EDC Science Weekly, June 30 – July 6, 2023

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Regulations/Policy, Methods/Tools/Screening, Commentaries, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Regulations/Policy

Implications of circular textile policies for the future regulation of hazardous substances in textiles in the European Union.

Is the 90-day dog study necessary for pesticide toxicity testing?

More EDC policy and regulations open for comment

Methods/Tools/Screening

Cross-species applicability of an adverse outcome pathway network for thyroid hormone system disruption.

Prioritization of risks posed by synthetic chemicals manufactured in China toward humans and the environment via persistence, bioaccumulation, mobility and toxicity properties.

Genotoxicity assessment: opportunities, challenges and perspectives for quantitative evaluations of dose-response data.

Sentinel supervised lung-on-a-chip: A new environmental toxicology platform for nanoplastic-induced lung injury.

More tools, reports, and resources

Commentaries

Epigenetic Inheritance and Transgenerational Environmental Justice.

Pesticides and epilepsy: An unexpected link. [letter]

FACT Finding: Folic Acid Supplementation May Lower Risk from Arsenic in Drinking Water. [Science Selection in EHP]

Reviews

Numerous Chemicals/Mixtures

The role of endocrine disruptors in female infertility.

Food contaminants and potential risk of diabetes development: A narrative review.

Is exposure to chemical pollutants associated with sleep outcomes? A systematic review.

Chronic kidney disease of unknown aetiology: A comprehensive review of a global public health problem.

Phthalates

Associations between prenatal exposure to phthalates and birth weight: A meta-analysis study.

Flame Retardants

New brominated flame retardant decabromodiphenyl ethane (DBDPE) in water sediments: A review of contamination characteristics, exposure pathways, ecotoxicological effects and health risks.

Cellular and physiological mechanisms of halogenated and organophosphorus flame retardant toxicity.

Metals/Metalloids

Disease-associated metabolic pathways affected by heavy metals and metalloid.

Epidemiological research progress in the effects of metal exposure on kidney.

Microplastics/Nanomaterials

The reproductive and transgenerational toxicity of microplastics and nanoplastics: A threat to mammalian fertility in both sexes.

The emerging role of microplastics in systemic toxicity: Involvement of reactive oxygen species (ROS).

Microplastics: Detection in human samples, cell line studies, and health impacts.

Nanomaterials: a review of emerging contaminants with potential health or environmental impact.

A meta-analytic review of microplastic pollution in the Indian Ocean: Ecological health and seafood safety risk implications.

Air Pollution

Effect of Air Pollution on Heart Failure: Systematic Review and Meta-Analysis.

A Narrative Review on the Impact of Air Pollution on Heart Failure Risk and Exacerbation.

Miscellaneous

Propylene oxide derived glycol ethers: A review of the alkyl glycol ethers potential to cause endocrine disruption.

Human Health Studies

Numerous Chemicals/Mixtures

Adolescent endocrine disrupting chemical exposure and academic achievement.

Phthalates

Persistent high exposure to exogenous phthalates and endogenous sex hormones associated with early pubertal onset among children: A 3.5-year longitudinal cohort study in China.

Associating phthalate exposure during pregnancy with preschooler’s FMI, ABSI and BRI trajectories via putative mechanism pathways.

Calcium supplementation and body mass index modify associations between prenatal phthalate exposure and perinatal bone ultrasound measures among pregnant women.

Associations between urinary phthalate metabolite concentrations and rheumatoid arthritis in the U.S. adult population.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Exposure to Agent Orange and Risk of Bladder Cancer Among US Veterans.

Perfluoroalkyl Substances

Decreased levels of perfluoroalkyl substances in patients receiving hemodialysis treatment.

Prenatal exposure to per- and polyfluoroalkyl substances and infant sleep disturbance: A prospective cohort study.

In utero exposure to poly- and perfluoroalkyl substances and children respiratory health in the three first years of life.

Metals/Metalloids

Short-term exposure to multiple metals mixture and mitochondrial DNA copy number among children: A panel study.

Effect of cadmium exposure on body composition deterioration: A propensity score-matched cohort study.

Neurological and Neurocognitive Impairments in Adults with a History of Prenatal Methylmercury Poisoning: Minamata Disease.

Association of blood cadmium and lead levels with self-reported reproductive lifespan and pregnancy loss: The national health and nutrition examination survey 1999-2018.

