EDC Science Weekly, Aug. 4-10, 2023

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week. Note: this newsletter will not be published next week due to vacation.

Science highlights

Events

Contents: Regulations/Policy, Methods/Tools/Screening, Commentaries, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Regulations/Policy

The regulation of endocrine-disrupting chemicals to minimize their impact on health.

More EDC policy and regulations open for comment

Methods/Tools/Screening

Innovative tools and methods for toxicity testing within PARC work package 5 on hazard assessment. [Part of the Frontiers in Toxicology research topic,

European Partnership on the Assessment of Risks from Chemicals (PARC): Focus on New Approach Methodologies (NAMs) in Risk Assessment]

Optimization of an adverse outcome pathway network on chemical-induced cholestasis using an artificial intelligence-assisted data collection and confidence level quantification approach.

Can the impact of micro- and nanoplastics on human health really be assessed using in vitro models? A review of methodological issues.

Advancing the use of New Approach Methodologies for assessing teratogenicity: building a tiered approach.

Decamethylcyclopentasiloxane affects estradiol production in female rats but not H295R cells.

Evaluation of a high-throughput H295R homogenous time resolved fluorescence assay for androgen and estrogen steroidogenesis screening.

More tools, reports, and resources

Commentaries

The Price of Proximity: Black Women Disproportionately Exposed to Superfund Metals. [Science Selection in EHP]

Reviews

Numerous Chemicals/Mixtures

Origin, dietary exposure, and toxicity of endocrine-disrupting food chemical contaminants: A comprehensive review.

Endocrine disrupting chemicals and their effects on the reproductive health in men.

BPA/Phenols

Isomer-specific analysis of nonylphenol and their transformation products in environment: A review.

Phthalates

Phthalates (PAEs) and reproductive toxicity: Hypothalamic-pituitary-gonadal (HPG) axis aspects.

Perfluoroalkyl Substances

Association between prenatal exposure to per- and polyfluoroalkyl substances and neurodevelopment in children: Evidence based on birth cohort.

Flame Retardants

A comprehensive review on the decabromodiphenyl ether (BDE-209)-induced male reproductive toxicity: Evidences from rodent studies.

The effects of brominated flame retardants (BFRs) on pro-atherosclerosis mechanisms.

Microplastics/Nanomaterials

Global hotspots and trends in interactions of microplastics and heavy metals: a bibliometric analysis and literature review.

Microplastics as an emerging contaminant of concern to our environment: a brief overview of the sources and implications.

Air Pollution

Associations of long-term particulate matter exposure with cardiometabolic diseases: A systematic review and meta-analysis.

Miscellaneous

Effects of polycyclic aromatic hydrocarbons (PAHs) on pregnancy, placenta, and placental trophoblasts.

Metformin beyond an anti-diabetic agent: A comprehensive and mechanistic review on its effects against natural and chemical toxins.

Human Health Studies

Numerous Chemicals/Mixtures

Associations between the chemical exposome and pregnancy induced hypertension.

Early-Life Exposure to a Mixture of Phenols and Phthalates in Relation to Child Social Behavior: Applying an Evidence-Based Prioritization to a Cohort with Improved Exposure Assessment.

Phthalates

Prenatal Exposure to phthalates and Emotional/behavioral development in young children.

Perfluoroalkyl Substances

Prenatal exposure to perfluoroalkyl substances and inflammatory biomarker concentrations.

Per- and Polyfluoroalkyl Substances (PFAS) and Lipid Trajectories in Women 45-56 Years of Age: The Study of Women’s Health Across the Nation. [see related Invited Perspective: PFAS and Dyslipidemia-The Perimenopausal Period as a Critical Time Window.]

Metals/Metalloids

The association between blood heavy metals level and sex hormones among postmenopausal women in the US.

Relationships between growth indicators, liver and kidney function markers, and blood concentrations of essential and potentially toxic elements in environmentally exposed young children.

Air Pollution

Miscellaneous

Association of exposure to polycyclic aromatic hydrocarbons with thyroid hormones in adolescents and adults, and the influence of the iodine status.

Laboratory Studies

Numerous Chemicals/Mixtures

Intersex manifestation in the rainbow darter (Etheostoma caeruleum): Are adult male fish susceptible to developing and recovering from intersex after exposure to endocrine active compounds?#

BPA/Phenols

Transcriptomics-based analysis of sex-differentiated mechanisms of hepatotoxicity in zebrafish after long-term exposure to bisphenol AF.

