EDC Science Weekly, July 14-20, 2023

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Regulations/Policy, Methods/Tools/Screening, Commentaries, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Regulations/Policy

Towards a better consideration of endocrine disruption within the technical guidance for deriving environmental quality standards.

More EDC policy and regulations open for comment

Methods/Tools/Screening

Effective communications strategies to increase the impact of environmental health research.

Modeling and insights into the structural characteristics of endocrine-disrupting chemicals.

Development of new approach methods for the identification and characterization of endocrine metabolic disruptors-a PARC project.

Hazards of current concentration-setting practices in environmental toxicology studies.

Alternatives to animal testing in toxicity testing: Current status and future perspectives in food safety assessments.

Zebrafish as model organisms for toxicological evaluations in the field of food science.

The ORIGINS Project Biobank: A Collaborative Bio Resource for Investigating the Developmental Origins of Health and Disease.

Newcastle 1000 (NEW1000) Study: an Australian population-based prospective pregnancy cohort study design and protocol.

More tools, reports, and resources

Commentaries

Editorial: Metabolomics and the exposome. [intro to a research topic in Frontiers in Public Health]

Protecting Children’s Environmental Health in a Changing Climate: A Model Collaboration of the Maternal and Child Health Section and the Environment Section of APHA.

Reviews

Numerous Chemicals/Mixtures

Bibliometric analysis of the association between drinking water pollution and bladder cancer.

Perfluoroalkyl Substances

Associations between maternal exposure to perfluoroalkylated substances (PFASs) and infant birth weight: a meta-analysis.

Plant responses to per- and polyfluoroalkyl substances (PFAS): a molecular perspective.

Pesticides

Moving past neonicotinoids and honeybees: A systematic review of existing research on other insecticides and bees.

Glyphosate and environmental toxicity with “one health” approach, a review.

Weak evidence base for bee protective pesticide mitigation measures.

Microplastics/Nanomaterials

Neurotoxicity of microplastics: a CiteSpace-based review and emerging trends study.

Nanoparticles-induced potential toxicity on human health: Applications, toxicity mechanisms, and evaluation models.

Air Pollution

Short-term exposure to air pollution and infant mortality: A systematic review and meta-analysis.

Human Health Studies

Numerous Chemicals/Mixtures

Extending Nontargeted Discovery of Environmental Chemical Exposures during Pregnancy and Their Association with Pregnancy Complications-A Cross-Sectional Study. [see related Invited Perspective: Application of Nontargeted Analysis in Characterizing the Maternal and Child Exposome.]

Association of endocrine disrupting chemicals exposure with human chorionic gonadotropin concentrations in pregnancy.

Mixtures of urinary concentrations of phenols and phthalate biomarkers in relation to the ovarian reserve among women attending a fertility clinic.

Maternal co-exposure to mercury and perfluoroalkyl acid isomers and their associations with child neurodevelopment in a Canadian birth cohort.

Chronic exposure to electronic waste poses risk to liver toxicity with molecular interaction of GSTM1, GSTT1 null variants, and GSTP1.

A pilot study of several environmental endocrine disrupting chemicals in children with autism spectrum disorder in south China.

Phthalates

Prenatal exposure to phthalates and child growth trajectories in the first 24 months of life.

The association between urinary phthalate metabolites and serum thyroid function in US adolescents.

A Study of the Relationship between Phthalate Exposure and the Occurrence of Adult Asthma in Taiwan.

Associations between exposure to phthalates and rheumatoid arthritis risk among adults in NHANES, 2007-2016.

Perfluoroalkyl Substances

Exposure to perfluoroalkyl substances (PFAS) and association with thyroid hormones in adolescent males.

Associations between per- and polyfluoroalkyl substances, liver function, and daily alcohol consumption in a sample of U.S. adults.

