EDC Science Weekly, May 12-18, 2023 – HEEDS

EDC Science Weekly, May 12-18, 2023

Post author:HEEDS
Post published:May 18, 2023
Post category:EDC Science Weekly

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Events, Methods/Tools/Screening, Commentaries, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Events

Webinar May 23: Industry Influence and Scientists: Protecting Scientific Integrity [CHE]

Webinar June 8: The Chemical Footprint of a Plastic Bottle [CHE]

Webinar June 13: CHE Café: Science, Storytelling & A New War on Cancer

Methods/Tools/Screening

Plasma Protein Binding Evaluations of Per- and Polyfluoroalkyl Substances for Category-Based Toxicokinetic Assessment.

Development of fish liver PLHC-1 spheroids and its applicability to investigate the toxicity of plastic additives.

Evaluating the food safety and risk assessment evidence-base of polyethylene terephthalate oligomers: Protocol for a systematic evidence map

ChemMaps.com v2.0: exploring the environmental chemical universe.

Development of a reference and proficiency chemical list for human steatosis endpoints in vitro.

In Vitro Approaches to Determine the Potential Carcinogenic Risk of Environmental Pollutants.

A pesticide and iPSC dopaminergic neuron screen identifies and classifies Parkinson-relevant pesticides.

Commentaries

Special Issue “Molecular Mechanisms of Bisphenol A Toxicity and Effects of Environmental Levels on Health”. [Intro to a special issue in the International Journal of Molecular Sciences]

Risk Assessment of Nanomaterials Toxicity. [Intro to a special issue in Nanomaterials]

Complex chemical mixtures: Approaches for assessing adverse human health effects

Reviews

Numerous Chemicals/Mixtures

Dietary exposure to endocrine disruptors in gut microbiota: A systematic review.

Endocrine Disruptors in Food, Estrobolome and Breast Cancer.

The association between polycystic ovary syndrome and environmental pollutants based on animal and human study; a systematic review.

Endocrine Disruptor-Induced Bone Damage Due to Hormone Dysregulation: A Review.

Water a major source of endocrine-disrupting chemicals: An overview on the occurrence, implications on human health and bioremediation strategies.

Developmental origins of diabetes mellitus: Environmental epigenomics and emerging patterns.

BPA/Phenols

The State of Research and Weight of Evidence on the Epigenetic Effects of Bisphenol A.

New Evidence on BPA’s Role in Adipose Tissue Development of Proinflammatory Processes and Its Relationship with Obesity.

A systematic review of biocompatibility and safety of orthodontic clear aligners and transparent vacuum-formed thermoplastic retainers: Bisphenol-A release, adverse effects, cytotoxicity, and estrogenic effects.

Estrogenic and non-estrogenic effects of Bisphenol A and its action mechanism in the zebrafish model: An overview of the past two decades of work

Phthalates

Phthalate esters: occurrence, toxicity, bioremediation, and advanced oxidation processes.

Cumulative Exposure to Phthalates and Their Alternatives and Associated Female Reproductive Health: Body Burdens, Adverse Outcomes, and Underlying Mechanisms.

Perfluoroalkyl Substances

PFAS contaminated asphalt and concrete – Knowledge gaps for future research and management.

Perfluoroalkyl and polyfluoroalkyl substances and hypertensive disorders of pregnancy: A systematic review and meta-analysis.

Evaluation of the research trends on perfluorinated compounds using bibliometric analysis: knowledge gap and future perspectives.

An overview on human exposure, toxicity, solid-phase microextraction and adsorptive removal of perfluoroalkyl carboxylic acids (PFCAs) from water matrices.

A systematic review on distribution, sources and sorption of perfluoroalkyl acids (PFAAs) in soil and their plant uptake.

Pesticides

Occupational Exposures and Risks of Non-Hodgkin Lymphoma: A Meta-Analysis.

Human exposure to pesticides and thyroid cancer: a worldwide systematic review of the literatures.

