EDC Science Weekly, June 23-29, 2023

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Regulations/Policy, Methods/Tools/Screening, Commentaries, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Regulations/Policy

Exploring the potential of ToxCast™ data for mechanism-based prioritization of chemicals in regulatory context: Case study with priority existing chemicals (PECs) under K-REACH

Distinctions between similarly and dissimilarly-acting mixture components unnecessarily complicate mixture risk assessments – implications for assessing low dose mixture exposures

Improving the regulatory environmental risk assessment of human pharmaceuticals: Required changes in the new legislation.

More EDC policy and regulations open for comment

Methods/Tools/Screening

A Case for Accelerating Standards to Achieve the FAIR Principles of Environmental Health Research Experimental Data.

Research advances in identification procedures of endocrine disrupting chemicals.

Non-targeted analysis (NTA) and suspect screening analysis (SSA): a review of examining the chemical exposome.

Putative adverse outcome pathway development based on physiological responses of female fathead minnows to model estrogen versus androgen receptor agonists.

Investigating Three Classification Methods for Per/Poly-Fluoroalkyl Substance (PFAS) Exposure from Electronic Health Records And Potential for Bias.

Tier-1 pesticide risk assessment for aquatic primary producers: A protectiveness check based on European Food Safety Authority endpoints.

Validation of a Method Scope Extension for Simple Biomonitoring of 353 Pollutants in Serum Samples.

A review of non-destructive biomonitoring techniques to assess the impacts of pollution on reproductive health in frogs and toads.

BPA Endocrine Disruptor Detection at the Cutting Edge: FPIA and ELISA Immunoassays.

More tools, reports, and resources

Commentaries

A Silent Threat: Exploring the Impact of Endocrine Disruption on Human Health. [intro to a special issue in the International Journal of Molecular Sciences]

Complex Mixtures and Multiple Stressors: Evaluating Combined Chemical Exposures and Cumulative Toxicity. [intro to a special issue in Toxics]

Dioxin and Dioxin-like Compounds and Human Health. [intro to another special issue in Toxics]

Unveiling the Hidden Dangers of Plasticizers: A Call for Immediate Action. [intro to yet another special issue in Toxics]

Editorial for Special Issue: Emerging Food Contaminants and Next Generation Toxicological Studies.

Editorial: Environmental pollutants in agroecosystem: toxicity, mechanism, and remediation. [intro to a research topic in Frontiers in Plant Science]

Balancing Acute and Chronic Occupational Risks: The Use of Nitrile Butadiene Rubber Undergloves by Firefighters to Reduce Exposure to Toxic Contaminants.

Reviews

Numerous Chemicals/Mixtures

Endocrine Disrupting Chemicals and Hippocampal Development: The Role of Estrogen and Androgen Signalling.

Early-life exposure to endocrine-disrupting chemicals and autistic traits in childhood and adolescence: a systematic review of epidemiological studies.

Effects of Xenobiotic Compounds on Preeclampsia and Potential Mechanisms.

BPA/Phenols

Bisphenol-S Influence on Oxidative Stress and Endocrine Biomarkers of Reproductive System: A Systematic Review and Meta-Analysis.

Bisphenols as promoters of the dysregulation of cellular junction proteins of the blood-testis barrier in experimental animals: A systematic review of the literature.

Βisphenol A and its analogs migrated from contact materials into food and beverages: An updated review in sample preparation approaches.

Phthalates

The associations between prenatal phthalate exposure and childhood glycolipid metabolism and blood pressure: An updated systematic review and a pilot meta-analysis of prospective cohort studies.

The Relationship between Phthalates and Diabetes: A Review.

Persistent Organic Pollutants/PFAS

Age at menarche and chemical exposure: per- and polyfluoroalkyl substances (PFAS), dichloro-diphenyl-trichloroethane (DDT), dichloro-diphenyl-dichloroethylene (DDE), and polychlorinated biphenyls (PCBs).

Poly- and Perfluoroalkyl Substances (PFAS): Do They Matter to Aquatic Ecosystems?

An insights of organochlorine pesticides categories, properties, eco-toxicity and new developments in bioremediation process.

Pesticides

Maternal pesticide exposure and risk of preterm birth: A systematic review and meta-analysis.