A Nested Case-Control Study of Serum Per- and Polyfluoroalkyl Substances and Testicular Germ Cell Tumors among U.S. Air Force Servicemen. [see related Invited Perspective: The Slow Road to Finding Out Whether the “Forever” Chemicals Cause Chronic Disease.]

The interference between effects of PFAS exposure on thyroid hormone disorders and cholesterol levels: an NHANES analysis.

Flame Retardants

Association of flame retardants, polybrominated diethyl ethers (PBDEs), with vitamin D in female subjects.

Pesticides

Health risks of neonicotinoids chronic exposure and its association with glucose metabolism: A case-control study in rural China.

Metals/Metalloids

The Contribution across Three Generations of Mercury Exposure to Attempted Suicide among Children and Youth in Grassy Narrows First Nation, Canada: An Intergenerational Analysis. [see related Invited Perspective: Linking the Intergenerational Impacts due to Mercury Exposure in Grassy Narrows First Nation, Canada.]

Associations of prenatal and childhood Pb exposure with allostatic load in adolescence: Findings from the ELEMENT cohort study.

Maternal Exposure to Potentially Toxic Metals and Bir#th Weight: Preliminary Results from the DSAN-12M Birth Cohort in the Recôncavo Baiano, Brazil.

Heavy metals and diminished ovarian reserve: single-exposure and mixture analyses amongst women consulting in French fertility centres.

Multi-omics analyses of serum metabolome, urine metabolome and gut microbiome reveal dysregulated glycerophospholipid metabolism in subacute cadmium-exposed wistar rats.

Neurodevelopmental associations of prenatal and postnatal methylmercury exposure among first-grade children in the Kinan region, Japan.

Air Pollution

Metabolomic alterations in healthy adults traveling to low-pollution areas: A natural experiment with ozone exposure.

Maternal exposure to aircraft emitted ultrafine particles during pregnancy and likelihood of ASD in children.

Diesel exhaust particles exposure induces liver dysfunction: Exploring predictive potential of human circulating microRNAs signature relevant to liver injury risk.

Changes in air pollution exposure after residential relocation and body mass index in children and adolescents: A natural experiment study.

Laboratory Studies

Numerous Chemicals/Mixtures

Exposure to mixed chemicals elevated triiodothyronine (T3) and follicle-stimulating hormone (FSH) levels: epidemiology and in silico toxicogenomic involvement.

Embryonic exposures to chemicals acting on brain aromatase lead to different locomotor effects in zebrafish larvae.

Role of Gastrointestinal Microbiota from Crucian Carp in Microbial Transformation and Estrogenicity Modification of Novel Plastic Additives.

BPA/Phenols

Oxidative stress increases in liver of lactating rats after BPF-low-dose exposure: perinatal effects in the offspring.

Important roles of Hif1a in maternal or adult BPA exposure induced pancreatic injuries.

The fat accumulation promotion effects of dihydrxytetraphenylmethane and its underlying mechanisms via transcriptome analysis.

Transcriptome Analysis of the Developmental Effects of Bisphenol F Exposure in Chinese Medaka (Oryzias sinensis).

Bisphenol A Analogues Inhibit Human and Rat 11β-Hydroxysteroid Dehydrogenase 1 Depending on Its Lipophilicity.

BPA interferes with granulosa cell development and oocyte meiosis in mouse preantral follicles.

G protein-coupled estrogen receptor activation by bisphenol-A disrupts lipid metabolism and induces ferroptosis in the liver.

Phthalates

Human relevant exposure to di-n-butyl phthalate tampers with the ovarian insulin-like growth factor 1 system and disrupts folliculogenesis in young adult mice.

Exposure to the non-phthalate plasticizer di-heptyl succinate is less disruptive to C57bl/6N mouse recovery from a myocardial infarction than DEHP, TOTM or related di-octyl succinate.

Behavior, Neural Structure, and Metabolism in Adult Male Mice Exposed to Environmentally Relevant Doses of Di(2-ethylhexyl) Phthalate Alone or in a Phthalate Mixture.

