EDC Science Weekly, June 2 – 8, 2023

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Highlights: EDC science highlights

Contents: Events, Regulations/Policy, Methods/Tools/Screening, Commentaries, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Events

Events

Regulations/Policy

EDC policy. Also see this new webpage from the Food Packaging Forum that lists proposed regulations open for comment.

Methods/Tools/Screening

New approach methods to improve human health risk assessment of thyroid hormone system disruption-a PARC project.

OECD harmonised template 201: Structuring and reporting mechanistic information to foster the integration of new approach methodologies for hazard and risk assessment of chemicals

Reducing uncertainties in quantitative adverse outcome pathways by analysis of thyroid hormone in the neonatal rat brain.

Coupling the H295R and ERα and AR U2OS CALUX assays enables simultaneous testing for estrogenic, anti-androgenic and steroidogenic modalities.

Toxicological Effects Assessment for Wildlife in the 21st Century: Review of Current Methods and Recommendations for a Path Forward.

Identifying Unknown Fluorine-Containing Compounds in Environmental Samples Using ¹⁹F NMR and Spectral Database Matching.

Quantitative analysis of ovarian surface photographs as a tool for assessment of chemical effects on folliculogenesis and ovulation in rats.

Derivatized versus non-derivatized LC-MS/MS techniques for the analysis of estrogens and estrogen-like endocrine disruptors in human plasma.

Simple and cheap CRISPR/Cas12a biosensor based on plug-and-play of DNA aptamers for the detection of endocrine-disrupting compounds.

Potential sources of microplastic contamination in laboratory analysis and a protocol for minimising contamination.

AOP-helpFinder 2.0: Integration of an event-event searches module

More tools and resources

Commentaries

A Call to Include Plastics in the Global Environment in the Class of Persistent, Bioaccumulative, and Toxic (PBT) Pollutants.

Scientists protest changes to U.S. pesticide data. [News item in Science]

Editorial: Role of genetics, epigenetics, and environmental factors in human complex diseases from the mitochondrial point of view. [intro to a research topic in Frontiers in Endocrinology]

Reviews

Numerous Chemicals/Mixtures

A review of the effects of environmental hazards on humans, their remediation for sustainable development, and risk assessment.

A rapid systematic scoping review of research on the impacts of water contaminated by chemicals on very young children.

BPA/Phenols

Systematic review of the potential carcinogenicity of bisphenol A in humans.

Alterations induced by Bisphenol A on cellular organelles and potential relevance on human health.

Phthalates

Phthalates’ exposure leads to an increasing concern on cardiovascular health.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Effect Of Persistent Organic Pollutants In Patients With Ischemic Stroke And All Stroke: A Systematic Review And Meta-Analysis.

Perfluoroalkyl Substances

Toxicological Mechanisms of Emerging Per-/poly-fluoroalkyl Substances: Focusing on Transcriptional Activity and Gene Expression Disruption.

Occurrence and Bioaccumulation Patterns of Per- and Polyfluoroalkyl Substances (PFAS) in the Marine Environment.

Recycling and the end of life assessment of fluoropolymers: recent developments, challenges and future trends.

Pesticides

The diabetogenic effects of pesticides: Evidence based on epidemiological and toxicological studies.

Impact of pesticides exposure during neurodevelopmental period on autism spectrum disorders – A focus on gut microbiota.

Exposure to atrazine by drinking water and the increased risk of neonatal complications in consequence: a meta-analysis.

Research progress and trend of effects of organophosphorus pesticides on aquatic organisms in the past decade.

Residues of carcinogenic pesticides in food: a systematic review.

Microplastics/Nanomaterials

Polystyrene microplastic particles in the food chain: Characteristics and toxicity. A review.

Reproductive toxicity of micro- and nanoplastics.

Micro- and nanoplastics: Contamination routes of food products and critical interpretation of detection strategies.

