EDC Science Weekly, May 26 – June 1, 2023

Post author:HEEDS
Post published:June 1, 2023
Post category:EDC Science Weekly

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Highlights: Industry cover-ups for pesticides and PFAS (see the Regulations/policy section below); PFAS in pharmaceuticals?

More EDC science highlights

Contents: Events, Regulations/Policy, Methods/Tools/Screening, Commentaries, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Events

Webinar June 7: Kids and Chemicals: PFAS Exposure and the Metabolism [CHE-Alaska]

Webinar June 8: The Chemical Footprint of a Plastic Bottle [CHE]

Webinar June 13: CHE Café: Science, Storytelling & A New War on Cancer

More events

Regulations/Policy

Non-disclosure of developmental neurotoxicity studies obstructs the safety assessment of pesticides in the European Union. [see related article in The Guardian]

The Devil they Knew: Chemical Documents Analysis of Industry Influence on PFAS Science [see related blog by PRHE]

More EDC policy. Also see this new webpage from the Food Packaging Forum that lists proposed regulations open for comment.

Methods/Tools/Screening

Development of a data-driven approach to Adverse Outcome Pathway network generation: a case study on the EATS-modalities.

Toxicity Weighting for Human Biomonitoring Mixture Risk Assessment: A Proof of Concept.

Priorities and Challenges in Methodology for Human Health Risk Assessment from Combined Exposure to Multiple Chemicals.

Assessing CaMPARI as new approach methodology for evaluating neurotoxicity.

Screening strategy for 1210 exogenous chemicals in serum by two-dimensional liquid chromatography-mass spectrometry.

More tools and resources

Commentaries

Advances in chemical analysis of micro- and nanoplastics. [intro to a special issue in Analytical and Bioanalytical Chemistry]

Endocrine Disruptors and Child H\ealth: Food Contaminant Monitoring in the European Union.

Editorial: Developmental origin of diseases: a special focus on the parental contribution towards offspring’s adult health. [intro to a special issue in Frontiers in Endocrinology]

Why ideas of ‘planetary boundaries’ must uphold environmental justice.

Is the Environmental Risk of Metformin Underestimated?

Reviews

Numerous Chemicals/Mixtures

Environmental Pollution and the Risk of Developing Metabolic Disorders: Obesity and Diabetes.

Reproductive toxicity of combined effects of endocrine disruptors on human reproduction.

Sex, Nutrition, and NAFLD: Relevance of Environmental Pollution.

Effects of endocrine disrupting compounds on female fertility.

Male Germ Cell Telomeres and Chemical Pollutants.

Human hair as a noninvasive matrix to assess exposure to micro-organic contaminants: State of the art review.

Iodine Deficiency, Maternal Hypothyroxinemia and Endocrine Disrupters Affecting Fetal Brain Development: A Scoping Review.

Viable remediation techniques to cleansing wastewaters comprising endocrine-disrupting compounds.

BPA/Phenols

Potential effects of bisphenol A on diabetes mellitus and its chronic complications: A narrative review.

Estrogenic and non-estrogenic effects of bisphenol A and its action mechanism in the zebrafish model: An overview of the past two decades of work.

Recent Advances in Sources, Migration, Public Health, and Surveillance of Bisphenol A and Its Structural Analogs in Canned Foods.

Phthalates

Hypospadias, cryptorchidism, and breast cancer in children born to New Zealand servicemen who served in Malaya and may have had exposure to dibutyl phthalate: review of a previous study and updated review of international literature.

Perfluoroalkyl Substances

Public Health Evaluation of PFAS Exposures and Breastfeeding: A Systematic Literature Review.

A Review: Per- and Polyfluoroalkyl Substances-Biological Degradation.

Flame Retardants

Occurrence and Health Effects of Hexabromocyclododecane: An Updated Review.

Pesticides

Nanotechnology-based pesticides: Environmental fate and ecotoxicity.

Could pesticide exposure be implicated in the high incidence rates of depression, anxiety and suicide in farmers? A systematic review.

Metals/Metalloids

Systemic impact of heavy metals and their role in cancer development: a review.

Microplastics/Nanomaterials

Adverse health effects and mechanisms of microplastics on female reproductive system: a descriptive review.

Effects of microplastics on the toxicity of co-existing pollutants to fish: A meta-analysis.

A global synthesis of microplastic contamination in wild fish species: Challenges for conservation, implications for sustainability of wild fish stocks and future directions.

Interactions of human drug transporters with chemical additives present in plastics: Potential consequences for toxicokinetics and health.