The Relationship between Blood Lead Level and Chronic Pain in US Adults: A Nationwide Cross-Sectional Study.

Exposure to Arsenic and Subclinical Cardiovascular Disease in 9- to 11-Year-Old Children, Syracuse, New York.

The role of heavy metals in the development of colorectal cancer.

Toenail arsenic species and metallome profiles associated with breast, cervical, prostate, and skin cancer prevalence in the Atlantic Partnership for Tomorrow’s Health cohort.

Air Pollution/PAHs

Association of Polycyclic Aromatic Hydrocarbons Urine Metabolites with Type 1 Diabetes.

Impacts of PAH accumulation on reproductive hormones, indices of oxidative stress and BPDE-albumin adduct in women with recurrent pregnancy loss.

Identifying sensitive windows of prenatal household air pollution on birth weight and infant pneumonia risk to inform future interventions.

Laboratory Studies

Numerous Chemicals/Mixtures

Developmental exposures to common environmental contaminants, DEHP and lead, alter adult brain and blood hydroxymethylation in mice.

Environmental metabolomics uncovers oxidative stress, amino acid dysregulation, and energy impairment in Daphnia magna with exposure to industrial effluents.

BPA/Phenols

Ex vivo effects of bisphenol A or zearalenone on the prepubertal rat testis.

Adulthood bisphenol A exposure induces anxiety in male mice via downregulation of alpha-1D adrenergic receptor in paraventricular thalamus.

High-Fat Diet Promotes Adipogenesis in Offspring Female Rats Induced by Perinatal Exposure to 4-Nonylphenol.

Phthalates

DEHP exposure impairs human skeletal muscle cell proliferation in primary culture conditions: preliminary study.

Multi- and trans-generational effects of di-n-octyl phthalate on behavior, lifespan and reproduction of Caenorhabditis elegans through neural regulation and lipid metabolism.

Involvement of the peroxisome proliferator-activated receptor gamma (Pparγ) and matrix metalloproteinases-2 and -9 (Mmp-2 and -9) in the mechanism of action of di(2-ethylhexyl)phthalate (DEHP) in cultured mouse brain astrocytes and neurons.

Phthalate acid esters promoted the enrichment of chlorine dioxide-resistant bacteria and their functions related to human diseases in rural polyvinyl chloride distribution pipes.

Parabens/Triclosan/Antimicrobials

Triclocarban exposure aggravates dextran sulfate sodium-induced colitis by deteriorating the gut barrier function and microbial community in mice.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Prenatal and Postnatal Exposure to Polychlorinated Biphenyls Alter Follicle Numbers, Gene Expression, and a Proliferation Marker in the Rat Ovary.

Perfluoroalkyl Substances

Perfluorooctane sulfonate (PFOS) causes aging damage in the liver through the mt-DNA-mediated NLRP3 signaling pathway.

Flame Retardants

Machine Learning Reveals Common Transcriptomic Signatures Across Rat Brain and Placenta Following Developmental Organophosphate Ester Exposure.

Proteomic analyses of primary human villous trophoblasts exposed to flame retardant BDE-47 using SWATH-MS.

Organotins

Lipid accumulation and gene expression changes induced by tributyltin exposure in primary hepatocytes of lined seahorse (Hippocampus erectus).

Transgenerational Effects and Mechanisms of Tributyltin Exposure on Neurodevelopment in the Male Offspring of Rats.

Pesticides

Glyphosate Causes Vascular Toxicity through Cellular Senescence and Lipid Accumulation.

Melatonin improves the quality of rotenone-exposed mouse oocytes through association with histone modifications.

Toxicological effect of endocrine disrupting insecticide (deltamethrin) on enzymatical, haematological and histopathological changes in the freshwater iridescent shark, Pangasius hypothalamus.

Using proteomics, q-PCR and biochemical methods complementing as a multiapproach to elicit the crucial responses of zebrafish liver exposed to neonicotinoid pesticide.

Chronic exposure to environmentally-relevant concentrations of imidacloprid impact survival and ecologically-relevant behaviors of fathead minnow larvae.

Developmental and cardiovascular toxicities of acetochlor and its chiral isomers in zebrafish embryos through oxidative stress.

Acute mancozeb-fungicide exposure induces neuro-ethology disruption, health disorders, and immune-oxidative dysfunction in Nile tilapia (Oreochromis niloticus).