Metals/Metalloids

Cadmium, Lead, Chronic Physiological Stress and Endometrial Cancer: How Environmental Policy Can Alter the Exposure of At-Risk Women in the United States.

Current Levels of Environmental Exposure to Cadmium in Industrialized Countries as a Risk Factor for Kidney Damage in the General Population: A Comprehensive Review of Available Data.

Microplastics/Nanomaterials

Critical gaps in nanoplastics research and their connection to risk assessment.

Microplastics as vectors of organic pollutants in aquatic environment: A review on mechanisms, numerical models, and influencing factors.

Role of soil microplastic pollution in climate change.

Microplastics as vectors of chemical contaminants and biological agents in freshwater ecosystems: Current knowledge status and future perspectives.

Dysregulation along the gut microbiota-immune system axis after oral exposure to titanium dioxide nanoparticles: A possible environmental factor promoting obesity-related metabolic disorders

Air Pollution

Ambient air pollution and infant health: a narrative review.

Air Pollution and Perinatal Mental Health: A Comprehensive Overview.

Miscellaneous

Natural and Natural-Based Polymers: Recent Developments in Management of Emerging Pollutants.

Human Health Studies

Numerous Chemicals/Mixtures

Transportation-Related Environmental Mixtures and Diabetes Prevalence and Control in Urban/Metropolitan Counties in the United States

BPA/Phenols

Bisphenol A substitutes and childhood obesity at 7 years: a cross-sectional study in Shandong, China.

Phthalates

Phthalates and phthalate metabolites in urine from Tianjin and implications for platelet mitochondrial DNA methylation.

The role of angiotensin I-converting enzyme gene polymorphism and global DNA methylation in the negative associations between urine di-(2-ethylhexyl) phthalate metabolites and serum adiponectin in a young Taiwanese population.

Perfluoroalkyl Substances

Prenatal exposure to legacy PFAS and neurodevelopment in preschool-aged Canadian children: The MIREC cohort.

Associations of prenatal exposure to per- and polyfluoroalkyl substances (PFAS) with measures of cognition in 7.5-month-old infants: An exploratory study.

Prenatal exposure to per- and polyfluoroalkyl substances and pregnancy outcome in Austria.

Impact of exposure to per- and polyfluoroalkyl substances on fecal microbiota composition in mother-infant dyads

Association between PFAS congeners exposure and asthma among US children in a nationally representative sample.

Pesticides

Genome-wide analysis of sex-specific differences in the mother-child PELAGIE cohort exposed to organophosphate metabolites.

Metals/Metalloids

Neurocognitive Analysis of Low-level Arsenic Exposure and Executive Function Mediated by Brain Anomalies Among Children, Adolescents, and Young Adults in India.

Metal mixture exposures and multiplexed autoantibody screening in Navajo communities exposed to uranium mine wastes.

Associations of exposure to blood and urinary heavy metal mixtures with psoriasis risk among U.S. adults: A cross-sectional study.

Association between urinary metal concentrations and abnormal estimated glomerular filtration rate in Chinese community-dwelling elderly: Exploring the mediating effect of triglycerides.

Do blood metals influence lipid profiles? Findings of a cross-sectional population-based survey.

Evaluation of School-Age Children’s Intelligence Quotient and Their Chronic Exposure to Trace Elements in Ambient Air.

Association between prenatal exposure to trace elements mixture and visual acuity in infants: A prospective birth cohort study.

Air Pollution

Long-Term Exposure to Ambient Air Pollution and Mortality among Four Million COVID-19 Cases in Italy: The EpiCovAir Study.

Mediation of metabolic syndrome in the association between long-term co-exposure to road traffic noise, air pollution and incident type 2 diabetes.

Long-term exposure to ultrafine particles and natural and cause-specific mortality.

Modeling spatially varying compliance effects of PM_2.5 exposure reductions on gestational diabetes mellitus in southern California: Results from electronic health record data of a large pregnancy cohort.

Acute effects of air pollution on type II diabetes mellitus hospitalization in Lanzhou, China.

