EDC Science Weekly, June 9 – 15, 2023

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Regulations/Policy, Methods/Tools/Screening, Commentaries, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Science highlights

Events

Regulations/Policy

Towards a future regulatory framework for chemicals in the European Union – Chemicals 2.0.

Applying genomics in regulatory toxicology: a report of the ECETOC workshop on omics threshold on non-adversity.

Practical guidance to evaluate in vitro dermal absorption studies for pesticide registration: An industry perspective.

Workshop report: Challenges faced in developing inhalation thresholds of Toxicological Concern (TTC) – State of the science and next steps.

More EDC policy. Also see this new webpage from the Food Packaging Forum that lists proposed regulations open for comment.

Methods/Tools/Screening

Methods

Occurrence of Per- and Polyfluoroalkyl Substance Contamination of Food Sources and Aquaculture Organisms Used in Aquatic Laboratory Experiments.

Cryptic species in ecotoxicology.

More tools, reports, and resources

Commentaries

The USGS plans to severely curtail the National Pesticide Synthesis Project.

Reviews

Numerous Chemicals/Mixtures

Human exposure to persistent and mobile chemicals: A review of sources, internal levels and health implications.

BPA/Phenols

Different types of bisphenols alter ovarian steroidogenesis: Special attention to BPA.

Perfluoroalkyl Substances

The relationship between perfluoroalkyl substances and hypertension: A systematic review and meta-analysis.

A Critical Review Amphibian PFAS Ecotoxicity Research Studies: Identification of Screening Levels in Water and Other Useful Resources for Site-specific Ecological Risk Assessments.

Pesticides

Peer review of the pesticide risk assessment of the active substance flutolanil.

Metals/Metalloids

Contaminant Metals as Cardiovascular Risk Factors: A Scientific Statement From the American Heart Association.

Heavy metal pollution in the aquatic environment: efficient and low-cost removal approaches to eliminate their toxicity: a review.

Microplastics/Nanomaterials

Microplastics transferring from abiotic to biotic in aquatic ecosystem: A mini review.

Insights into Anthropogenic Micro- and Nanoplastic Accumulation in Drinking Water Sources and Their Potential Effects on Human Health.

Microplastic pollution and associated health hazards: Impact of COVID-19 pandemic.

Recent advances in micro (nano) plastics in the environment: Distribution, health risks, challenges and future prospects.

Toxicological effects of selenium nanoparticles in laboratory animals: A review.

Pharmaceuticals/Personal Care Products

Factors Determining the Susceptibility of Fish to Effects of Human Pharmaceuticals.

Miscellaneous

Fate, detection technologies and toxicity of heterocyclic PAHs in the aquatic and soil environments.

Chronic Kidney Disease of Unknown Origin: Think Beyond Common Etiologies.

Human Health Studies

Numerous Chemicals/Mixtures

Joint effects of phenol, chlorophenol pesticide, phthalate, and polycyclic aromatic hydrocarbon on bone mineral density: comparison of four statistical models.

Groundwater constituents and the incidence of kidney cancer.

Length of employment in workplaces handling hazardous chemicals and risk of cancer among Japanese men.

Association of a mixture of phthalates and phenols with frailty among middle-aged and older adults: A population-based cross-sectional study.

BPA/Phenols

Maternal exposure to benzophenone derivatives and their impacts on offspring’s birth outcomes in a Middle Eastern population.

Phthalates

Perinatal and postnatal exposure to phthalates and early neurodevelopment at 6 months in healthy infants born at term.

Phthalates exposure and pubertal development in a 15-year follow-up birth cohort study in Taiwan.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Persistent organic pollutants associate with liver disease in a Finnish general population sample.

Perfluoroalkyl Substances

Estimated exposure to perfluoroalkyl substances during infancy and serum-adipokine concentrations in later childhood.

Plasma concentrations of per- and polyfluoroalkyl substances in pregnancy and breastfeeding duration in Project Viva.

Association between Serum Per- and Polyfluoroalkyl Substance Levels and Risk of Central and Peripheral Precocious Puberty in Girls.

Flame Retardants

Prenatal organophosphate ester exposure and executive function in Norwegian preschoolers.

Organophosphate esters, airway inflammation, and lung function among U.S. participants: A nationally representative cross-sectional study from NHANES, 2011-2012.

Pesticides

Prenatal and Childhood Exposure to Organophosphate Pesticides and Behavior Problems in Adolescents and Young Adults in the CHAMACOS Study.

Effect of prenatal exposure to organophosphates and pyrethroid pesticides on neonatal anthropometric measures and gestational age.

Pregnancy pesticide exposure and child development in low- and middle-income countries: A prospective analysis of a birth cohort in rural Bangladesh and meta-analysis.

Exposure to herbicides mixtures in relation to type 2 diabetes mellitus among Chinese rural population: Results from different statistical models.

Assessing the impact of coexposure on the measurement of biomarkers of exposure to the pyrethroid lambda-cyhalothrin in agricultural workers.