Microplastic pollution in riverine ecosystems: threats posed on macroinvertebrates.

Microplastics in coastal and oceanic surface waters and their role as carriers of pollutants of emerging concern in marine organisms.

Microplastics and Antibiotic Resistance: The Magnitude of the Problem and the Emerging Role of Hospital Wastewater.

Air Pollution

Air Pollution: A Silent Key Driver of Dementia.

Human Health Studies

Numerous Chemicals/Mixtures

Challenges of studying the dietary exposure to chemical mixtures: Example of the association with mortality risk in the E3N French prospective cohort.

Association between environmental chemical exposure and albumin-to-creatinine ratio is modified by hypertension status in women of reproductive age.

Bisphenol and phthalate exposure during pregnancy and the development of childhood lung function and asthma. The generation R study.

BPA/Phenols

Prenatal bisphenol exposure and intelligence quotient in children at six years of age: A prospective cohort study.

Prenatal Exposure to Bisphenol A: Is There an Association between Bisphenol A in Second Trimester Amniotic Fluid and Fetal Growth?

Phthalates

Association between phthalate exposure and the risk of depressive symptoms in the adult population of the United States.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Association between Organochlorine Pesticides and Vitamin D in Female Subjects.

An Analysis of Reproductive Outcomes for Conceptions of Participants of the Air Force Health Study.

Prenatal exposure to persistent organic pollutants and molar-incisor hypomineralization among 12-year-old children in the French mother-child cohort PELAGIE.

Perfluoroalkyl Substances

Per- and Polyfluoroalkyl Substances (PFAS) Mixture during Pregnancy and Postpartum Weight Retention in the New Hampshire Birth Cohort Study (NHBCS).

Maternal Serum, Cord and Human Milk Levels of Per- and Polyfluoroalkyl Substances (PFAS), Association with Predictors and Effect on Newborn Anthropometry.

Associations between exposure to a mixture of perfluoroalkyl and polyfluoroalkyl substances and age at menarche in adolescent girls utilizing three statistical models.

Association between prenatal or early postnatal exposure to perfluoroalkyl substances and language development in 18 to 36-month-old children from the Odense Child Cohort.

Newborn metabolomic signatures of maternal per- and polyfluoroalkyl substance exposure and reduced length of gestation.

Association between perfluoroalkyl and polyfluoroalkyl substances exposure and fetal overgrowth: A prospective birth cohort study conducted in China.

Association of Early Pregnancy Perfluoroalkyl and Polyfluoroalkyl Substance Exposure With Birth Outcomes.

Association between perfluoroalkyl and polyfluoroalkyl internal exposure and serum α-Klotho levels in middle-old aged participants.

Perfluorooctanoic Acid (PFOA) Exposure and Abnormal Alanine Aminotransferase: Using Clinical Consensus Cutoffs Compared to Statistical Cutoffs for Abnormal Values.

Combined Effects of Multiple Per- and Polyfluoroalkyl Substances Exposure on Allostatic Load Using Bayesian Kernel Machine Regression.

Pesticides

Urinary neonicotinoid insecticides and adiposity measures among 7-year-old children in northern China: A cross-sectional study.

An Exploratory Study of the Metabolite Profiling from Pesticides Exposed Workers.

The determinants of thyroid function among vegetable farmers with primary exposure to chlorpyrifos: A cross-sectional study in Central Java, Indonesia.

Assessing farmer’s exposure to pesticides and the risk for non-communicable diseases: A biomonitoring study.

Metals/Metalloids

Prenatal metal levels and congenital anomalies of the kidney and urinary tract: The Japan Environment and Children’s Study.

Metal Homeostasis and Exposure in Distinct Phenotypic Subtypes of Insulin Resistance among Children with Obesity.

Associations between multiple urinary metals and the risk of hypertension in community-dwelling older adults.

The Relationship of Arsenic Exposure with Hypertension and Wide Pulse Pressure: Preliminary Evidence from Coal-Burning Arsenicosis Population in Southwest China.

Association and Interaction between Heavy Metals and Hyperuricemia in a Taiwanese Population.

Chronic Kidney Disease Induced by Cadmium and Diabetes: A Quantitative Case-Control Study.

Assessment of Cadmium (Cd) and Lead (Pb) Blood Concentration on the Risk of Endometrial Cancer.

Relationship between urinary biomarkers of early kidney damage and exposure to inorganic toxins in a pediatric population of Apizaco, Tlaxcala, Mexico.

Air Pollution

Risk of type 2 diabetes after diagnosed gestational diabetes is enhanced by exposure to PM2.5.