Ambient air pollution and emergency department visits and hospitalisation for cardiac arrest: a population-based case-crossover study in Reykjavik, Iceland.

Environmental exposure to industrial air pollution is associated with decreased male fertility.

Miscellaneous

Risk of Parkinson Disease Among Service Members at Marine Corps Base Camp Lejeune. [see related The Water, the Air, the Marines-Camp Lejeune, Trichloroethylene, and Parkinson Disease.]

Laboratory Studies

BPA/Phenols

Cumulative and potential synergistic effects of seven different bisphenols on human granulosa cells in vitro

Genetic background in the rat affects endocrine and metabolic outcomes of Bisphenol F exposure.

Effects of bisphenol F, bisphenol S, and bisphenol AF on cultured human osteoblasts.

Phthalates

Maternal exposure to dibutyl phthalate regulates MSH6 crotonylation to impair homologous recombination in fetal oocytes.

Regulation of the cell cycle and P13K/AKT/mTOR signaling pathway by phthalates in normal human breast cells.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Breast cancer progression and kynurenine pathway enzymes are induced by hexachlorobenzene exposure in a Her2-positive model.

BPDE exposure promotes trophoblast cell pyroptosis and induces miscarriage by up-regulating lnc-HZ14/ZBP1/NLRP3 axis.

TCDD dysregulation of lncRNA expression, liver zonation and intercellular communication across the liver lobule.

Perfluoroalkyl Substances

Unraveling the mechanisms of perfluorooctanesulfonic acid-induced dopaminergic neurotoxicity and microglial activation in developing zebrafish.

Perfluorooctanoic acid (PFOA) and hexafluoropropylene oxide-dimer acid (GenX): Hepatic stress and bile acid metabolism with different pathways.

Per- and Polyfluoroalkyl Substances (PFAS) in mixtures show additive effects on transcriptomic points of departure in human liver spheroids.

Pesticides

Pyrethroid-based insecticides exert transgenerational, persistent, and chronic effects in Caenorhabditis elegans.

Low-dose glyphosate exposure alters gut microbiota composition and modulates gut homeostasis.

Triazophos-induced Respiratory and Behavioral Effects and Development of Adverse Outcome Pathway (AOP) for short-term Exposed Freshwater Snail, Bellamya Bengalensis.

Behavioral, biochemical, and endocrine responses of zebrafish to 30-min exposure with environmentally relevant concentrations of imidacloprid-based insecticide.

The Pesticide Chlordecone Promotes Parkinsonism-like Neurodegeneration with Tau Lesions in Midbrain Cultures and C. elegans Worms.

Low Level Mancozeb Exposure Causes Copper Bioaccumulation in the Renal Cortex of Rats Leading to Tubular Injury.

Developmental defects induced by thiabendazole are mediated via apoptosis, oxidative stress and alteration in PI3K/Akt and MAPK pathways in zebrafish.

Steatosis and Metabolic Disorders Associated with Synergistic Activation of the CAR/RXR Heterodimer by Pesticides.

Metals/Metalloids

Paternal genetic effects of cadmium exposure during pregnancy on hormone synthesis disorders in ovarian granulosa cells of offspring.

Hepatoprotective and Neuroprotective Effects of Naringenin against Lead-Induced Oxidative Stress, Inflammation, and Apoptosis in Rats.

Microplastics/Nanomaterials

Hematological Consequences of Polyethylene Microplastics Toxicity in Male Rats: Oxidative stress, Genetic, and Epigenetic links.

The combined toxic effects of polystyrene microplastics and different forms of arsenic on the zebrafish embryos (Danio rerio).

Air Pollution

PPARγ As a Potential Target for Adipogenesis Induced by Fine Particulate Matter in 3T3-L1 Preadipocytes.

Miscellaneous

6PPD and its metabolite 6PPDQ induce different developmental toxicities and phenotypes in embryonic zebrafish.

