditional organophosphate esters in office air from Hangzhou, East China: Seasonal variations, influencing factors and human exposure assessment.

Spatial and temporal patterns of organophosphate Esters flame retardants and plasticizers in airborne particles over the Mediterranean sea.

Metals/Metalloids

Blood concentrations of metals, essential trace elements, rare earth elements and other chemicals in the general adult population of Barcelona: Distribution and associated sociodemographic factors.

Microplastics/Nanomaterials

Nanoplastics from disposable paper cups and microwavable food containers.

Retention of microplastics and tyre wear particles in stormwater ponds.

Forecasting global plastic production and microplastic emission using advanced optimised discrete grey model.

Air Pollution

Estimating personal exposures to household air pollution and plastic garbage burning among adolescent girls in Jalapa, Guatemala.

Pharmaceuticals/Personal Care Products

Bioaccumulation of pharmaceuticals and stimulants in macrobenthic food web in the European Arctic as determined using stable isotope approach.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. The searchable archives are at https://groups.google.com/d/forum/edc_research or online at https://heeds.org/category/edc-science-weekly/. Compiled by Sarah Howard of Healthy Environment and Endocrine Disruptor Strategies (HEEDS), a program of Environmental Health Sciences.

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