Pharmaceuticals/Personal Care Products

Antiviral drugs in wastewater are on the rise as emerging contaminants: A comprehensive review of spatiotemporal characteristics, removal technologies and environmental risks.

Occurrence, removal and risk evaluation of ibuprofen and acetaminophen in municipal wastewater treatment plants: A critical review.

Human Health Studies

BPA/Phenols

Association between Bisphenol A exposure and body composition parameters in children.

Phthalates

Oxidatively generated DNA damage mediates the associations of exposure to phthalates with uterine fibroids and endometriosis: Findings from TREE cohort.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Gene-environment interaction in long-term effects of polychlorinated biphenyls exposure on glucose homeostasis and type 2 diabetes: The modifying effects of genetic risk and lifestyle.

Perfluoroalkyl Substances

Association of Early Pregnancy Perfluoroalkyl and Polyfluoroalkyl Substance Exposure With Birth Outcomes.

Associations of Gestational Perfluoroalkyl Substances Exposure with Early Childhood BMI z-Scores and Risk of Overweight/Obesity: Results from the ECHO Cohorts. [see related Invited Perspective: PFAS and the Childhood Obesity Phenotype-Challenges and Opportunities.]

Plasma levels of per- and polyfluoroalkyl substances (PFAS) are associated with altered levels of proteins previously linked to inflammation, metabolism and cardiovascular disease.

Folate concentrations and serum perfluoroalkyl and polyfluoroalkyl substance concentrations in adolescents and adults in the USA (National Health and Nutrition Examination Study 2003-16): an observational study.

Associations between serum per- and polyfluoroalkyl substances and asthma morbidity in the National Health and Nutrition Examination Survey (2003-18).

Flame Retardants

Organophosphate esters concentrations in human serum and their associations with Sjögren syndrome.

Pesticides

Exposure to pesticide components causes recurrent pregnancy loss by increasing placental oxidative stress and apoptosis: a case-control study.

Metals/Metalloids

Association of obesity, diabetes, and hypertension with arsenic in drinking water in the Comarca Lagunera province (north-central Mexico).

Long-term exposure to airborne metals and risk of cancer in the French cohort Gazel.

Air Pollution

Long-term air pollution exposure and markers of cardiometabolic health in the National Longitudinal Study of Adolescent to Adult Health (Add Health).

Prenatal exposure to PM_2.5 and its constituents with children’s BMI Z-score in the first three years: A birth cohort study.

Miscellaneous

Human sperm proteome reveals the effect of environmental borne seminal polyaromatic hydrocarbons exposome in etiology of idiopathic male factor infertility.

Synthetic Phenolic Antioxidants and Their Metabolites in Follicular Fluid and Association with Diminished Ovarian Reserve: A Case-Control Study.

Laboratory Studies

BPA/Phenols

Assessment of single and combined effects of bisphenol-A and its analogue bisphenol-S on biochemical and histopathological responses of sea cucumber Holothuria poli.

Developmental neurotoxic effects of bisphenol A and its derivatives in Drosophila melanogaster.

Comparative study of the effect of oleuropein and hydroxytyrosol rich extracts on the reproductive toxicity induced by bisphenol A in male rats: biochemical, histopathological, and molecular analyses.

Oxidative damage contributes to bisphenol S-induced development block at 2-cell stage preimplantation embryos in mice through inhibiting of embryonic genome activation.

Phthalates

Di (2-ethyl) hexyl phthalate induces liver injury in chickens by regulating PTEN/PI3K/AKT signaling pathway via reactive oxygen species.

Gestational dibutyl phthalate exposure impairs primordial folliculogenesis in mice through autophagy activation and NOTCH2 signal interruption.

Effects of the in-utero dicyclohexyl phthalate and di-n-hexyl phthalate administration on the oxidative stress-induced histopathological changes in the rat liver tissue correlated with serum biochemistry and hematological parameters.