Chemical toxicity screening of tire particle leachates from vehicles and their effects on organisms across three trophic levels.

Exposure/Environment Studies

Numerous Chemicals/Mixtures

Environmental impact of endocrine-disrupting chemicals and heavy metals in biological samples of petrochemical industry workers with perspective management.

A robust multi-residue method for the monitoring of 25 endocrine disruptors at ultra-trace levels in surface waters by SPE-LC-MS/MS.

BPA/Phenols

Dermal exposure to bisphenols in pregnant women’s and baby clothes: Risk characterization.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Organochlorine Pollutants in Human Breast Milk from North of the Far Eastern Region of Russia.

Safety Evaluation and Probabilistic Health Risk Assessment of Cow Milk Produced in Northern Italy According to Dioxins and PCBs Contamination Levels.

Perfluoroalkyl Substances

Health Risk Exposure Assessment of Migration of Perfluorooctane Sulfonate and Perfluorooctanoic Acid from Paper and Cardboard in Contact with Food under Temperature Variations.

Sociodemographic Factors Are Associated with the Abundance of PFAS Sources and Detection in U.S. Community Water Systems.

Self-Collection Blood Test for PFASs: Comparing Volumetric Microsamplers with a Traditional Serum Approach.

Centurial Persistence of Forever Chemicals at Military Fire Training Sites.

Perfluorooctanoic acid in the sediment matrices of Arctic fjords, Svalbard.

Forever no more: Complete mineralization of per- and polyfluoroalkyl substances (PFAS) using an optimized UV/sulfite/iodide system.

Per- and polyfluoroalkyl substances (PFASs) in water and sediment from a temperate watershed in China: Occurrence, sources, and ecological risks.

Per- and polyfluorinated alkyl substances (PFAS) in Pennsylvania surface waters: A statewide assessment, associated sources, and land-use relations.

Lithium-ion battery recycling: a source of per- and polyfluoroalkyl substances (PFAS) to the environment?

Flame Retardants

Levels and profiles of pentabromodiphenyl ether contaminants in human breast milk from Riyadh, Saudi Arabia.

Pesticides

Pesticide Exposure among Latinx Children in Rural Farmworker and Urban Non-Farmworker Communities: Associations with Locality and Season.

Farmland practices are driving bird population decline across Europe.

Occurrence and environmental risk assessment of 22 pesticides in Brazilian freshwaters.

Statement of the Scientific Panel on Plant Protection Products and their Residues (PPR Panel) on the design and conduct of groundwater monitoring studies supporting groundwater exposure assessments of pesticides.

Metals/Metalloids

Behavioral determinants of arsenic-safe water use among Great Plains Indian Nation private well users: results from the Community-Led Strong Heart Water Study Arsenic Mitigation Program.

Volatile organic compounds and metals/metalloids exposure in children after e-waste control: Implications for priority control pollutants and exposure mitigation measures.

Pharmaceuticals/Personal Care Products

Knowledge and attitude about drug pollution in pharmacy students: A questionnaire-based cross sectional study.

Miscellaneous

Occurrence and risk assessment of PAHs from athletic fields under typical rainfall events.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me and ask to join the EDC Science Weekly group EDC_re…@googlegroups.com. The searchable archives are at https://groups.google.com/d/forum/edc_research or online at https://heeds.org/category/edc-science-weekly/. Compiled by Sarah Howard of Healthy Environment and Endocrine Disruptor Strategies (HEEDS), a program of Environmental Health Sciences.