Ultimate fate, transformation, and toxicological consequences of herbicide pretilachlor to biotic components and associated environment: An overview.

Metals/Metalloids

Correlation between daily life aluminium exposure and breast cancer risk: A systematic review.

Microplastics/Nanomaterials

A critical review on the evaluation of toxicity and ecological risk assessment of plastics in the marine environment.

Current approaches, and challenges on identification, remediation and potential risks of emerging plastic contaminants: A review.

A mixed method assessment of research productivity on microplastics in various compartments in the environment.

Microplastic sources, formation, toxicity and remediation: a review.

Systematic Review of Nano- and Microplastics’ (NMP) Influence on the Bioaccumulation of Environmental Contaminants: Part II-Freshwater Organisms.

Are Microplastics Toxic? A Review from Eco-Toxicity to Effects on the Gut Microbiota.

Air Pollution

Towards A Cardio-Environmental Risk Model: Environmental Determinants of Cardiovascular Disease.

Noise, Air, and Heavy Metal Pollution as Risk Factors for Endothelial Dysfunction.

Miscellaneous

The role of microRNAs in the toxic mechanisms of furan and 3-MCPD and links to cancer risk – a review.

Toxic effects and toxicological mechanisms of chlorinated paraffins: A review for insight into species sensitivity and toxicity difference.

Estrogens in plants and emerging risks to human health.

Human Health Studies

BPA/Phenols

Association of parabens and bisphenols with lung function in children aged 5-12 years from Shanghai, China.

Associations of Maternal Urinary Concentrations of Phenols, Individually and as a Mixture, with Serum Biomarkers of Thyroid Function and Autoimmunity: Results from the EARTH Study.

Phthalates

Longitudinal association of prepubertal urinary phthalate metabolite concentrations with pubertal progression among a cohort of boys.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Prenatal exposure to multiple persistent organic pollutants in association with adiposity markers and blood pressure in preadolescents.

Perfluoroalkyl Substances

Levels of PFAS concentrations in the placenta and pregnancy complications.

Concentrations and association between exposure to mixed perfluoroalkyl and polyfluoroalkyl substances and glycometabolism among adolescents.

Factors affecting serum PFAS concentrations among US females with surgically and naturally induced menopause: data from NHANES 2003-2018.

Pesticides

History of high household pesticide use and Parkinson’s disease in Brazil.

Association of pesticide exposure with cognitive function in farmers.

Metals/Metalloids

Sex-specific relationships between prenatal exposure to metal mixtures and birth weight in a Chinese birth cohort.

Metal mixtures and DNA methylation measures of biological aging in American Indian populations.

Trimester-specific effects of maternal exposure to single and mixed metals on cord serum inflammatory cytokines levels: A prospective birth cohort study.

Correlation of heavy metals’ exposure with the prevalence of coronary heart disease among US adults: findings of the US NHANES from 2003 to 2018.

Air Pollution

Wildfire smoke exposure and early childhood respiratory health: a study of prescription claims data.

Laboratory Studies

Numerous Chemicals/Mixtures

Explore the Dosimetric Relationship between the Intake of Chemical Contaminants and Their Occurrence in Blood and Urine.

Environmentally relevant doses of endocrine disrupting chemicals affect male fertility by interfering with sertoli cell glucose metabolism in mice.

DNA Damage Estimation after Chronic and Combined Exposure to Endocrine Disruptors: An In Vivo Real-Life Risk Simulation Approach.

BPA/Phenols

Bisphenol S stimulates Leydig cell proliferation but inhibits differentiation in pubertal male rats through multiple mechanisms.

PBTK-TD model of the phagocytosis activity in three-spined stickleback exposed to BPA.

Bisphenol A (BPA) Directly Activates the G Protein-Coupled Estrogen Receptor 1 and Triggers the Metabolic Disruption in the Gonadal Tissue of Apostichopus japonicus.

Bisphenol-A Neurotoxic Effects on Basal Forebrain Cholinergic Neurons In Vitro and In Vivo.