Parabens/Triclosan/Antimicrobials

MiR-133b as a crucial regulator of TCS-induced cardiotoxicity via activating β-adrenergic receptor signaling pathway in zebrafish embryos.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Enantiomeric Fractions Reveal Differences in the Atropselective Disposition of 2,2′,3,5′,6-Pentachlorobiphenyl (PCB 95) in Wildtype, Cyp2abfgs-Null, and CYP2A6-Humanized Mice.

Perfluoroalkyl Substances

Perfluorodecanoic acid promotes high-fat diet-triggered adiposity and hepatic lipid accumulation by modulating the NLRP3/caspase-1 pathway in male C57BL/6J mice.

Perfluoroundecanoic acid induces DNA damage, reproductive and pathophysiological dysfunctions via oxidative stress in male Swiss mice.

Antibiotic induced restructuring of the gut microbiota does not affect oral uptake and accumulation of perfluorooctane sulfonic acid (PFOS) in rats.

Influence of dietary bioactive compounds on the bioavailability and excretion of PFOA and its alternative HFPO-TA: Mechanism exploration.

Long-chain perfluoroalkyl carboxylates induce cytoskeletal abnormalities and activate epithelial-mesenchymal transition in both renal cell carcinoma 3D cultures and Caki-1 xenografted mouse model.

Accumulation and glucocorticoid signaling suppression by four emerging perfluoroethercarboxylic acids based on animal exposure and cell testing.

Novel Insights on 6:6 Perfluoroalkyl Phosphonic Acid-Induced Melanin Synthesis Disorders Leading to Pigmentation in Tadpoles.

Flame Retardants

Mitochondrial Dysfunction Was Involved in Decabromodiphenyl Ethane-Induced Glucolipid Metabolism Disorders and Neurotoxicity in Zebrafish Larvae.

Pesticides

Developmental brain lipidomics is influenced by postnatal chlorpyrifos exposure and APOE genetic background in mice.

Developmental Neurotoxicity of Trichlorfon in Zebrafish Larvae.

New insights into triazole fungicide-caused hematopoietic abnormality in zebrafish based on GRα screening developmental toxicity.

Lambda-cyhalothrin-induced pancreatic toxicity in adult albino rats.

Mutagenicity, hepatotoxicity, and neurotoxicity of glyphosate and fipronil commercial formulations in Amazon turtles neonates (Podocnemis expansa).

Synergistic effects on oxidative stress, apoptosis and necrosis resulting from combined toxicity of three commonly used pesticides on HepG2 cells.

Study of liver toxicity and DNA damage due to exposure to the pesticide Mancozeb in an experimental animal model – A pilot model.

LAR Downregulation Protects the Astrocytic U251 and Cocultured SH-SY5Y Cells in a Rotenone-Induced Parkinson’s Disease Cell Model.

Rotenone Blocks the Glucocerebrosidase Enzyme and Induces the Accumulation of Lysosomes and Autophagolysosomes Independently of LRRK2 Kinase in HEK-293 Cells.

Reproductive effects of pubertal exposure to neonicotinoid thiacloprid in immature male mice.

Exposure to Low Concentrations of AMPA Influences Morphology and Decreases Survival During Larval Development in a Widespread Amphibian Species.

Glyphosate impairs aversive learning in bumblebees.

Glyphosate affects larval gut microbiota and metamorphosis of honey bees with differences between rearing procedures.

Metals/Metalloids

Decreased Arsenic Disposition and Alteration of its Metabolic Profile in mice Coexposed to Fluoride.

Arsenic exposure induces small intestinal toxicity in mice by barrier damage and inflammation response via activating RhoA/ROCK and TLR4/Myd88/NF-κB signaling pathways.

Like father, like daughter:Paternal cadmium exposure causes hepatic glucose metabolic disorder and phospholipids accumulation in adult female offspring.

