EDC Science Weekly, July 28 – Aug. 3, 2023

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Regulations/Policy, Methods/Tools/Screening, Commentaries, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Regulations/Policy

Could the world go PFAS-free? Proposal to ban ‘forever chemicals’ fuels debate. [News feature in Nature]

More EDC policy and regulations open for comment

Methods/Tools/Screening

Developing a National-Scale Exposure Index for Combined Environmental Hazards and Social Stressors and Applications to the Environmental Influences on Child Health Outcomes (ECHO) Cohort.

Computational Modeling of Human Serum Albumin Binding of Per- and Polyfluoroalkyl Substances Employing QSAR, Read-Across, and Docking.

High-Throughput Screening to Advance In Vitro Toxicology: Accomplishments, Challenges, and Future Directions.

Why adverse outcome pathways need to be FAIR.

Benchmark dose modeling for epidemiological dose-response assessment using prospective cohort studies.

Predicting Dose-Dependent Carcinogenicity of Chemical Mixtures Using a Novel Hybrid Neural Network Framework and Mathematical Approach.

Practical application guide for the discovery of novel PFAS in environmental samples using high resolution mass spectrometry.

Identification and Prioritization of Environmental Organic Pollutants: From an Analytical and Toxicological Perspective.

More tools, reports, and resources

Commentaries

Editorial: The environment-animal-human web: a “One Health” view of toxicological risk analysis, volume II. [intro to a research topic in Frontiers in Public Health]

Mechanisms of Toxicity: Metabolomics Promises New Clarity on Air Pollution. [Science Selection in EHP]

Perfluorohexyloctane: Do we really need a PFAS for the treatment of Dry Eye Disease?

Reviews

Numerous Chemicals/Mixtures

Impact of Chemicals on the Age of Menarche: A Literature Review.

Environmental endocrine disruptors and pregnane X receptor action: A review.

A Brief Look at Hashimoto’s Disease, Adrenal Incidentalomas, Obesity and Insulin Resistance-Could Endocrine Disruptors Be the Other Side of the Same Coin?

Cumulative risk assessment for combinations of environmental and psychosocial stressors: a systematic review.

BPA/Phenols

Prenatal exposure to bisphenol A and neonatal health outcomes: A systematic review.

Bisphenol A substitutes and obesity: a review of the epidemiology and pathophysiology.

Phthalates

The Association between Maternal Urinary Phthalate Concentrations and Blood Pressure in Pregnancy: A Systematic Review and Meta-Analysis.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Polychlorinated biphenyls and risk of metabolic syndrome and comparison with the risk of diabetes: A systematic review and meta-analysis.

Perfluoroalkyl Substances

Research Progress on Neurodevelopmental Toxicity in Offspring after Indirect Exposure to PFASs in Early Life.

Current Review of Increasing Animal Health Threat of Per- and Polyfluoroalkyl Substances (PFAS): Harms, Limitations, and Alternatives to Manage Their Toxicity.

Toxicity of Per- and Polyfluoroalkyl Substances to Nematodes.

Flame Retardants

Established and emerging organophosphate esters (OPEs) and the expansion of an environmental contamination issue: A review and future directions.

Pesticides

Peer review of the pesticide risk assessment of the active substance glyphosate. [from EFSA]

Peer review of the pesticide risk assessment of the active substance milbemectin.

Screening of Toxic Effects of Neonicotinoid Insecticides with a Focus on Acetamiprid: A Review.

Pesticides and Bladder Cancer: Mechanisms Leading to Anti-Cancer Drug Chemoresistance and New Chemosensitization Strategies.

Metals/Metalloids

Arsenic in brown rice: do the benefits outweigh the risks?

Microplastics/Nanomaterials

The hepatotoxicity assessment of micro/nanoplastics: A preliminary study to apply the adverse outcome pathways.

Air Pollution

The influence of environmental particulate matter exposure during late gestation and early life on the risk of neurodevelopmental disorders: A systematic review of experimental evidences.

