EDC Science Weekly, June 16 – 22, 2023

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Regulations/Policy, Methods/Tools/Screening, Commentaries, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Regulations/Policy

Supporting legislative action: Urinary levels of phthalates and phenols among influencers in the ‘Plastics in the spotlight’ advocacy initiative.

More EDC policy and regulations open for comment

Methods/Tools/Screening

FAIR environmental and health registry (FAIREHR)- supporting the science to policy interface and life science research, development and innovation.

In vitro profiling of pesticides within the Tox21 10 K compound library for bioactivity and potential toxicity.

Machine learning-driven QSAR models for predicting the mixture toxicity of nanoparticles.

AOP Report: Aryl Hydrocarbon Receptor (Ahr) Activation Leads to Early Life Stage Mortality via Sox9 Repression Induced Craniofacial and Cardiac Malformations.

Novel In Vitro Intestinal Microbiome Model to Study Lipidomic and Metabolomic Adaptations Due to Exposure to Glyphosate, Perfluorooctanoic Acid, and Docusate Sodium.

More tools, reports, and resources

Commentaries

Socioeconomic Status and Air Pollution: A Double Blow for Diabetes. [Science Selection in EHP]

Reviews

Numerous Chemicals/Mixtures

How Many Chemicals in Commerce Have Been Analyzed in Environmental Media? A 50 Year Bibliometric Analysis.

Epigenetics and the Exposome: DNA Methylation as a Proxy for Health Impacts of Prenatal Environmental Exposures.

Current knowledge on the effects of environmental contaminants in early life nutrition.

Prevention of Parkinson’s disease: from risk factors to early interventions.

Prenatal socioenvironmental exposures and autism spectrum disorder: A web of confusion.

BPA/Phenols

Toxicity of Bisphenol in Pregnant Females: First Review of Literature in Humans.

Phthalates

Phthalate exposure and the metabolic syndrome: A systematic review and meta-analysis.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Review of DDT, DDE, DDD, DDMU and DDMS Toxicity Data for Organisms Used in Estuarine and Marine Sediment Toxicity Tests.

Flame Retardants

Endocrine disrupting and carcinogenic effects of decabromodiphenyl ether.

Pesticides

A comparative review and computational assessment of acetochlor toxicity in fish: A novel endocrine disruptor?

Pesticide exposure and the microbiota-gut-brain axis.

Non-traditional risk factors of progression of chronic kidney disease in adult population: a scoping review.

Metals/Metalloids

A State-of-the-Science Review on Metal Biomarkers.

Challenges and strategies for preventing intestinal damage associated to mercury dietary exposure.

Microplastics/Nanomaterials

Titanium dioxide nanoparticles: revealing the mechanisms underlying hepatotoxicity and effects in the gut microbiota.

Air Pollution

Long-Term Exposure to Traffic-Related Air Pollution and Diabetes: A Systematic Review and Meta-Analysis.

Pharmaceuticals/Personal Care Products

Toxicological effects, residue levels and risks of endocrine-disrupting chemicals in Chinese medicine: a review.

Miscellaneous

A comparative review and computational assessment of acetochlor toxicity in fish: A novel endocrine disruptor?

Human Health Studies

Numerous Chemicals/Mixtures

Exposure to phthalate metabolites, bisphenol A, and psychosocial stress mixtures and pregnancy outcomes in the Atlanta African American maternal-child cohort.

The mediating role of telomere length in multi-pollutant exposure associated with metabolic syndrome in adults.

Assessment of synthetic musks, polychlorinated biphenyls and brominated flame retardants in adipose tissue of obese northern Portuguese women – Metabolic implications.

Phthalates

Association of urinary phthalate metabolites with all-cause and cardiovascular disease mortality among adults with diabetes mellitus: National Health and Nutrition Examination Survey 2005-2014.

Prenatal exposure to phthalates and gender-specific play behavior at seven years of age in the SELMA study.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Exposure of Akwesasne Mohawk women to polychlorinated biphenyls and hexachlorobenzene is associated with increased serum levels of thyroid peroxidase autoantibodies.