Epigallocatechin gallate alleviates mono-2-ethylhexyl phthalate-induced male germ cell pyroptosis by inhibiting the ROS/mTOR/NLRP3 pathway.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Estradiol protects female mice from hyperuricemia induced by PCB138 exposure.

Structure-Activity Relationship of Lower Chlorinated Biphenyls and Their Human-Relevant Metabolites for Astrocyte Toxicity.

Novel Use of Cell Profiling Technology to Visualize Mitochondrial Responses of Humpback Whale Fibroblasts to Chemical Exposure.

Perfluoroalkyl Substances

Effect of prenatal perfluoroheptanoic acid exposure on spermatogenesis in offspring mice.

Perfluorohexanesulfonic acid (PFHxS) induces oxidative stress and causes developmental toxicities in zebrafish embryos.

Integrative multi-omics reveals analogous developmental neurotoxicity mechanisms between perfluorobutanesulfonic acid and perfluorooctanesulfonic acid in zebrafish.

Leydig cell development in pubertal male rats is blocked by perfluorotetradecanoic acid through decreasing AMPK-mTOR-autophagy pathway.

Perfluorooctanoic acid dominates the molecular-level effects of a mixture of equal masses of perfluorooctanoic acid and perfluorooctane sulfonic acid in earthworm.

Perfluorooctanoic acid-induced cell death via the dual roles of ROS-MAPK/ERK signaling in ameloblast-lineage cells.

Dose additive maternal and offspring effects of oral maternal exposure to a mixture of three PFAS (HFPO-DA, NBP2, PFOS) during pregnancy in the Sprague-Dawley rat.

Perfluorooctanoic acid (PFOA) affects steroidogenesis and antioxidant defence in granulosa cells from swine ovary.

Flame Retardants

Maternal PBDE exposure disrupts gut microbiome and promotes hepatic pro-inflammatory signaling in humanized PXR-transgenic mouse offspring over time.

Tris(1,3-dichloro-2-propyl) Phosphate Inhibits Early Embryonic Development by Binding to Gsk-3β Protein in Zebrafish.

Tris(2-chloroethyl) Phosphate Exerts Hepatotoxic Impacts on Zebrafish by Disrupting Hypothalamic-Pituitary-Thyroid and Gut-Liver Axes.

Curcumin alleviates spleen immunotoxicity induced by decabrominated diphenyl ethers (BDE-209) by improving immune function and inhibiting inflammation and apoptosis in broilers.

Pesticides

Glyphosate without Co-formulants affects embryonic development of the south african clawed frog Xenopus laevis.

Sublethal doses of glyphosate modulates mitochondria and oxidative stress in honeybees by direct feeding.

Induction of apoptosis, oxidative stress, hormonal, and histological alterations in the reproductive system of thiamethoxam-exposed female rats.

Embryonic development, hatchling performance and metabolic profile after egg exposure to environmentally relevant levels of chlorpyrifos in an aquatic turtle.

Recovery of Ceratophrys ornata tadpoles exposed to environmental concentrations of chlorpyrifos: evaluation of biomarkers of exposure.

Acute exposure to organophosphorus pesticide metabolites compromises buffalo sperm function and impairs fertility.

Novel trajectories of the NK1R antagonist aprepitant in rotenone-induced Parkinsonism-like symptoms in rats: Involvement of ERK5/KLF4/p62/Nrf2 signaling axis.

Metals/Metalloids

Proteomic Study on the Mechanism of Arsenic Neurotoxicity in the Rat Cerebral Cortex and the Protective Mechanism of Dictyophora Polysaccharides against Arsenic Neurotoxicity.

Metabolic effect of low fluoride levels in the islets of NOD mice: integrative morphological, immunohistochemical, and proteomic analyses.

Microplastics/Nanomaterials

Accumulation and release of organic pollutants by conventional and biodegradable microplastics in the marine environment.

Co-exposure to environmentally relevant concentrations of cadmium and polystyrene nanoplastics induced oxidative stress, ferroptosis and excessive mitophagy in mice kidney.