Pharmaceuticals/Personal Care Products

Environmental Risks of Pharmaceutical Mixtures in Aquatic Ecosystems: Reflections on a Decade of Research.

Miscellaneous

A review of liquid crystal monomers: Environmental occurrence, degradation, toxicity, and human exposure of an emerging class of E-waste pollutants.

Occurrence, Fate, Human Exposure, and Toxicity of Commercial Photoinitiators.

Premature thelarche: An Updated Review.

Detection of anti-androgenic activity of chemicals in fish studies: a data review.

The Price of Human Evolution: Cancer-Testis Antigens, the Decline in Male Fertility and the Increase in Cancer.

Human Health Studies

Numerous Chemicals/Mixtures

Exposome epidemiology for suspect environmental chemical exposures during pregnancy linked to subsequent breast cancer diagnosis.

Occurrence, placental transfer, and health risks of emerging endocrine-disrupting chemicals in pregnant women.

Phthalates

Phthalates, physical activity, and diet, which are the most strongly associated with obesity? A case-control study of Chinese children.

Phthalate exposure in the neonatal intensive care unit is associated with development of bronchopulmonary dysplasia.

Sex-specific associations between maternal phthalate exposure and neurodevelopmental outcomes in children at 2 years of age in the APrON cohort.

Association between Di-2-ethylhexyl phthalate and nonalcoholic fatty liver disease among US adults: Mediation analysis of body mass index and waist circumference in the NHANES.

Parabens/Triclosan/Antimicrobials

Environmental exposure to paraben and its association with blood pressure: A cross-sectional study in China.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Serum levels of polychlorinated biphenyls and polybrominated diphenyl ethers in early pregnancy and their associations with gestational diabetes mellitus.

Perfluoroalkyl Substances

Perfluoroalkyl substances (PFAS) and lead (Pb) as “cardiovascular disruptors” in 9-11-year-old children living in Syracuse, New York, United States.

Exposure characteristics of legacy and novel per- and polyfluoroalkyl substances in blood and association with hypertension among low-exposure population.

Flame Retardants

Maternal exposure to organophosphate flame retardants and neonatal anthropometric measures.

Pesticides

Association between urinary neonicotinoid insecticide levels and dyslipidemia risk: A cross-sectional study in Chinese community-dwelling elderly.

Metals/Metalloids

Thyroid disrupting effects of multiple metals exposure: Comprehensive investigation from the thyroid parenchyma to hormonal function in a prospective cohort study.

Prenatal Cadmium Exposure and Maternal Sex Steroid Hormone Concentrations across Pregnancy.

Associations between area-level arsenic exposure and adverse birth outcomes: An Echo-wide cohort analysis.

Association between multiple metal(loid)s exposure and renal function: a cross-sectional study from southeastern China.

Air Pollution

Traffic-associated air pollution is associated with spontaneous extremely preterm birth and other adverse perinatal outcomes.

Ambient Air Pollution and Risk of Enterotomy, Gastrointestinal Cancer, and All-Cause Mortality among 4,708 Individuals with Inflammatory Bowel Disease: A Prospective Cohort Study.

Associations between Short-Term Exposure to Fine Particulate Matter and Acute Myocardial Infarction: A Case-Crossover Study.

Miscellaneous

Serum Concentrations of Benzaldehyde, Isopentanaldehyde and Sex Hormones: Evidence from the National Health and Nutrition Examination Survey.

Laboratory Studies

Numerous Chemicals/Mixtures

Environmentally realistic concentrations of chlorinated, brominated, and fluorinated persistent organic pollutants induce the unfolded protein response as a shared stress pathway in the liver of Atlantic cod (Gadus morhua).

A bioanalytical approach for assessing the effects of soil extracts from solid waste dumpsite in Calabar (Nigeria) on lipid and estrogenic signaling of fish Poeciliopsis lucida hepatocellular carcinoma-1 cells in vitro and in vivo African catfish (Clarias gariepinus).