Environmental, social and behavioral risk factors in association with spatial clustering of childhood cancer incidence.

Metals/Metalloids

Patterns of global burden of 13 diseases attributable to lead exposure, 1990-2019.

Associations Between Individual and Combined Metal Exposures in Whole Blood and Kidney Function in U.S. Adults Aged 40 Years and Older.

Physical activity attenuates the association between blood cadmium exposure and cardiovascular disease: findings from the National Health and Nutrition Examination Survey 2007-2018.

Global DNA methylation and the association between metal exposure and chronic kidney disease.

Metabolic biomarkers linking urinary arsenic species to gestational diabetes mellitus: A cross-sectional study in Chinese pregnant women.

Urinary arsenic and spontaneous pregnancy loss – a hypothesis-generating case-control investigation in western Romania.

Air Pollution

Individual and joint effect of indoor air pollution index and ambient particulate matter on fetal growth: a prospective cohort study.

Assessing the timing and the duration of exposure to air pollution on cardiometabolic biomarkers in patients suspected of coronary artery disease.

Effects of ambient fine particulates, nitrogen dioxide, and ozone on maturation of functional brain networks across early adolescence.

Prenatal ambient air pollutant mixture exposure and neurodevelopment in urban children in the Northeastern United States.

Miscellaneous

Nonlinear low dose hematotoxicity of benzene; a pooled analyses of two studies among Chinese exposed workers.

Associations of the digit ratio with adolescent behavior problems are inconsistent with an intrauterine androgenic origin.

Laboratory Studies

Numerous Chemicals/Mixtures

Toxicity identification evaluation for hydraulic fracturing flowback and produced water during shale gas exploitation in China: Evidence from tissue residues and gene expression.

Elucidating environmental factors and their combined effects on CKDu in Sri Lanka using zebrafish.

BPA/Phenols

The effects of trans fat diet intake on metabolic parameters and pancreatic tissue in offspring of prenatal bisphenol A exposed rats.

Preliminary study on the role of aryl hydrocarbon receptor in the neurotoxicity of three typical bisphenol compounds (BPA, BPS and TBBPA) at environmentally relevant concentrations to adult zebrafish (Danio rerio).

Bisphenol A decreases the developmental toxicity and histopathological alterations caused by polystyrene nanoplastics in developing marine medaka Oryzias melastigma.

Transcriptome-Wide Analysis of Low-Concentration Exposure to Bisphenol A, S, and F in Prostate Cancer Cells.

Interaction of metabolism-related pathway gene variants with bisphenol A exposure on serum lipid profiles.

Bisphenol S Reduces Pig Spermatozoa Motility through Different Intracellular Pathways and Mechanisms than Its Analog Bisphenol A.

Short-Term Exposure to Bisphenol A Does Not Impact Gonadal Cell Steroidogenesis In Vitro.

KDM2A interacts with estrogen receptor α to promote bisphenol A and S-induced breast cancer cell proliferation by repressing TET2 expression.

Phthalates

The effect of apigenin, an aryl hydrocarbon receptor antagonist, in Phthalate-Exacerbated eosinophilic asthma model.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Miniaturized method for the quantification of persistent organic pollutants and their metabolites in HepG2 cells: assessment of their biotransformation.

Toxic effects of Aroclor 1254 on rat liver and modifying roles of selenium.

Knock-down of aryl hydrocarbon receptor (AhR) affects the lncRNA-mediated response of porcine granulosa cells (AVG-16 cell line) to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).

Perfluoroalkyl Substances

Aldosterone Biosynthesis Is Potently Stimulated by Perfluoroalkyl Acids: A Link between Common Environmental Pollutants and Arterial Hypertension.

Effects of perfluorooctanoic acid (PFOA) on gene expression profiles via nuclear receptors in HepaRG cells: Comparative study with in vitro transactivation assays.

Mixtures of per- and poly-fluoroalkyl substances (PFAS) reduce the in vitro activation of human T cells and basophils.

Developmental toxicity of perfluorohexane sulfonate at human relevant dose during pregnancy via disruption in placental lipid homeostasis.

Flame Retardants

Organophosphate Esters Disrupt Steroidogenesis in KGN Human Ovarian Granulosa Cells.

Toxicity and risk priority ranking of polybrominated diphenyl ethers (PBDEs): A relative receptor-bound concentration approach.

Mechanisms of cell death induced by hexabromocyclododecane (HBCD) involves apoptosis, autophagy, and ER stress.

Pesticides

Chronic Exposure to Chlorpyrifos Damages Thyroid Activity and Imbalances Hepatic Thyroid Hormones Signaling and Glucose Metabolism: Dependency of T3-FOXO1 Axis by Hyperglycemia.

Mechanism analysis and improved molecular modification: Design of high efficiency and environmentally friendly triazole fungicide substitutes.

Exposure to environmental concentrations of glyphosate induces cardiotoxicity through cellular senescence and reduced cell proliferation capacity.