Phthalates

Dibutyl phthalate induces epithelial-mesenchymal transition of renal tubular epithelial cells via the Ang II/AMPKα2/Cx43 signaling pathway.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Transgenerational sperm DMRs escape DNA methylation erasure during embryonic development and epigenetic inheritance.

Perfluoroalkyl Substances

Maternal transfer of F-53B inhibited neurobehavior in zebrafish offspring larvae and potential mechanisms: Dopaminergic dysfunction, eye development defects and disrupted calcium homeostasis.

Structural and molecular changes in the rat myocardium following perfluoroctane sulfonate (PFOS) exposure are mitigated by quercetin via modulating HSP 70 and SERCA 2.

Effects of Perfluorooctanoic Acid on Gut Microbiota and Microbial Metabolites in C57BL/6J Mice.

Flame Retardants

Development of a Rat Physiologically Based Kinetic Model (PBK) for three Organophosphate Flame Retardants (TDCIPP, TCIPP, TCEP).

Lipid metabolic disturbance induced by triphenyl phosphate and hydroxy metabolite in HepG2 cells.

Cadmium (Cd) and 2,2′,4,4′-tetrabromodiphenyl ether (BDE-47) co-exposure induces acute kidney injury through oxidative stress and RIPK3-dependent necroptosis.

Pesticides

Impaired Physiological Responses and Neurotoxicity Induced by a Chlorpyrifos-Based Formulation in Caenorhabditis elegans are not Solely Dependent on the Active Ingredient.

Permissible concentration of mancozeb in Brazilian drinking water elicits oxidative stress and bioenergetic impairments in embryonic zebrafish.

Herbicide propisochlor exposure induces intestinal barrier impairment, microbiota dysbiosis and gut pyroptosis.

Multiomics implicate gut microbiota in low cypermethrin (CP) exposure induced multiorgan toxicological effects in pubertal male rats.

Exploring RNA methylation as a promising biomarker for assessing sublethal effects of fipronil on honeybees (Apis mellifera L.).

Bifenthrin, a Ubiquitous Contaminant, Impairs the Development and Behavior of the Threatened Longfin Smelt during Early Life Stages.

Neuroprotective potential of berberine against acetamiprid induced toxicity in rats: Implication of oxidative stress, mitochondrial alterations, and structural changes in brain regions.

Chronic exposure to tebuconazole alters thyroid hormones and plumage quality in house sparrows (Passer domesticus).

The herbicides glyphosate and glufosinate and the cyanotoxin β-N-methylamino-l-alanine induce long-term motor disorders following postnatal exposure: the importance of prior asymptomatic maternal inflammatory sensitization.

Effects of Glyphosate on Female Reproductive Output in the Marine Polychaete Worm Ophryotrocha diadema.

Neonicotinoid Imidacloprid Affects the Social Behavior of Adult Zebrafish by Damaging Telencephalon Neurons through Oxidation Stress, Inflammation, and Apoptosis.

Metals/Metalloids

Mercury intoxication disrupts tonic signaling in B cells, and may promote autoimmunity due to abnormal phosphorylation of STIM-1 and other autoimmunity risk associated phosphoproteins involved in BCR signaling.

Integrated metabolomics and network pharmacology revealing the mechanism of arsenic-induced hepatotoxicity in mice.

Tyrosol and Olive Oil Ameliorate Sodium Arsenate-Induced Nephrotoxicity by Modulating of Oxidative Stress and Histological Changes in Mice.

Insight into the effect of a heavy metal mixture on neurological damage in rats through combined serum metabolomic and brain proteomic analyses.

Microplastics/Nanomaterials

Co-exposure of polycarbonate microplastics aggravated the toxic effects of imidacloprid on the liver and gut microbiota in mice.

Long-Term Influence of PCB- and PBDE-Spiked Microplastic Spheres Fed through Rotifers to Atlantic Cod (Gadus morhua) Larvae.

Environmental factors strongly influence the leaching of di(2-ethylhexyl) phthalate from polyvinyl chloride microplastics.

A preliminary study about the potential risks of the UV-weathered microplastic: The proteome-level changes in the brain in response to polystyrene derived weathered microplastics.

Impacts of polypropylene microplastics on lipid profiles of mouse liver uncovered by lipidomics analysis and Raman spectroscopy.