BPA/Phenols

Vitamin E (α-Tocopherol) Does Not Ameliorate the Toxic Effect of Bisphenol S on the Metabolic Analytes and Pancreas Histoarchitecture of Diabetic Rats.

Angiogenic Activity and Mechanism for Bisphenols on Endothelial Cell and Mouse: Evidence of a Structural-Selective Effect.

Nutrient-Sensing Ghrelin Receptor in Macrophages Modulates Bisphenol A-Induced Intestinal Inflammation in Mice.

Antiinflammatory effect of the ethanolic extract of Korean native herb Potentilla rugulosa Nakai in Bisphenol-a-stimulated A549 cells.

Phthalates

Dibutyl Phthalate Adsorbed on Multiwalled Carbon Nanotubes Causes Fetal Developmental Toxicity in Balb/C Mice.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Polychlorinated Biphenyls (PCBs) Impact Prostatic Collagen Density and Bladder Volume in Young Adult Mice Exposed during in Utero and Lactational Development.

NMR metabolomics study of chronic low-dose exposure to a cocktail of persistent organic pollutants.

Perfluoroalkyl Substances

Cross-Species Transcriptomics Analysis Highlights Conserved Molecular Responses to Per- and Polyfluoroalkyl Substances.

Examining the impact of nanoplastics and PFAS exposure on immune functions through inhibition of secretory immunoglobin A in human breast milk.

Environmental explanation of prostate cancer progression based on the comprehensive analysis of perfluorinated compounds.

Transcriptome and Metabolome Analyses Reveal Perfluorooctanoic Acid-Induced Kidney Injury by Interfering with PPAR Signaling Pathway.

The toxic mechanism of 6:2 Cl-PFESA in adolescent male rats: Endocrine disorders and liver inflammation regulated by the gut microbiota-gut-testis/liver axis.

Hepatotoxicity assessment investigations on PFASs targeting L-FABP using binding affinity data and machine learning-based QSAR model.

Flame Retardants

BDE-47 Induces Mitochondrial Dysfunction and Endoplasmic Reticulum Stress to Inhibit Early Porcine Embryonic Development.

The Organophosphate Esters Used as Flame Retardants and Plasticizers affect H295R Adrenal Cell Phenotypes and Functions.

TBBPA causes inflammation and cell death via the ROS/NF-κB pathway in the gastric mucosa.

Organotins

Endoplasmic Reticulum Stress and Autophagy Are Involved in Hepatotoxicity Induced by Tributyltin.

Pesticides

Potential adverse outcome pathway (AOP) of emamectin benzoate mediated cardiovascular toxicity in zebrafish larvae (Danio rerio).

Multiple Assays on Non-Target Organisms to Determine the Risk of Acute Environmental Toxicity in Tebuconazole-Based Fungicides Widely Used in the Black Sea Coastal Area.

Benchmark Dose Approach to DNA and Liver Damage by Chlorpyrifos and Imidacloprid in Male Rats: The Protective Effect of a Clove-Oil-Based Nanoemulsion Loaded with Pomegranate Peel Extract.

Metformin ameliorates cardiopulmonary toxicity induced by chlorpyrifos.

Developmental toxicity, immunotoxicity and cardiotoxicity induced by methidathion in early life stages of zebrafish.

Proteomic responses in the human dopaminergic LUHMES cell line to imidacloprid and its metabolites imidacloprid-olefin and desnitro-imidacloprid.

Acute and chronic effects of sublethal neonicotinoid thiacloprid to Asian honey bee (Apis cerana cerana).

Metals/Metalloids

Gene expression analyses reveal potential mechanism of inorganic arsenic-induced apoptosis in zebrafish.

Microplastics/Nanomaterials

Exposure to Zinc Oxide Nanoparticles Increases Estradiol Levels and Induces an Antioxidant Response in Antral Ovarian Follicles In Vitro.