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EHN EHN

Endocrine-disrupting chemicals: hazards and opportunities (ECHO) course
by Sarah Howard on October 31, 2024 at 2:50 pm
This course focuses on the chemical, biological, and societal challenges of endocrine-disrupting chemicals (EDCs) and new opportunities for moving forward. ECHO is a two-week intensive bootcamp-style career development course for graduate students, postdoctoral fellows, and professionals in the field. It is held at Woods Hole, Massachusetts.
Lou Guillette Jr. Memorial Symposium
by Sarah Howard on October 22, 2024 at 1:30 pm
On March 14-15, 2025, HEEDS is hosting the Lou Guillette Jr. Memorial Symposium on endocrine disrupting science at the University of Florida. It will celebrate the life and legacy of Dr. Guillette, gather together his trainees and colleagues, and focus on the research topics that Lou made famous. Information here.
Webinar: The overturning of Chevron deference: impacts on environmental health decision making
by Sarah Howard on October 17, 2024 at 4:21 pm
In this Nov. 13 webinar, legal experts will discuss the implications of the overturning of Chevron deference and its profound impact on science, public health and decision-making. Sponsored by CHE and UCSF's EaRTH Center.

EHN EHN

Ultra-processed foods and plastic packaging make for the ultimate toxic pair, scientists say
by Katherine McMahon,Sarah Howard on October 25, 2024 at 10:37 am
A recent paper published in Globalization and Health explores the relationship between ultra-processed foods (UPFs), plastic packaging, and their combined threat to public health. “Consumers do not have the power to solve a problem of this scale, and thus it is the responsibility of policymakers to ensure that transitions away from unhealthy, unsustainable foods are accompanied by structural measures that support demand and access to healthy foods.”
Microplastic exposure linked to reduced sperm quality in humans
by Katherine McMahon,Sarah Howard on October 23, 2024 at 4:29 pm
Exposure to microplastics is associated with a decrease in sperm concentration, motility, and shape, according to a new study published in The Lancet. “The identification of non-stick pan coating material PTFE as a particularly hazardous microplastic for male fertility underscores the importance of targeted interventions to reduce exposure to this and similar substances.”
Exposure to PFAS in ski wax may be linked to high cholesterol
by Katherine McMahon,Sarah Howard on October 16, 2024 at 7:42 pm
According to a new study published in Environmental Research, skiers and snowboarders may face health risks from their exposure to PFAS via ski wax, which can contain up to 100% PFAS by mass. “Interventions to remove PFAS from fluorinated wax could decrease direct exposure to skiers and reduce PFAS release into the environment.”

EHN EHN

Stricter toxic chemical rules reduce Californians’ exposures
by Kristina Marusic on October 31, 2024 at 11:25 am
Californians have lower levels of toxic chemicals linked to cancer, birth defects and reproductive harm in their bodies than people in the rest of the country, according to a new study. The study, published in Environmental Health Perspectives and conducted by researchers at Silent Spring Institute, a nonprofit scientific research organization, and the University of California at Berkeley (UC Berkeley), looked at nationwide data on the levels of 37 toxic chemicals in people’s blood before and after California introduced its stringent regulations. It found that for 18 of these chemicals, Californians have lower levels in their bodies than the rest of the country.
EPA dismissed data on the neurotoxicity of common insecticides
by Katherine McMahon,Sarah Howard on October 30, 2024 at 5:56 pm
A recent paper in Frontiers in Toxicology examined research submitted by industry to the U.S. Environmental Protection Agency (EPA) on the neurotoxicity of neonicotinoids - the most widely used class of insecticides in the U.S. and worldwide - and found that the data was evaluated improperly by the agency. Why this matters: Neonicotinoids are widely used not only for commercial agriculture but also for more personal uses like home gardens and in some flea and tick treatments for pets. Humans are regularly exposed to neonicotinoids – which are structurally similar to nicotine – through the environment, food and water. Neonicotinoids’ popularity partly comes from the belief that their harmful effects are mostly limited to insects, but studies like this one demonstrate that mammals may also be harmed by the chemicals, and highlight the urgent need for stronger regulations around their use.
Pesticide regulations ignore critical threats to insect health and ecosystems
by EHN Curators on October 30, 2024 at 10:26 am
In a study revealing regulatory gaps, researchers found that pesticides impact insect behavior and survival at non-lethal doses, especially in warmer temperatures, calling into question the effectiveness of current pesticide safety protocols. Dave Goulson writes for The Conversation.