Association of polychlorinated biphenyls with vitamin D in female subjects.

Perfluoroalkyl Substances

Immune response to COVID-19 vaccination in a population with a history of elevated exposure to per- and polyfluoroalkyl substances (PFAS) through drinking water.

Close association of PFASs exposure with hepatic fibrosis than steatosis: evidences from NHANES 2017-2018.

Environmental pollutant pre- and polyfluoroalkyl substances are associated with electrocardiogram parameters disorder in adults.

Plasma eicosapentaenoic acid, a biomarker of fish consumption, is associated with perfluoroalkyl carboxylic acid exposure in residents of Kyoto, Japan: a cross-sectional study.

Flame Retardants

Serum Organophosphate Flame retardants and plasticizers in Chinese females of childbearing age: Association with serum reproductive and thyroid hormones.

Urinary levels of organophosphate flame retardants metabolites in a young population from Southern Taiwan and potential health effects.

Pesticides

Maternal exposure to neonicotinoid insecticides and fetal growth restriction: A nested case-control study in the guangxi Zhuang birth cohort.

Metals/Metalloids

An evaluation of the effects of mixed heavy metals on prediabetes and type 2 diabetes: epidemiological and toxicogenomic analysis.

Anthropometric measures and arsenic methylation among pregnant women in rural northern Bangladesh.

Prenatal and concurrent blood mercury concentrations and associations with IQ in canadian preschool children.

Air Pollution

Association between First Trimester Exposure to Ambient PM2.5 and NO2 and Congenital Heart Defects: A Population-Based Cohort Study of 1,342,198 Live Births in Canada. [see related Invited Perspective: Air Pollution and Congenital Heart Defects (CHDs)-a Summary of Two Decades and Future Direction in Research.]

Maternal exposure to ambient air pollution mixture and premature rupture of membranes: Evidence from a large cohort in Southern California (2008-2018).

Maternal Particulate Matter Exposure and Gestational Diabetes Mellitus: A Population-Based Cohort Study.

Long-term exposure to air pollution and risk of SARS-CoV-2 infection and COVID-19 hospitalization or death: Danish nationwide cohort study.

Miscellaneous

Dose-response association of polycyclic aromatic hydrocarbon with self-reported trouble sleeping in adults: evidence from the National Health and Nutrition Examination Survey.

Prenatal exposure to polycyclic aromatic hydrocarbons and cognition in early childhood.

Association between maternal use of spray formulations and offspring urological anomalies: The Japan Environment and Children’s Study.

Laboratory Studies

Numerous Chemicals/Mixtures

Multiomics reveals new biomarkers and mechanistic insights into the combined toxicity effects of 2,2′,4,4′,5,5′-hexachlorobiphenyl and atrazine exposures in MCF-7 cells.

BPA/Phenols

Cucumeropsis mannii seed oil protects against Bisphenol A-induced testicular mitochondrial damages.

Cucumeropsis mannii seed oil ameliorates Bisphenol-A-induced adipokines dysfunctions and dyslipidemia.

Acute exposure to realistic concentrations of Bisphenol-A trigger health damage in fish: Blood parameters, gene expression, oxidative stress.

Microanatomy and behaviour of the date mussel’s adductor and foot muscles after chronic exposure to bisphenol A, with inhibition of ATPase enzyme activities and DNA damage.

Single and multispecies microalgae toxicological tests assessing the impact of several BPA analogues used by industry.

Damage Effects of Bisphenol A against Sepsis Induced Acute Lung Injury.

Phthalates

Biochemical and Multi-Omics Approaches To Obtain Molecular Insights into the Catabolism of the Plasticizer Benzyl Butyl Phthalate in Rhodococcus sp. Strain PAE-6.

Parabens/Triclosan/Antimicrobials

Mechanistic exploration on neurodevelopmental toxicity induced by upregulation of alkbh5 targeted by triclosan exposure to larval zebrafish.