Propineb induced notochord deformity, craniofacial malformation, and osteoporosis in zebrafish through dysregulated reactive oxygen species generation.

Fluchloralin induces developmental toxicity in heart, liver, and nervous system during early zebrafish embryogenesis.

Long-term and low dose oral malathion exposure causes morphophysiological changes in the colon of rats.

Environmentally relevant concentrations of fipronil selectively disrupt venous vessel development in zebrafish embryos/larvae.

Gene expression in bumble bee larvae differs qualitatively between high and low concentration imidacloprid exposure levels.

Glyphosate and a glyphosate-based herbicide affect bumblebee gut microbiota.

Metals/Metalloids

Mitigation of maternal fecal microbiota transplantation on neurobehavioral deficits of offspring rats prenatally exposed to arsenic: Role of microbiota-gut-brain axis.

Multigenerational genetic effects of paternal cadmium exposure on ovarian granulosa cell apoptosis.

Microplastics/Nanomaterials

Systemic effects of nanoplastics on multi-organ at the environmentally relevant dose: The insights in physiological, histological, and oxidative damages.

Titanium Dioxide Nanoparticles: Effects on Development and Male Reproductive System.

Investigation of nephrotoxicity on mice exposed to polystyrene nanoplastics and the potential amelioration effects of DHA-enriched phosphatidylserine.

Transcriptomic profiling reveals differential cellular response to copper oxide nanoparticles and polystyrene nanoplastics in perfused human placenta.

Miscellaneous

Exposure to 6-PPD quinone enhances lipid accumulation through activating metabolic sensors of SBP-1 and MDT-15 in Caenorhabditis elegans.

Exposure/Environment Studies

Numerous Chemicals/Mixtures

Untargeted MSⁿ-Based Monitoring of Glucuronides in Fish: Screening Complex Mixtures for Contaminants with Biological Relevance.

BPA/Phenols

Cetaceans as Bioindicators to Assess Alkylphenol Exposure and Hormone-Disrupting Effects in the South China Sea.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Passive-Sampler-Derived PCB and OCP Concentrations in the Waters of the World─First Results from the AQUA-GAPS/MONET Network.

Perfluoroalkyl Substances

PFAS soil concentrations surrounding a hazardous waste incinerator in East Liverpool, Ohio, an environmental justice community.

Levels of per- and polyfluoroalkyl substances (PFAS) in Norwegian children stratified by age and sex – Data from the Bergen Growth Study 2.

Discovery of 35 novel classes of per- and polyfluoroalkyl substances in representative commercial fluorinated products in China.

Environmental Fate of Cl-PFPECAs: Accumulation of Novel and Legacy Perfluoroalkyl Compounds in Real-World Vegetation and Subsoils.

Mass flow of per- and polyfluoroalkyl substances (PFAS) in a Swedish municipal wastewater network and wastewater treatment plant.

Contamination of the urban river network with perfluoroalkyl acids (PFAAs) introduced during river regulations.

Temporal Trends of Legacy and Emerging PFASs from 2011 to 2021 in Agricultural Soils of Eastern China: Impacts of the Stockholm Convention.

Riverine microbial communities impacted by per- and polyfluoroalkyl substances (PFAS) emissions from a fluoropolymer-manufacturing plant.

Bioaccumulation and risk mitigation of legacy and novel perfluoroalkyl substances in seafood: Insights from trophic transfer and cooking method.

Legacy and novel perfluoroalkyl substances in raw and cooked squids: Perspective from health risks and nutrient benefits.

Flame Retardants

Brominated flame retardants in breast milk from the United States: First detection of bromophenols in U.S. breast milk.

Legacy and novel brominated flame retardants in a lab-constructed freshwater ecosystem: Distribution, bioaccumulation, and trophic transfer.

Organophosphate esters (OPEs) in plastic food packaging: non-target recognition, and migration behavior assessment.

Pesticides

Influences of glyphosate residues and different concentrate feed proportions in dairy cow rations during early gestation on performance, blood parameters, functional properties and DNA damage of blood cells in cows and their offspring.

Behavioral and physiological response of the passerine bird Agelaioides badius to seeds coated with imidacloprid.

The situation of chlorpyrifos in Mexico: a case study in environmental samples and aquatic organisms.

Neonicotinoid insecticides and their metabolites: Specimens tested, analytical methods and exposure characteristics in humans.

Combining crop-exposure matrices and land use data to estimate indices of environmental and occupational exposure to pesticides.

Metals/Metalloids

Potentially toxic metals in dust, blood, and hairs from exposed security dogs in an oil and gas industry.

Miscellaneous

Comparison of Trihalomethane exposure assessment metrics in epidemiologic analyses of reproductive and developmental outcomes.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. The searchable archives are at https://groups.google.com/d/forum/edc_research or online at https://heeds.org/category/edc-science-weekly/. Compiled by Sarah Howard of Healthy Environment and Endocrine Disruptor Strategies (HEEDS), a program of Environmental Health Sciences.

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