The association between chemical constituents of ambient fine particulate matter and obesity in adults: A large population-based cohort study.

The policy implemented by the government and the protection effect of PM2.5 decreasing on blood pressure in adolescents: From a quasi-experimental study.

Pharmaceuticals/Personal Care Products

Diminished ovarian reserve in adolescent cancer survivors treated with heavy metal chemotherapy.

Miscellaneous

Environmental melamine exposure and adverse kidney outcomes in patients with type 2 diabetes mellitus.

Association of polycyclic aromatic hydrocarbon internal exposure and urinary iodine concentration with thyroid volume in children.

Associations between prenatal exposure to polycyclic aromatic hydrocarbons and thyroid hormones in umbilical cord blood.

Residential proximity to petrol stations and risk of childhood leukemia.

Laboratory Studies

Numerous Chemicals/Mixtures

Multigenerational Effects of a Complex Human-Relevant Exposure during Folliculogenesis and Preimplantation Embryo Development: The FEDEXPO Study.

Loss of Nuclear/DNA Integrity in Mouse Epididymal Spermatozoa after Short-Term Exposure to Low Doses of Dibutyl Phthalate or Bisphenol AF and Its Mitigation by Oral Antioxidant Supplementation.

BPA/Phenols

Bisphenol A interferes with lncRNA Fhadlos2 and RUNX3 association in adolescent mouse ovary.

Bisphenol S Increases Cell Number and Stimulates Migration of Endometrial Epithelial Cells.

Global gene expression analysis reveals novel transcription factors associated with long-term low-level exposure of EA.hy926 human endothelial cells to bisphenol A.

Identification of aquatic ecological risk of bisphenol S in four Asian countries based on the SSD and alternative toxicity data of model species Danio rerio.

Bisphenol A-induced autophagy ameliorates human B cell death through Nrf2-mediated regulation of Atg7 and Beclin1 expression by Syk activation.

Phthalates

Distribution of Micro-Nano PS, DEHP, and/or MEHP in Mice and Nerve Cell Models In Vitro after Exposure to Micro-Nano PS and DEHP.

Mono-(2-ethylhexyl) Phthalate (MEHP)-Induced Telomere Structure and Function Disorder Mediates Cell Cycle Dysregulation and Apoptosis via c-Myc and Its Upstream Transcription Factors in a Mouse Spermatogonia-Derived (GC-1) Cell Line.

Prenatal DEHP Exposure Induces Premature Testicular Aging by Promoting Leydig Cell Senescence through the MAPK Signaling Pathways.

Migration of di(2-ethylhexyl) phthalate, diisononylcyclohexane-1,2-dicarboxylate and di(2-ethylhexyl) terephthalate from transfusion medical devices in labile blood products: A comparative study.

Parabens/Triclosan/Antimicrobials

Rhus tripartite methanolic extract alleviates propylparaben-induced reproductive toxicity via anti-inflammatory, antioxidant, 5-α reductase in male rats.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Connecting suborganismal data to bioenergetic processes: killifish embryos exposed to a dioxin-like compound.

The p,p’-DDE disturbs the M1 function without affecting the M2 phenotype nor unstimulated Bone Marrow-Derived Macrophages from BALB/c mice.

Resveratrol ameliorates ortho- polychlorinated biphenyls’ induced toxicity in ovary cells.

Perfluoroalkyl Substances

Environmental exposure and ecotoxicological properties of a new generation fluorosurfactant (cC6O4): A comparison with selected legacy perfluoroalkyl acids (PFAA).

Perfluorooctane sulfonate and perfluorooctanoic acid inhibit progesterone-responsive capacitation through cAMP/PKA signaling pathway and induce DNA damage in human sperm.

Category-Based Toxicokinetic Evaluations of Data-Poor Per- and Polyfluoroalkyl Substances (PFAS) using Gas Chromatography Coupled with Mass Spectrometry.

Immunotoxicity and Transcriptome Analyses of Zebrafish (Danio rerio) Embryos Exposed to 6:2 FTSA.

Mitochondrial dysfunction in metabolic disorders induced by per- and polyfluoroalkyl substance mixtures in zebrafish larvae.

PFOA exposure induces aberrant glucose and lipid metabolism in the rat liver through the AMPK/mTOR pathway.

Perfluoroalkyl Substances (PFAS) Affect Inflammation in Lung Cells and Tissues.

Per/polyfluoroalkyl substances modulate plasmid transfer of antibiotic resistance genes: A balance between oxidative stress and energy support.