Exposure to methylparaben at environmentally realistic concentrations significantly impairs neuronal health in adult zebrafish.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Female-to-male differential transcription patterns of miRNA-mRNA networks in the livers of dioxin-exposed mice.

Anthocyanin-rich blue potato meals protect against polychlorinated biphenyl-mediated disruption of short-chain fatty acid production and gut microbiota profiles in a simulated human digestion model.

Perfluoroalkyl Substances

Reproductive and immune effects emerge at similar thresholds of PFHxS in deer mice.

Toxic effects of perfluorocaproic acid (PFHxA) on crucian carp (Carassius auratus) and the response of the intestinal microbial community.

Flame Retardants

Maternal transfer of resorcinol-bis(diphenyl)-phosphate perturbs gut microbiota development and gut metabolism of offspring in rats.

Assessments of the effects of tris(1,3-dichloro-2-propyl) phosphate (TDCPP) on human intestinal health from the aspects of intestinal flora changes and cytotoxicity to human cells.

Pesticides

Subacute exposure to Roundup® changes steroidogenesis and gene expression of the glutathione-glutaredoxin system in rat ovaries: Implications for ovarian toxicity of this glyphosate-based herbicide.

Mammary Gland Development in Male Rats Perinatally Exposed to Propiconazole, Glyphosate, or their Mixture.

Study on the characterization of pesticide modes of action similarity and the multi-endpoint combined toxicity of pesticide mixtures to Caenorhabditis elegans.

Terbutryn causes developmental toxicity in zebrafish (Danio rerio) via apoptosis and major organ malformation in the early stages of embryogenesis.

Lycopene attenuates chlorpyrifos-induced hepatotoxicity in rats via activation of Nrf2/HO-1 axis.

The relationship between the cholinergic mechanism of toxicity and oxidative stress in rats during subacute diazinon poisoning.

Immunomodulatory effect of imidacloprid on macrophage RAW 264.7 cells.

Delayed in sensorimotor reflex ontogeny, slow physical growth, and impairments in behaviour as well as dopaminergic neuronal death in mice offspring following prenatally rotenone administration.

High doses of GrassOut Max poses reproductive hazard by affecting male reproductive function and early embryogenesis in Swiss albino mice.

Metals/Metalloids

Cadmium influence on lipid metabolism in Sprague-Dawley rats through linoleic acid and glycerophospholipid metabolism pathways.

Microplastics/Nanomaterials

Uptake, bioaccumulation, biodistribution and depuration of polystyrene nanoplastics in zebrafish (Danio rerio).

Incomplete recovery of gut microbiota in marine medaka (Oryzias melastigma) during the depuration phase, after exposure to sulfamethazine/nanoplastics.

Ingesting microplastics or nanometals during development harms the tropical pollinator Partamona helleri (Apinae: Meliponini).

SKN-1/Nrf2-dependent regulation of mitochondrial homeostasis modulates transgenerational toxicity induced by nanoplastics with different surface charges in Caenorhabditis elegans.

Large polystyrene microplastics results in hepatic lipotoxicity in mice.

Miscellaneous

The role of DNA methylation on gene expression in the vertebrae of ancestrally benzo[a]pyrene exposed F1 and F3 male medaka.

Assessment of behavioural effects of three water-soluble polymers in zebrafish embryos.

Four-week repeated exposure to tire-derived 6-PPD quinone causes multiple organ injury in male BALB/c mice.

Evaluation of multigenerational effects of 2-ethylhexyl 4-hydroxybenzoate in Japanese medaka.

Exposure/Environment Studies

Numerous Chemicals/Mixtures

A thirty-year contaminant trend analysis in great lakes native American fish harvests 1991-2021.

Priority screening of contaminants of emerging concern in drinking water sources of eastern China: Assessing risks based on exposure-activity ratios (EARs).

Distribution of phthalate metabolites, benzophenone-type ultraviolet filters, parabens, triclosan and triclocarban in paired human hair, nail and urine samples.