Epigallocatechin-3-gallate ameliorates polystyrene microplastics-induced anxiety-like behavior in mice by modulating gut microbe homeostasis.

Multi-biomarkers hazard assessment of microplastics with different polymers by acute embryo test and chronic larvae test with zebrafish (Danio rerio).

Acute toxicity of triclosan, caffeine, nanoplastics, microplastics, and their mixtures on Daphnia magna.

Pharmaceuticals/Personal Care Products

Mechanism analysis of synthetic musks-induced miscarriage risk in pregnant women: Molecular and adverse outcome pathways perspectives.

Multigenerational impacts of EE2 on reproductive fitness and immune competence of marine medaka.

Toxicity assessment of binary mixtures of BP3 with 4-MBC (UV-filters), and BP3 with DEET (insect repellent) using the aquatic midge Chironomus riparius.

Miscellaneous

Untargeted screening and in silico toxicity assessment of semi- and non-volatile compounds migrating from polysaccharide-based food contact materials.

Evaluation of the Impact of BaP Exposure on the Gut Microbiota and Allergic Responses in an OVA-Sensitized Mouse Model.

Defining potential targets of prenatal androgen excess: Expression analysis of androgen receptor on hypothalamic neurons in the fetal female mouse brain.

Multi-omics reveals 2-bromo-4,6-dinitroaniline (BDNA)-induced hepatotoxicity and the role of the gut-liver axis in rats.

Exposure/Environment Studies

Numerous Chemicals/Mixtures

Exposure of Swedish adolescents to elements, persistent organic pollutants (POPs), and rapidly excreted substances – The Riksmaten adolescents 2016-17 national survey.

Screening of phthalate and non-phthalate plasticizers and bisphenols in Sicilian women’s blood.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Fluorinated liquid-crystal monomers in paired breast milk and indoor dust: A pilot prospective study.

Diffusive fluxes of persistent organic pollutants between Arctic atmosphere, surface waters and sediments.

Re-evaluation of TEFs for dioxin-like PCDDs, PCDFs, and PCBs for fishes.

Preliminary results from the Tunisian monitoring program on POPs in air under the Stockholm Convention.

Perfluoroalkyl Substances

Per- and Polyfluoroalkyl Substances in Personal Hygiene Products: The Implications for Human Exposure and Emission to the Environment.

Evidence of compost contamination with per- and polyfluoroalkyl substances (PFAS) from “compostable” food serviceware.

Prevalence of per- and polyfluoroalkyl substances (PFASs) in marine seafood from the Gulf of Guinea.

Perfluoroalkyl substances in Romanian wastewater treatment plants: Transfer to surface waters, environmental and human risk assessment.

Nationwide distribution of per- and polyfluoroalkyl substances (PFAS) in road dust from India.

Long-term trend data for PFAS in soils from German ecosystems, including TOP assay.

Legacy and novel perfluoroalkyl substances in major economic species of invertebrates in South China Sea: Health implication from consumption.

Metals/Metalloids

Data to Action: Community-Based Participatory Research to Address Concerns about Metal Air Pollution in Overburdened Neighborhoods near Metal Recycling Facilities in Houston.

Large-scale arsenic mobilization from legacy sources in anoxic aquifers: Multiple methods and multi-decadal perspectives.

Microplastics/Nanomaterials

New Evidence of Microplastics in the Lower Respiratory Tract: Inhalation through Smoking.

Metal leaching from plastics in the marine environment: An ignored role of biofilm.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me and ask to join the EDC Science Weekly group EDC_re…@googlegroups.com. The searchable archives are at https://groups.google.com/d/forum/edc_research or online at https://heeds.org/category/edc-science-weekly/. Compiled by Sarah Howard of Healthy Environment and Endocrine Disruptor Strategies (HEEDS), a program of Environmental Health Sciences.

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Sarah Howard | she/her
HEEDS Program Manager
Environmental Health Sciences
sho…@ehsciences.org
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