Flame Retardants

Tris(1,3-dichloro-2-propyl) phosphate causes female-biased growth inhibition in zebrafish: Linked with gut microbiota dysbiosis.

Disruption of neurosteroid synthesis and release by tris(2,3-dibromopropyl)isocyanurate in primary mouse cortical astrocytes in vitro.

Pesticides

Ultrastructural Evaluation of Mouse Oocytes Exposed In Vitro to Different Concentrations of the Fungicide Mancozeb.

Immunotoxicity of relevant mixtures of pesticides and metabolites on THP-1 cells

MicroRNA‑30a‑5p regulates cypermethrin-induced apoptosis of Sertoli cells by targeting KLF9 in vitro.

The health risk of acetochlor metabolite CMEPA is associated with lipid accumulation induced liver injury.

Neurotoxic effects of exposure to glyphosate in rat striatum: Effects and mechanisms of action on dopaminergic neurotransmission.

Exposure to the fungicide prothioconazole and its metabolite prothioconazole-desthio induced hepatic metabolism disorder and oxidative stress in mice.

Gut microbiota composition and gene expression changes induced in the Apis cerana exposed to acetamiprid and difenoconazole at environmentally realistic concentrations alone or combined.

Solitary bee behaviour and pollination service delivery is differentially impacted by neonicotinoid and pyrethroid insecticides.

Metals/Metalloids

Long-term Effects of Prenatal Arsenic Exposure from Gestational Day 9 to Birth on Lung, Heart, and Immune Outcomes in the C57BL/6 Mouse Model.

Disturbance of gut microbiota aggravates cadmium-induced neurotoxicity in zebrafish larvae through V-ATPase.

Microplastics/Nanomaterials

Additive effects of microplastics on accumulation and toxicity of cadmium in male zebrafish.

Toxicity and Biodistribution of Fragmented Polypropylene Microplastics in ICR Mice.

Combined exposure to polystyrene nanoplastics and bisphenol A induces hepato- and intestinal-toxicity and disturbs gut microbiota in channel catfish (Ictalurus punctatus).

Combined exposure to microplastics and amitriptyline caused intestinal damage, oxidative stress and gut microbiota dysbiosis in zebrafish (Danio rerio).

Alleviation of neurotoxicity induced by polystyrene nanoplastics by increased exocytosis from neurons.

Dietary polystyrene nanoplastics exposure alters hepatic glycolipid metabolism, triggering inflammatory responses and apoptosis in Monopterus albus.

The internal dose makes the poison: higher internalization of polystyrene particles induce increased perturbation of macrophages.

Polystyrene nanoplastics decrease nutrient accumulation, disturb sex hormones, and inhibit reproductive development in juvenile Macrobrachium nipponense.

Pharmaceuticals/Personal Care Products

Reduced Survival and Disruption of Female Reproductive Output in Two Copepod Species (Acartia clausi and A. tonsa) Exposed to the Model Endocrine Disruptor 17α-Ethinylestradiol.

Miscellaneous

Prenatal exposure to benzo[a]pyrene depletes ovarian reserve and masculinizes embryonic ovarian germ cell transcriptome transgenerationally.

Dietary crude oil exposure during sex differentiation skewed adult sex ratio towards males in the zebrafish.

Exposure/Environment Studies

Numerous Chemicals/Mixtures

The transfer of environmental contaminants (Brominated and Chlorinated dioxins and biphenyls, PBDEs, HBCDDs, PCNs and PFAS) from recycled materials used for bedding to the eggs and tissues of chickens.

Perfluoroalkyl Substances and POPs

Persistent organic pollutants (POPs) and per- and polyfluoroalkyl substances (PFASs) in liver from wild and farmed tilapia (Oreochromis niloticus) from Lake Kariba, Zambia: Levels and geographic trends and considerations in relation to environmental quality standards (EQSs).

Unknown Organofluorine Mixtures in U.S. Adult Serum: Contribution from Pharmaceuticals?

Watershed scale PFAS fate and transport model for source identification and management implications.

PFAS surveillance in abiotic matrices within vital aquatic habitats throughout Florida.

Forever legacies? Profiling historical PFAS contamination and current influence on groundwater used for drinking water.

Community-facing toxicokineticmodels to estimate PFAS serum levels based on life history and drinking water exposures.

Estimation of per- and poly-fluoroalkyl substances mass loads in the Danube River using passive sampling.

Comparison of eco-improvement on constructed wetlands with nano zero valent iron introduction under different levels of PFOA stress: Perspectives on plant, microbe, and PFOA removal.