BPA/Phenols

A large-scale nationwide study of urinary phenols in the Chinese population.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Congener-specific accumulation of persistent organic pollutants in marine fish from the Northeast Atlantic Ocean.

Analysis of polychlorinated biphenyls (PCBs) in dairy products by modified QuEChERS/GC-QqQ-MS/MS method: A risk assessment study.

Environmental fate of sulfonated-PCBs: Soil partitioning properties, bioaccumulation, persistence, and mobility.

Bioaccumulation and potential impacts of persistent organic pollutants and contaminants of emerging concern in guitarfishes and angelsharks from Southeastern Brazil.

Organochlorine pesticides in vegetable oils: An overview of occurrence, toxicity, and chromatographic determination in the past twenty-two years (2000-2022).

Perfluoroalkyl Substances

Identifying and sharing per-and polyfluoroalkyl substances hot-spot areas and exposures in drinking water.

Estimation of Serum PFOA Concentrations from Drinking and Non-Drinking Water Exposures.

Domestic Dogs and Horses as Sentinels of Per- and Polyfluoroalkyl Substance Exposure and Associated Health Biomarkers in Gray’s Creek North Carolina.

Emission of Per- and Polyfluoroalkyl Substances from a Waste-to-Energy Plant─Occurrence in Ashes, Treated Process Water, and First Observation in Flue Gas.

Bioaccumulation, tissue distribution, and maternal transfer of novel PFOS alternatives (6:2 Cl-PFESA and OBS) in wild freshwater fish from Poyang Lake, China.

The occurrence, tissue distribution, and PBT potential of per- and polyfluoroalkyl substances in the freshwater organisms from the Yangtze river via nontarget analysis.

Flame Retardants

Socio-Economic Factors Impact US Dietary Exposure to Halogenated Flame Retardants.

Pesticides

Chronic Health Risk for Chinese Adults and Breastfed Infants on Dietary Exposure to Chlorothalonil and Its Main Metabolite.

Chlorpyrifos fate in the Arctic: Importance of analyte structure in interactions with Arctic dissolved organic matter.

Active metabolite of the neurotoxic rodenticide bromethalin along with anticoagulant rodenticides detected in birds of prey in the northeastern United States.

Occurrence of pesticide residues in honey from apiaries with incidents of honeybee poisoning in East China and a corresponding risk assessment for honeybees and Chinese consumers.

Metals/Metalloids

Construction of Models To Predict the Effectiveness of E-Waste Control through Capture of Volatile Organic Compounds and Metals/Metalloids Exposure Fingerprints: A Six-Year Longitudinal Study.

Impact of lowering the US maximum contaminant level on arsenic exposure: Differences by race, region, and water arsenic in NHANES 2003-2014.

Microplastics/Nanomaterials

Size-dependent long-term weathering converting floating polypropylene macro- and microplastics into nanoplastics in coastal seawater environments.

Towards a plastic-less planet. Gender and individual responsibility predict the effect of imagery nudges about marine (micro)plastic pollution on R-behavior intentions.

Microplastic ingestion and plastic additive detection in pelagic squid and fish: Implications for bioindicators and plastic tracers in open oceanic food webs.

Pharmaceuticals/Personal Care Products

Predicting Environmental Risks of Pharmaceuticals.

Miscellaneous

Linear alkylbenzene sulfonate threats to surface waters at the national scale: A neglected traditional pollutant.

Short- and medium-chain chlorinated paraffins in T-shirts and socks.

——-

This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me and ask to join the EDC Science Weekly group EDC_re…@googlegroups.com. The searchable archives are at https://groups.google.com/d/forum/edc_research or online at https://heeds.org/category/edc-science-weekly/. Compiled by Sarah Howard of Healthy Environment and Endocrine Disruptor Strategies (HEEDS), a program of Environmental Health Sciences.

If you enjoy this newsletter, please feel free to donate here! Thank you!