Long-term exposure to polystyrene nanoparticles at environmentally relevant concentration causes suppression in heme homeostasis signal associated with transgenerational toxicity induction in Caenorhabditis elegans.

Co-exposure to polystyrene microplastics and di-(2-ethylhexyl) phthalate aggravates allergic asthma through the TRPA1-p38 MAPK pathway.

A Glow before Darkness: Toxicity of Glitter Particles to Marine Invertebrates.

The neurodevelopmental toxicity induced by combined exposure of nanoplastics and penicillin in embryonic zebrafish: The role of aging processes.

Small polystyrene microplastics interfere with the breakdown of milk proteins during static in vitro simulated human gastric digestion.

Dietary Microplastic Administration during Zebrafish (Danio rerio) Development: A Comprehensive and Comparative Study between Larval and Juvenile Stages.

Microplastics cause reproductive toxicity in male mice through inducing apoptosis of spermatogenic cells via p53 signaling.

Photoaged microplastics induce neurotoxicity associated with damage to serotonergic, glutamatergic, dopaminergic, and GABAergic neuronal systems in Caenorhabditis elegans.

Pharmaceuticals/Personal Care Products

Contributions of Pharmaceuticals to DBP Formation and Developmental Toxicity in Chlorination of NOM-containing Source Water.

Antiepileptic drugs are endocrine disruptors for the human fetal testis ex vivo.

4-Methylbenzylidene camphor triggers estrogenic effects via the brain-liver-gonad axis in zebrafish larvae.

Miscellaneous

Responses of soil and collembolan (Folsomia candida) gut microbiomes to 6PPD-Q pollution.

Moderate body lipid accumulation in mice attenuated benzene-induced hematotoxicity via acceleration of benzene metabolism and clearance.

Exposure/Environment Studies

BPA/Phenols

Bisphenol A and Bisphenol S in Hemodialyzers.

Chlorination of bisphenols in water: Understanding the kinetics and formation mechanism of 2-butene-1,4-dial and analogues.

Phthalates

Exposure Trends to the Non-phthalate Plasticizers DEHTP, DINCH, and DEHA in Children from 2012 to 2017: The Hokkaido Study.

Perfluoroalkyl Substances

Survey on the current leachate treatments of public municipal solid waste landfills and the potential impact of per- and polyfluorinatedalkyl substances in the Eastern and Northwestern United States.

Physiological effects of PFAS exposure in seabird chicks: A multi-species study of thyroid hormone triiodothyronine, body condition and telomere length in South Western France.

Flame Retardants

New Perspective to Understand and Prioritize the Ecological Impacts of Organophosphate Esters and Transformation Products in Urban Stormwater and Sewage Effluents.

Alternative and legacy flame retardants in marine mammals from three northern ocean regions.

Metals/Metalloids

Breastmilk cadmium levels and estimated infant exposure: a multicenter study of associated factors in a resource-limited country.

Lactational Exposure of Human Infants to Metal (loid)s: A Comparison of Industrial and Urban Inhabitants in North of the Persian Gulf.

Mercury’s complex legacy.

Microplastics/Nanomaterials

Is Zooplankton an Entry Point of Microplastics into the Marine Food Web?

Plastic mulching, and occurrence, incorporation, degradation, and impacts of polyethylene microplastics in agroecosystems.

Environmentally Friendly Approach to the Reduction of Microplastics during Domestic Washing: Prospects for Machine Vision in Microplastics Reduction.

Sustainable Filtering Systems to Reduce Microfiber Emissions from Textiles during Household Laundering.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. The searchable archives are at https://groups.google.com/d/forum/edc_research or online at https://heeds.org/category/edc-science-weekly/. Compiled by Sarah Howard of Healthy Environment and Endocrine Disruptor Strategies (HEEDS), a program of Environmental Health Sciences.

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