Flame Retardants

Higher ecological risks and lower bioremediation potentials identified for emerging OPEs than legacy PCBs in the Beibu Gulf, China.

Feed as a source of polybrominated diphenyl ethers (PBDEs).

Pesticides

Anticoagulant rodenticides are associated with increased stress and reduced body condition of avian scavengers in the Pacific Northwest.

Metals/Metalloids

The importance of monitoring endocrine-disrupting chemicals and essential elements in biological samples of fertilizer industry workers.

Microplastics/Nanomaterials

Effects of agricultural land types on microplastic abundance: A nationwide meta-analysis in China.

Miscellaneous

Risk characterization of human exposure to polycyclic aromatic hydrocarbons in vulnerable groups.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. The searchable archives are at https://groups.google.com/d/forum/edc_research or online at https://heeds.org/category/edc-science-weekly/. Feel free to forward this email. Compiled by Sarah Howard of Healthy Environment and Endocrine Disruptor Strategies (HEEDS), a program of Environmental Health Sciences.

If you enjoy this newsletter, please feel free to donate here! Thank you!

EHN EHN

Webinar: Impacts of PFAS on the immune system
by Sarah Howard on October 2, 2024 at 3:36 pm
In this Oct. 10 webinar, Professor Grandjean will present his work on the impacts of per- and polyfluoroalkyl substances (PFAS) on vaccine responses, and the implications for immunity against infectious diseases. Sponsored by Europe's Health and Environment Alliance (HEAL).
Webinar: Male autism spectrum disorder & prenatal BPA exposure
by Sarah Howard on September 25, 2024 at 9:37 pm
This Oct. 17 webinar features Dr. Anne-Louise Ponsonby discussing a study that found higher prenatal BPA levels are associated with increased autism spectrum disorder symptoms (ASD) at age 2 and an ASD diagnosis by age 9 in males with low aromatase genetic pathway activity scores. Sponsored by the EDC Strategies Partnership.
Swiss symposium on endocrine disrupting chemicals
by Sarah Howard on September 20, 2024 at 6:34 pm
On Oct. 28, the Food Packaging Forum is co-hosting a symposium on endocrine disrupting chemicals with a leading research university. Speakers include Drs. Pete Myers and Jerry Heindel of Environmental Health Sciences.

EHN EHN

PFAS may impact immune response to vaccines, studies suggest
by Katherine McMahon,Sarah Howard on October 4, 2024 at 10:14 pm
A recent study published in Environmental Research found that adults with higher exposure to PFAS developed fewer antibodies after receiving their third COVID-19 booster. “While factors such as age, sex, and underlying health conditions have been studied extensively, research on the potential impact of environmental factors, such as PFAS exposure, on the SARS-CoV-2 mRNA vaccine response remain limited.”
Organic foods may help lower the risk of metabolic diseases like obesity and diabetes
by Katherine McMahon,Sarah Howard on October 2, 2024 at 11:26 pm
A new review published in the European Journal of Clinical Nutrition examines the health benefits of a diet rich in organically grown food compared to conventionally farmed products. “The lower concentration of pesticide residues and heavy metals is one of the most important advantages of organic food.”
High levels of endocrine disrupting chemicals found in breast milk across China
by Katherine McMahon,Sarah Howard on September 27, 2024 at 4:47 pm
A recent study published in Environment International examined concentrations of endocrine disrupting chemicals (EDCs) in the breast milk of new moms from 20 Chinese cities. “It is worth noting that breastfeeding has a lot of proven benefits, and the study findings reported here are only one of the factors worth considering when mothers decide to breastfeed their children.”

EHN EHN

Water utilities oppose EPA’s PFAS limits, slowing clean water progress
by EHN Curators on October 4, 2024 at 11:02 am
Several U.S. water utilities, represented by trade groups, are legally challenging new U.S. Environmental Protection Agency rules to limit toxic PFAS, echoing decades of industry resistance to clean water regulations. Tom Perkins reports for The Guardian.
A marine biologist calls for urgent global action on plastic pollution
by EHN Curators on October 4, 2024 at 10:53 am
Richard Thompson, who first identified microplastics, warns that without international agreement on a global treaty, plastic pollution could triple by 2060. Richard Schiffman reports for Yale Environment 360.
B. Braun’s Stephanie Pitts on California’s new toxic chemical ban
by EHN Curators on October 1, 2024 at 1:19 pm
California has passed a law banning the use of a toxic chemical produced by certain kinds of plastics from the state’s medical devices. Medical Device Network meets with B. Braun’s senior director of healthcare strategy to understand why California is first to ban DHEP.