Single and combined effects of polyethylene microplastics and acetochlor on accumulation and intestinal toxicity of zebrafish (Danio rerio).

Sulfonate-Modified Polystyrene Nanoparticle at Precited Environmental Concentrations Induces Transgenerational Toxicity Associated with Increase in Germline Notch Signal of Caenorhabditis elegans.

Air Pollution

Diesel exhaust particles alter gut microbiome and gene expression in the bumblebee Bombus terrestris.

Miscellaneous

Mechanistic insight into the adverse outcome of tire wear and road particle leachate exposure in zebrafish (Danio rerio) larvae.

Paternal low-dose benzo(a)pyrene exposure in rats impairs sexual development and fertility of the paternal lineage in F2 generation: A transgenerational study.

Exposure/Environment Studies

Numerous Chemicals/Mixtures

Screening and prioritization of organic chemicals in a large river basin by suspect and non-target analysis.

A study of 101 organic substances in gully pot sediments accumulated over a one-year period in Stockholm, Sweden.

Decadal assessment of microplastics, pharmaceuticals, and pesticides as contaminants of emerging concerns (CECs) in Kenya’s surface waters, a review.

Phthalates

Associations of urinary phthalate metabolites with household environments among mothers and their preschool-age children.

Phthalate diester occurrence in marine feed and food (Mediterranean Sea).

Parabens/Triclosan/Antimicrobials

Paraben exposure through drugs in the neonatal intensive care unit: a regional cohort study.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Individual Risk Assessment for Population Living on the Territories Long-Term Polluted by Organochlorine Pesticides.

Perfluoroalkyl Substances

Plasma eicosapentaenoic acid, a biomarker of fish consumption, is associated with perfluoroalkyl carboxylic acid exposure in residents of Kyoto, Japan: a cross-sectional study.

PFAS levels in paired drinking water and serum samples collected from an exposed community in Central North Carolina.

Occurrence of per- and polyfluorinated alkyl substances in wastewater treatment plants in Northern Italy.

Occurrence and biomagnification of perfluoroalkyl substances (PFAS) in Lake Michigan fishes.

Per- and polyfluoroalkyl substances (PFAS) in United States tapwater: Comparison of underserved private-well and public-supply exposures and associated health implications.

Legacy perfluoroalkyl acids and their oxidizable precursors in plasma samples of Norwegian women.

Per- and polyfluoroalkyl substances in Chinese surface waters: A review.

Pesticides

Urinary Cypermethrin Metabolites among Conventional and Organic Farmers in Thailand.

Atrazine and its degradation products in drinking water source and supply: Risk assessment for environmental and human health in Campinas, Brazil.

Metals/Metalloids

Comparison of the accumulation of toxic metal biomarkers in Asian subgroups and other races in the United States: NHANES 2015-2016.

Two-century sediment records of atmospheric mercury variations in North China and their relations with regional and global emissions.

Probabilistic benefit-risk analysis of fish: Nutritional benefit versus methylmercury-contaminated risk.

Are Lithium batteries so eco-friendly? Ecotoxicological impacts of Lithium in estuarine bivalves.

Microplastics/Nanomaterials

Effects of microplastics and nanoplastics in shrimp: Mechanisms of plastic particle and contaminant distribution and subsequent effects after uptake.

Exploring public risk perceptions of microplastics: Findings from a cross-national qualitative interview study among German and Italian citizens.

Assessment of microplastic contamination in an eastern Pacific tuna (Katsuwonus pelamis) and evaluation of its health risk implication through molecular docking and metabolomics studies.

Microplastics in marine-derived traditional Chinese medicine, potential threat to patients.

Pharmaceuticals/Personal Care Products

Assessment of the presence of UV filters and UV stabilizers in stranded dolphin blubber.

Miscellaneous

Historical trends of traditional, emerging, and halogenated polycyclic aromatic hydrocarbons recorded in core sediments from the coastal areas of the Yellow and Bohai seas.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. The searchable archives are at https://groups.google.com/d/forum/edc_research or online at https://heeds.org/category/edc-science-weekly/. Compiled by Sarah Howard of Healthy Environment and Endocrine Disruptor Strategies (HEEDS), a program of Environmental Health Sciences.

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