Metals/Metalloids

Effects of the real-life metal(oid)s mixture on female reproductive function: Less is different.

Sesamin alleviated fluoride – induced thyroid endocrine disruption in zebrafish (Danio rerio).

SLC1A5 regulates cell proliferation and self-renewal through β-catenin pathway mediated by redox signaling in arsenic-treated uroepithelial cells.

Hepatoprotective and anti-hyperglycemic effects of ferulic acid in arsenic-exposed mice.

Arsenic exposure induced anxiety-like behaviors in male mice via influencing the GABAergic Signaling in the prefrontal cortex.

Gestational arsenic exposure induces anxiety-like behaviors in F1 female mice by dysregulation of neurological and immunological markers.

Microplastics/Nanomaterials

Multigenerational effects of co-exposure to dimethylarsinic acid and polystyrene microplastics on the nematode Caenorhabditis elegans.

Size-specific effects of microplastics and lead on zebrafish.

Effects of microplastics and tetracycline on intestinal injury in mice.

Toxicity of microplastics and triclosan, alone and in combination, to the fertilisation success of a broadcast spawning bivalve Tegillarca granosa.

Rainbow trout (Oncorhynchus mykiss) physiological response to microplastics and enrofloxacin: Novel pathways to investigate microplastic synergistic effects on pharmaceuticals.

Polystyrene nanoplastics exacerbated Pb-induced liver toxicity in mice.

Predicting adsorption capacity of pharmaceuticals and personal care products on long-term aged microplastics using machine learning.

Air Pollution

Subchronic exposure to 1,2-naphthoquinone induces adipose tissue inflammation and changes the energy homeostasis of mice, partially due to TNFR1 and TLR4.

Diesel Exhaust Particle (DEP)-induced glucose intolerance is driven by an intestinal innate immune response and NLRP3 activation in mice.

Miscellaneous

Micron-size tire tread particles leach organic compounds at higher rates than centimeter-size particles: Compound identification and profile comparison.

Toxicity and mutagenicity studies of 6PPD-quinone in a marine invertebrate species and bacteria.

Exposure/Environment Studies

Numerous Chemicals/Mixtures

Occurrence of bisphenol A, nonylphenol, octylphenol and heavy metals in groundwater from selected communities in Ibadan, Nigeria.

Perfluoroalkyl Substances

Assessing per- and polyfluoroalkyl substances in globally sourced food packaging.

Per- and polyfluoroalkyl substances (PFAS) contamination in a microtidal urban estuary: Sources and sinks.

Long-duration monitoring and mass balance of PFAS at a wastewater treatment plant following the release of aqueous film-forming foam concentrate.

Bioaccumulation and metabolic impact of environmental PFAS residue on wild-caught urban wetland tiger snakes (Notechis scutatus).

Flame Retardants

Organohalogenated flame retardants and organophosphate esters from home and preschool dust in Sweden: Pollution characteristics, indoor sources and intake assessment.

Novel and legacy brominated flame retardants in snakes and frogs: Tissue distribution, biomagnification, and maternal transfer.

Pesticides

Urinary glyphosate and AMPA levels in a cross-sectional study of postmenopausal women: Associations with organic eating behavior and dietary intake.

Metals/Metalloids

Dissolved arsenic and lead concentrations in rooftop harvested rainwater: Community generated dataset.

HBM4EU-MOM: Prenatal methylmercury-exposure control in five countries through suitable dietary advice for pregnancy – Study design and characteristics of participants.

Analysis and Risk Assessment of Essential and Toxic Elements in Algerian Canned Tuna Fish.

Regional and racial/ethnic inequalities in public drinking water fluoride concentrations across the US.

Association between mediterranean diet and metal(loid) exposure in 4-5-year-old children living in Spain.

Assessment of lead, cadmium, and mercury levels in the breast milk in Pakistani women.

Microplastics/Nanomaterials

Human health risk model for microplastic exposure in the Arctic region.

Miscellaneous

Chlorinated paraffins in multimedia during residential interior finishing: Occurrences, behavior, and health risk.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. The searchable archives are at https://groups.google.com/d/forum/edc_research or online at https://heeds.org/category/edc-science-weekly/. Compiled by Sarah Howard of Healthy Environment and Endocrine Disruptor Strategies (HEEDS), a program of Environmental Health Sciences.

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