SIRT1 regulates osteoblast senescence through SOD2 acetylation and mitochondrial dysfunction in the progression of Osteoporosis caused by Cadmium exposure.

Long-term chronic food-derived arsenic exposure induce the urinary system metabolic dysfunction in mice.

Microplastics/Nanomaterials

Probiotics improve polystyrene microplastics-induced male reproductive toxicity in mice by alleviating inflammatory response.

Effects of combined exposure of PVC and PFOA on the physiology and biochemistry of Microcystin aeruginosa.

Underestimated health risks: Dietary restriction magnify the intestinal barrier dysfunction and liver injury in mice induced by polystyrene microplastics.

Effects of copper oxide nanoparticles on reproductive system of zebrafish.

Aging behavior of microplastics accelerated by mechanical fragmentation: alteration of intrinsic and extrinsic properties.

The synergetic effects of 4-nonylphenol and polyethylene microplastics in Cyprinus carpio juveniles using blood biomarkers.

Polystyrene nanoplastics induce haematotoxicity with cell oxeiptosis and senescence involved in C57BL/6J mice.

Combining photocatalytic collection and degradation of microplastics using self-asymmetric Pac-Man TiO₂. [so… is Pac Man a solution to microplastics??]

Miscellaneous

Tire-Derived Transformation Product 6PPD-Quinone Induces Mortality and Transcriptionally Disrupts Vascular Permeability Pathways in Developing Coho Salmon.

Exposure/Environment Studies

Numerous Chemicals/Mixtures

Phthalates, adipates, BPA, and pesticides in school meals.

Prevalence of endocrine disrupting chemicals in the urban wastewater treatment systems of Dehradun, India: Daunting presence of estrone.

BPA/Phenols

Bisphenol A release from food and beverage containers – A review.

Phthalates

Levels and health risk assessments of Phthalate acid esters in indoor dust of some microenvironments within Ikeja and Ota, Nigeria.

Assessment of endocrine disruptor pollutants and their metabolites in environmental water samples using a sustainable natural deep eutectic solvent-based analytical methodology.

Perfluoroalkyl Substances

Perfluoroalkyl Substances in Seabird Eggs from Canada’s Pacific Coast: Temporal Trends (1973-2019) and Interspecific Patterns.

First Investigation of the Physiological Distribution of Legacy and Emerging Perfluoroalkyl Substances in Raw Bovine Milk According to the Component Fraction.

Research Progress of Perfluoroalkyl Substances in Edible Oil-A Review.

Flame Retardants

Global survey of dioxin- and thyroid hormone-like activities in consumer products and toys.

Are UK E-waste recycling facilities a source of environmental contamination and occupational exposure to brominated flame retardants?

Metals/Metalloids

Urinary concentrations of heavy metals in pregnant women living near a petrochemical area according to the industrial activity.

Determinants affecting the blood mercury levels of preschool children in Shanghai, China: A cross-sectional study.

Microplastics/Nanomaterials

Novel Insights into the Dermal Bioaccessibility and Human Exposure to Brominated Flame Retardant Additives in Microplastics.

Air Pollution

Can oestrogenic activity in air contribute to the overall body burden of endocrine disruptors?

Concentrations and co-occurrence of 101 emerging and legacy organic pollutants in the ultrafine, fine and coarse fractions of airborne particulates associated with treatment of waste from electrical and electronic equipment.

Per- and polyfluoroalkyl substances in ambient fine particulate matter in the Pearl River Delta, China: Levels, distribution and health implications.

Miscellaneous

Biomonitoring of polycyclic aromatic hydrocarbons in Brazilian pregnant women: Urinary levels and health risk assessment.

——-

This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. The searchable archives are at https://groups.google.com/d/forum/edc_research or online at https://heeds.org/category/edc-science-weekly/. Compiled by Sarah Howard of Healthy Environment and Endocrine Disruptor Strategies (HEEDS), a program of Environmental Health Sciences.

If you enjoy this newsletter, please feel free to donate here! Thank you!