Curcumin alleviates bisphenol AF-induced oxidative stress and apoptosis in caprine endometrial epithelial cells via the Nrf2 signaling pathway.

Phthalates

Global gene expression analysis reveals a subtle effect of DEHP in human granulosa cell line HGrC1.

Dibutyl phthalate disrupts energy metabolism and morphology in the gills and induces hepatotoxicity in zebrafish.

Exposure to a phthalate mixture disrupts ovulatory progesterone receptor Signaling in human granulosa cells in vitro.

Di(2-ethylhexyl) phthalate induces reproductive toxicity and transgenerational reproductive aging in Caenorhabditis elegans.

Parabens/Triclosan/Antimicrobials

Mechanistic illustration on lipid-metabolism disorders induced by triclosan exposure from the viewpoint of m⁶A-RNA epigenetic modification.

Perfluoroalkyl Substances

Ecotoxicity of single and mixture of perfluoroalkyl substances (PFOS and PFOA) in soils to the earthworm Aporrectodea caliginosa.

Organotins

Non-target ROIMCR LC-MS analysis of the disruptive effects of TBT over time on the lipidomics of Daphnia magna.

Pesticides

Transgenerational effects of developmental neurotoxicity induced by exposure to a no-observed-adverse-effect level (NOAEL) of neonicotinoid pesticide clothianidin.

Endocrine disruptive toxicity of cypermethrin in Labeo catla: Involvement of genes and proteins related to the HPG axis.

Effects of glyphosate exposure on gut-liver axis: Metabolomic and mechanistic analysis in grass carp (Ctenopharyngodon idellus).

Ascorbic acid modulates testicular toxicity of Ampligo® 150 ZC insecticide in male rabbit (Oryctolagus cuniculus).

Triazole fungicides exert neural differentiation alteration through H3K27me3 modifications: In vitro and in silico study.

Metals/Metalloids

Melatonin therapy reverses lead exposure-induced testicular damage in rats despite the lack of effect on serum testosterone levels.

Microplastics/Nanomaterials

Correlation between cellular uptake and cytotoxicity of polystyrene micro/nanoplastics in HeLa cells: A size-dependent matter.

Simulated gastrointestinal digestion of polylactic acid (PLA) biodegradable microplastics and their interaction with the gut microbiota.

The effects of a polystyrene nanoplastic on the immune response and gut microbiota of Eriocheir sinensis and its post-recovery state.

Polystyrene nanoplastics aggravate reproductive system damage in obese male mice by perturbation of the testis redox homeostasis.

Polyethylene microplastics impede the innate immune response by disrupting the extracellular matrix and signaling transduction.

Miscellaneous

Effects of perchlorate and exogenous T4 on growth, development and tail resorption of Rana chensinensis.

Exposure/Environment Studies

Numerous Chemicals/Mixtures

Multi-omic responses of fish exposed to complex chemical mixtures in the Shenandoah River watershed.

Non-targeted and suspect screening analysis using ion exchange chromatography-Orbitrap tandem mass spectrometry reveals polar and very mobile xenobiotics in Danish drinking water.

BPA/Phthalates

A descriptive analysis of first trimester urinary concentrations of 14 bisphenol analogues in the MIREC Canadian pregnancy cohort.

Concentrations of bisphenols and phthalate esters in the muscle of Mediterranean striped dolphins (Stenella coeruleoalba).

Perfluoroalkyl Substances

Determination of several PFAS groups in food packaging material from fast-food restaurants in France.

Associations between PFAS concentrations and the oxidative status in a free-living songbird (Parus major) near a fluorochemical facility.

Metals/Metalloids

Contribution of arsenic and uranium in private wells and community water systems to urinary biomarkers in US adults: The Strong Heart Study and the Multi-Ethnic Study of Atherosclerosis.

The Occurrence of Arsenic in the Body.

Microplastics/Nanomaterials

Nasal lavage technique reveals regular inhalation exposure of microplastics, not associated from face mask use.

Human health risk assessment for consumption of microplastics and plasticizing substances through marine species.

Occurrence of microplastic pollution in rivers globally: Driving factors of distribution and ecological risk assessment.

Pharmaceuticals/Personal Care Products

Ecological risks induced by consumption and emission of Pharmaceutical and personal care products in Qinghai-Tibet Plateau: Insights from the polar regions.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. The searchable archives are at https://groups.google.com/d/forum/edc_research or online at https://heeds.org/category/edc-science-weekly/. Compiled by Sarah Howard of Healthy Environment and Endocrine Disruptor Strategies (HEEDS), a program of Environmental Health Sciences.

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